The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Construction of Transgenic Mice with Tissue-Specific Acceleration of Mitochondrial DNA Mutagenesis
Abstract
Transgenic mice having rapid accumulation of mitochondrial DNA (mtDNA) mutations specifically in the heart were created. These mice contained a transgene encoding a proofreading-deficient, mouse mitochondrial DNA polymerase (pol gamma) driven by the promoter for the cardiac-specific alpha-myosin heavy chain. Starting shortly after birth greater than 95% of all pol gamma mRNA in the heart was transgene derived; expression in other tissues was low or absent. Mutations in cardiac mtDNA began to accumulate by 7 days after birth. At 1 month of age the frequency of point mutations was 0.014% as determined by DNA sequencing of cloned mtDNA. By long-extension PCR multiple different deletion mutations that had removed several thousand basepairs of genomic sequence were also detected. Sequencing of two deletion molecules showed that one was flanked at the breakpoint by direct repeat sequences. The expression of proofreading-deficient pol gamma had no apparent deleterious effect on mitochondrial DNA and protein content, gene expression, or respiratory function. However, associated with the rise in mtDNA mutation levels was the development of cardiomyopathy as evidenced by enlarged hearts in the transgenic mice. These mice may prove to be useful models to study the pathogenic effects of elevated levels of mitochondrial DNA mutations in specific tissues.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In mice, transgenic overexpression of exonuclease-deficient Pol γ in cardiac tissue caused a greater than 23-fold increase in mtDNA point mutations and detectable levels of large mtDNA deletions (Zhang et al., 2000).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Zhang et al., 2000
Citations
Cites
Rapid and efficient site-specific mutagenesis without phenotypic selection.
Kunkel, T. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.488 · Cited by 7,309
Current protocols in molecular biology
Sargent, T. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90147-9 · Cited by 7,281
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection
Kunkel, T. A., Roberts, J. D., & Zakour, R. A. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)54085-x · Cited by 5,191
Structural features in eukaryotic mRNAs that modulate the initiation of translation.
Kozak, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54860-2 · Cited by 1,826
Diseases of the mitochondrial DNA
Wallace, D. C. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005523 · Cited by 1,319
Kunkel, T. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400006200 · Cited by 754
Trounce, I. A., Kim, Y. L., Jun, A. S., & Wallace, D. C. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)64044-0 · Cited by 749
PCR fidelity of pfu DNA polymerase and other thermostable DNA polymerases
Cline, J. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.18.3546 · Cited by 736
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
Cortopassi, G. A., Shibata, D. K., Soong, N.-W., & Arnheim, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7370 · Cited by 639
Cited by
Sorted by citations
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Brain aging and neurodegeneration: from a mitochondrial point of view
Grimm, A., & Eckert, A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14037 · Cited by 565
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
McCulloch, S. D., & Kunkel, T. A. (2008) · Cell Research · doi:10.1038/cr.2008.4 · Cited by 569
Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective
Lewis, W., Day, B. J., & Copeland, W. C. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1201 · Cited by 496
DNA Polymerase γ, The Mitochondrial Replicase
Kaguni, L. S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161455 · Cited by 414
Mitochondrial point mutations do not limit the natural lifespan of mice
Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics · doi:10.1038/ng1988 · Cited by 404
Morita, M., Stamp, G., Robins, P., Dulic, A., Rosewell, I. R., Hrivnak, G., Daly, G., Lindahl, T. L., & Barnes, D. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6719-6727.2004 · Cited by 380
DNA Polymerase γ in Mitochondrial DNA Replication and Repair
Graziewicz, M. A., Longley, M. J., & Copeland, W. C. (2006) · Chemical Reviews · doi:10.1021/cr040463d · Cited by 301
Lamantea, E., Tiranti, V., Bordoni, A., Toscano, A., Bono, F., Servidei, S., Papadimitriou, A., Spelbrink, H., Silvestri, L., Casari, G., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10278 · Cited by 270
Longley, M. J., Nguyen, D., Kunkel, T. A., & Copeland, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105230200 · Cited by 270
Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?
