Cited by 211Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network

Open access
Kapogiannis, Dimitrios, Reiter, David A., Willette, Auriel A., Mattson, Mark P.·2013·NeuroImage

Abstract

The balance between excitatory glutamatergic projection neurons and inhibitory GABAergic interneurons determines the function of cortical microcircuits. How these neurotransmitters relate to the functional status of an entire macro-scale network remains unknown. The posteromedial cortex (PMC) is the default mode network (DMN) node with the greatest functional connectivity; therefore, we hypothesized that PMC glutamate and GABA predict intrinsic functional connectivity (iFC) across the entire DMN. In 20 healthy men, we combined J-resolved magnetic resonance spectroscopy to measure glutamate and GABA in the PMC and resting fMRI followed by group Independent Components Analysis to extract the entire DMN. We showed that, controlling for age and partial GM volume in the MRS voxel, PMC glutamate and GABA explained about half of the variance of DMN iFC (represented by the network's beta coefficient for rest). Glutamate correlated positively and GABA correlated negatively with DMN iFC; in an alternative statistical model which included the glutamate/GABA ratio, the ratio correlated positively with DMN iFC. Age had no independent association with DMN iFC. No other network was associated with PMC glutamate or GABA. We conclude that regional neurotransmitter concentrations in a network node strongly predict network but not global brain iFC.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2012.09.029

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Schulte RF Lange T Beck J Meier D Boesiger P 2006b Improved two-dimensional J-resolved spectroscopy Nmr in Biomedicine 19 264 270 16541465

Cited by

Sorted by citations

Authors
Kapogiannis, D., Reiter, D. A., Willette, A. A., & Mattson, M. P.
Affiliations
National Institute on Aging (US)
Corresponding author
Kapogiannis, Dimitrios
Venue
NeuroImage
Publisher
Elsevier BV
Published
2013-01
Volume
64
Pages
112-119
ISSN
1053-8119 (ISSN-L)
OpenAlex
W1971032414
Cited by
211
References
67
Citations by year
2026: 11 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 23 · 2020: 19 · 2019: 17 · 2018: 18 · 2017: 19 · 2016: 14 · 2015: 11 · 2014: 18 · 2013: 4 · 2012: 1
FWCI
5.57
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
posteromedial cortex, default mode network, intrinsic functional connectivity, glutamate, GABA, glutamate/GABA ratio, neurotransmitter concentrations, cortical microcircuits, excitation-inhibition balance, resting-state functional connectivity, age effects
MeSH terms
Brain Mapping, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Pathways, Magnetic Resonance Spectroscopy, Tissue Distribution, Neurotransmitter Agents, Glutamic Acid, Connectome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review