Biology of human TH1 and TH2 cells

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,506

Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages

Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852

Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

Robinson, D. S., Hamid, Q., Ying, S., Tsicopoulos, A., Barkans, J., Bentley, A. M., Corrigan, C., Durham, S. R., & Kay, A. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201303260504 · Cited by 2,768

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

Stein, H., Mason, D., Gerdes, J., O'Connor, N., Wainscoat, J., Pallesen, G., Gatter, K., Falini, B., Delsol, G., Lemke, H., et al. (1985) · Blood · doi:10.1182/blood.v66.4.848.848 · Cited by 1,846

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M. P., Maggi, E., Trinchieri, G., & Romagnani, S. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.4.1199 · Cited by 1,665

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L., & Locksley, R. M. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.1.59 · Cited by 1,454

A TH1→TH2 switch is a critical step in the etiology of HIV infection

Clerici, M., & Shearer, G. M. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90208-3 · Cited by 1,390

Lymphokine Production by Human T Cells in Disease States

Romagnani, S. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.227 · Cited by 1,343

Human TH1 and TH2 subsets: doubt no more

Romagnani, S. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90120-i · Cited by 1,089

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R. (1991) · Science · doi:10.1126/science.1681588 · Cited by 1,028

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

Marsh, D. G., Neely, J. D., Breazeale, D. R., Ghosh, B., Freidhoff, L. R., Ehrlich-Kautzky, E., Schou, C., Krishnaswamy, G., & Beaty, T. H. (1994) · Science · doi:10.1126/science.8178175 · Cited by 1,003

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

Seder, R. A., Paul, W. E., Davis, M. M., & Fazekas de St Groth, B. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.4.1091 · Cited by 997

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

Smith, C. A., Davis, T., Anderson, D., Solam, L., Beckmann, M. P., Jerzy, R., Dower, S. K., Cosman, D., & Goodwin, R. G. (1990) · Science · doi:10.1126/science.2160731 · Cited by 959

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production

Del Prete, G., De Carli, M., Almerigogna, F., Giudizi, M. G., Biagiotti, R., & Romagnani, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.2.353 · Cited by 927

Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin's disease and a subset of normal lymphoid cells

Schwab, U., Stein, H., Gerdes, J., Lemke, H., Kirchner, H., Schaadt, M., & Diehl, V. (1982) · Nature · doi:10.1038/299065a0 · Cited by 862

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

Yoshimoto, T., & Paul, W. E. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1285 · Cited by 841

Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma.

Hamid, Q., Azzawi, M., Ying, S., Moqbel, R., Wardlaw, A. J., Corrigan, C. J., Bradley, B., Durham, S. R., Collins, J. V., & Jeffery, P. K. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115166 · Cited by 833

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

Romagnani, S. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90083-j · Cited by 780

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

Hsieh, C. S., Heimberger, A. B., Gold, J. S., O'Garra, A., & Murphy, K. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6065 · Cited by 747

Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones

Piccinni, M. P., Giudizi, M. G., Biagiotti, R., Beloni, L., Giannarini, L., Sampognaro, S., Parronchi, P., Manetti, R., Annunziato, F., & Livi, C. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.1.128 · Cited by 743

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

Selmaj, K., Raine, C. S., Cannella, B., & Brosnan, C. F. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115102 · Cited by 738

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

Khoury, S. J., Hancock, W. W., & Weiner, H. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.5.1355 · Cited by 708

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

Del Prete, G. F., De Carli, M., Mastromauro, C., Biagiotti, R., Macchia, D., Falagiani, P., Ricci, M., & Romagnani, S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115300 · Cited by 694

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones

Maggi, E., Parronchi, P., Manetti, R., Simonelli, C., Piccinni, M. P., Rugiu, F. S., De Carli, M., Ricci, M., & Romagnani, S. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2142 · Cited by 684

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

Parronchi, P., Macchia, D., Piccinni, M. P., Biswas, P., Simonelli, C., Maggi, E., Ricci, M., Ansari, A. A., & Romagnani, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4538 · Cited by 617

Interleukin 4 is localized to and released by human mast cells.