VANBILSEN, M., Smeets, P., Gilde, A. J., & Vandervusse, G. J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.014 · Cited by 259
Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γ
Lim, S. E., & Copeland, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101114200 · Cited by 227
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues
Nekhaeva, E., Bodyak, N. D., Kraytsberg, Y., McGrath, S., van Orsouw, N. J., Pluzhnikov, A., Wei, J. Y., Vijg, J., & Khrapko, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072670199 · Cited by 205
The Role of Mitochondrial DNA Mutations in Mammalian Aging
Kujoth, G. C., Bradshaw, P. C., Haroon, S., & Prolla, T. A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030024 · Cited by 193
Mechanisms linking mtDNA damage and aging
Pinto, M., & Moraes, C. T. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.005 · Cited by 179
DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180
Kasahara, T., Kubota, M., Miyauchi, T., Noda, Y., Mouri, A., Nabeshima, T., & Kato, T. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001824 · Cited by 178
The mitochondrial free radical theory of ageing - Where do we stand?
Gruber, J. (2008) · Frontiers in bioscience · doi:10.2741/3174 · Cited by 171
A brief overview of mechanisms of mitochondrial toxicity from NRTIs
Kohler, J. J., & Lewis, W. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20223 · Cited by 157
Ponamarev, M. V., Longley, M. J., Nguyen, D., Kunkel, T. A., & Copeland, W. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200100200 · Cited by 156
Maintaining Ancient Organelles
Vega, R. B., Horton, J. L., & Kelly, D. P. (2015) · Circulation Research · doi:10.1161/circresaha.116.305420 · Cited by 147
Consequences of mutations in human DNA polymerase γ
Longley, M. J., Graziewicz, M. A., Bienstock, R. J., & Copeland, W. C. (2005) · Gene · doi:10.1016/j.gene.2005.03.029 · Cited by 141
Mitochondrial genome maintenance in health and disease
Copeland, W. C., & Longley, M. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.03.010 · Cited by 147
Effects of Alcohol and Oxidative Stress on Liver Pathology: The Role of the Mitochondrion
Cahill, A., CUNNINGHAM, C. C., Adachi, M., Ishii, H., Bailey, S. M., Fromenty, B., & Davies, A. M. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02621.x · Cited by 139
Clinical and Molecular Features of POLG-Related Mitochondrial DiseasePreprint
Stumpf, J. D., Saneto, R. P., & Copeland, W. C. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011395 · Cited by 141
Mouse models of ageing and their relevance to disease
Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.001 · Cited by 125
Targeting the Mitochondria in Heart Failure
Sabbah, H. N. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.07.009 · Cited by 130
The mitochondrial theory of aging: dead or alive?
Jacobs, H. T. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00032.x · Cited by 117
Mitochondrial DNA mutations, oxidative stress, and aging
Golden, T. R., & Melov, S. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00288-3 · Cited by 116
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations
Stumpf, J. D., & Copeland, W. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0530-4 · Cited by 125
Zhang, D. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00695-8 · Cited by 115
Self-citationModeling mitochondrial function in aging neurons
Melov, S. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.004 · Cited by 117
Mitochondrial DNA mutations and aging: devils in the details?
Khrapko, K., & Vijg, J. (2009) · Trends in Genetics · doi:10.1016/j.tig.2008.11.007 · Cited by 112
Mouse models of mitochondrial DNA defects and their relevance for human disease
Tyynismaa, H., & Suomalainen, A. (2009) · EMBO Reports · doi:10.1038/embor.2008.242 · Cited by 105
Oxidative damage diminishes mitochondrial DNA polymerase replication fidelity
Anderson, A. P., Luo, X., Russell, W. K., & Yin, Y. W. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1018 · Cited by 106
DNA Polymerase Gamma in Mitochondrial DNA Replication and Repair
Copeland, W. C., & Longley, M. J. (2003) · The Scientific World JOURNAL · doi:10.1100/tsw.2003.09 · Cited by 91
DNA polymerases in the mitochondria A critical review of the evidence
Copeland, W. C. (2016) · Frontiers in bioscience · doi:10.2741/4510 · Cited by 91
Mitochondrial DNA determines androgen dependence in prostate cancer cell lines
Higuchi, M., Kudo, T., Suzuki, S., Evans, T. T., Sasaki, R., Wada, Y., Shirakawa, T., Sawyer, J. R., & Gotoh, A. (2005) · Oncogene · doi:10.1038/sj.onc.1209190 · Cited by 86
