Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence
Open accessAbstract
Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence.
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Other data have demonstrated the importance of following a specific, even personally tailored, dietary pattern.
“Other data have demonstrated the importance of following a specific, even personally tailored, dietary pattern (81).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [81]
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Intermittent and periodic fasting – Evidence and perspectives in multiple sclerosis
Lorefice, L., Pitzalis, M., & Żołędziewska, M. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105744 · Cited by 6 · see citing works
Prevention of Neurologic Disease with Fasting
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Ramadan Intermittent Fasting and Its Beneficial Effects of Health: A Review Article
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Intermittent fasting in osteoarthritis: from mechanistic insights to therapeutic potential
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Bariatric Surgery-Associated Myelopathy
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Characteristics of fasting users among internal medicine patients in Germany
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Fasting Physiology and Therapeutic Diets: A Look Back to the Future.
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Fasting-Mimicking Diets in Longevity and Disease
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Geoepidemiology and the key role of sex chromosomes on autoimmune diseases
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When wrinkles appear on the immune system can it be reversed?
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Metabolic adventures in aging research
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FASTING TECHNIQUES – CHANGING THE WAY, YOU LOOK AT THERAPY
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- Authors
- Choi, I. Y., Lee, C., & Longo, V. D.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Longo, Valter D.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 455
- Pages
- 4-12
- ISSN
- 0303-7207 (ISSN-L)
- PMC
- PMC5862044
- OpenAlex
- W2581841465
- Cited by
- 133
- References
- 122
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 14 · 2018: 6 · 2017: 8
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG052558)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- fasting-mimicking diet, autoimmune disease, immunosenescence, lymphocyte metabolism, T cell function, dietary intervention, aging, nutrition
- MeSH terms
- Immunosenescence, Aging, Animals, Arthritis, Rheumatoid, Autoimmune Diseases, Diabetes Mellitus, Type 1, Diet, Disease Models, Animal, Fasting, Humans, Multiple Sclerosis, Nutritional Status, T-Lymphocytes, Caloric Restriction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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