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Cited by 544

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

Fishman, J. B., Rubin, J. B., Handrahan, J. V., Connor, J. R., Fine, R. E.·1987·Journal of Neuroscience Research
DOI 10.1002/jnr.490180206
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Abstract

The perfusion of rat brain with 125 I‐transferrin resulted in a receptor‐mediated uptake of transferrin into the endothelium of the blood‐brain barrier followed by its detecation in the brain. During a pulsechase experiment, 125 I‐transferrin accumulated in the endothelial cells during the pulse, with a decrease of this intraendothelial radioactivity during the chase associated a concomitant increase in the nonvascular elements of the brain. The receptor‐mediated movement of transferrin across the blood‐brain barrier suggests that the brain may derive its iron through the transcytosis of iron‐loaded transferrin across the brain microvasculature. We discuss the likelihood that aluminum and other potentially toxic heavy metals, which also bind tightly to transferrin, may enter the brain by this pathway. We also discuss the possibility that other large molecules including neuroactive peptides and neurotrophic viruses may enter the brain through a similar receptor‐mediated, vesicular transcytotic route.

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Metadata

Authors
Fishman, J. B., Rubin, J. B., Handrahan, J. V., Connor, J. R., & Fine, R. E.
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
1987-01
Volume
18
Issue
2
Pages
299-304
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
DOI
10.1002/jnr.490180206
OpenAlex
W2110569992
Cited by
544
References
2
FWCI
12.12
Type
journal article
Language
en
Open access
closed

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