Cited by 187Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesComplex Network Analysis Techniques

Mapping Structural Connectivity Using Diffusion MRI : Challenges and Opportunities

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Yeh, Chun‐Hung, Jones, Derek K., Liang, Xiaoyun, Descoteaux, Maxime, Connelly, Alan·2021·Journal of Magnetic Resonance Imaging

Abstract

Diffusion MRI-based tractography is the most commonly-used technique when inferring the structural brain connectome, i.e., the comprehensive map of the connections in the brain. The utility of graph theory-a powerful mathematical approach for modeling complex network systems-for analyzing tractography-based connectomes brings important opportunities to interrogate connectome data, providing novel insights into the connectivity patterns and topological characteristics of brain structural networks. When applying this framework, however, there are challenges, particularly regarding methodological and biological plausibility. This article describes the challenges surrounding quantitative tractography and potential solutions. In addition, challenges related to the calculation of global network metrics based on graph theory are discussed.Evidence Level: 5Technical Efficacy: Stage 1.

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Authors
Yeh, C., Jones, D. K., Liang, X., Descoteaux, M., & Connelly, A.
Affiliations
  • The University of Melbourne (AU)
  • Cardiff University (GB)
  • Université de Sherbrooke (CA)
Corresponding author
Yeh, Chun‐Hung
Venue
Journal of Magnetic Resonance Imaging
Publisher
Wiley
Published
2020-06-17
Volume
53
Issue
6
Pages
1666-1682
ISSN
  • 1053-1807 (ISSN-L)
  • 1522-2586
OpenAlex
W3035809474
Cited by
187
References
113
Citations by year
2026: 20 · 2025: 37 · 2024: 42 · 2023: 21 · 2022: 35 · 2021: 27 · 2020: 5
FWCI
3.24
Type
journal article
Language
en
Open access
Locations
  • Journal of Magnetic Resonance Imaging (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • PubMed Central (acceptedVersion, cc-by)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Funders
  • Australian Research Council
  • National Health and Medical Research Council
  • Wellcome Trust (096646/Z/11/Z, 104943/Z/14/Z)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
Keywords
diffusion MRI tractography, graph theory, structural brain networks, network topology, connectome mapping
MeSH terms
Brain, Image Processing, Computer-Assisted, Neural Pathways, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Connectome

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