The Homeobox Gene Otx of the Jellyfish Podocoryne carnea: Role of a Head Gene in Striated Muscle and Evolution
Open accessAbstract
In many bilaterian animals members of the Otx gene family are expressed in head or brain structures. Cnidarians, however, have no clearly homologous head and no distinct brain; but an Otx homolog from the jellyfish Podocoryne carnea is highly conserved in sequence and domain structure. Sequence similarities extend well beyond the homeodomain and Podocoryne Otx can be aligned over its entire length to human OTX1, OTX2, and CRX. The overall structure of Otx is better conserved from Podocoryne to deuterostomes while protostomes appear to be more derived. In contrast, functions seem to be conserved from protostomes to vertebrates but not in Podocoryne or echinoderms. Podocoryne Otx is expressed only during medusa bud formation and becomes restricted to the striated muscle of medusae. Cnidaria are the most basal animals with striated muscle. Podocoryne polyps have no striated muscle and no Otx expression; both appear only during the asexual medusa budding process. The common ancestor of all animals that gave rise to cnidarians, protostomes, and deuterostomes already had an Otx gene more similar to today's Podocoryne and human homologs than to Drosophila otd, while the head-specific function appears to have evolved only later.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other regulatory and structural genes also confirm that Podocoryne and Hydra use structurally comparable genes differently.
“This is also confirmed with other regulatory and structural genes (Gro ¨ger et al., 1999;Mu ¨ller et al., 1999)”
From Conservation of Hox/ParaHox-Related Genes in the Early Development of a Cnidarian (2001) · cites this paper as Müller et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222 · see citing works
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674 · see citing works
Multiple sequence alignment with Clustal X
Jeanmougin, F., Thompson, J. D., Gouy, M., Higgins, D. G., & Gibson, T. J. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01285-7 · Cited by 2,652 · see citing works
Induction of Ectopic Eyes by Targeted Expression of the <i>eyeless</i> Gene in <i>Drosophila</i>
Halder, G., Callaerts, P., & Gehring, W. J. (1995) · Science · doi:10.1126/science.7892602 · Cited by 1,573 · see citing works
Furukawa, T., Morrow, E. M., & Cepko, C. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80439-0 · Cited by 901 · see citing works
Ton, C. C. T., Hirvonen, H., Miwa, H., Weil, M. M., Monaghan, P., Jordan, T., van Heyningen, V., Hastie, N. D., Meijers-Heijboer, H. E. J., Drechsler, M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90284-6 · Cited by 862 · see citing works
Gehring, W. J., Affolter, M., & Bürglin, T. R. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002415 · Cited by 861 · see citing works
Nested expression domains of four homeobox genes in developing rostral brain
Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A., & Boncinelli, E. (1992) · Nature · doi:10.1038/358687a0 · Cited by 793 · see citing works
Acampora, D., Mazan, S., Lallemand, Y., Avantaggiato, V., Maury, M., Simeone, A., & Brûlet, P. (1995) · Development · doi:10.1242/dev.121.10.3279 · Cited by 702 · see citing works
The zootype and the phylotypic stage
Slack, J. M. W., Holland, P. W. H., & Graham, C. F. (1993) · Nature · doi:10.1038/361490a0 · Cited by 699 · see citing works
Simeone, A., Acampora, D., Mallamaci, A., Stornaiuolo, A., D’Apice, M. R., Nigro, V., & Boncinelli, E. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05935.x · Cited by 616 · see citing works
