FGF21 mediates the lipid metabolism response to amino acid starvation
Open accessAbstract
Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.
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Hepatic and circulating FGF21 levels increase in response to low-protein content or amino acid deprivation in an ATF4-dependent mechanism.
“Hepatic and circulating FGF21 levels also increase in response to low-protein content or amino acid deprivation [152,[155], [156], [157], [158], [159], [160]] in an ATF4-dependent mechanism [155,161,162].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [157]
Low-protein diets, amino acid starvation, and the amino acid-depleting drug asparaginase induce plasma FGF21 levels.
“Low-protein diets (73, 85), amino acid starvation (25, 121), and the amino acid–depleting drug asparaginase (138) also induce plasma FGF21 levels.”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [25]
FGF21 is markedly induced in response to protein restriction but not caloric restriction.
“FGF21 is markedly induced in response to protein restriction (25, 73, 85) but not caloric restriction (73, 148).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [25]
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Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works
Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works
Handschin, C., & Spiegelman, B. M. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0037 · Cited by 1,090 · see citing works
Fibroblast Growth Factor 21 Corrects Obesity in Mice
Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031 · see citing works
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00067-1 · Cited by 847 · see citing works
Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774 · see citing works
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works
Self-citationATF4-dependent transcription mediates signaling of amino acid limitation
Kilberg, M. S., Shan, J., & Su, N. Y. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.05.008 · Cited by 595 · see citing works
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works
Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512 · see citing works
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420 · see citing works
FGF21 is an Akt‐regulated myokine
Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works
Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377 · see citing works
Self-citationFibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis
Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology · doi:10.1210/en.2009-0532 · Cited by 362 · see citing works
PPARα is a key regulator of hepatic FGF21
Lundåsen, T., Hunt, M., Nilsson, L.-M., Sanyal, S., Angelin, B., Alexson, S., & Rudling, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.068 · Cited by 361 · see citing works
Hotta, Y., Nakamura, H., Konishi, M., Murata, Y., Takagi, H., Matsumura, S., Inoue, K., Fushiki, T., & Itoh, N. (2009) · Endocrinology · doi:10.1210/en.2009-0119 · Cited by 352 · see citing works
Thermogenic Responses in Brown Fat Cells Are Fully UCP1-dependent
Matthias, A., Ohlson, K. B. E., Fredriksson, J. M., Jacobsson, A., Nedergaard, J., & Cannon, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000547200 · Cited by 342 · see citing works
Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y. Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S.-C., Graham, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00348.2009 · Cited by 340 · see citing works
β-Adrenergic Activation of p38 MAP Kinase in Adipocytes
Cao, W., Medvedev, A. V., Daniel, K. W., & Collins, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101049200 · Cited by 327 · see citing works
Guo, F., & Cavener, D. R. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.001 · Cited by 301 · see citing works
Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., & Wong, K. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.044826 · Cited by 294 · see citing works
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
De Sousa-Coelho, A. L., Marrero, P. F., & Haro, D. (2012) · Biochemical Journal · doi:10.1042/bj20111748 · Cited by 246 · see citing works
Self-citationIntegrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
Fisher, F. M., Estall, J. L., Adams, A. C., Antonellis, P. J., Bina, H. A., Flier, J. S., Kharitonenkov, A., Spiegelman, B. M., & Maratos–Flier, E. (2011) · Endocrinology · doi:10.1210/en.2011-0281 · Cited by 229 · see citing works
Díaz-Delfín, J., Hondares, E., Iglesias, R., Giralt, M., Caelles, C., & Villarroya, F. (2012) · Endocrinology · doi:10.1210/en.2012-1193 · Cited by 195 · see citing works
Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice
Johnson, C. L., Weston, J. Y., Chadi, S. A., Fazio, E. N., Huff, M. W., Kharitonenkov, A., Köester, A., & Pin, C. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.064 · Cited by 180 · see citing works
Cheng, Y., Meng, Q., Wang, C., Li, H., Huang, Z., Chen, S., Xiao, F., & Guo, F. (2009) · Diabetes · doi:10.2337/db09-0929 · Cited by 170 · see citing works
Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line
