Cited by 56Fibroblast Growth Factor ResearchAdipose Tissue and MetabolismDietary Effects on Health

A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)

Pérez‐Martí, Albert, Garcia‐Guasch, Maite, Tresserra‐Rimbau, Anna, Carrilho‐Do‐Rosário, Alexandra, Estruch, Ramon, Salas‐Salvadó, Jordi, Martínez‐González, Miguel Ángel, Lamuela‐Raventós, Rosa +3 more·2017·Molecular Nutrition & Food Research

Abstract

SCOPE: Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity. Since FGF21 production is regulated by various nutritional factors, we analyze the impact of low protein intake on circulating levels of this growth hormone in mice and in a sub cohort of the PREDIMED (Prevención con Dieta Mediterránea) trial. We also describe the role of hepatic FGF21 in metabolic adaptation to a low-protein diet (LPD). METHODS AND RESULTS: We fed control and liver-specific Fgf21 knockout (LFgf21KO) mice a LPD. This diet increased FGF21 production by inducing its overexpression in liver, and this correlated with a body weight decrease without changes in food intake. The LPD also caused FGF21-dependent browning in subcutaneous white adipose tissue (scWAT), as indicated by an increase in the expression of uncoupling protein 1 (UCP1). In a subgroup of 78 individuals from the PREDIMED trial, we observed an inverse correlation between protein intake and circulating FGF21 levels. CONCLUSION: Our results reinforce the involvement of FGF21 in coordinating energy homeostasis under a range of nutritional conditions. Moreover, here we describe an approach to increase the endogenous production of FGF21, which if demonstrated functional in humans, could generate a treatment for obesity.

Integrity signals

Registry

Crossref · 10.1002/mnfr.201600725

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The increase in FGF21 in response to low protein results in increased energy expenditure and lower body weight gain.

    “This robust increase in FGF21 results in increased energy expenditure and lower body weight gain [155,156,160,163] (Figure 2)”

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Pérez‐Martí, A., Garcia‐Guasch, M., Tresserra‐Rimbau, A., Carrilho‐Do‐Rosário, A., Estruch, R., Salas‐Salvadó, J., Martínez‐González, M. Á., Lamuela‐Raventós, R., Marrero, P. F., Haro, D., & Relat, J.
Affiliations
  • Institut de Biomedicina de la Universitat de Barcelona (ES)
  • Instituto de Salud Carlos III (ES)
  • CIBEROBN Instituto de Salud Carlos III Madrid Spain
  • Department of Nutrition, Food Sciences and Gastronomy School of Pharmacy and Food Science University of Barcelona Torribera Food Campus Santa Coloma de Gramenet Barcelona Spain
Corresponding author
  • Haro, Diego
  • Relat, Joana
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2017-03-02
Volume
61
Issue
8
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2571982167
Cited by
56
References
42
Citations by year
2026: 4 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 3
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
Funders
  • Ministerio de Economía y Competitividad (SAF2013‐41093)
  • Comisión Interministerial de Ciencia y Tecnología (AGL2013‐49083‐C3‐1‐R, AGL2016‐79113‐R)
  • Universitat de Barcelona
  • Instituto de Salud Carlos III
  • Ministerio de Educación, Cultura y Deporte
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
FGF21, low-protein diet, weight loss, white adipose tissue browning, UCP1, obesity treatment, energy homeostasis, protein intake, PREDIMED trial, Mediterranean diet
MeSH terms
Aged, Aged, 80 and over, Animals, Female, Fibroblast Growth Factors, Gene Expression Regulation, Humans, Liver, Male, Middle Aged, Weight Loss, Mice, Knockout, Diet, Protein-Restricted, Activating Transcription Factor 4, Adipose Tissue, White

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review