Linking GABA and glutamate levels to cognitive skill acquisition during development
Open accessAbstract
Developmental adjustments in the balance of excitation and inhibition are thought to constrain the plasticity of sensory areas of the cortex. It is unknown however, how changes in excitatory or inhibitory neurochemical expression (glutamate, γ‐aminobutyric acid (GABA)) contribute to skill acquisition during development. Here we used single‐voxel proton magnetic resonance spectroscopy (1 H‐MRS) to reveal how differences in cortical glutamate vs. GABA ratios relate to face proficiency and working memory abilities in children and adults. We show that higher glutamate levels in the inferior frontal gyrus correlated positively with face processing proficiency in the children, but not the adults, an effect which was independent of age‐dependent differences in underlying cortical gray matter. Moreover, we found that glutamate/GABA levels and gray matter volume are dissociated at the different maturational stages. These findings suggest that increased excitation during development is linked to neuroplasticity and the acquisition of new cognitive skills. They also offer a new, neurochemical approach to investigating the relationship between cognitive performance and brain development across the lifespan.Hum Brain Mapp 36:4334–4345, 2015. ©2015 The Authors. Human Brain Mapping Published byWiley Periodicals, Inc.
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A higher excitation/inhibition ratio during development is linked to neuroplasticity and the acquisition of new cognitive skills.
“This contrasts with another study showing that a higher excitation/inhibition ratio during development is linked to neuroplasticity and the acquisition of new cognitive skills (Cohen Kadosh et al., 2015).”
From Vasopressin regulates social play behavior in sex-specific ways through glutamate modulation in the lateral septum (2025) · cites this paper as Cohen Kadosh et al., 2015
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- Authors
- Cohen Kadosh, K., Krause, B., King, A. J., Near, J., & Cohen Kadosh, R.
- Affiliations
- Department of Experimental Psychology University of Oxford Oxford United Kingdom
- University of Oxford (GB)
- McGill University (CA)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2015-09-09
- Volume
- 36
- Issue
- 11
- Pages
- 4334-4345
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC4832309
- OpenAlex
- W2144374538
- Cited by
- 64
- References
- 84
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 1
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Human Brain Mapping (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- Wellcome Trust (076508, 338065, 0883781)
- Deutscher Akademischer Austauschdienst
- Studienstiftung des Deutschen Volkes
- Economic and Social Research Council
- Jesus College, University of Cambridge
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- glutamate, GABA, glutamate/GABA ratio, excitation-inhibition balance, cognitive skill acquisition, brain development, face processing, working memory, inferior frontal gyrus, gray matter volume, neuroplasticity, children and adults, 1H NMR
- MeSH terms
- Facial Recognition, Adult, Child, Child Development, gamma-Aminobutyric Acid, Humans, Learning, Memory, Short-Term, Neuronal Plasticity, Prefrontal Cortex, Glutamic Acid, Young Adult, Gray Matter, Proton Magnetic Resonance Spectroscopy
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