Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Cited by (161)

Items 101–161 of 161

1. Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health
   Davey Smith, George · 2011 · Genes & Nutrition
2. Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.
   White, Jon, Sofat, Reecha, Hemani, Gibran, Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, Kruger, Felix A, Giambartolomei, Claudia, Swerdlow, Daniel I et al. · 2016 · The Lancet Diabetes & Endocrinology
3. Pleiotropy-robust Mendelian randomization.
   van Kippersluis, Hans, Rietveld, Cornelius A · 2018 · International Journal of Epidemiology
4. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
   Voight, Benjamin F, Peloso, Gina M, Orho-Melander, Marju, Frikke-Schmidt, Ruth, Barbalic, Maja, Jensen, Majken K, Hindy, George, Hólm, Hilma, Ding, Eric L, Johnson, Toby et al. · 2012 · The Lancet
5. Depression and Interleukin-6 Signaling: A Mendelian Randomization Study
   Kelly, Kristen M., Smith, Jennifer A., Mezuk, Briana · 2021 · Brain, Behavior, and Immunity
6. The Society for Social Medicine John Pemberton Lecture 2011. Developmental overnutrition—an old hypothesis with new importance?*
   Lawlor, Debbie A · 2013 · International Journal of Epidemiology
7. The use of negative control outcomes in Mendelian randomization to detect potential population stratification
   Sanderson, Eleanor, Richardson, Tom G, Hemani, Gibran, Davey Smith, George · 2021 · International Journal of Epidemiology
8. Association between psychological distress and liver disease mortality: A meta-analysis of individual study participants
   Russ, Tom C., Kivimäki, Mika, Morling, Joanne R., Starr, John M., Stamatakis, Emmanuel, Batty, G. David · 2015 · Gastroenterology
9. Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits
   Pavlides, Jennifer M. Whitehead, Zhu, Zhihong, Gratten, Jacob, McRae, Allan F., Wray, Naomi R., Yang, Jian · 2016 · Genome Medicine
10. A Review of Genetic Association Studies of Obstructive Sleep Apnea: Field Synopsis and Meta-Analysis
    Varvarigou, Vasileia, Dahabreh, Issa J., Malhotra, Atul, Kales, Stefanos N. · 2011 · Sleep
11. The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study
    Xu, Lin, Borges, Maria Carolina, Hemani, Gibran, Lawlor, Debbie A. · 2017 · Diabetologia
12. Independent Causal Effect of Remnant Cholesterol on Atherosclerotic Cardiovascular Outcomes: A Mendelian Randomization Study
    Navarese, Eliano P., Vine, Donna, Proctor, Spencer, Grzelakowska, Klaudyna, Berti, Sergio, Kubica, Jacek, Raggi, Paolo · 2023 · Arteriosclerosis, Thrombosis, and Vascular Biology
13. Are Mendelian randomization investigations immune from bias due to reverse causation?
    Burgess, Stephen, Swanson, Sonja A, Labrecque, Jeremy A · 2021 · European Journal of Epidemiology
14. Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With <i>CETP</i> Gene Polymorphisms
    Sofat, Reecha, Hingorani, Aroon D., Smeeth, Liam, Humphries, Steve E., Talmud, Philippa J., Cooper, Jackie, Shah, Tina, Sandhu, Manjinder S., Ricketts, Sally L., Boekholdt, S. Matthijs et al. · 2010 · Circulation
15. Intimate Relationships and Depression: Searching for Causation in the Sea of Association
    Whisman, Mark A., Sbarra, David A., Beach, Steven R.H. · 2021 · Annual Review of Clinical Psychology
16. Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
    Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias et al. · 2017 · PLOS ONE
17. Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian Randomization study
    Walker, Venexia M, Kehoe, Patrick G, Martin, Richard M, Davies, Neil M · 2018
18. The Effect of Iron Status on Risk of Coronary Artery Disease: A Mendelian Randomization Study—Brief Report
