The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination
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Significance: People with multiple sclerosis have a microbiota distinct from healthy controls, and there is growing interest in how these differences might contribute to the onset and progression of CNS autoimmunity. However, the impact that the microbiota may also have on the endogenous regeneration of myelin—remyelination—has not yet been explored. Here we show that inflammatory responses during remyelination depend upon the microbiota, being modulated by antibiotics or probiotics or in germ-free mice. In contrast, these interventions had minimal impact on the activity of oligodendrocyte progenitor cells, with only supratherapeutic doses of antibiotics having an inhibitory effect. Our results suggest that endogenous CNS remyelination is largely resilient to interventions that modify the microbiota.
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OPC differentiation and extent of remyelination are unaltered in cuprizone-treated GF mice compared with their SPF counterparts.
“However, the OPC differentiation and extent of remyelination were unaltered in cuprizone-treated GF mice when compared to their SPF counterparts.269”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [269]
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Duncan, I. D., & Watters, J. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918897116 · Cited by 11 · see citing works
The Impact of IgA and the Microbiota on CNS Disease
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- Authors
- McMurran, C. E., Guzman de la Fuente, A., Penalva, R., Ben Menachem-Zidon, O., Dombrowski, Y., Falconer, J., Gonzalez, G. A., Zhao, C., Krause, F. N., Young, A. M. H., Griffin, J. L., Jones, C. A., Hollins, C., Heimesaat, M. M., Fitzgerald, D. C., & Franklin, R. J. M.
- Affiliations
- Wellcome/MRC Cambridge Stem Cell Institute (GB)
- Wellcome–MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom;
- Wellcome–Wolfson Institute for Experimental Medicine, Queen’s University Belfast, BT9 7BL Belfast, United Kingdom;
- Queen's University Belfast (GB)
- University of Cambridge (GB)
- Respiratory, Inflammation and Autoimmunity Research, MedImmune Ltd., CB21 6GH Cambridge, United Kingdom;
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Fitzgerald, Denise C.
- Franklin, Robin J. M.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2019-11-18
- Volume
- 116
- Issue
- 50
- Pages
- 25311-25321
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6911206
- OpenAlex
- W2991319492
- Cited by
- 39
- References
- 65
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 1
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Funders
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- European Committee for Treatment and Research in Multiple Sclerosis
- Wellcome Trust (110138/Z/15/Z)
- Leverhulme Trust
- Multiple Sclerosis Society
- Rosetrees Trust
- Jean Shanks Foundation
- BIRAX
- Directorate for Biological Sciences
- Medical Research Council (MR/P01836X/1, MC_PC_12009, MC_PC_13030, MR/P011705/1)
- Biotechnology and Biological Sciences Research Council (BB/J01026X/1, BB/N003721/1)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- gut microbiota, central nervous system demyelination, remyelination, multiple sclerosis, antibiotic therapy, probiotics, germ-free mice, oligodendrocyte precursor cells, neuroinflammation, oral microbiota
- MeSH terms
- Gastrointestinal Microbiome, Remyelination, Animals, Anti-Bacterial Agents, Cell Differentiation, Central Nervous System, Female, Humans, Male, Mice, Inbred C57BL, Multiple Sclerosis, Oligodendroglia, Stem Cells, Probiotics, Mice
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