Vilà-Brau, A., Sousa‐Coelho, A. L. D., Mayordomo, C., Haro, D., & Marrero, P. F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.235044 · Cited by 137 · see citing works
Hansen, B. S., Vaughan, M. H., & Wang, L.-J. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45112-0 · Cited by 114 · see citing works
Zhang, Y., Lei, T., Huang, J., Wang, S. B., Zhou, L., Yang, Z., & Chen, X. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.003 · Cited by 110 · see citing works
FGF21: A Missing Link in the Biology of Fasting
Reitman, M. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.010 · Cited by 106 · see citing works
Pan, Y., Chen, H., Thiaville, M. M., & Kilberg, M. S. (2006) · Biochemical Journal · doi:10.1042/bj20061261 · Cited by 86 · see citing works
Cheng, Y., Zhang, Q., Meng, Q., Xia, T., Huang, Z., Wang, C., Liu, B., Chen, S., Xiao, F., Du, Y., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0028 · Cited by 65 · see citing works
Thiaville, M. M., Pan, Y., Gjymishka, A., Zhong, C., Kaufman, R. J., & Kilberg, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708320200 · Cited by 62 · see citing works
Uebanso, T., Taketani, Y., Yamamoto, H., Amo, K., Tanaka, S., Arai, H., Takei, Y., Masuda, M., Yamanaka‐Okumura, H., & Takeda, E. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.03.023 · Cited by 39 · see citing works
Archer, A., Venteclef, N., Mode, A., Pedrelli, M., Gabbi, C., Clément, K., Parini, P., Gustafsson, J.-Α., & Korach-André, M. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1151 · Cited by 33 · see citing works
Wang, T., Shah, Y. M., Matsubara, T., Zhen, Y., Tanabe, T., Nagano, T., Fotso, S., Krausz, K. W., Zabriskie, T. M., Idle, J. R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090175 · Cited by 27 · see citing works
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Sorted by citations
Understanding the Physiology of FGF21
Fisher, F. M., & Maratos-Flier, E. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105339 · Cited by 912 · see citing works
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.016 · Cited by 509 · see citing works
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Degirolamo, C., Sabbà, C., & Moschetta, A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.9 · Cited by 424 · see citing works
Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
Owen, B. M., Mangelsdorf, D. J., & Kliewer, S. A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.002 · Cited by 286 · see citing works
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Fructose ingestion acutely stimulates circulating FGF21 levels in humans
Dushay, J. R., Toschi, E., Mitten, E. K., Fisher, F. M., Herman, M. A., & Maratos-Flier, E. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.09.008 · Cited by 233 · see citing works
Keipert, S., Ost, M., Johann, K., Imber, F., Jastroch, M., van Schothorst, E. M., Keijer, J., & Klaus, S. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2013 · Cited by 221 · see citing works
Machado, S. A., Pasquarelli-do-Nascimento, G., da Silva, D. S., Farias, G. R., Santos, I. D. O., Baptista, L. B., & Magalhães, K. G. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00694-0 · Cited by 229 · see citing works
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works
Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works
Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework
Solon-Biet, S. M., Cogger, V. C., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A. C., Warren, A., Durrant-Whyte, J., Walters, K. A., Krycer, J. R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.001 · Cited by 212 · see citing works
Laeger, T., Albarado, D. C., Burke, S. J., Trosclair, L., Hedgepeth, J. W., Berthoud, H.-R., Gettys, T. W., Collier, J. J., Münzberg, H., & Morrison, C. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.044 · Cited by 206 · see citing works
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Maida, A., Zota, A., Sjøberg, K. A., Schumacher, J., Sijmonsma, T. P., Pfenninger, A., Christensen, M. M., Gantert, T., Fuhrmeister, J., Rothermel, U., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85946 · Cited by 170 · see citing works
Going Back to the Biology of FGF21: New Insights
Lewis, J. E., Ebling, F. J. P., Samms, R. J., & Tsintzas, K. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.05.007 · Cited by 164 · see citing works
Fibroblast growth factor 21 and its novel association with oxidative stress
Gómez-Sámano, M. Á., Grajales-Gómez, M., Zuarth-Vázquez, J. M., Navarro-Flores, M. F., Martínez-Saavedra, M., Juárez-León, Ó. A., Morales-García, M., Enriquez-Estrada, V. M., Gomez-Perez, F. J., & Ramos, D. C. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.024 · Cited by 164 · see citing works
Fibroblast growth factor-21, energy balance and obesity
Giralt, M., Gavaldà‐Navarro, A., & Villarroya, F. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.018 · Cited by 146 · see citing works
Dietary Protein, Metabolism, and Aging
Soultoukis, G. A., & Partridge, L. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014422 · Cited by 147 · see citing works
Kim, K. H., & Lee, M.-S. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.4.245 · Cited by 146 · see citing works
Amino Acid Sensing in Metabolic Homeostasis and Health.
