Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems

Schröter, Laura; Ventura, Natascia

doi:10.1002/smll.202201680

Cited by 99Microplastics and Plastic PollutionNanoparticles: synthesis and applicationsEnvironmental Toxicology and Ecotoxicology

Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems

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Schröter, Laura, Ventura, Natascia·2022·Small

DOI 10.1002/smll.202201680

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Abstract

Nanoplastic particles (NPs) can be produced or derived from the degradation of several daily used products and can therefore be found in the air, water, and food. Every day, these microscopic particles are confronted by different routes of exposure. Recent investigations have shown the internalization of these particles, differing in size and modification, in vivo in aquatic organisms and terrestrial organisms, as well as in vitro in different human cell lines. During the last years, the number of studies investigating the effects of NPs using widely different model systems and experimental approaches is exponentially growing, thus providing information about NPs, especially about polystyrene particle toxicity on health. To facilitate the grasping of the most relevant information, an overview is provided on the toxic effects of NPs coming from studies in cellular systems and in vivo in model organisms and on aspects which can be of particular relevance for particle toxicity (e.g., particle internalization mechanisms and structural modifications). Major achievements and gaps in the field as well as the point of view on how more systematic studies and exploitation of in vivo model organisms may improve the knowledge on important aspects of NPs are also pointed out.

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Authors: Schröter, L., & Ventura, N.
Affiliations: Leibniz Institute of Environmental Medicine (DE)
Heinrich Heine University Düsseldorf (DE)
Corresponding author: Ventura, Natascia
ORCID: Schröter, Laura
Ventura, Natascia
Venue: Small
Publisher: Wiley
Published: 2022-07-10
Volume: 18
Issue: 31
Pages: e2201680-e2201680
ISSN: 1613-6810 (ISSN-L)
1613-6829
DOI: 10.1002/smll.202201680
OpenAlex: W4284989167
Cited by: 99
References: 163
Citations by year: 2026: 20 · 2025: 34 · 2024: 22 · 2023: 23
FWCI: 1.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Small (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (VE663‐6/1)
Topics: Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords: nanoplastic toxicity, polystyrene nanoparticles, particle internalization, particle surface modification, particle size effects, cell culture model, aquatic organisms, terrestrial organisms, human cell lines, exposure routes, environmental contamination
MeSH terms: Microplastics, Humans, Models, Theoretical, Polystyrenes, Water Pollutants, Chemical, Nanoparticles, Aquatic Organisms

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Nanoplastic Toxicity: Insights and Challenges from Experimental Model Systems

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

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