Fucoidan from Laminaria cichorioides inhibits AP‐1 transactivation and cell transformation in the mouse epidermal JB6 cells

Lee, Na Yeon; Ermakova, Svetlana P.; Choi, Hoo‐Kyun; Kusaykin, Michail I.; Shevchenko, Natalya M.; Zvyagintseva, Tatyana N.; Choi, Hong Seok

doi:10.1002/mc.20428

Cited by 40Seaweed-derived Bioactive CompoundsEchinoderm biology and ecologyGenomics, phytochemicals, and oxidative stress

Fucoidan from Laminaria cichorioides inhibits AP‐1 transactivation and cell transformation in the mouse epidermal JB6 cells

Lee, Na Yeon, Ermakova, Svetlana P., Choi, Hoo‐Kyun, Kusaykin, Michail I., Shevchenko, Natalya M., Zvyagintseva, Tatyana N., Choi, Hong Seok·2008·Molecular Carcinogenesis

DOI 10.1002/mc.20428

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Abstract

Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has anticoagulant and antithrombotic activities. Unlike heparine, fucoidan is known to exhibit anticarcinogenic activities. However, the underlying molecular mechanisms of the chemopreventive activities of fucoidan are not understood. Here we report that fucoidan from Laminaria cichorioides inhibited the epidermal growth factor (EGF) or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic cell transformation, but had less cytotoxic effects on JB6 mouse epidermal cells. The EGF-induced phosphorylation of extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinases, and c-Jun was inhibited by fucoidan, resulting from the inhibition of phosphorylation of epidermal growth factor receptor (EGFR). Fucoidan dose-dependently attenuated the c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity. In vitro binding assay revealed that fucoidan directly interacted with EGF, suggested that antitumor promoting effect of fucoidan might be due to preventing the binding of EGF to its cell surface receptor (EGFR). These findings are the first to reveal a molecular basis for the anticarcinogenic action of fucoidan and may partially account for the reported chemopreventive effects of brown seaweeds.

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Anticarcinogenic action of fucoidan from S. cichorioides is connected with its ability to interact directly with EGF and prevent its binding to EGFR.
“It has been suggested that the anticarcinogenic action of fucoidan from S. cichorioides is connected with its ability to interact directly with epidermal growth factor (EGF) and prevents its binding to EGF receptor (EGFR).”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [66]
In experiments with neoplastic transformation of JB6 mouse epidermal cells induced by EGF or TPA, inhibition of EGFR phosphorylation was followed by inhibition of some ERK activities, resulting in inhibition of AP-1 nuclear factor transactivation.
“Actually, in experiments with neoplastic transformation of JB6 mouse epidermal cells induced by EGF or 12-O-tetradecanoylphorbol-13 acetate, a Russian-Korean group of scientists reported that inhibition of EGFR phosphorylation was followed by inhibition of the activities of some extracellular signal regulated kinases that resulted in the inhibition of AP-1 nuclear factor transactivation [66,67].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [66]

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Authors: Lee, N. Y., Ermakova, S. P., Choi, H., Kusaykin, M. I., Shevchenko, N. M., Zvyagintseva, T. N., & Choi, H. S.
Affiliations: Chosun University (KR)
Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences (RU)
Corresponding author: Choi, Hong Seok
ORCID: Ermakova, Svetlana P.
Choi, Hoo‐Kyun
Venue: Molecular Carcinogenesis
Publisher: Wiley
Published: 2008-02-26
Volume: 47
Issue: 8
Pages: 629-637
ISSN: 0899-1987 (ISSN-L)
1098-2744
DOI: 10.1002/mc.20428
OpenAlex: W2119304084
Cited by: 40
References: 51
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 3
FWCI: 4.00
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: fucoidan, brown seaweed polysaccharides, chemoprevention, cell transformation, AP-1 transactivation, c-fos, c-Jun, epidermal growth factor receptor, EGFR phosphorylation, ERK1/2, JNK, JB6 epidermal cells, sulfated polysaccharides
MeSH terms: Epidermal Cells, Animals, Cell Adhesion, Cell Line, Cell Transformation, Neoplastic, Epidermal Growth Factor, Laminaria, Phosphorylation, Polysaccharides, Tetradecanoylphorbol Acetate, Transcriptional Activation, Transcription Factor AP-1, MAP Kinase Signaling System, Mice

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Fucoidan from Laminaria cichorioides inhibits AP‐1 transactivation and cell transformation in the mouse epidermal JB6 cells

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