Hepcidin, A New Iron Regulatory Peptide

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

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A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

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Transferrin receptor is necessary for development of erythrocytes and the nervous system

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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

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Regulation of Iron Metabolism by Hepcidin

Nemeth, E., & Ganz, T. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111303 · Cited by 756

Regulation of iron transport and the role of transferrin

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Suppression of hepcidin during anemia requires erythropoietic activity

Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S. (2006) · Blood · doi:10.1182/blood-2006-06-028787 · Cited by 472

The role of iron in type 2 diabetes in humans

Rajpathak, S. N., Crandall, J. P., Wylie-Rosett, J., Kabat, G. C., Rohan, T. E., & Hu, F. B. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.04.005 · Cited by 363

Hypoxic regulation of erythropoiesis and iron metabolism

Haase, V. H. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00174.2010 · Cited by 347

Iron metabolism in the anemia of chronic disease

Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322

Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones

Peeling, P., Dawson, B., Goodman, C., Landers, G., & Trinder, D. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0726-6 · Cited by 292

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

Lesbordes-Brion, J.-C., Viatte, L., Bennoun, M., Lou, D.-Q., Ramey, G., Houbron, C., Hamard, G., Kahn, A., & Vaulont, S. (2006) · Blood · doi:10.1182/blood-2006-02-003376 · Cited by 257

The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney

Kulaksiz, H., Theilig, F., Bachmann, S., Gehrke, S. G., Rost, D., Janetzko, A., Cetin, Y., & Stremmel, W. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05729 · Cited by 241

Hepcidin in Human Iron Disorders: Diagnostic Implications

Kroot, J. J., Tjalsma, H., Fleming, R. E., & Swinkels, D. W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2009.140053 · Cited by 246

The molecular basis of ferroportin-linked hemochromatosis

De Domenico, I., Ward, D. M., Nemeth, E., Vaughn, M. B., Musci, G., Ganz, T., & Kaplan, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503804102 · Cited by 230

Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis

Sow, F. B., Florence, W. C., Satoskar, A. R., Schlesinger, L. S., Zwilling, B. S., & Lafuse, W. P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0407216 · Cited by 229

Hepcidin Expression in the Liver: Relatively Low Level in Patients with Chronic Hepatitis C

Fujita, N., Sugimoto, R., Takeo, M., Urawa, N., Mifuji, R., Tanaka, H., Kobayashi, Y., Iwasa, M., Watanabe, S., Adachi, Y., et al. (2007) · Molecular Medicine · doi:10.2119/2006-00057.fujita · Cited by 211

β-thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

Ginzburg, Y., & Rivella, S. (2011) · Blood · doi:10.1182/blood-2011-03-283614 · Cited by 201

Role of alcohol in the regulation of iron metabolism

Harrison-Findik, D. D. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i37.4925 · Cited by 156

Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis

Forejtnikovà, H., Vieillevoye, M., Zermati, Y., Lambert, M., Pellegrino, R. M., Guihard, S., Gaudry, M., Camaschella, C., Lacombe, C., Roetto, A., et al. (2010) · Blood · doi:10.1182/blood-2010-04-281360 · Cited by 152

Anemia of chronic disease: pathophysiology and laboratory diagnosis.

THOMAS, C., & THOMAS, L. (2005) · Laboratory Hematology · doi:10.1532/lh96.04049 · Cited by 124

Functional differences between hepcidin 1 and 2 in transgenic mice

Lou, D.-Q., Nicolas, G., Lesbordes, J.-C., Viatte, L., Grimber, G., Szajnert, M.-F., Kahn, A., & Vaulont, S. (2004) · Blood · doi:10.1182/blood-2003-07-2524 · Cited by 123

Training Surface and Intensity: Inflammation, Hemolysis, and Hepcidin Expression

PEELING, P., DAWSON, B., GOODMAN, C., LANDERS, G., WIEGERINCK, E. T., SWINKELS, D. W., & TRINDER, D. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318192ce58 · Cited by 107

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell‐line HepG2 induced by thalassaemic sera

Weizer‐Stern, O., Adamsky, K., Amariglio, N., Levin, C., Koren, A., Breuer, W., Rachmilewitz, E., Breda, L., Rivella, S., Ioav Cabantchik, Z., et al. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06258.x · Cited by 80

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

Weizer-Stern, O., Adamsky, K., Amariglio, N., Rachmilewitz, E., Breda, L., Rivella, S., & Rechavi, G. (2006) · American Journal of Hematology · doi:10.1002/ajh.20549 · Cited by 71

Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice

Mok, H., Jelinek, J., Pai, S., Cattanach, B. M., Prchal, J. T., Youssoufian, H., & Schumacher, A. (2004) · Development · doi:10.1242/dev.01081 · Cited by 73

Iron‐ and inflammation‐induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo†

Lou, D., Lesbordes, J., Nicolas, G., Viatte, L., Bennoun, M., Van Rooijen, N., Kahn, A., Renia, L., & Vaulont, S. (2005) · Hepatology · doi:10.1002/hep.20663 · Cited by 62

Hepcidin: A novel peptide hormone regulating iron metabolism

Singh, B., Arora, S., Agrawal, P., & Gupta, S. K. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.02.014 · Cited by 61

Is the iron regulatory hormone hepcidin a risk factor for alcoholic liver disease?

Harrison-Findik, D.-D. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1186 · Cited by 56

Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency

Finkenstedt, A., Bianchi, P., Theurl, I., Vogel, W., Witcher, D. R., Wroblewski, V. J., Murphy, A. T., Zanella, A., & Zoller, H. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07535.x · Cited by 51

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats

Theurl, M., Nairz, M., Schroll, A., Sonnweber, T., Asshoff, M., Haschka, D., Seifert, M., Willenbacher, W., Wilflingseder, D., Posch, W., et al. (2014) · Haematologica · doi:10.3324/haematol.2013.099481 · Cited by 42

The effect of the competitive season in professional basketball on inflammation and iron metabolism

Dzedzej, A., Ignatiuk, W., Jaworska, J., Grzywacz, T., Lipińska, P., Antosiewicz, J., Korek, A., & Ziemann, E. (2016) · Biology of Sport · doi:10.5604/20831862.1201811 · Cited by 18