Mitochondrial dynamics: orchestrating the journey to advanced age
Biala, A. K., Dhingra, R., & Kirshenbaum, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.015 · Cited by 82
Khrapko, K., Kraytsberg, Y., de Grey, A. D., Vijg, J., & Schon, E. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00209.x · Cited by 80
Adhihetty, P. J., Taivassalo, T., Haller, R. G., Walkinshaw, D. R., & Hood, D. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2007 · Cited by 75
Perier, C., Bender, A., García‐Arumí, E., Melia, M., Bové, J., Laub, C., Klopstock, T., Elstner, M., Mounsey, R. B., Teismann, P., et al. (2013) · Brain · doi:10.1093/brain/awt196 · Cited by 75
Quantification of random mutations in the mitochondrial genome
Vermulst, M., Bielas, J. H., & Loeb, L. A. (2008) · Methods · doi:10.1016/j.ymeth.2008.10.008 · Cited by 71
Single-molecule PCR: an artifact-free PCR approach for the analysis of somatic mutations
Kraytsberg, Y., & Khrapko, K. (2005) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.5.5.809 · Cited by 68
Regulation of mitochondrial DNA content and cancer
Higuchi, M. (2006) · Mitochondrion · doi:10.1016/j.mito.2006.12.001 · Cited by 65
Mitochondrial Microheteroplasmy and a Theory of Aging and Age-Related Disease
Smigrodzki, R. M., & Khan, S. M. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.172 · Cited by 62
Insights regarding mitochondrial DNA copy number alterations in human cancer (Review)
Radzak, S. M. A., Khair, S. Z. N. M., Ahmad, F., Patar, A., Idris, Z., & Yusoff, A. A. M. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5160 · Cited by 59
Frequent Intracellular Clonal Expansions of Somatic mtDNA Mutations
Coller, H. A., Bodyak, N. D., & Khrapko, K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02113.x · Cited by 59
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice
Woodall, B. P., Orogo, A. M., Najor, R. H., Cortez, M. Q., Moreno, E. R., Wang, H., Divakaruni, A. S., Murphy, A. N., & Gustafsson, Å. B. (2019) · JCI Insight · doi:10.1172/jci.insight.127713 · Cited by 55
Mitochondrial DNA mutations and ageing
Greaves, L. C., & Turnbull, D. M. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.018 · Cited by 53
Genome-Wide Analyses of Gene Expression during Mouse Endochondral Ossification
James, C. G., Stanton, L., Agoston, H., Ulici, V., Underhill, T. M., & Beier, F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008693 · Cited by 52
Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders.
Copeland, W. C., Ponamarev, M. V., Nguyen, D., Kunkel, T. A., & Longley, M. J. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3723 · Cited by 51
Mitochondrial DNA mutations activate programmed cell survival in the mouse heart
Zhang, D., Mott, J. L., Chang, S.-W., Stevens, M., Mikolajczak, P., & Zassenhaus, H. P. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00670.2004 · Cited by 49
Self-citationStochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico
Poovathingal, S. K., Gruber, J., Halliwell, B. B., & Gunawan, R. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000572 · Cited by 47
Direct repeats in mitochondrial DNA and mammalian lifespan
Khaidakov, M., Siegel, E. R., & Reis, R. J. S. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.07.008 · Cited by 49
Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations
Mott, J. L., Zhang, D., Stevens, M., Chang, S.-W., Denniger, G., & Zassenhaus, H. P. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(00)00159-7 · Cited by 49
Self-citationMitochondrial DNA Mutations in Aging
Khrapko, K., & Turnbull, D. M. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00002-7 · Cited by 47
Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A
Mott, J. L., Zhang, D., Freeman, J. C., Mikolajczak, P. C., Chang, S.-J., & Zassenhaus, H. P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.104 · Cited by 48
Self-citationKong, Y. X. G., Bergen, N. V., Trounce, I. A., Bui, B. V., Chrysostomou, V., Waugh, H. S., Vingrys, A. J., & Crowston, J. G. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00690.x · Cited by 43
Precise modelling of mitochondrial diseases using optimized mitoBEs
Zhang, X., Zhang, X., Ren, J., Li, J., Wei, X., Yu, Y. F., Yi, Z., & Wei, W. (2025) · Nature · doi:10.1038/s41586-024-08469-8 · Cited by 44
Safdar, A., Annis, S., Kraytsberg, Y., Laverack, C. A., Saleem, A., Popadin, K. Y., Woods, D. C., Tilly, J. L., & Khrapko, K. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.06.011 · Cited by 44
Do mtDNA deletions drive premature aging in mtDNA mutator mice?