Freund, C. L., Gregory, C. Y., Furukawa, T., Papaioannou, M. G., Looser, J., Ploder, L., Bellingham, J., Ng, D., Herbrick, J.-A., Duncan, A. M. V., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80440-7 · Cited by 564 · see citing works
Hanes, S. D., & Brent, R. (1989) · Cell · doi:10.1016/0092-8674(89)90063-9 · Cited by 464 · see citing works
The origin and evolution of animal appendages
Panganiban, G. E. F., Irvine, S. M., Lowe, C. J., Roehl, H. H., Lavine, L. C., Sherbon, B. J., Grenier, J. K., Fallon, J. F., Kimble, J. E., Walker, M. H., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5162 · Cited by 450 · see citing works
Guidebook to the homeobox genes
Duboule, D. (1994) · Medical Entomology and Zoology · Cited by 391 · see citing works
Ang, S., Conlon, R. A., Jin, O., & Rossant, J. (1994) · Development · doi:10.1242/dev.120.10.2979 · Cited by 336 · see citing works
Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA
Piper, D. E., Batchelor, A. H., Chang, C., Cleary, M. L., & Wolberger, C. (1999) · Cell · doi:10.1016/s0092-8674(00)80662-5 · Cited by 328 · see citing works
Finkelstein, R., Smouse, D., Capaci, T. M., Spradling, A. C., & Perrimon, N. (1990) · Genes & Development · doi:10.1101/gad.4.9.1516 · Cited by 324 · see citing works
Structure of a DNA-bound Ultrabithorax–Extradenticle homeodomain complex
Passner, J. M., Ryoo, H. D., Shen, L., Mann, R. S., & Aggarwal, A. K. (1999) · Nature · doi:10.1038/17833 · Cited by 312 · see citing works
The Taxonomy of Developmental Control in <i>Caenorhabditis elegans</i>
Ruvkun, G., & Hobert, O. (1998) · Science · doi:10.1126/science.282.5396.2033 · Cited by 305 · see citing works
Radical alterations in the roles of homeobox genes during echinoderm evolution
Lowe, C. J., & Wray, G. A. (1997) · Nature · doi:10.1038/39580 · Cited by 301 · see citing works
Vertebrate evolution by interspecific hybridisation – are we polyploid?
Spring, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01351-8 · Cited by 297 · see citing works
Self-citationEpilepsy and brain abnormalities in mice lacking the Otx1 gene
Acampora, D., Mazan, S., Avantaggiato, V., Barone, P., Tuorto, F., Lallemand, Y., Brûlet, P., & Simeone, A. (1996) · Nature Genetics · doi:10.1038/ng1096-218 · Cited by 280 · see citing works
Guidebook to the Homeobox Genes
Freund, C. L., & McInnes, R. R. (1995) · Europe PMC (PubMed Central) · Cited by 265 · see citing works
From fly head to mammalian forebrain: the story of otd and Otx
Finkelstein, R., & Boncinelli, E. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90033-7 · Cited by 215 · see citing works
Umesono, Y., Watanabe, K., & Agata, K. (1999) · Development Genes and Evolution · doi:10.1007/s004270050224 · Cited by 202 · see citing works
The Elementary Nervous System Revisited
Mackie, G. O. (1990) · American Zoologist · doi:10.1093/icb/30.4.907 · Cited by 197 · see citing works
A comprehensive classification of homeobox genes
Bürglin, T. R. (1994) · doi:10.1093/oso/9780198599395.003.0003 · Cited by 189 · see citing works
Evolution of homeobox genes: Q50 Paired-like genes founded the Paired class
Galliot, B., de Vargas, C., & Miller, D. J. (1999) · Development Genes and Evolution · doi:10.1007/s004270050243 · Cited by 188 · see citing works
Miura, H., Yanazawa, M., Kato, K., & Kitamura, K. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00062-2 · Cited by 179 · see citing works
Schummer, M., Scheurlen, I., Schaller, C., & Galliot, B. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05233.x · Cited by 174 · see citing works
