Cited by 123Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

FGF21 mediates the lipid metabolism response to amino acid starvation

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De Sousa-Coelho, Ana Luísa, Relat, Joana, Hondares, Elayne, Pérez-Martí, Albert, Ribas, Francesc, Villarroya, Francesc, Marrero, Pedro F., Haro, Diego·2013·Journal of Lipid Research

Abstract

Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.

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Crossref · 10.1194/jlr.m033415

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  • Hepatic and circulating FGF21 levels increase in response to low-protein content or amino acid deprivation in an ATF4-dependent mechanism.

    “Hepatic and circulating FGF21 levels also increase in response to low-protein content or amino acid deprivation [152,[155], [156], [157], [158], [159], [160]] in an ATF4-dependent mechanism [155,161,162].”
  • Low-protein diets, amino acid starvation, and the amino acid-depleting drug asparaginase induce plasma FGF21 levels.

    “Low-protein diets (73, 85), amino acid starvation (25, 121), and the amino acid–depleting drug asparaginase (138) also induce plasma FGF21 levels.”
  • FGF21 is markedly induced in response to protein restriction but not caloric restriction.

    “FGF21 is markedly induced in response to protein restriction (25, 73, 85) but not caloric restriction (73, 148).”

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Authors
De Sousa-Coelho, A. L., Relat, J., Hondares, E., Pérez-Martí, A., Ribas, F., Villarroya, F., Marrero, P. F., & Haro, D.
Affiliations
  • Institut de Biomedicina de la Universitat de Barcelona (ES)
  • Centro de Investigación Biomédica en Red (ES)
Corresponding author
Haro, Diego
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2013-07
Volume
54
Issue
7
Pages
1786-1797
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2002182028
Cited by
123
References
41
Citations by year
2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 3 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 16 · 2016: 12 · 2015: 10 · 2014: 5 · 2013: 2
FWCI
4.33
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
FGF21, amino acid starvation, leucine deprivation, lipid metabolism, lipogenic gene expression, liver, white adipose tissue, brown adipose tissue, hormone-sensitive lipase, UCP1, starvation response
MeSH terms
Amino Acids, Animals, Fibroblast Growth Factors, Humans, Mice, Knockout, Lipid Metabolism, Mice, Hep G2 Cells

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