Kraytsberg, Y., Simon, D. K., Turnbull, D. M., & Khrapko, K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00484.x · Cited by 42
Abnormal Ca2+Dynamics in Transgenic Mice with Neuron-Specific Mitochondrial DNA Defects
Kubota, M., Kasahara, T., Nakamura, T., Ishiwata, M., Miyauchi, T., & Kato, T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3933-06.2006 · Cited by 41
Toxicogenetics of Antiretroviral Therapy: Genetic Factors that Contribute to Metabolic Complications
TARR, P. E., & Telenti, A. (2007) · Antiviral Therapy · doi:10.1177/135965350701200714 · Cited by 37
Lewis, W. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00814.2002 · Cited by 38
Is mitochondrial DNA turnover slower than commonly assumed?
Poovathingal, S. K., Gruber, J., Lakshmanan, L. N., Halliwell, B. B., & Gunawan, R. (2012) · Biogerontology · doi:10.1007/s10522-012-9390-7 · Cited by 32
Golob, M. J., Tian, L., Wang, Z., Zimmerman, T. A., Caneba, C. A., Hacker, T. A., Song, G., & Chesler, N. C. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.12.044 · Cited by 33
Yao, Y., Ellison, F. M., McCoy, J. P., Chen, J., & Young, N. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl457 · Cited by 31
The plasma membrane redox system: a candidate source of aging-related oxidative stress
de Grey, A. D. N. J. (2005) · AGE · doi:10.1007/s11357-005-1630-1 · Cited by 29
Rahn, J. J., Bestman, J. E., Stackley, K. D., & Chan, S. S. L. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1139 · Cited by 30
“Energenetics” of Heart Failure
van Bilsen, M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1302.020 · Cited by 29
Principal Aspects Regarding the Maintenance of Mammalian Mitochondrial Genome Integrity
Vasileiou, P. V. S., Mourouzis, I. S., & Pantos, C. I. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081821 · Cited by 27
Iommarini, L., Peralta, S., Torraco, A., & Díaz, F. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.01.008 · Cited by 28
Mitochondrial Effects of Plant-Made Compounds
Biasutto, L., Szabó, I., & Zoratti, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4021 · Cited by 25
Jacobs, H. T. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02480-5 · Cited by 23
Cardiac Response to Oxidative Stress Induced by Mitochondrial Dysfunction
Kim, H. K., Nilius, B., Kim, N., Ko, K. S., Rhee, B. D., & Han, J. (2016) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2015_5004 · Cited by 26
A prevalent POLG CAG microsatellite length allele in humans and African great apes
Rovio, A. T., Abel, J., Ahola, A. L., Andrés, A. M., Bertranpetit, J., Blancher, A., Bontrop, R. E., Chemnick, L. G., Cooke, H. J., Cummins, J. M., et al. (2004) · Mammalian Genome · doi:10.1007/s00335-004-3049-x · Cited by 24
Mitochondrial Mutations in Mammalian Aging: An Over-Hasty About-Turn?