Otx1 and Otx2 in the development and evolution of the mammalian brain
Simeone, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6790 · Cited by 142 · see citing works
Mori, H., Miyazaki, Y., Morita, T., Nitta, H., & Mishina, M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90004-3 · Cited by 132 · see citing works
Acampora, D., Avantaggiato, V., Tuorto, F., Barone, P., Reichert, H., Finkelstein, R., & Simeone, A. (1998) · Development · doi:10.1242/dev.125.9.1691 · Cited by 126 · see citing works
Wada, S., Katsuyama, Y., Sato, Y., Itoh, C., & Saiga, H. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00600-4 · Cited by 122 · see citing works
Schmid, V. J., & Alder, H. (1984) · Cell · doi:10.1016/0092-8674(84)90275-7 · Cited by 121 · see citing works
Self-citationSeidel, F., & Tardent, P. (1978) · Fischer eBooks · Cited by 121 · see citing works
Williams, N. A., & Holland, P. W. H. (1996) · Nature · doi:10.1038/383490a0 · Cited by 119 · see citing works
orthodenticleIs Required for Photoreceptor Cell Development in theDrosophilaEye
Vandendries, E. R., Johnson, D. L., & Reinke, R. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0020 · Cited by 111 · see citing works
Leuzinger, S., Hirth, F., Gerlich, D. W., Acampora, D., Simeone, A., Gehring, W. J., Finkelstein, R., Furukubo-Tokunaga, K., & Reichert, H. (1998) · Development · doi:10.1242/dev.125.9.1703 · Cited by 109 · see citing works
CnOtx, a Member of the Otx Gene Family, Has a Role in Cell Movement in Hydra
Smith, K. M., Gee, L., Blitz, I. L., & Bode, H. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9337 · Cited by 96 · see citing works
Developmental rescue of Drosophila cephalic defects by the human Otx genes
Nagao, T., Leuzinger, S., Acampora, D., Simeone, A., Finkelstein, R., Reichert, H., & Furukubo-Tokunaga, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3737 · Cited by 86 · see citing works
Gene and domain duplication in the chordate Otx gene family: insights from amphioxus Otx
Williams, N. A., & Holland, P. W. H. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025961 · Cited by 84 · see citing works
Reber‐Müller, S., SPISSINGER, T., Schuchert, P., Spring, J., & Schmid, V. J. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1177 · Cited by 79 · see citing works
Self-citationThe cnidarian premises of metazoan evolution: From triploblasty, to coelom formation, to metamery
Boero, F., Gravili, C., Pagliara, P., Piraino, S., Bouillon, J., & Schmid, V. (1998) · Italian Journal of Zoology · doi:10.1080/11250009809386722 · Cited by 77 · see citing works
Self-citationExpression of the Head GeneLox22-Otxin the LeechHelobdellaand the Origin of the Bilaterian Body Plan
Bruce, A. E. E., & Shankland, M. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8968 · Cited by 73 · see citing works
Otx cognates in a lamprey, Lampetra japonica
Ueki, T., Kuratani, S., Hirano, S., & Aizawa, S. (1998) · Development Genes and Evolution · doi:10.1007/s004270050176 · Cited by 72 · see citing works
Li, X., Chuang, C.-K., Mao, C., Angerer, L. M., & Klein, W. H. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8610 · Cited by 70 · see citing works
Gauchat, D., Kreger, S., Holstein, T. W., & Galliot, B. (1998) · Development · doi:10.1242/dev.125.9.1637 · Cited by 66 · see citing works
Two orthodenticle-related genes in the short-germ beetle Tribolium castaneum
Li, Y., Brown, S. J., Hausdorf, B., Tautz, D., Denell, R. E., & Finkelstein, R. (1996) · Development Genes and Evolution · doi:10.1007/s004270050028 · Cited by 66 · see citing works
Cnidarian homeoboxes and the zootype
