The stability of and intercorrelations among cardiovascular, immune, endocrine, and psychological reactivity
Open accessAbstract
One hundred fifteen college students were exposed to an evaluative speech task twice, separated by 2 weeks. At both sessions, we assessed cardiovascular, endocrine, immune, and psychological response at baseline and during the task. We found stability across sessions for stress-induced increases in anxiety and task engagement, heart rate, blood pressure, norepinephrine (but not epinephrine), cortisol, natural killer cell cytotoxicity, and numbers of circulating CD3+, CD8+, and CD56+ (but not CD4+ or CD19+) lymphocytes. The stable cardiovascular, immune, and endocrine reactivities were intercorrelated, providing evidence of a unified physiological stress response across these outcomes. Although stable stress-induced increases in task engagement were associated with the physiological stress responses, stress-induced anxiety was not.
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Brain indices may be sufficiently reliable to join the collection of established susceptibility markers.
“These values are comparable to the stability of other susceptibility factors (e.g., physiological measures; Cohen and Hamrick, 2003, Cohen et al., 2000), suggesting that brain indices may be sufficiently reliable to join the collection of established susceptibility markers.”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Cohen et al., 2000
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“However, sex was not able to mediate the correlation between cortisol and subjective feelings of stress (Dedovic et al., 2009; Hodes and Epperson, 2019; Kumsta et al., 2007).”
Background
- Authors
- Cohen, S., Hamrick, N. M. S., Rodriguez, M. S., Feldman, P. J., Rabin, B. S., & Manuck, S. B.
- Affiliations
- Carnegie Mellon University (US)
- University College London (GB)
- University of Pittsburgh (US)
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 22
- Issue
- 3
- Pages
- 171-179
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- OpenAlex
- W2125172377
- Cited by
- 177
- References
- 52
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 14 · 2013: 6 · 2012: 16
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- KiltHub Repository (submittedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- John D. and Catherine T. MacArthur Foundation
- University of Pittsburgh
- Deutsches Krebsforschungszentrum
- National Institutes of Health (5r01mh050429-08, 5r01mh050430-04)
- Medical Center, University of Pittsburgh
- National Institute of Mental Health (MH-50429, MH 50430)
- National Center for Research Resources (M01RR000056)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Emotion and Mood Recognition
- Keywords
- stress reactivity, anxiety, task engagement, heart rate, blood pressure, norepinephrine, cortisol, NK cell cytotoxicity, lymphocyte subsets, immune response, physiological stress response, university students
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Anxiety, Blood Pressure, Catecholamines, Cytotoxicity, Immunologic, Factor Analysis, Statistical, Female, Heart Rate, Humans, Hydrocortisone, Male, Stress, Physiological, Stress, Psychological, Lymphocyte Subsets
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