Regression of experimental hamster cancer by beta carotene and algae extracts

Schwartz, Joel; Shklar, Gerald

doi:10.1016/s0278-2391(87)80011-3

Cited by 109Seaweed-derived Bioactive CompoundsCancer and biochemical researchMedicinal Plant Research

Regression of experimental hamster cancer by beta carotene and algae extracts

Schwartz, Joel, Shklar, Gerald·1987·Journal of Oral and Maxillofacial Surgery

DOI 10.1016/s0278-2391(87)80011-3

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Abstract

The effect of algae extract on tumor regression was studied. Phycotene (extract of Spirulina and Dunaliella algae) 250 micrograms in 0.1 ml MEM (minimum essential medium) was injected locally into DMBA (7, 12 dimethylbenz(a)anthracene)-induced squamous cell carcinomas of hamster buccal pouch in 20 animals. DMBA-induced carcinomas in 20 hamsters were injected locally with beta carotene 250 micrograms in 0.1 ml MEM; DMBA-induced carcinomas in 20 animals were injected locally with canthaxanthin, 250 micrograms in 0.1 ml MEM, and DMBA-induced carcinomas in 20 animals were injected locally with 13-cis-retinoic acid, 250 micrograms in 0.1 ml MEM. Twenty animals with DMBA-induced carcinomas were sham-injected controls using 0.1 ml MEM. The various agents were injected into the tumor bearing right buccal pouches twice-weekly for four weeks. Total tumor regression was found in 30% of phycotene animals, 20% of beta carotene animals and 15% of canthaxanthin animals after four weeks. Partial tumor regression was found in the remaining 70% of phycotene animals, 80% of beta carotene animals and 85% of canthaxanthin animals. None of the 13-cis-retinoic acid animals had total tumor regression, but 70% showed partial regression. No tumor regression was found in the DMBA control group and the sham-injected group.

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Total tumor regression was found in 30% and partial tumor regression was found in the remaining 70% of the animals after four weeks with phycotene extract of Arthrospira platensis and Dunaliella algae.
“Total tumor regression was found in 30% and partial tumor regression was found in the remaining 70% of the animals after four weeks.”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [130]
The phycocyanin isolated from Arthrospira platensis showed anticancer activity against squamous cell carcinoma in hamsters.
“The phycocyanin isolated from Arthrospira platensis showed anticancer activity against squamous cell carcinoma in hamsters [130].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [130]
There was no evidence of toxicity in any of the animals receiving the algae extracts.
“There was no evidence of toxicity in any of the animals receiving the algae extracts [130,131].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [130]

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Menkes, M., Comstock, G. W., Vuilleumier, J. P., Helsing, K. J., Rider, A. A., & Brookmeyer, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152003 · Cited by 537 · see citing works
Chapter 15 Serial Cultivation of Normal Human Epidermal Keratinocytes
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Chapman, C. R., & Benedetti, C. (1979) · Anesthesiology · doi:10.1097/00000542-197908000-00009 · Cited by 124 · see citing works
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SCHWARTZ, J. L., Suda, D., & Light, G. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90451-1 · Cited by 102 · see citing works
Self-citation
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Shklar, G., SCHWARTZ, J. L., Grau, D., Trickler, D. P., & Wallace, K. D. (1980) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(80)90330-8 · Cited by 102 · see citing works
Self-citation
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Shklar, G., SCHWARTZ, J. L., Trickler, D. P., & Niukian, K. (1987) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/78.5.987 · Cited by 67 · see citing works
Self-citation
Effect of Nitrous Oxide Concentration on Event-related
Benedetti, C., Chapman, C. R., Colpitts, Y. H., & Chen, A. C. N. (1982) · Anesthesiology · doi:10.1097/00000542-198205000-00006 · Cited by 59 · see citing works
Vitamin E inhibition of hamster buccal pouch carcinogenesis
Weerapradist, W., & Shklar, G. (1982) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(82)90100-1 · Cited by 44 · see citing works
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Odukoya, O., SCHWARTZ, J. L., Weichselbaum, R. W., & Shklar, G. (1983) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/71.6.1253 · Cited by 41 · see citing works
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Rorie, D. K., Tyce, G. M., & Sill, J. C. (1986) · Anesthesia & Analgesia · doi:10.1213/00000539-198606000-00002 · Cited by 20 · see citing works