Martínez, D. E., Bridge, D., Masuda-Nakagawa, L. M., & Cartwright, P. (1998) · Nature · doi:10.1038/31616 · Cited by 66 · see citing works
Pan, T.-L., Gröger, H., Schmid, V. J., & Spring, J. (1998) · Development Genes and Evolution · doi:10.1007/s004270050180 · Cited by 64 · see citing works
Self-citationTransdifferentiation in Medusae
Schmid, V. J. (1992) · International review of cytology · doi:10.1016/s0074-7696(08)62077-x · Cited by 62 · see citing works
Self-citationAerne, B. L., Baader, C. D., & Schmid, V. J. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1168 · Cited by 54 · see citing works
Self-citationMokady, O., Dick, M. H., Lackschewitz, D., Schierwater, B., & Buss, L. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3673 · Cited by 53 · see citing works
Masuda-Nakagawa, L. M., Gröer, H., Aerne, B. L., & Schmid, V. J. (2000) · Development Genes and Evolution · doi:10.1007/s004270050022 · Cited by 51 · see citing works
Self-citationFrey, J. (1968) · Development Genes and Evolution · doi:10.1007/bf00581742 · Cited by 49 · see citing works
A molecular snapshot of the metazoan ‘Eve’
Shenk, M. A., & Steele, R. E. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90003-6 · Cited by 43 · see citing works
Function and Evolution of Otx Proteins
Klein, W. H., & Li, X. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0449 · Cited by 42 · see citing works
Wada, S., & Saiga, H. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00012-x · Cited by 42 · see citing works
Life stage specific expression of a myosin heavy chain in the hydrozoan Podocoryne carnea
Schuchert, P., Reber-Müller, S., & Schmid, V. (1993) · Differentiation · doi:10.1111/j.1432-0436.1993.tb00654.x · Cited by 41 · see citing works
Self-citationBlum, M., Robertis, E. M. D., Kojis, T., Heinzmann, C., Klisak, I. J., Geissert, D., & Sparkes, R. S. (1994) · Genomics · doi:10.1006/geno.1994.1281 · Cited by 39 · see citing works
Neuropeptides in coelenterates: a review
Grimmelikhuijzen, C. J. P., Graff, D., Koizumi, O., Westfall, J. A., & McFarlane, I. D. (1991) · Hydrobiologia · doi:10.1007/bf00026513 · Cited by 38 · see citing works
Sakamoto, N., Akasaka, K., Mitsunaga‐Nakatsubo, K., Takata, K., Nishitani, T., & Shimada, H. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8455 · Cited by 35 · see citing works
Yanze, N., Gröger, H., Müller, P., & Schmid, V. J. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9347 · Cited by 28 · see citing works
Self-citationNerve net differentiation in medusa development of Podocoryne carnea
Gröger, H., & Schmid, V. J. (2000) · Scientia Marina · doi:10.3989/scimar.2000.64s1107 · Cited by 24 · see citing works
Self-citationNeuropeptides in coelenterates: a review
Grimmelikhuijzen, C. J. P., Graff, D., Koizumi, O., Westfall, J. A., & McFarlane, I. D. (1991) · Springer eBooks · doi:10.1007/978-94-011-3240-4_78 · Cited by 23 · see citing works
Backfoot, a Novel Homeobox Gene, Maps to Human Chromosome 5 (BFT) and Mouse Chromosome 13 (Bft)
Shang, J., Li, X., Ring, H. Z., Clayton, D. A., & Francke, U. (1997) · Genomics · doi:10.1006/geno.1996.4558 · Cited by 20 · see citing works
- Self-citation
Flagged first, then by citations
2 of the 75 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Martindale, M. Q., Pang, K., & Finnerty, J. R. (2004) · Development · doi:10.1242/dev.01119 · Cited by 396 · see citing works
The last common bilaterian ancestor
Erwin, D. H., & Davidson, E. H. (2002) · Development · doi:10.1242/dev.129.13.3021 · Cited by 320 · see citing works
Cnidarians: An evolutionarily conserved model system for regeneration?
