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Cited by 332

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Instrumental variable methods in comparative safety and effectiveness research

Open access
Brookhart, M. Alan, Rassen, Jeremy A., Schneeweiss, Sebastian·2010·Pharmacoepidemiology and Drug Safety
DOI 10.1002/pds.1908
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Abstract

Instrumental variable (IV) methods have been proposed as a potential approach to the common problem of uncontrolled confounding in comparative studies of medical interventions, but IV methods are unfamiliar to many researchers. The goal of this article is to provide a non‐technical, practical introduction to IV methods for comparative safety and effectiveness research. We outline the principles and basic assumptions necessary for valid IV estimation, discuss how to interpret the results of an IV study, provide a review of instruments that have been used in comparative effectiveness research, and suggest some minimal reporting standards for an IV analysis. Finally, we offer our perspective of the role of IV estimation vis‐à‐vis more traditional approaches based on statistical modeling of the exposure or outcome. We anticipate that IV methods will be often underpowered for drug safety studies of very rare outcomes, but may be potentially useful in studies of intended effects where uncontrolled confounding may be substantial. Copyright © 2010 John Wiley & Sons, Ltd.

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Metadata

Authors
Brookhart, M. A., Rassen, J. A., & Schneeweiss, S.
Venue
Pharmacoepidemiology and Drug Safety
Publisher
Wiley
Published
2010-06
Volume
19
Issue
6
Pages
537-554
ISSN
  • 1053-8569 (ISSN-L)
  • 1099-1557
DOI
10.1002/pds.1908
OpenAlex
W2169711166
Cited by
332
References
71
FWCI
18.58
Type
journal article
Language
en
Open access
green

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