Mapping Structural Connectivity Using Diffusion MRI : Challenges and Opportunities
Open accessAbstract
Diffusion MRI-based tractography is the most commonly-used technique when inferring the structural brain connectome, i.e., the comprehensive map of the connections in the brain. The utility of graph theory-a powerful mathematical approach for modeling complex network systems-for analyzing tractography-based connectomes brings important opportunities to interrogate connectome data, providing novel insights into the connectivity patterns and topological characteristics of brain structural networks. When applying this framework, however, there are challenges, particularly regarding methodological and biological plausibility. This article describes the challenges surrounding quantitative tractography and potential solutions. In addition, challenges related to the calculation of global network metrics based on graph theory are discussed.Evidence Level: 5Technical Efficacy: Stage 1.
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“tography data alone, which are often used to define the connectivity strength [227, 424, 513, 411].”
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“Together with mathematical tools from graph theory (Kaiser, 2011; Rubinov and Sporns, 2010; Sizemore et al., 2018; Yeh et al., 2020), tractography studies have helped reveal a number of important network properties in the human brain such as efficiency (Latora and Marchiori, 2001), modularity (Sporns and Betzel, 2016)…”
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A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
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Brain connectomes in youth at risk for serious mental illness: an exploratory analysis
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Blurred streamlines: A novel representation to reduce redundancy in tractography
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An open, analysis-ready, and quality controlled resource for pediatric brain white-matter researchPreprint
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Structural brain network organization in children with prenatal alcohol exposure
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Gyral and sulcal connectivity in the human cerebral cortex
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Can structure predict function at individual level in the human connectome?
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High‐Order line graphs of fMRI data in major depressive disorder
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Graph analysis of guilt processing network highlights links with subclinical anxiety and self-blame
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Clinical connectomics: Mapping structural brain networks in disease
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Application of omics-based biomarkers in substance use disorders
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Ordinal Pattern Tree: A New Representation Method for Brain Network Analysis
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A spatiotemporal complexity architecture of human brain activityPreprint
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Atlas-based templates vs. subject-specific tractography: resolving the debate
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- Authors
- Yeh, C., Jones, D. K., Liang, X., Descoteaux, M., & Connelly, A.
- Affiliations
- The University of Melbourne (AU)
- Cardiff University (GB)
- Université de Sherbrooke (CA)
- Corresponding author
- Yeh, Chun‐Hung
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2020-06-17
- Volume
- 53
- Issue
- 6
- Pages
- 1666-1682
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- PMC
- PMC7615246
- OpenAlex
- W3035809474
- Cited by
- 187
- References
- 113
- Citations by year
- 2026: 20 · 2025: 37 · 2024: 42 · 2023: 21 · 2022: 35 · 2021: 27 · 2020: 5
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- PubMed Central (acceptedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Funders
- Australian Research Council
- National Health and Medical Research Council
- Wellcome Trust (096646/Z/11/Z, 104943/Z/14/Z)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
- Keywords
- diffusion MRI tractography, graph theory, structural brain networks, network topology, connectome mapping
- MeSH terms
- Brain, Image Processing, Computer-Assisted, Neural Pathways, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Connectome
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