Bradding, P., Feather, I. H., Howarth, P. H., Mueller, R., Roberts, J. A., Britten, K., Bews, J. P., Hunt, T. C., Okayama, Y., & Heusser, C. H. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.5.1381 · Cited by 573

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

Secrist, H., Chelen, C. J., Wen, Y., Marshall, J. D., & Umetsu, D. T. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.6.2123 · Cited by 539

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

Smith, C. A., Gruss, H.-J., Davis, T., Anderson, D., Farrah, T., Baker, E., Sutherland, G. R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90361-s · Cited by 529

Ability of HIV to Promote a T H 1 to T H 0 Shift and to Replicate Preferentially in T H 2 and T H 0 Cells

Maggi, E., Mazzetti, M., Ravina, A., Annunziato, F., de Carli, M., Piccinni, M. P., Manetti, R., Carbonari, M., Pesce, A. M., del Prete, G., et al. (1994) · Science · doi:10.1126/science.8023142 · Cited by 495

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

Manetti, R., Gerosa, F., Giudizi, M. G., Biagiotti, R., Parronchi, P., Piccinni, M. P., Sampognaro, S., Maggi, E., Romagnani, S., & Trinchieri, G. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1273 · Cited by 436

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones

Parronchi, P., De Carli, M., Manetti, R., Simonelli, C., Sampognaro, S., Piccinni, M. P., Macchia, D., Maggi, E., Del Prete, G., & Romagnani, S. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.9.2977 · Cited by 427

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

Chehimi, J., Starr, S. E., Frank, I., D'Andrea, A., Ma, X., MacGregor, R. R., Sennelier, J., & Trinchieri, G. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1361 · Cited by 419

Systemic Lupus Erythematosus

Mills, J. A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406303302608 · Cited by 407

Role of Cytokines and CD4+ T‐Cell Subsets in the Regulation of Parasite Immunity and Disease

Scott, P., Pearce, E., Cheever, A. W., Coffman, R. L., & Sher, A. (1989) · Immunological Reviews · doi:10.1111/j.1600-065x.1989.tb00557.x · Cited by 398

High Frequency of IL-4–Producing CD4+ Allergen-Specific T Lymphocytes in Atopic Dermatitis Lesional Skin

van der Heijden, F. L., Wierenga, E. A., Bos, J. D., & Kapsenberg, M. L. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12480966 · Cited by 386

Skin-derived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis

van Reijsen, F. C., Bruijnzeel-Koomen, C. A. F. M., Kalthoff, F. S., Maggi, E., Romagnani, S., Westland, J. K. T., & Mudde, G. C. (1992) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(92)90070-i · Cited by 383

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

Street, N. E., Schumacher, J. H., Fong, T. A. T., Bass, H., Fiorentino, D. F., Leverah, J. A., & Mosmann, T. R. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.5.1629 · Cited by 381

Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation.

Brunner, T., Heusser, C. H., & Dahinden, C. A. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.3.605 · Cited by 380

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

Campbell, I. L., Kay, T. W., Oxbrow, L., & Harrison, L. C. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115055 · Cited by 374

Preferential expression of CD30 by human CD4 + T cells producing Th2‐type cytokines

Del Prete, G., De Carli, M., Almerigogna, F., Daniel, G. K., Delios, M. M., Zancuoghi, G., Vinante, F., Pizzolo, G., & Romagnani, S. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.1.7821763 · Cited by 365

TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity

Goldman, M., Druet, P., & Gleichmann, E. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90034-q · Cited by 358

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

Gajewski, T. F., Joyce, J., & Fitch, F. W. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.1.15 · Cited by 347

Allergen exposure induces the activation of allergen‐specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders

Del Prete, G. F., De Carli, M., D'Elios, M. M., Maestrelli, P., Ricci, M., Fabbri, L., & Romagnani, S. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230707 · Cited by 343

Clonal Proliferation of Type 2 Helper T Cells in a Man with the Hypereosinophilic Syndrome

Cogan, E., Schandene, L., Crusiaux, A., Cochaux, P., Velu, T., & Goldman, M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199402243300804 · Cited by 310

Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis

Maggi, E., Biswas, P., Del Prete, G., Parronchi, P., Macchia, D., Simonelli, C., Emmi, L., De Carli, M., Tiri, A., & Ricci, M. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.4.1169 · Cited by 304

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

Rook, G. A. W., Hernandez-Pando, R., & Lightman, S. L. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90075-2 · Cited by 289

Regulation of the development of type 2 T-helper cells in allergy

Romagnani, S. (1994) · Current Opinion in Immunology · doi:10.1016/0952-7915(94)90002-7 · Cited by 268

Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

Maggi, E., Giudizi, M. G., Biagiotti, R., Annunziato, F., Manetti, R., Piccinni, M. P., Parronchi, P., Sampognaro, S., Giannarini, L., Zuccati, G., et al. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.2.489 · Cited by 267

Functional subsets of allergen-reactive human CD4+ T cells

Kapsenberg, M. L., Wierenga, E. A., Bos, J. D., & Jansen, H. M. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90137-i · Cited by 240

Insulitis in type 1 (insulin‐dependent) diabetes mellitus in man—macrophages, lymphocytes, and interferon‐γ containing cells

Foulis, A. K., McGill, M., & Farquharson, M. A. (1991) · The Journal of Pathology · doi:10.1002/path.1711650203 · Cited by 235

CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO+ T cells.