Holstein, T. W., Hobmayer, E., & Technau, U. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10227 · Cited by 225 · see citing works
Evolution of striated muscle: Jellyfish and the origin of triploblasty
Seipel, K., & Schmid, V. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.03.032 · Cited by 172 · see citing works
Self-citationOrigins of neurogenesis, a cnidarian view
Galliot, B., Quiquand, M., Ghila, L., de Rosa, R., Miljkovic-Licina, M., & Chera, S. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.563 · Cited by 168 · see citing works
Precambrian Animal Life: Probable Developmental and Adult Cnidarian Forms from Southwest China
Chen, J.-Y., Oliveri, P., Gao, F., Dornbos, S. Q., Li, C.-W., Bottjer, D. J., & Davidson, E. H. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0714 · Cited by 165 · see citing works
Spring, J., Yanze, N., Jösch, C., Middel, A. M., Winninger, B., & Schmid, V. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0616 · Cited by 152 · see citing works
Self-citationA simple plan-Cnidarians and the origins of developmental mechanisms
Ball, E. E., Hayward, D. C., Saint, R., & Miller, D. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1402 · Cited by 123 · see citing works
The Trox-2 Hox/ParaHox gene of Trichoplax (Placozoa) marks an epithelial boundary
Jakob, W., Sagasser, S., Dellaporta, S. L., Holland, P. W. H., Kuhn, K., & Schierwater, B. (2004) · Development Genes and Evolution · doi:10.1007/s00427-004-0390-8 · Cited by 116 · see citing works
The Mesoderm Specification Factor Twist in the Life Cycle of Jellyfish
Spring, J., Yanze, N., Middel, A. M., Stierwald, M., Gröger, H., & Schmid, V. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9956 · Cited by 115 · see citing works
Self-citationConservation of Hox/ParaHox-Related Genes in the Early Development of a Cnidarian
Yanze, N., Spring, J., Schmidli, C., & Schmid, V. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0299 · Cited by 99 · see citing works
Self-citationStierwald, M., Yanze, N., Bamert, R. P., Kammermeier, L., & Schmid, V. J. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.06.018 · Cited by 95 · see citing works
Self-citationDefining phyla: evolutionary pathways to metazoan body plans
Collins, A. G., & Valentine, J. W. (2001) · Evolution & Development · doi:10.1046/j.1525-142x.2001.01048.x · Cited by 90 · see citing works
The Cambrian "explosion" of metazoans and molecular biology: would Darwin be satisfied?
Conway-Morris, S. (2003) · The International Journal of Developmental Biology · doi:10.1387/ijdb.14756326 · Cited by 88 · see citing works
The logic of gene regulatory networks in early vertebrate forebrain patterning
Beccari, L. L., Marco-Ferreres, R., & Bovolenta, P. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.10.004 · Cited by 71 · see citing works
de Jong, D. M., Hislop, N. R., Hayward, D. C., Reece-Hoyes, J. S., Pontynen, P. C., Ball, E. E., & Miller, D. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.034 · Cited by 71 · see citing works
Müller, P., Seipel, K., Yanze, N., Reber-Müller, S., Streitwolf-Engel, R., Stierwald, M., Spring, J. Ü., & Schmid, V. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00091-x · Cited by 69 · see citing works
Self-citationInsights from diploblasts; the evolution of mesoderm and muscle
Burton, P. M. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21150 · Cited by 69 · see citing works
Induction of reverse development in two marine Hydrozoans