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Antioxidant activity of the microalga Spirulina maxima
Miranda, M. S., Cintra, R. M. G. C., Barros, S. B. D. M., & Mancini-Filho, J. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000800007 · Cited by 390 · see citing works
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Karkos, P. D., Leong, S. C., Karkos, C. D., Sivaji, N., & Assimakopoulos, D. A. (2008) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen058 · Cited by 332 · see citing works
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Ishimi, Y., Sugiyama, F., Ezaki, J., Fujioka, M., & Jian, W. U. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.363 · Cited by 32 · see citing works
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He, Y., Root, M. M., Parker, R. S., & Campbell, T. C. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514532 · Cited by 26 · see citing works
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The Hamster Cheek Pouch Model of Carcinogenesis and Chemoprevention
Gimenez-Conti, I. B., & Slaga, T. J. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3468-6_9 · Cited by 24 · see citing works
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Vonshak, A. (1997) · CRC Press eBooks · doi:10.1201/9781482272970-19 · Cited by 21 · see citing works
Beta-carotene in vitro stimulates tumor necrosis factor alpha and interleukin 1 alpha secretion by human peripheral blood mononuclear cells
Abdel‐Fattah, G., Watzl, B., Huang, D. S., & WATSON, R. R. (1993) · Nutrition Research · doi:10.1016/s0271-5317(05)80589-5 · Cited by 21 · see citing works
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SCHWARTZ, J. L., & Shklar, G. (1989) · Phytotherapy Research · doi:10.1002/ptr.2650030605 · Cited by 17 · see citing works
Self-citation
Chemoprevention of upper aerodigestive tract cancers: A report of the third upper aerodigestive cancer task force workshop
Lippman, S. M., Lee, J. S., Lotan, R., & Hong, W. K. (1990) · Head & Neck · doi:10.1002/hed.2880120103 · Cited by 16 · see citing works
Synergistic Effects of Some Pairs of Antioxidants and Related Agents on Mouse Leukaemia L5 178Y Cell Growth In-vitro
Suzuki, T., Ezure, T., & Ishida, M. (1998) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1998.tb03330.x · Cited by 14 · see citing works
Chemoprevention of squamous cell carcinoma of the oral cavity
Brown, K. S., & Kane, M. A. (2006) · Otolaryngologic Clinics of North America · doi:10.1016/j.otc.2005.11.010 · Cited by 13 · see citing works
Free radicals as carcinogens and their quenchers as anticarcinogens
Santamaria, L., & Bianchi-Santamaria, A. (1991) · Medical Oncology and Tumor Pharmacotherapy · doi:10.1007/bf02987170 · Cited by 12 · see citing works
Chemoprevention of Penzo[a]pyrene-induced Carcinogen and Lipid Peroxidation in Mice by Lipophilic Algae Extracts (Phycotene)
Abdel-Baky, H. H., Gouda, E. M., ., A. N. E.-B., & El‐Baroty, G. S. (2002) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2002.185.193 · Cited by 11 · see citing works
In vitro Antioxidant Activity of Marine Diatoms
Karthikeyan, P. (2013) · IOSR Journal of Environmental Science Toxicology and Food Technology · doi:10.9790/2402-0523237 · Cited by 11 · see citing works
In vivoandin vitroeffects of β‐carotene and algae extracts in murine tumor models
Combs, W., Sonis, S. T., Fitzgerald, J., Tracy, C., & Wilson, R. H. (1989) · Nutrition and Cancer · doi:10.1080/01635588909514038 · Cited by 9 · see citing works
Spirulina Unveiled: A Comprehensive Review on Biotechnological Innovations, Nutritional Proficiency, and Clinical Implications
Mittal, R. K., Krishna, G., Sharma, V., Purohit, P., & Mishra, R. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010304524240514023735 · Cited by 8 · see citing works
Efficacy of spirulina in management of oral submucous fibrosis − a systematic review
Kulkarni, R., Kalaskar, A. R., Kalaskar, R., & Gupta, N. (2022) · Journal of Oral Medicine and Oral Surgery · doi:10.1051/mbcb/2021052 · Cited by 8 · see citing works
Intérêt thérapeutique de la spiruline chez l’homme: revue général
Barry, M., Ouédraogo, M., Sourabie, S., & Guissou, I. (2015) · International Journal of Biological and Chemical Sciences · doi:10.4314/ijbcs.v8i6.33 · Cited by 8 · see citing works
Prevention of Oral Cancer
Malki, A. M., Raad, S. B., & Abu-El-Ruz, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-48054-1_12 · Cited by 8 · see citing works
Spirulina: From Ancient Food to Innovative Super Nutrition of the Future and Its Market Scenario as a Source of Nutraceutical
Singh, S. K., Shukla, L., Yadav, N., Singh, P. K., Singh, S. M., Yadav, M. K., Kaushalendra, K., & Kumar, A. (2023) · Springer eBooks · doi:10.1007/978-981-99-0181-4_4 · Cited by 8 · see citing works
Antioxidative and Hepatoprotective Effects of Spirulina
Wu, L.-C., & Ho, J. A. (2007) · CRC Press eBooks · doi:10.1201/9781420052572.ch6 · Cited by 6 · see citing works
Evaluation of Different Biological Activities of Spirulina platensis Extracts
El-Din, S. M. M. (2019) · Egyptian Journal of Botany · doi:10.21608/ejbo.2019.11910.1306 · Cited by 4 · see citing works
Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis
Desai, K. M., Hallikerimath, S. R., & Kale, A. D. (2017) · International Journal of Oral Care & Research · doi:10.5005/jp-journals-10051-0125 · Cited by 4 · see citing works
Overall Review on Therapeutic effects of Spirulina supplement
Shinde, S., Bhosale, M. S., Tambe, T., & Sonawane, P. (2022) · Research Journal of Science and Technology · doi:10.52711/2349-2988.2022.00019 · Cited by 4 · see citing works
Novel Development of Pasta Enriched with Spirulina platensis Microalgae: Biochemical and Histological Parameters
El-Sharnouby, G. A., Abughoush, M. H., & Choudhury, I. H. (2024) · Jordan Journal of Agricultural Sciences · doi:10.35516/jjas.v20i1.1142 · Cited by 3 · see citing works
Spirulina and Immunity
Keen, C. L., Belay, A., Gershwin, M. E., & Borchers, A. T. (2007) · CRC Press eBooks · doi:10.1201/9781420052572.ch8 · Cited by 3 · see citing works
DAFE'-E-SART'AN (ANTICANCER) ACTIVITY OF T'AH'LAB (SPIRULINA) - A REVIEW
Alam, M. A., Haider, N., Husain, S., Ahmad, S., & Alam, T. (2013) · Cited by 3 · see citing works
Effect of antibacterial properties of cyanobacterial Spirulina platensis
Xalxo, R. K., Sao, S., & Sahu, P. (2013) · Cited by 3 · see citing works
Spirulina and Immunity
Borchers, A. T., Belay, A., & Keen, C. L. (2007) · doi:10.1201/9781420052572-11 · Cited by 3 · see citing works
SPIRULINA – A WONDER NUTRACEUTICAL AGAINST CANCER: A REVIEW
Kaur, K., & Kaur, S. (2021) · PLANT ARCHIVES · doi:10.51470/plantarchives.2021.v21.no1.177 · Cited by 2 · see citing works
Spirulina Species
Smet, P. A. G. M. D. (1997) · Adverse effects of herbal drugs · doi:10.1007/978-3-642-60367-9_12 · Cited by 2 · see citing works
Spirulina Platensis: A Natural Product with many Biological Properties
Dixit, P., Ahmad, I., & Jafar, T. (2025) · doi:10.38124/ijisrt/25nov468 · Cited by 1 · see citing works
Environmental Chemicals
Schwartz, H. (1972) · Science News · doi:10.2307/3957443 · Cited by 1 · see citing works

