Relationship between apathy and diffusion tensor imaging metrics of the brain in Alzheimer's disease
Abstract
OBJECTIVE: Alzheimer's disease (AD) research has largely concentrated on the study of cognitive decline, but the associated behavioral and neuropsychiatric symptoms are of equal importance in the clinical profile of the disease. Apathy is the most common neuropsychiatric manifestation in AD. Clinical, multimodal neuroimaging studies and pathologic studies of apathy in AD have suggested an association with frontal dysfunction but without a definitive localization. In this study, we examined the association between apathy and white matter integrity using diffusion tensor imaging (DTI). METHODS: Twenty-one AD patients underwent DTI and neuropsychiatric and cognitive assessments. All fractional anisotropy (FA) maps were normalized to the standard space, and the association between the apathy scale and DTI metrics were evaluated voxel basically. RESULTS: Statistical parametric mapping analysis showed that there were statistically negative correlations between the apathy scale and FA values in the right anterior cingulate, right thalamus, and bilateral parietal regions using age, Mini-Mental State Examination score and sex as nuisance variables. CONCLUSIONS: Apathy in AD is associated with impaired white matter integrity in the anterior cingulate and medial thalamus. These results reinforce the confluence of evidence from other investigational modalities in implicating limbic dysfunction and related neuronal circuits in the neurobiology of apathy in AD.
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Apathy in Alzheimer's disease is associated with decreased anterior cingulate cortex white matter integrity by diffusion tensor imaging.
“Similarly apathy is associated with decreased perfusion in ACC (Benoit et al., 2004; Lanctôt et al., 2007; Robert et al., 2006), decreased ACC white matter integrity by DTI (Hahn et al., 2013; Kim et al., 2011; Ota et al., 2012) and increased amyloid burden in right ACC (Mori et al., 2014).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Ota et al., 2012
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- Authors
- Ota, M., Sato, N., Nakata, Y., Arima, K., & Uno, M.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Corresponding author
- Ota, Miho
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2011-08-24
- Volume
- 27
- Issue
- 7
- Pages
- 722-726
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W1570035252
- Cited by
- 58
- References
- 34
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 4 · 2013: 7
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- apathy, Alzheimer's disease, neuropsychiatric symptoms, white matter integrity, fractional anisotropy, anterior cingulate cortex, thalamus, parietal cortex, diffusion tensor imaging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Middle Aged, Brief Psychiatric Rating Scale, Anisotropy, Diffusion Tensor Imaging, Apathy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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