Hu, X.-M., & Guo, F. (2020) · Endocrine reviews · doi:10.1210/endrev/bnaa026 · Cited by 123 · see citing works
Fibroblast growth factor 21 in non-alcoholic fatty liver disease
Tucker, B., Li, H., Long, X., Rye, K., & Ong, K. L. (2019) · Metabolism · doi:10.1016/j.metabol.2019.153994 · Cited by 132 · see citing works
Yap, Y. W., Rusu, P. M., Chan, A. Y., Fam, B. C., Jungmann, A., Solon‐Biet, S. M., Barlow, C. K., Creek, D. J., Huang, C., Schittenhelm, R. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16568-z · Cited by 118 · see citing works
Douris, N., Melman, T., Pecherer, J. M., Pissios, P., Flier, J. S., Cantley, L. C., Locasale, J. W., & Maratos–Flier, E. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.07.009 · Cited by 101 · see citing works
Hill, C. M., Laeger, T., Albarado, D. C., McDougal, D. H., Berthoud, H.-R., Münzberg, H., & Morrison, C. D. (2017) · Scientific Reports · doi:10.1038/s41598-017-07498-w · Cited by 97 · see citing works
Biliverdin reductase and bilirubin in hepatic disease
Weaver, L., Hamoud, A.-R. A., Stec, D. E., & Hinds, T. D. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00026.2018 · Cited by 98 · see citing works
Dyslipidemia in retinal metabolic disorders
Fu, Z., Chen, C. T., Cagnone, G., Heckel, É., Sun, Y., Cakir, B., Tomita, Y., Huang, S., Li, Q., Britton, W. R., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201910473 · Cited by 92 · see citing works
Bhattacharya, A., Sun, S., Wang, H., Liu, M. R., Long, Q., Yin, L., Kersten, S., Zhang, K., & Qi, L. (2018) · The EMBO Journal · doi:10.15252/embj.201899277 · Cited by 88 · see citing works
Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges
Martínez‐Garza, Ú., Torres‐Oteros, D., Yarritu, A., Marrero, P. F., Haro, D., & Relat, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194692 · Cited by 87 · see citing works
Wang, Z., Mai, K., Xu, W., Zhang, Y., Liu, Y., & Ai, Q. (2015) · Aquaculture · doi:10.1016/j.aquaculture.2015.12.019 · Cited by 82 · see citing works
Yueh, M., He, F., Chen, C., Vu, C., Tripathi, A., Knight, R. D., Karin, M., Chen, S., & Tukey, R. H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017129117 · Cited by 77 · see citing works
Jackson, T. C., & Kochanek, P. M. (2019) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2019.0001 · Cited by 77 · see citing works
Haro, D., Marrero, P., & Relat, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061386 · Cited by 56 · see citing works
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
Cangelosi, A. L., Puszynska, A. M., Roberts, J. M., Armani, A., Nguyen, T. P., Spinelli, J., Kunchok, T., Wang, B., Chan, S. H., Lewis, C. A., et al. (2022) · Science · doi:10.1126/science.abi9547 · Cited by 64 · see citing works
Fasting-induced hormonal regulation of lysosomal function
Chen, L., Wang, K., Long, A., Jia, L., Zhang, Y., Deng, H., Li, Y., Han, J., & Wang, Y. (2017) · Cell Research · doi:10.1038/cr.2017.45 · Cited by 71 · see citing works
Spann, R. A., Morrison, C. D., & den Hartigh, L. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.802541 · Cited by 75 · see citing works
Ribas, F., Villarroya, J., Hondares, E., Giralt, M., & Villarroya, F. (2014) · Biochemical Journal · doi:10.1042/bj20140403 · Cited by 69 · see citing works
Self-citationFibroblast growth factor-21 controls dietary protein intake in male mice
Larson, K. R., Chaffin, A. T.-B., Goodson, M. L., Fang, Y., & Ryan, K. K. (2019) · Endocrinology · doi:10.1210/en.2018-01056 · Cited by 68 · see citing works
