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Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse
Abstract
Doubly transgenic mice expressing both a mutated amyloid precursor protein and a mutated presenilin-1 protein accumulate A(beta) deposits as they age. The early A(beta) deposits were found to be primarily composed of fibrillar A(beta) and resembled compact amyloid plaques. As the mice aged, nonfibrillar A(beta) deposits increased in number and spread to regions not typically associated with amyloid plaques in Alzheimer's disease. The fibrillar, amyloid-containing deposits remained restricted to cortical and hippocampal structures and did not increase substantially beyond the 12-month time point. Even at early time points, the fibrillar deposits were associated with dystrophic neurites and activated astrocytes expressing elevated levels of glial fibrillary acidic protein. Microglia similarly demonstrated increased staining for complement receptor-3 in the vicinity of A(beta) deposits at early time points. However, when MHC-II staining was used to assess the degree of microglial activation, full activation was not detected until mice were 12 months or older. Overall, the regional pattern of A(beta) staining resembles that found in Alzheimer disease; however, a progression from diffuse A(beta) to more compact amyloid deposits is not observed in the mouse model. It is noted that the activation of microglia at 12 months is coincident with the apparent stabilization of fibrillar A(beta) deposits, raising the possibility that activated microglia might clear fibrillar A(beta) deposit…
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“Animal models of amyloid pathology offer an experimental platform to studying AD (Gordon et al., 2002).”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Gordon et al., 2002
In the citing paper
“In fact, based on the kinetics of appearance of reactivity markers, previous studies concluded that astrocyte alterations would precede microglia reactivity (Chun et al., 2018; Gordon et al., 2002; Tournier et al., 2020).”
From Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease (2024) · cites this paper as Gordon et al., 2002
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Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856
Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506
Self-citationIncreased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486
Self-citation
Research works printed but not linked: 4
- Holcomb, 1998, Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes, Nat. Med., 4, 97, 10.1038/nm0198-097 · DOI · Paper page
- Jantzen, 2000, Modification of microglial reactivity in mAPP/mPS1 transgenic mice using NCX-2216, Neurosci. Abstr., 30, 379.8
- Morgan, D., and M. N. Gordon. 1996. Aging and molecular biology. Pages 468–487 in D. Magnusson, Ed., The Lifespan Development of Individuals. Cambridge Univ. Press, New York.
- Savage, 1995, Elevated Aβ levels in Alzheimer's disease brain are associated with a selective accumulation of Aβ42 in parenchymal amyloid deposits, and both Aβ40 and Aβ42 in cerebrovascular deposits, Amyloid Int. J. Exp. Clin. Invest., 2, 234
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Self-citationMalm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301
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Lord, A., Kalimo, H., Eckman, C., Zhang, X.-Q., Lannfelt, L., & Nilsson, L. N. G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.007 · Cited by 260
Dickey, C. A., Loring, J. F., Montgomery, J., Gordon, M. N., Eastman, P. S., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05219.2003 · Cited by 242
Self-citationChlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice
Little, C. S., Hammond, C. J., MacIntyre, A., Balin, B. J., & Appelt, D. M. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00127-1 · Cited by 243
Wilcock, D. M., DiCarlo, G., Henderson, D., Jackson, J., Clarke, K., Ugen, K. E., Gordon, M. N., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03745.2003 · Cited by 232
Self-citationNorris, C. M., Kadish, I., Blalock, E. M., Chen, K.-C., Thibault, V., Porter, N. M., Landfield, P. W., & Kraner, S. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0365-05.2005 · Cited by 229
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Self-citationWilcock, D., Gordon, M., & Morgan, D. (2006) · Nature Protocols · doi:10.1038/nprot.2006.277 · Cited by 193
Self-citationMorgan, D., Gordon, M. N., Tan, J., Wilcock, D. M., & Rojiani, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178444.33972.e0 · Cited by 176
Self-citationDhanasekaran, M., Holcomb, L. A., Hitt, A. R., Tharakan, B., Porter, J. W., Young, K. A., & Manyam, B. V. (2009) · Phytotherapy Research · doi:10.1002/ptr.2405 · Cited by 175
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Schliebs, R. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6962-9 · Cited by 167
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Self-citationSelenica, M. B., Benner, L., Housley, S. B., Manchec, B., Lee, D. C., Nash, K. R., Kalin, J. H., Bergman, J. A., Kozikowski, A. P., Gordon, M. N., et al. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt241 · Cited by 148
Self-citationChaperone signalling complexes in Alzheimer's disease
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Tohda, C., Matsumoto, N., Zou, K., Meselhy, M. R., & Komatsu, K. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300388 · Cited by 142
Yang, J., Zaim Wadghiri, Y., Minh Hoang, D., Tsui, W., Sun, Y., Chung, E., Li, Y., Wang, A., de Leon, M., & Wisniewski, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.023 · Cited by 135
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Self-citationA New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51
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Lee, D. C., Ruiz, C. R., Lebson, L. A., Selenica, M. B., Rizer, J., Hunt, J. B., Rojiani, R., Reid, P., Kammath, S., Nash, K. R., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.014 · Cited by 122
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Ruiz, H. H., Chi, T., Shin, A. C., Lindtner, C., Hsieh, W., Ehrlich, M. E., Gandy, S., & Buettner, C. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.01.008 · Cited by 107