    Gill, Dipender, Del Greco M., Fabiola, Walker, Ann P., Srai, Surjit K.S., Laffan, Michael A., Minelli, Cosetta · 2017 · Arteriosclerosis Thrombosis and Vascular Biology
19. Selection Bias When Estimating Average Treatment Effects Using One-sample Instrumental Variable Analysis
    Hughes, Rachael A., Davies, Neil M., Davey Smith, George, Tilling, Kate · 2019 · Epidemiology
20. Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis
    Ross, Stephanie, D’Mello, Matthew, Anand, Sonia S., Eikelboom, John, CARDIoGRAMplusC4D Consortium*, Stewart, Alexandre F.R., Samani, Nilesh J., Roberts, Robert, Paré, Guillaume · 2015 · Circulation: Cardiovascular Genetics
21. Improving bias and coverage in instrumental variable analysis with weak instruments for continuous and binary outcomes
    Burgess, Stephen, Thompson, Simon G. · 2012 · Statistics in Medicine
22. Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes
    Xie, Weijia, Wood, Andrew R., Lyssenko, Valeriya, Weedon, Michael N., Knowles, Joshua W., Alkayyali, Sami, Assimes, Themistocles L., Quertermous, Thomas, Abbasi, Fahim, Paananen, Jussi et al. · 2013 · Diabetes
23. Exploring and mitigating potential bias when genetic instrumental variables are associated with multiple non-exposure traits in Mendelian randomization
    Yang, Qian, Sanderson, Eleanor, Tilling, Kate, Borges, M Carolina, Lawlor, Deborah A · 2019
24. Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
    Vermeulen, Jentien M., Wootton, Robyn E., Treur, Jorien L., Sallis, Hannah M., Jones, Hannah J., Zammit, Stanley, van den Brink, Wim, Goodwin, Guy M., de Haan, Lieuwe, Munafò, Marcus R. · 2021 · The British Journal of Psychiatry
25. Clinical Effect of Naturally Random Allocation to Lower Systolic Blood Pressure Beginning Before the Development of Hypertension
    Ference, Brian A., Julius, Stevo, Mahajan, Nitin, Levy, Phillip D., Williams, Kim Allan, Flack, John M. · 2014 · Hypertension
26. Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals
    Rasmussen, Katrine L., Tybjærg‐Hansen, Anne, Nordestgaard, Børge G., Frikke‐Schmidt, Ruth · 2018 · Alzheimer's &amp; Dementia
27. Body mass index and breast cancer survival: a Mendelian randomization analysis
    Guo, Qi, Burgess, Stephen, Turman, Constance, Bolla, Manjeet K, Wang, Qin, Lush, Michael, Abraham, Jean, Aittomäki, Kristiina, Andrulis, Irene L, Apicella, Carmel et al. · 2017 · International Journal of Epidemiology
28. Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension
    Guessous, Idris, Dobrinas, Maria, Kutalik, Zoltán, Pruijm, Menno, Ehret, Georg, Maillard, Marc, Bergmann, Sven, Beckmann, Jacques S., Cusi, Daniele, Rizzi, Federica et al. · 2012 · Human Molecular Genetics
29. Cortical structure and the risk for Alzheimer’s disease: A bidirectional Mendelian randomization study
    Wu, Bang-Sheng, Zhang, Ya-Ru, Li, Hong-Qi, Kuo, Kevin, Chen, Shi-Dong, Dong, Qiang, Liu, Yong, Yu, Jin-Tai · 2021 · Translational Psychiatry
30. Impact of glucose level on micro- and macrovascular disease in the general population: a Mendelian randomization study
    Emanuelsson, Frida, Marott, Sarah, Tybjærg-Hansen, Anne, Nordestgaard, Børge G., Benn, Marianne · 2020 · Diabetes Care
31. Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits
    Silverwood, Richard J, Holmes, Michael V, Dale, Caroline E, Lawlor, Debbie A, Whittaker, John C, Smith, George Davey, Leon, David A, Palmer, Tom, Keating, Brendan J, Zuccolo, Luisa et al. · 2014 · International Journal of Epidemiology
32. The Causal Role of Alcohol Use in Adolescent Externalizing and Internalizing Problems: A Mendelian Randomization Study