Schmich, J., Kraus, Y. A., Vito, D. D., Graziussi, D., Boero, F., & Piraino, S. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.062152js · Cited by 60 · see citing works
Mazza, M. E., Pang, K., Martindale, M. Q., & Finnerty, J. R. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21158 · Cited by 57 · see citing works
Chatelain, G., Fossat, N., Brun, G., & Lamonerie, T. (2006) · Journal of Molecular Medicine · doi:10.1007/s00109-006-0048-2 · Cited by 57 · see citing works
Conserved and divergent genes in apex and axis development of cnidarians
Galliot, B. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00141-6 · Cited by 56 · see citing works
Structural Evolution of Otx Genes in Craniates
Germot, A., Lecointre, G., Plouhinec, J.-L., Mentec, C. L., Girardot, F., & Mazan, S. (2001) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a003955 · Cited by 51 · see citing works
Otx genes in the evolution of the vertebrate brain
Acampora, D., Annino, A., Tuorto, F., Puelles, E., Lucchesi, W., Papalia, A., & Simeone, A. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.02.005 · Cited by 50 · see citing works
Nederbragt, A. J., Welscher, P. T., van den Driesche, S., van Loon, A. E., & Dictus, W. J. A. G. (2002) · Development Genes and Evolution · doi:10.1007/s00427-002-0246-z · Cited by 47 · see citing works
Phylogenetic Context and Basal Metazoan Model Systems
Collins, A. G. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.4.585 · Cited by 45 · see citing works
Nakanishi, N., Yuan, D., Hartenstein, V., & Jacobs, D. K. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00427.x · Cited by 42 · see citing works
The homeobox gene Msx in development and transdifferentiation of jellyfish striated muscle
Galle, S., Yanze, N., & Seipel, K. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.052009sg · Cited by 39 · see citing works
Self-citationOrthodenticle and empty spiracles genes are expressed in a segmental pattern in chelicerates
Simonnet, F., Célérier, M.-L., & Quéinnec, É. (2006) · Development Genes and Evolution · doi:10.1007/s00427-006-0093-4 · Cited by 36 · see citing works
The Significance of Muscle Cells for the Origin of Mesoderm in Bilateria
Rieger, R. M. (2003) · Integrative and Comparative Biology · doi:10.1093/icb/43.1.47 · Cited by 35 · see citing works
Getting the Proto-Pax by the Tail
Vorobyov, E., & Horst, J. (2006) · Journal of Molecular Evolution · doi:10.1007/s00239-005-0163-7 · Cited by 34 · see citing works
The Developmental Origins of Animal Bodyplans
Erwin, D. H. (2007) · Springer eBooks · doi:10.1007/1-4020-5202-2_6 · Cited by 33 · see citing works
Nielsen, M. G., Popodi, E. M., Minsuk, S. B., & Raff, R. A. (2003) · Development Genes and Evolution · doi:10.1007/s00427-003-0299-7 · Cited by 33 · see citing works
Ge, J., Liu, C., Tan, J., Bian, L., & Chen, S. (2018) · Development Genes and Evolution · doi:10.1007/s00427-018-0621-z · Cited by 30 · see citing works
Sanders, S. M., & Cartwright, P. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv153 · Cited by 26 · see citing works
Origin and Evolution of the First Nervous System
Lichtneckert, R., & Reichert, H. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370878-8/00157-9 · Cited by 23 · see citing works
HeOtx expression in an indirectly developing polychaete correlates with gastrulation by invagination
Arenas‐Mena, C., & Wong, K. S. (2007) · Development Genes and Evolution · doi:10.1007/s00427-007-0150-7 · Cited by 24 · see citing works
Basic Nervous System Types: One or Many?
