Distinct contributions of human hippocampal theta to spatial cognition and anxiety
Open accessAbstract
Current views of the hippocampus assign this structure, and its prominent theta rhythms, a key role in both cognition and affect. We studied this duality of function in humans, where no direct evidence exists. Whole-head magnetoencephalographic (MEG) data were recorded to measure theta activity while healthy participants (N = 25) navigated two virtual Morris water mazes, one in which they risked receiving aversive shocks without warning to induce anxiety and one in which they were safe from shocks. Results showed that threat of shock elevated anxiety level and enhanced navigation performance as compared to the safe condition. MEG source analyses revealed that improved navigation performance during threat was preferentially associated with increased left septal (posterior) hippocampal theta (specifically 4-8 Hz activity), replicating previous research that emphasizes a predominant role of the septal third of the hippocampus in spatial cognition. Moreover, increased self-reported anxiety during threat was preferentially associated with increased left temporal (anterior) hippocampal theta (specifically 2-6 Hz activity), consistent with this region's involvement in mediating conditioned and innate fear. Supporting contemporary theory, these findings highlight simultaneous involvement of the human hippocampus in spatial cognition and anxiety, and clarify their distinct correlates.
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In humans, increased self-reported anxiety during threat is associated with increased theta rhythm in the anterior hippocampus.
“in humans, increased self-reported anxiety during threat is associated with increased theta rhythm in the anterior hippocampus (21)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [21]
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- Authors
- Cornwell, B. R., Arkin, N., Overstreet, C., Carver, F. W., & Grillon, C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cornwell, Brian R.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2012-03-30
- Volume
- 22
- Issue
- 9
- Pages
- 1848-1859
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC3390451
- OpenAlex
- W2063983402
- Cited by
- 73
- References
- 91
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 1
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health (T32MH020030)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- hippocampal theta rhythm, spatial cognition, anxiety, hippocampal subfields, anterior hippocampus, virtual Morris water maze, fear conditioning, navigation performance, MEG source localization
- MeSH terms
- Adult, Affect, Algorithms, Anxiety, Cognition, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Models, Psychological, Regression Analysis, Task Performance and Analysis, Theta Rhythm, User-Computer Interface, Magnetoencephalography, Maze Learning, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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