    Chao, Miao, Li, Xinying, McGue, Matt · 2017 · Alcoholism: Clinical and Experimental Research
33. Thinking big: large-scale collaborative research in observational epidemiology
    Thompson, Alexander · 2009 · European Journal of Epidemiology
34. Smoking Is Associated with, but Does Not Cause, Depressed Mood in Pregnancy – A Mendelian Randomization Study
    Lewis, Sarah J., Araya, Ricardo, Davey Smith, George, Freathy, Rachel, Gunnell, David, Palmer, Tom, Munafò, Marcus · 2011 · PLoS ONE
35. Cellular dynamics across aged human brains uncover a multicellular cascade leading to Alzheimer’s disease
    Green, Gilad Sahar, Yang, Hyun‐Sik, Fujita, Masashi, Taga, Mariko, Regev, Aviv, Menon, Vilas, Bennett, David A. A, Habib, Naomi, De Jager, Philip L · 2023 · Alzheimer's &amp; Dementia
36. Mendelian Randomization analysis of the causal effect of adiposity on hospital costs
    Dixon, Padraig, Hollingworth, William, Harrison, Sean, Davies, Neil M., Davey Smith, George · 2020 · Journal of Health Economics
37. Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization
    Taylor, Peter N., Richmond, Rebecca, Davies, Neil, Sayers, Adrian, Stevenson, Kirsty, Woltersdorf, Wolfram, Taylor, Andrew, Groom, Alix, Northstone, Kate, Ring, Susan et al. · 2016 · The Journal of Clinical Endocrinology &amp; Metabolism
38. Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment
    Howe, Laurence J, Tudball, Matthew, Davey Smith, George, Davies, Neil M · 2022 · International Journal of Epidemiology
39. Survivor bias in Mendelian randomization analysis
    Vansteelandt, Stijn, Dukes, Oliver, Martinussen, Torben · 2018 · Biostatistics
40. Impact of high glucose levels and glucose lowering on risk of ischaemic stroke: a Mendelian randomisation study and meta-analysis
    Benn, Marianne, Emanuelsson, Frida, Tybjærg-Hansen, Anne, Nordestgaard, Børge G. · 2021 · Diabetologia
41. Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization
    Zheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F. M., Yau, Michelle S., Hartley, April E., Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P., Frysz, Monika et al. · 2023 · Arthritis &amp; Rheumatology
42. Mendelian randomization studies in the elderly
    Boef, Anna G. C., le Cessie, Saskia, Dekkers, Olaf M. · 2015 · Epidemiology
43. Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach
    Wu, Zhijun, Lou, Yuqing, Qiu, Xiaochun, Liu, Yan, Lu, Lin, Chen, Qiujing, Jin, Wei · 2014 · BMC Medical Genetics
44. Multi-cellular communities are perturbed in the aging human brain and Alzheimer’s disease
    Cain, Anael, Taga, Mariko, McCabe, Cristin, Green, Gilad, Hekselman, Idan, White, Charles C., Lee, Dylan I., Gaur, Pallavi, Rozenblatt-Rosen, Orit, Zhang, Feng et al. · 2020
45. Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia
    Renee Ruhaak, L, van der Laarse, Arnoud, Cobbaert, Christa M · 2019 · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
46. Alcohol consumption and cognitive performance: a <scp>M</scp> endelian randomization study
    Kumari, Meena, Holmes, Michael V., Dale, Caroline E., Hubacek, Jaroslav A., Palmer, Tom M., Pikhart, Hynek, Peasey, Anne, Britton, Annie, Horvat, Pia, Kubinova, Ruzena et al. · 2014 · Addiction
47. EPIDEMIOLOGIC RESEARCH ON INTERPERSONAL VIOLENCE AND COMMON PSYCHIATRIC DISORDERS: WHERE DO WE GO FROM HERE?: Review: Violence and Common Psychiatric Disorders
    Cerdá, Magdalena, DiGangi, Julia, Galea, Sandro, Koenen, Karestan · 2012 · Depression and Anxiety
48. Population attributable fractions for risk factors for spontaneous preterm births in 81 low- and middle-income countries: A systematic analysis.