Maida, A., Chan, J. S. K., Sjøberg, K. A., Zota, A., Schmoll, D., Kiens, B., Herzig, S., & Rose, A. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.009 · Cited by 68 · see citing works
Lees, E. K., Banks, R., Cook, C., Hill, S., Morrice, N., Grant, L., Mody, N., & Delibegović, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-10381-3 · Cited by 68 · see citing works
A nutritional perspective on UCP1-dependent thermogenesis
Bonet, M. L., Mercader, J., & Palou, A. (2017) · Biochimie · doi:10.1016/j.biochi.2016.12.014 · Cited by 66 · see citing works
FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
Kim, K. H., & Lee, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0160 · Cited by 63 · see citing works
Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota
Golonka, R. M., Xiao, X., Abokor, A. A., Joe, B., & Vijay–Kumar, M. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108360 · Cited by 60 · see citing works
Gasparin, F. R. S., Carreño, F. O., Mewes, J. M., Gilglioni, E. H., Pagadigorria, C. L. S., Natali, M. R. M., Utsunomiya, K. S., Constantin, R. P., Ouchida, A. T., Curti, C., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.04.004 · Cited by 58 · see citing works
Wang, X., Xiao, H., Ling-lin, L., Cheng, D., Li, X.-J., & Si, L. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.06.020 · Cited by 57 · see citing works
Pérez‐Martí, A., Garcia‐Guasch, M., Tresserra‐Rimbau, A., Carrilho‐Do‐Rosário, A., Estruch, R., Salas‐Salvadó, J., Martínez‐González, M. Á., Lamuela‐Raventós, R., Marrero, P. F., Haro, D., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600725 · Cited by 56 · see citing works
de Oliveira, M. C., Gilglioni, E. H., de Boer, B. A., Runge, J. H., de Waart, D. R., Salgueiro, C. L., Ishii‐Iwamoto, E. L., Elferink, R. P. J. O., & Gaemers, I. C. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.012 · Cited by 53 · see citing works
Harris, L.-A. L. S., Smith, G. I., Patterson, B. W., Ramaswamy, R. S., Okunade, A. L., Kelly, S. C., Porter, L. C., Klein, S., Yoshino, J., & Mittendorfer, B. (2017) · Diabetes · doi:10.2337/db16-1475 · Cited by 53 · see citing works
Jian, H., Xu, Q., Wang, X., Liu, Y., Miao, S., Li, Y., Mou, T., Dong, X., & Zou, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.849767 · Cited by 52 · see citing works
Hashidume, T., Kato, A., Tanaka, T., Miyoshi, S., Itoh, N., Nakata, R., Inoue, H., Oikawa, A., Nakai, Y., Shimizu, M., et al. (2016) · Scientific Reports · doi:10.1038/srep28183 · Cited by 52 · see citing works
Martin, A., Ecklu-Mensah, G., Ha, C. W. Y., Hendrick, G., Layman, D. K., Gilbert, J. A., & Devkota, S. (2021) · Nature Communications · doi:10.1038/s41467-021-24074-z · Cited by 51 · see citing works
Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
Kim, K. H., & Lee, M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9272-6 · Cited by 49 · see citing works
Yan, J., Wang, J., Huang, H., Huang, Y., Mi, T., Zhang, C., & Zhang, L. (2017) · PubMed Central · Cited by 48 · see citing works
Metabolic roles of endocrine fibroblast growth factors
Fernandes-Freitas, I., & Owen, B. M. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.09.014 · Cited by 45 · see citing works
Sandoval, V., Femenias, A., Martínez‐Garza, Ú., Sanz‐Lamora, H., Castagnini, J. M., Quifer‐Rada, P., Lamuela-Raventós, R. M., Marrero, P. F., Haro, D., & Relat, J. (2019) · Antioxidants · doi:10.3390/antiox8090360 · Cited by 46 · see citing works
Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure
Solon‐Biet, S. M., Clark, X., Bell-Anderson, K. S., Rusu, P. M., Perks, R., Freire, T., Pulpitel, T., Senior, A. M., Hoy, A. J., Aung, O., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113536 · Cited by 41 · see citing works
Amiri, M., Braidy, N., & Aminzadeh, M. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9914-2 · Cited by 38 · see citing works
Chatterjee, T. K., Basford, J. E., Yiew, K. H., Stepp, D. W., Hui, D. Y., & Weintraub, N. L. (2014) · Adipocyte · doi:10.4161/adip.28814 · Cited by 39 · see citing works
Chalvon-Demersay, T., Even, P. C., Tomé, D., Chaumontet, C., Piedcoq, J., Gaudichon, C., & Azzout-Marniche, D. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.002 · Cited by 37 · see citing works
Izaguirre, M., Gil, M. J., Monreal, I., Montecucco, F., Frühbeck, G., & Catalán, V. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0866-3 · Cited by 37 · see citing works
Li, S., Zou, T., Chen, J., Li, J., & You, J. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.033 · Cited by 37 · see citing works
Regulation of thermogenic adipocytes during fasting and cold
Reinisch, I., Schreiber, R., & Prokesch, A. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110869 · Cited by 34 · see citing works
Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis
Khan, M. S. H., Spann, R. A., Münzberg, H., Yu, S., Albaugh, V. L., He, Y., Berthoud, H., & Morrison, C. D. (2021) · Nutrients · doi:10.3390/nu13114103 · Cited by 35 · see citing works
Modulation of energy balance by fibroblast growth factor 21
Ramos, D. C., & Aguilar-Salinas, C. A. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0023 · Cited by 34 · see citing works
Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
Sawicki, K. T., Chang, H., Shapiro, J. S., Bayeva, M., Jesus, A. D., Finck, B. N., Wertheim, J. A., Blackshear, P. J., & Ardehali, H. (2018) · JCI Insight · doi:10.1172/jci.insight.95948 · Cited by 33 · see citing works
FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk
CHAFFIN, A. T. B., Larson, K. R., Huang, K.-P., Wu, C.-T., Nadejda, G., Fang, Y., Jayakrishnan, D., Sauza, K. A. S., Sims, L. C., Mohajerani, N., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155848 · Cited by 31 · see citing works
Alonge, K. M., Meares, G. P., & Hillgartner, F. B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.762922 · Cited by 31 · see citing works
Endocrine Fibroblast Growth Factors in Relation to Stress Signaling
Shimizu, M., & Sato, R. (2022) · Cells · doi:10.3390/cells11030505 · Cited by 24 · see citing works
Role of liver FGF21-KLB signaling in ketogenic diet-induced amelioration of hepatic steatosis
Guo, W., Cao, H., Shen, Y., Li, W., Wang, W. J., Cheng, L., Cai, M., & Xu, F. L. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00277-3 · Cited by 24 · see citing works
Pérez‐Martí, A., Sandoval, V., Marrero, P. F., Haro, D., & Relat, J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0034 · Cited by 24 · see citing works
Jung, J. G., Yi, S., Choi, S., KANG, Y. Y., Kim, T. H., Jeon, J. Y., Bae, M. A., Ahn, J. H., Jeong, H., Hwang, E. S., et al. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0100 · Cited by 23 · see citing works
FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions
Maruyama, R., Shimizu, M., Hashidume, T., Inoue, J., Itoh, N., & Sato, R. (2018) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.64.200 · Cited by 21 · see citing works
Selective Regulation of FGF19 and FGF21 Expression by Cellular and Nutritional Stress
