A multielectrode array for intrafascicular recording and stimulation in sciatic nerve of cats

Branner, Almut; Normann, Richard Alan

doi:10.1016/s0361-9230(99)00231-2

Cited by 234Neuroscience and Neural EngineeringMuscle activation and electromyography studiesVagus Nerve Stimulation Research

A multielectrode array for intrafascicular recording and stimulation in sciatic nerve of cats

Branner, Almut, Normann, Richard Alan·2000·Brain Research Bulletin

DOI 10.1016/s0361-9230(99)00231-2

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Abstract

The feasibility of implanting an array of penetrating electrodes into peripheral nerves is studied in acute experiments in the cat sciatic nerve. A novel, silicon-based array of microelectrodes, the Utah Electrode Array, was used, which contains 25 or 100 1-mm long electrodes that project out from a silicon substrate. Electrode arrays of this complexity, when inserted in the peripheral nerve, could cause significant compression of the nerve and block the conduction of action potentials. Using a high velocity insertion technique, the electrode array was implanted into the sciatic nerve. Compound action potentials were evoked by and recorded with cuff electrodes. Compound action potentials recorded 1 h after insertion were only slightly altered from those recorded before insertion. Single units were readily extracted from evoked multiunit neural recordings in response to cutaneous stimulation and limb rotation around joints. Current injections into the nerve through the electrodes evoked muscle twitches with currents in the 10 microA range. Recording and stimulation stability were demonstrated for periods of up to 60 h. We have shown that high density arrays of electrodes can be inserted into the peripheral nerve and can provide a stable recording and stimulating interface to individual peripheral nerve axons. Such an array may be useful in future neuroscience research and potential neuroprosthetic applications.

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Electrodes in the Utah array selectively recorded single-unit responses from mechanoreceptors, although only in 10-20% of the electrodes, and evoked graded recruitment of force in muscle groups in a highly selective fashion with current injections in the 1-20 μA range.
“Electrodes in the array were capable of selectively recording single-unit responses from mechanoreceptors, although only in 10-20% of the electrodes, and evoked graded recruitment of force in muscle groups in a highly selective fashion with current injections in the 1-20 m A range (Branner and Norman, 2000; Branner et al., 2001) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Branner and Norman, 2000
Production of a defined geometric surface area (GSA) of the electrode tips was possible using either an oxygen plasma etching technique or excimer laser ablation.
“We have shown that the production of a defined geometric surface area (GSA) of the electrode tips was possible using either an oxygen plasma etching technique [1,21] or by excimer laser ablation [22].”
From A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures (2013) · cites this paper as [1]
Currently, there is one high electrode-density (6.25 electrodes/mm2), high electrode-count (96 electrodes) penetrating device available for neuromodulation of large structures (>4 mm) in the peripheral nervous system.
“Currently, there is one high electrode-density (6.25 electrodes/mm 2 ), high electrodecount (96 electrodes) penetrating device available for neuromodulation of large structures (> 4 mm) in the peripheral nervous system [1].”
From A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures (2013) · cites this paper as [1]
The electrode proportions, impedances, number of functionally distinct electrodes, and SNR of HD-USEAs are comparable to the conventionally spaced Utah electrode arrays.
“The electrode proportions, impedances, number of functionally distinct electrodes and SNR of HD-USEAs are comparable to the conventionally spaced Utah electrode arrays [1,13].”
From A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures (2013) · cites this paper as [1]
The conventionally spaced, lower density USEA can be implanted acutely (<1 day) and chronically (>6 months) with insult to the epineurium or perineurium limited to the areas penetrated by the microelectrodes.
“The conventionally spaced, lower density USEA can be implanted both acutely (<1 days) [1] and chronically (>6 months) [40,41] with insult to the epineurium or perinerium limited to the areas penetrated by the microelectrodes.”
From A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures (2013) · cites this paper as [1]

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Authors: Branner, A., & Normann, R. A.
Affiliations: University of Utah (US)
Corresponding author: Normann, Richard Alan
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2000-03
Volume: 51
Issue: 4
Pages: 293-306
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/s0361-9230(99)00231-2
OpenAlex: W1970923678
Semantic Scholar: 99213097ea1e1f7e51940a5e1ab0673dd53a0f0c
Cited by: 234
References: 53
Citations by year: 2026: 1 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 13 · 2017: 10 · 2016: 10 · 2015: 18 · 2014: 17 · 2013: 8 · 2012: 15
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: University of Alberta
Deutscher Akademischer Austauschdienst
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: Utah electrode array, microelectrode arrays, sciatic nerve, peripheral nerve recording, peripheral nerve stimulation, nerve compression, compound action potential, single-unit recording, multi-unit recording, muscle twitch, neuroprosthetics
MeSH terms: Action Potentials, Animals, Cats, Electric Stimulation, Microelectrodes, Muscle Contraction, Sciatic Nerve, Muscle, Skeletal

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A multielectrode array for intrafascicular recording and stimulation in sciatic nerve of cats

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