Cited by 133Dietary Effects on HealthT-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

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Choi, In Young, Lee, Changhan, Longo, Valter D.·2017·Molecular and Cellular Endocrinology

Abstract

Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence.

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Crossref · 10.1016/j.mce.2017.01.042

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Authors
Choi, I. Y., Lee, C., & Longo, V. D.
Affiliations
University of Southern California (US)
Corresponding author
Longo, Valter D.
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2017-11
Volume
455
Pages
4-12
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2581841465
Cited by
133
References
122
Citations by year
2026: 5 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 6 · 2017: 8
FWCI
1.58
Type
journal article
Language
en
Open access
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R01AG052558)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
fasting-mimicking diet, autoimmune disease, immunosenescence, lymphocyte metabolism, T cell function, dietary intervention, aging, nutrition
MeSH terms
Immunosenescence, Aging, Animals, Arthritis, Rheumatoid, Autoimmune Diseases, Diabetes Mellitus, Type 1, Diet, Disease Models, Animal, Fasting, Humans, Multiple Sclerosis, Nutritional Status, T-Lymphocytes, Caloric Restriction, Mice

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