Autonomic and Neuroendocrine Responses to a Psychosocial Stressor in Adults with Autistic Spectrum Disorder
Abstract
Objective of the study was to replicate in adults our previous findings of decreased heart rate and normal endocrine responses to stress in autistic children and to elucidate the discrepancy between autonomic and endocrine stress responses by including epinephrine, norepinephrine, oxytocin and vasopressin measurements. Ten autistic spectrum disorder (ASD) adults were compared to 14 healthy controls in their response to a psychosocial stressor (public speaking). ASD patients showed decreased heart rate, but normal cortisol responses, consistent with our prior findings in children. No differences in norepinephrine, epinephrine, oxytocin or vasopressin responses to stress were found. However, in contrast to previous findings in low functioning autistic children, ASD adults showed increased basal oxytocin levels, which may be related to developmental factors.
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The blunted heart rate response was previously suggested to be a manifestation of response saturation due to basal hyperarousal.
“and was previously suggested to be a manifestation of response saturation due to basal hyperarousal.”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [16]
The blunted heart rate response pattern has been reported consistently in three studies examining autonomic nervous system reactivity to psychosocial challenges.
“This pattern has been reported consistently in three studies examining ANS reactivity to psychosocial challenges [15-17]”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [16]
In Fragile X syndrome, oxytocin administered to eight adolescent and adult males significantly increased overall eye gaze during a brief social interaction compared to placebo, and lower doses appeared to show a greater effect than higher doses.
“Compared to placebo, oxytocin administered to eight adolescent and adult males with FXS significantly increased overall eye gaze during a brief social interaction.59 Interestingly, lower doses of oxytocin in this sample appeared to show a greater effect than the higher administered dose, consistent with a recent study in healthy adults.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [59]
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- Authors
- Jansen, L. M. C., Gispen-de Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B. E., & van Engeland, H.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Jansen, Lucres M. C.
- ORCID
- Jansen, Lucres M. C.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2006-07-25
- Volume
- 36
- Issue
- 7
- Pages
- 891-899
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2129921086
- Cited by
- 177
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 17 · 2013: 16 · 2012: 8
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Hersenstichting
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, autistic adults, psychosocial stress, stress response, autonomic nervous system, neuroendocrine response, heart rate, cortisol, epinephrine, norepinephrine, oxytocin, vasopressin, public speaking, developmental differences
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Autistic Disorder, Autonomic Nervous System, Epinephrine, Female, Humans, Male, Norepinephrine, Oxytocin, Psychology, Speech, Stress, Psychological, Vasopressins
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