de Grey, A. D. N. J. (2004) · Rejuvenation Research · doi:10.1089/rej.2004.7.171 · Cited by 24
Mitochondrial Dysfunction and Oxidative Stress
Kato, T., Kapczinski, F. P., & Berk, M. (2010) · Wiley eBooks · doi:10.1002/9780470661277.ch18 · Cited by 24
Mitochondrial DNA deletions in mice in men: Substantia nigra is much less affected in the mouse
Guo, X., Kudryavtseva, E., Bodyak, N. D., Nicholas, A., Dombrovsky, I., Yang, D., Kraytsberg, Y., Simon, D. K., & Khrapko, K. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.005 · Cited by 23
Rocher, C., Letellier, T., Copeland, W. C., & Lestienne, P. P. (2002) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(02)00024-0 · Cited by 23
Treadmill Exercise Alleviates Aging-induced Apoptosis in Rat Cardiac Myocytes
Ko, I., Kim, S., Kim, C., & Jee, Y. (2013) · International journal of gerontology · doi:10.1016/j.ijge.2013.01.001 · Cited by 23
Role of Apoptosis in Heart Failure
Grazette, L. P., & Rosenzweig, A. (2005) · Heart Failure Clinics · doi:10.1016/j.hfc.2005.03.007 · Cited by 23
Laurent, D., Mathew, J., Mitry, M. A., Taft, M., Force, A., & Edwards, J. G. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu029 · Cited by 22
Mitochondrial DNA in Lung Cancer
Liu, F., Sanin, D. E., & Wang, X. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6674-0_2 · Cited by 21
Selective mtDNA mutation accumulation results in β-cell apoptosis and diabetes development
Bensch, K. G., Mott, J. L., Chang, S.-W., Hansen, P. A., Moxley, M. A., Chambers, K. T., Graaf, W. F.-D., Zassenhaus, H. P., & Corbett, J. A. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90839.2008 · Cited by 21
Self-citationHicks, S. D., Labinskyy, N., Piteo, B., Laurent, D., Mathew, J., Gupte, S. A., & Edwards, J. G. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2012 · Cited by 20
Kraytsberg, Y., Nicholas, A., Caro, P., & Khrapko, K. (2008) · Methods · doi:10.1016/j.ymeth.2008.10.005 · Cited by 19
Dubec, S. J., Aurora, R., & Zassenhaus, H. P. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0617 · Cited by 20
Self-citationStumpf, J. D., & Copeland, W. C. (2013) · Genetics · doi:10.1534/genetics.113.150920 · Cited by 18
Mitochondrial DNA Mutations, Apoptosis, and the Misfolded Protein Response
Mott, J. L., Zhang, D., & Zassenhaus, H. P. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.216 · Cited by 16
Self-citationMitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target
Xiang, M., Yang, M., Zhang, L., Ouyang, X., Sarapultsev, A., Luo, S., & Hu, D. (2025) · Antioxidants · doi:10.3390/antiox14091138 · Cited by 17
Fayzulin, R. Z., Perez, M., Kozhukhar, N., Spadafora, D., Wilson, G. L., & ALEXEYEV, M. F. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv140 · Cited by 16
Mouse models of mtDNA replication diseases
Tyynismaa, H., & Suomalainen, A. (2010) · Methods · doi:10.1016/j.ymeth.2010.03.009 · Cited by 14
Zhang, D., Ezekiel, U. R., Chang, S.-W., & Zassenhaus, H. P. (2005) · Cardiovascular Pathology · doi:10.1016/j.carpath.2005.01.006 · Cited by 14
Self-citationA transgenic model to study the pathogenesis of somatic mtDNA mutation accumulation in β‐cells
Bensch, K. G., DeGraaf, W., Hansen, P. A., Zassenhaus, H. P., & Corbett, J. A. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00776.x · Cited by 12
Self-citationFarge, G., Touraille, S., Goff, S. L., Petit, N., Renoux, M., Morel, F., & Alziari, S. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02737.x · Cited by 11
Transgenic mouse models of mitochondrial toxicity associated with HIV/AIDS and antiretrovirals
Koczor, C. A., Kohler, J. J., & Lewis, W. (2010) · Methods · doi:10.1016/j.ymeth.2009.12.013 · Cited by 11
Mitochondrial DNA mutations cause resistance to opening of the permeability transition pore
Mott, J. L., Zhang, D., Chang, S.-W., & Zassenhaus, H. P. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.04.014 · Cited by 11
Self-citationMouse models of DNA polymerases
Menezes, M. R., & Sweasy, J. B. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21731 · Cited by 9
Metadata
- Authors
- Zhang, D., Mott, J. L., Chang, S.-W., Denniger, G., Feng, Z., & Zassenhaus, H. P.
- Affiliations
- Saint Louis University (US)
- Corresponding author
- Zassenhaus, Hans Peter
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 69
- Issue
- 2
- Pages
- 151-161
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2005953994
- Semantic Scholar
- 06cd373df65f3ec58a4f2624719fa0f5a724bec7
- Cited by
- 124
- References
- 44
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- transgenic mice, alpha-myosin heavy chain promoter, cardiomyopathy, mitochondrial DNA deletions, direct repeats, tissue-specific mutagenesis, heart
- MeSH terms
- DNA Polymerase gamma, Animals, DNA-Directed DNA Polymerase, DNA, Mitochondrial, Genes, Dominant, Heart, Mice, Transgenic, Mitochondria, Heart, Mutation, Organ Specificity, Mutagenesis, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review