Ellis, T. M., Simms, P. E., Slivnick, D. J., Jäck, H. M., & Fisher, R. I. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.5.2380 · Cited by 203

Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity.

Del Prete, G. F., De Carli, M., Ricci, M., & Romagnani, S. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.4.809 · Cited by 194

Functional consequences of engagement of the T cell receptor by low affinity ligands

Alexander, J., Snoke, K., Ruppert, J., Sidney, J., Wall, M., Southwood, S., Oseroff, C., Arrhenius, T., Gaeta, F. C., & Colón, S. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.1.1 · Cited by 171

CD30 expression by CD8+ T cells producing type 2 helper cytokines. Evidence for large numbers of CD8+CD30+ T cell clones in human immunodeficiency virus infection.

Manetti, R., Annunziato, F., Biagiotti, R., Giudizi, M. G., Piccinni, M., Giannarini, L., Sampognaro, S., Parronchi, P., Vinante, F., Pizzolo, G., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2407 · Cited by 147

Th1 and Th2 T-helper cells exert opposite regulatory effects on procoagulant activity and tissue factor production by human monocytes

Prete, G. D., Carli, M., Lammel, R. M., D’Elios, M. M., Daniel, K., Giusti, B., Abbate, R., & Romagnani, S. (1995) · Blood · doi:10.1182/blood.v86.1.250.bloodjournal861250 · Cited by 116

Circulating levels of soluble CD30, a marker of cells producing Th2-type cytokines, are increased in patients with systemic lupus erythematosus and correlate with disease activity.

Caligaris‐Cappio, F., Bertero, M., Converso, M., Stacchini, A., Vinante, F., Romagnani, S., & Pizzolo, G. (1995) · PubMed · Cited by 109

Human bone marrow non-B, non-T cells produce interleukin 4 in response to cross-linkage of Fc epsilon and Fc gamma receptors.

Piccinni, M., Macchia, D., Parronchi, P., Giudizi, M. G., Bani, D., Alterini, R., Grossi, A., Ricci, M., Maggi, E., & Romagnani, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8656 · Cited by 97

Locally active steroid hormones may facilitate compartmentalization of immunity by regulating the types of lymphokines produced by helper T cells

Daynes, R. A., Meikle, A. W., & Araneo, B. A. (1991) · Research in Immunology · doi:10.1016/0923-2494(91)90010-g · Cited by 93

Predominance of Th1‐type T cells in synovial fluid of patients with Yersinia‐induced reactive arthritis

Schlaak, J., Hermann, E., Ringhoffer, M., Probst, P., Gallati, H., Büschenfelde, K. M. Z., & Fleischer, B. (1992) · European Journal of Immunology · doi:10.1002/eji.1830221103 · Cited by 82

Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease

Brod, S. A., Benjamin, D. I., & Hafler, D. A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.3.810 · Cited by 73

Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones.

Carli, M., Berthold, S., Fickenscher, H., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.5022 · Cited by 66

IL4 dictates T-cell differentiation

Swain, S. L. (1993) · Research in Immunology · doi:10.1016/s0923-2494(05)80013-6 · Cited by 66

Activation of HIV expression by CD30 triggering in CD4+ T cells from HIV-infected individuals

Maggi, E., Annunziato, F., Manetti, R., Biagiotti, R., Giudizi, M. G., Ravine, A., Almerigognat, F., Soiani, N., Alderson, M. R., & Romagnani, S. (1995) · Immunity · doi:10.1016/1074-7613(95)90094-2 · Cited by 53

Interleukin-1 favours the in vitro development of type 2 T helper (Th2) human T-cell clones

Manetti, R., Barak, V., Piccinni, M., et al. (1994) · Research in Immunology · doi:10.1016/s0923-2494(94)80019-7 · Cited by 51

Activation of functionally distinct subsets of CD4+ T lymphocytes

Williams, M. E., Chang, T. L., Burke, S. K., et al. (1991) · Research in Immunology · doi:10.1016/0923-2494(91)90006-5 · Cited by 37

DNA VACCINES

Donnelly, J. J., Ulmer, J. B., Shiver, J. W., & Liu, M. A. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.617 · Cited by 987

Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review

Potvin, S., Stip, E., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.024 · Cited by 858

Host factors and the pathogenesis of HIV-induced disease

Fauci, A. S. (1996) · Nature · doi:10.1038/384529a0 · Cited by 829

Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes

Fu, Z., R. Gilbert, E., & Liu, D. (2013) · Current Diabetes Reviews · doi:10.2174/157339913804143225 · Cited by 732

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

Lucey, D. R., Clerici, M., & Shearer, G. M. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.4.532 · Cited by 666