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Stevanovic, K. D., Yunus, A., Joly‐Amado, A., Gordon, M. N., Morgan, D., Gulick, D., & Gamsby, J. J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.015 · Cited by 91
Self-citationDickey, C. A., Kraft, C., Jinwal, U. K., Koren, J., Johnson, A. G., Anderson, L. C., Lebson, L. A., Lee, D. C., Dickson, D. W., de Silva, R., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080764 · Cited by 86
Self-citationCarty, N., Lee, D. C., Dickey, C. A., Ceballos‐Diaz, C., Jansen‐West, K. R., Golde, T. E., Gordon, M. N., Morgan, D., & Nash, K. R. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.10.010 · Cited by 88
Self-citationIn Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Garibotto, V., & Millet, P. (2020) · Cells · doi:10.3390/cells9091941 · Cited by 79
Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice
Dickey, C. A., Gordon, M. N., Wilcock, D. M., Herber, D. L., Freeman, M. J., & Morgan, D. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-7 · Cited by 76
Self-citationCao, J., Amakye, W. K., Qi, C., Liu, X., Ma, J., & Ren, J. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02543-x · Cited by 76
Rogers, K., Felsenstein, K. M., Hrdlicka, L., Tu, Z., Albayya, F., Lee, W., Hopp, S., Miller, M.-J., Spaulding, D., Yang, Z., et al. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-61 · Cited by 75
Rasool, S., Martínez‐Coria, H., Wu, J., LaFerla, F. M., & Glabe, C. G. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12305 · Cited by 74
Partial rescue of memory deficits induced by calorie restriction in a mouse model of tau deposition
Brownlow, M. L., Joly‐Amado, A., Azam, S., Elza, M., Selenica, M. B., Pappas, C. A., Small, B. J., Engelman, R. W., Gordon, M. N., & Morgan, D. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.001 · Cited by 80
Self-citationKung, M., Hou, C., Zhuang, Z., Cross, A. J., Maier, D. L., & Kung, H. (2004) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-004-1487-z · Cited by 72
Grandjean, J., Schroeter, A., He, P., Tanadini, M., Keist, R., Krstic, D., Konietzko, U., Klohs, J., Nitsch, R. M., & Rudin, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4762-13.2014 · Cited by 70
“DOI:10.1523/JNEUROSCI.4762-13.2014 Copyright © 2014 the authors 0270-6474/14/3413780-10$15.00/0 Animal models of amyloid pathology offer an experimental platform to studying AD (Gordon et al., 2002).”
BackgroundInfluentialCatecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice
O’Neil, J. N., Mouton, P. R., Tizabi, Y., Ottinger, M. A., Lei, D.-L., Ingram, D. K., & Manaye, K. F. (2007) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2007.05.008 · Cited by 68
Carty, N. C., Nash, K., Lee, D. C., Mercer, M., Gottschall, P. E., Meyers, C., Muzyczka, N., Gordon, M. N., & Morgan, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.148 · Cited by 55
Self-citationLiu, Y., Deng, Y., Liu, H., Yin, C., Li, X., & Gong, Q. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.11.002 · Cited by 68
Lawlor, P. A., Bland, R. J., Das, P., Price, R. W., Holloway, V., Smithson, L., Dicker, B. L., During, M. J., Young, D., & Golde, T. E. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-11 · Cited by 67
Hale, G., & Good, M. A. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.884 · Cited by 71
Modulation of adult-born neurons in the inflamed hippocampus
Bélarbi, K., & Rosi, S. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00145 · Cited by 68
Lanz, T. A., Fici, G. J., & Merchant, K. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.073965 · Cited by 66
Ketogenic therapy in neurodegenerative and psychiatric disorders: From mice to men
Kraeuter, A.-K., Phillips, R., & Sarnyai, Z. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109913 · Cited by 67
Astrocytic TSPO upregulation appears before microglial TSPO in Alzheimer’s disease
Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Fraser, B. H., Grégoire, M.-C., Kövari, E., & Millet, P. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-200136 · Cited by 65
An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice
Frost, J. L., Liu, B., Rahfeld, J., Kleinschmidt, M., O’Nuallain, B., Le, K. X., Lues, I., Caldarone, B. J., Schilling, S., Demuth, H., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.021 · Cited by 64
Degeneration of β-amyloid-associated cholinergic structures in transgenic APPSW mice
Lüth, H., Apelt, J., Ihunwo, A., Arendt, T., & Schliebs, R. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02658-1 · Cited by 60
Gallagher, J. J., Finnegan, M. E., Grehan, B., Dobson, J., Collingwood, J. F., & Lynch, M. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110614 · Cited by 64
APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)
Lalonde, R., Fukuchi, K., & Strazielle, C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.011 · Cited by 66
Metadata
- Authors
- Gordon, M. N., Holcomb, L. A., Jantzen, P. T., DiCarlo, G., Wilcock, D., Boyett, K. W., Connor, K., Melachrino, J., O'Callaghan, J. P., & Morgan, D.
- Affiliations
- University of South Florida (US)
- National Institute for Occupational Safety and Health (US)
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 173
- Issue
- 2
- Pages
- 183-195
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2152286012
- Cited by
- 247
- References
- 42
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 16 · 2012: 15
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG018478, AG 15490, R01AG015490, AG18478)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid-beta, amyloid plaques, presenilin 1, amyloid precursor protein, microglial activation, complement receptor 3, MHC class II, astrocytes, glial fibrillary acidic protein, dystrophic neurites, mouse model
- MeSH terms
- Aging, Alzheimer Disease, Animals, Histocompatibility Antigens Class II, Astrocytes, Brain, Brain Stem, Cell Count, Disease Models, Animal, Glial Fibrillary Acidic Protein, Immunohistochemistry, Membrane Proteins, Mice, Transgenic, Neurons, Receptors, Complement, Neurites, Amyloid beta-Protein Precursor, Neurofibrillary Tangles, Microglia, Disease Progression, Mice, Presenilin-1
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