Hirth, F., & Reichert, H. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370878-8/00107-5 · Cited by 22 · see citing works
INTEGRIN AND TALIN IN THE JELLYFISH PODOCORYNE CARNEA
Reber‐Müller, S., Studer, R. O., Müller, P., Yanze, N., & Schmid, V. J. (2001) · Cell Biology International · doi:10.1006/cbir.2000.0708 · Cited by 20 · see citing works
Self-citationBall, E. E., de Jong, D. M., Schierwater, B., Shinzato, C., Hayward, D. C., & Miller, D. J. (2007) · Integrative and Comparative Biology · doi:10.1093/icb/icm028 · Cited by 18 · see citing works
Dewel, R. A., Dewel, W. C., & McKinney, F. K. (2001) · Historical Biology · doi:10.1080/10292380109380592 · Cited by 14 · see citing works
Maternal factor OTX2 regulates human embryonic genome activation and early development
Wang, Q., Zhang, C., Dang, Y., Sun, J., Zou, Z., Li, C., Ma, S., Li, Z., Liu, H., Ma, X., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02350-8 · Cited by 12 · see citing works
Coevolution of the Tlx homeobox gene with medusa development (Cnidaria: Medusozoa)
Travert, M. K., Boohar, R., Sanders, S. M., Boosten, M., Leclère, L., Steele, R. E., & Cartwright, P. (2023) · Communications Biology · doi:10.1038/s42003-023-05077-6 · Cited by 11 · see citing works
Seipel, K., Yanze, N., Müller, P., Streitwolf, R., & Schmid, V. J. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20061 · Cited by 9 · see citing works
Self-citationShimizu, H., & Namikawa, H. (2009) · Evolution & Development · doi:10.1111/j.1525-142x.2009.00368.x · Cited by 7 · see citing works
Ge, M., Liú, W., Ma, C., Yan, Z., Liang, H., Xu, Z. Q., Mariottini, G. L., Zhang, J., Zhao, X., Yang, Y., et al. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103509 · Cited by 5 · see citing works
Otx2 expression and implications for olfactory imprinting in the anemonefish, Amphiprion percula
Veilleux, H. D., van Herwerden, L., Cole, N. J., Don, E. K., Santis, C. D., Dixson, D. L., Wenger, A. S., & Munday, P. L. (2013) · Biology Open · doi:10.1242/bio.20135496 · Cited by 4 · see citing works
Riebli, N., & Reichert, H. (2016) · Wiley eBooks · doi:10.1002/9781118316757.ch6 · Cited by 3 · see citing works
Li, Y., Peng, S., Liu, Y., He, K., Sun, K. W., Yu, Z., Ma, Y., Wang, F., Xu, P., Sun, T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.06.527379 · Cited by 2 · see citing works
Distribution of nematocytes differs in two types of gonophores in hydrozoan Sarsia loveniiPreprint
Vetrova, A. A., Prudkovsky, A. A., & Kremnyov, S. V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.22.533798 · Cited by 2 · see citing works
A chromosome-level reference genome for the colonial marine hydrozoan Podocoryna americana
Chang, E. S., Connelly, M. T., Travert, M. K., Barreira, S. N., Rivera, A. M., Katzer, A. M., Yu, R., Cartwright, P., & Baxevanis, A. D. (2026) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkag160 · Cited by 1 · see citing works
Oonuma, K., Hirose, D., Takatori, N., & Saiga, H. (2014) · Development Growth & Differentiation · doi:10.1111/dgd.12118 · Cited by 1 · see citing works
In Memoriam - Volker Schmid (1939-2008)
Gehring, W. J., Galliot, B., & Piraino, S. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082708wg · Cited by 1 · see citing works
Ball, E. E., de Jong, D., Schierwater, B., Shinzato, C., Hayward, D. C., & Miller, D. J. (2010) · Science Publishers eBooks · doi:10.1201/b10425-12 · Cited by 1 · see citing works
Role of Otx transcription factors in brain development
Simeone, A., Martı́nez-Barberá, J. P., Puelles, E., & Acampora, D. (2003) · Advances in developmental biology and biochemistry · doi:10.1016/s1569-1799(03)13007-9
Condamine, T. (2018) · theses.fr (ABES) · doi:10.70675/7bd509e2z4d99z495czafd0z1adf840e0228
- Authors
- Müller, P., Yanze, N., Schmid, V., & Spring, J.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Spring, Jürg
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 216
- Issue
- 2
- Pages
- 582-594
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1992943436
- Cited by
- 57
- References
- 75
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Stiftung für die Erforschung der Muskelkrankheiten
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- Podocoryne carnea, jellyfish, cnidarian evolution, striated muscle, Otx1, Otx2, CRX, protostomes, deuterostomes
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Molecular Sequence Data, Phylogeny, RNA, Messenger, Sequence Alignment, Conserved Sequence, In Situ Hybridization, Homeodomain Proteins, Muscle, Skeletal, Gene Expression Regulation, Developmental, Evolution, Molecular, Scyphozoa, Otx Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
