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Cited by 323

The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.

The pathobiology of the septin gene family

Open access
Hall, Peter A, Russell, SE Hilary·2004·The Journal of Pathology
DOI 10.1002/path.1654
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Abstract

Septins are an evolutionarily conserved group of GTP‐binding and filament‐forming proteins that belong to the large superclass of P‐loop GTPases. While originally discovered in yeast as cell division cycle mutants with cytokinesis defects, they are now known to have diverse cellular roles which include polarity determination, cytoskeletal reorganization, membrane dynamics, vesicle trafficking, and exocytosis. Septin proteins form homo‐ and hetero‐oligomeric polymers which can assemble into higher‐order filaments. They are also known to interact with components of the cytoskeleton, ie actin and tubulin. The precise role of GTP binding is not clear but a current model suggests that it is associated with conformational changes which alter binding to other proteins. There are at least 12 human septin genes, and although information on expression patterns is limited, most undergo complex alternative splicing with some degree of tissue specificity. Nevertheless, an increasing body of data implicates the septin family in the pathogenesis of diverse disease states including neoplasia, neurodegenerative conditions, and infections. Here the known biochemical properties of mammalian septins are reviewed in the light of the data from yeast and other model organisms. The data implicating septins in human disease are considered and a model linking these data is proposed. It is posited that septins can act as regulatable scaffolds where the stoichiometry of septin associations, modifications, GTP status, and the interactions with other proteins allow the regulation of key cellular processes including polarity determination. Derangements of such septin scaffolds thus explain the role of septins in disease states. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Metadata

Authors
Hall, P. A., & Russell, S. H.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2004-10-19
Volume
204
Issue
4
Pages
489-505
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.1654
OpenAlex
W2083555181
Cited by
323
References
159
FWCI
6.01
Type
journal article
Language
en
Open access
bronze

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