SHIMIZU, M., MORIMOTO, H., Maruyama, R., Inoue, J., & Sato, R. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.154 · Cited by 21 · see citing works
Örd, T., Örd, D., & Örd, T. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.01.014 · Cited by 20 · see citing works
Ippagunta, S. M., Kharitonenkov, A., Adams, A. C., & Hillgartner, F. B. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy022 · Cited by 21 · see citing works
Moro, J., Roisné-Hamelin, G., Chaumontet, C., Even, P. C., Blais, A., Cansell, C., Piedcoq, J., Gaudichon, C., Tomé, D., & Azzout‐Marniche, D. (2022) · Nutrients · doi:10.3390/nu15010197 · Cited by 19 · see citing works
Wang, J., Zhong, M.-Y., Liu, Y., Yu, J.-Y., Wang, Y., Zhang, X., & Sun, H. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01417-2 · Cited by 19 · see citing works
Nagasawa, I., Koido, M., Tani, Y., Tsukahara, S., Kunimasa, K., & Tomida, A. (2020) · iScience · doi:10.1016/j.isci.2020.101028 · Cited by 19 · see citing works
Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancer
Karin, M., & Kim, J. Y. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100096 · Cited by 18 · see citing works
Myokines: Novel therapeutic targets for diabetic nephropathy
Yang, M., Luo, S., Yang, J., Chen, W., He, L., Liu, D., Zhao, L., & Wang, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1014581 · Cited by 18 · see citing works
Sandoval, V., Rodríguez‐Rodríguez, R., Martínez‐Garza, Ú., Rosell‐Cardona, C., Lamuela-Raventós, R. M., Marrero, P. F., Haro, D., & Relat, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700606 · Cited by 17 · see citing works
Wilson, R. B., Chen, Y. J., Sutherland, B. G., Sawyez, C. G., Zhang, R., Woolnough, T., Hetherington, A. M., Peters, K. M., Patel, K., Kennelly, J. P., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105208 · Cited by 16 · see citing works
Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients
Post, A., Groothof, D., Schutten, J. C., Kelly, D., Swarte, J. C., Flores-Guerrero, J. L., van der Veen, Y., Kema, I. P., Özyilmaz, A., Enya, A., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.01.036 · Cited by 16 · see citing works
McCarty, M. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0056 · Cited by 16 · see citing works
Yuan, X., Huang, H., Huang, Y., Wang, J., Yan, J., Ding, L., Zhang, C., & Zhang, L. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217694435 · Cited by 14 · see citing works
Kiluk, P., Baran, A. M., Kaminski, T. W., Maciaszek, M., & Flisiak, I. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122206 · Cited by 14 · see citing works
Chen, L., Xu, R., McDonald, J. D., Bruno, R. S., Choueiry, F., & Zhu, J. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c03662 · Cited by 14 · see citing works
Placental fibroblast growth factor 21 is not altered in late-onset preeclampsia
Nitert, M. D., Scholz‐Romero, K., Kubala, M. H., McIntyre, D. H., Callaway, L. K., & Barrett, H. L. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0006-3 · Cited by 13 · see citing works
Kim, S. Q., Spann, R. A., Khan, M. S. H., Berthoud, H., Münzberg, H., Albaugh, V. L., He, Y., McDougal, D. H., Soto, P. L., Yu, S., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110010 · Cited by 10 · see citing works
The Role of the FGF19 Family in the Pathogenesis of Gestational Diabetes: A Narrative Review
Sadowska, A., Poniedziałek‐Czajkowska, E., & Mierzyński, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417298 · Cited by 9 · see citing works