Regression of experimental oral carcinomas by local injection of β‐carotene and canthaxanthin
SCHWARTZ, J. L., & Shklar, G. (1988) · Nutrition and Cancer · doi:10.1080/01635588809513967 · Cited by 80 · see citing works
Self-citation
A cyanobacteria extract and β‐carotene stimulate an antitumor host response against an oral cancer cell line
SCHWARTZ, J. L., & Shklar, G. (1989) · Phytotherapy Research · doi:10.1002/ptr.2650030605 · Cited by 17 · see citing works
Self-citation
Beta carotene is associated with the regression of hamster buccal pouch carcinoma and the induction of tumor necrosis factor in macrophages
SCHWARTZ, J. L., Suda, D., & Light, G. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90451-1 · Cited by 102 · see citing works
Self-citation
Prevention of experimental oral cancer by extracts of Spirulina-Dunaliella algae
Schwartz, J., Shklar, G., Reid, S., & Trickier, D. (1988) · Nutrition and Cancer · doi:10.1080/01635588809513979 · Cited by 136 · see citing works
Self-citation
Retardation of experimental oral cancer development by retinyl acetate
Burge‐Bottenbley, A., & Shklar, G. (1983) · Nutrition and Cancer · doi:10.1080/01635588309513788 · Cited by 46 · see citing works
Self-citation

Authors: Schwartz, J., & Shklar, G.
Affiliations: Harvard University (US)
Corresponding author: Shklar, Gerald
ORCID: Schwartz, Joel
Venue: Journal of Oral and Maxillofacial Surgery
Publisher: Elsevier BV
Published: 1987-06
Volume: 45
Issue: 6
Pages: 510-515
ISSN: 0278-2391 (ISSN-L)
DOI: 10.1016/s0278-2391(87)80011-3
OpenAlex: W2012180377
Cited by: 109
References: 13
Citations by year: 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 5 · 2012: 4
FWCI: 13.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Oral and Maxillofacial Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: tumor regression, beta-carotene, algae extract, Spirulina, Dunaliella, canthaxanthin, isotretinoin, buccal pouch, hamster, oral cancer, chemoprevention
MeSH terms: Cyanobacteria, Chlorophyta, Animals, Carcinoma, Squamous Cell, Carotenoids, Cricetinae, Male, Mesocricetus, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Multiple Primary, Plant Extracts, Remission Induction, Tretinoin, Vitamin E, Isotretinoin, Canthaxanthin

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Regression of experimental hamster cancer by beta carotene and algae extracts

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