    Bryce, Emily, Gurung, Sabi, Tong, Hannah, Katz, Joanne, Lee, Anne CC, Black, Robert E, Walker, Neff · 2022 · Journal of Global Health
49. Alcohol consumption and risk of atrial fibrillation: Observational and genetic estimates of association
    Tolstrup, Janne Schurmann, Wium-Andersen, Marie Kim, Ørsted, David Dynnes, Nordestgaard, Børge Grønne · 2016 · European Journal of Preventive Cardiology
50. Assessment of bidirectional relationships between 98 genera of the human gut microbiota and amyotrophic lateral sclerosis: a 2-sample Mendelian randomization study
    Zhang, Linjing, Zhuang, Zhenhuang, Zhang, Gan, Huang, Tao, Fan, Dongsheng · 2022 · BMC Neurology
51. Reporting and guidelines for mendelian randomization analysis: A systematic review of oncological studies
    Lor, Gary C.Y., Risch, Harvey A., Fung, W.T., Au Yeung, S.L., Wong, Irene O.L., Zheng, Wei, Pang, Herbert · 2019 · Cancer Epidemiology
52. The association between schizophrenia and white blood cells count: A bidirectional two-sample mendelian randomization study
    Gao, Zibo, Li, Biao, Guo, Xinru, Bai, Wei, Kou, Changgui · 2023 · BMC Psychiatry
53. Constrained instruments and their application to Mendelian randomization with pleiotropy
    Jiang, Lai, Oualkacha, Karim, Didelez, Vanessa, Ciampi, Antonio, Rosa‐Neto, Pedro, Benedet, Andrea L., Mathotaarachchi, Sulantha, Richards, John Brent, Greenwood, Celia M. T., and for the Alzheimer’s Disease Neuroimaging Initiative · 2019 · Genetic Epidemiology
54. Causal associations of gut microbiota and metabolites on sepsis: a two-sample Mendelian randomization study
    Zhao, Jian, Pan, Xin, Hao, Di, Zhao, Yi, Chen, Yuanzhuo, Zhou, Shuqin, Peng, Hu, Zhuang, Yugang · 2023 · Frontiers in Immunology
55. Using Genetic Instruments to Estimate Interactions in Mendelian Randomization Studies
    North, Teri-Louise, Davies, Neil M., Harrison, Sean, Carter, Alice R., Hemani, Gibran, Sanderson, Eleanor, Tilling, Kate, Howe, Laura D. · 2019 · Epidemiology
56. Interpreting noncoding genetic variation in complex traits and human disease
    Ward, Lucas D, Kellis, Manolis · 2012 · Nature Biotechnology
57. Causal Relationships between Lipid-Lowering Drug Target and Aortic Disease and Calcific Aortic Valve Stenosis: A Two-Sample Mendelian Randomization
    Yang, Liang, Xu, Mingyuan, Gao, Xixi, Liu, Jingwen, Zhang, Dingkai, Zhang, Zhaohua, Ye, Zhidong, Wen, Jianyan, Liu, Peng · 2024 · Reviews in Cardiovascular Medicine
58. Genetic analyses reveal association between rosacea and cardiovascular diseases
    Gao, Yafang, Xu, Chengan, Yan, Qiqi · 2025 · Scientific Reports
59. Mendelian Randomization Analysis Dissects the Relationship between NAFLD, T2D, and Obesity and Provides Implications to Precision Medicine
    Liu, Zhipeng, Zhang, Yang, Graham, Sarah, Pique-Regi, Roger, Dong, Xiaocheng Charlie, Chen, Y. Eugene, Willer, Cristen, Liu, Wanqing · 2019
60. Potential genetic association between coffee/caffeine consumption and erectile dysfunction: a Mendelian randomization study and meta-analysis
    Xiang, Nana, Hu, Yanhua, Peng, Wenchun, Luo, Mei, Chen, Hong, Zhang, Qiuhua · 2024 · Frontiers in Endocrinology
61. MR-MAS: an end-to-end multi-agent system for autonomous Mendelian randomization analysis
    Wei, Wendi, Fan, Yuling, Li, Lin, Le, Thuc Duy, Li, Xiaomei, Cheng, Debo, Feng, Zaiwen · 2026 · Bioinformatics