Localization of FGF21 Protein and Lipid Metabolism-Related Genes in Camels
Gao, Y., Zhao, S., Zhang, W., Tang, H., Yan, M., Yong, F., Bai, X., Wu, X., Zhang, Y., & Zhang, Q. (2023) · Life · doi:10.3390/life13020432 · Cited by 7 · see citing works
Catalano, L., Aminzadeh-Gohari, S., Weber, D. D., Poupardin, R., Stefan, V. E., Smiles, W. J., Tevini, J., Feichtinger, R. G., Derdak, S. V., Bilban, M., et al. (2023) · Metabolites · doi:10.3390/metabo13080910 · Cited by 7 · see citing works
Autophagy-related 7 (ATG7) regulates food intake and liver health during asparaginase exposure
Zalma, B. A., Ibrahim, M., Rodriguez-Polanco, F. C., Bhavsar, C. T., Rodriguez, E. M., Lopes, E. C., Farooq, S. A., Levy, J. L., Wek, R. C., White, E., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108171 · Cited by 6 · see citing works
Weber, S. L., Hustedt, K., Schnepel, N., Visscher, C., & Muscher‐Banse, A. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087153 · Cited by 6 · see citing works
Xu, L., Yu, H., Yin, J., Li, L., Zhou, J., Li, M., Li, Q., Chen, H., Liu, F., Bao, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep43123 · Cited by 6 · see citing works
FOXO1 represses PPARα-Mediated induction of FGF21 gene expression
Sousa‐Coelho, A. L. D., Gacias, M., O'Neill, B. T., Relat, J., Link, W., Haro, D., & Marrero, P. F. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.01.012 · Cited by 5 · see citing works
Pharmacological Advances to the Treatment of Obesity
Londoño-Lemos, M. E. (2018) · Journal of Childhood Obesity · doi:10.21767/2572-5394.100043 · Cited by 5 · see citing works
NEW INSIGHTS INTO BROWN ADIPOSE TISSUE AS A PHARMACOLOGICAL TARGET IN OBESITY
Andrei, A. M. (2020) · FARMACIA · doi:10.31925/farmacia.2020.1.1 · Cited by 5 · see citing works
Brain amino acid sensing for organismal amino acid homeostasis
Tsang, A. H. K., Samson, L., & Blouet, C. (2025) · Open Biology · doi:10.1098/rsob.250092 · Cited by 4 · see citing works
Vaezi, S., Freeling, J., de Vargas, B. O., Weidauer, L. A., Shoemaker, M. E., Sanders, W. M., & Dey, M. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.10.010 · Cited by 4 · see citing works
Bibliometric analysis of fibroblast growth factor 21 research over the period 2000 to 2021
She, Q.-Y., Li, L., Liu, M.-H., Tan, R.-Y., Zhong, Y.-W., Bao, J., & Xie, J.-D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1011008 · Cited by 9 · see citing works
- Authors
- De Sousa-Coelho, A. L., Relat, J., Hondares, E., Pérez-Martí, A., Ribas, F., Villarroya, F., Marrero, P. F., & Haro, D.
- Affiliations
- Institut de Biomedicina de la Universitat de Barcelona (ES)
- Centro de Investigación Biomédica en Red (ES)
- Corresponding author
- Haro, Diego
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 54
- Issue
- 7
- Pages
- 1786-1797
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC3679382
- OpenAlex
- W2002182028
- Cited by
- 123
- References
- 41
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 3 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 16 · 2016: 12 · 2015: 10 · 2014: 5 · 2013: 2
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- FGF21, amino acid starvation, leucine deprivation, lipid metabolism, lipogenic gene expression, liver, white adipose tissue, brown adipose tissue, hormone-sensitive lipase, UCP1, starvation response
- MeSH terms
- Amino Acids, Animals, Fibroblast Growth Factors, Humans, Mice, Knockout, Lipid Metabolism, Mice, Hep G2 Cells
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