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Physical activity and the endocannabinoid system: an overview
Open accessAbstract
Recognized as a "disease modifier", physical activity (PA) is increasingly viewed as a more holistic, cost-saving method for prevention, treatment and management of human disease conditions. The traditional view that PA engages the monoaminergic and endorphinergic systems has been challenged by the discovery of the endocannabinoid system (ECS), composed of endogenous lipids, their target receptors, and metabolic enzymes. Indeed, direct and indirect evidence suggests that the ECS might mediate some of the PA-triggered effects throughout the body. Moreover, it is now emerging that PA itself is able to modulate ECS in different ways. Against this background, in the present review we shall discuss evidence of the cross-talk between PA and the ECS, ranging from brain to peripheral districts and highlighting how ECS must be tightly regulated during PA, in order to maintain its beneficial effects on cognition, mood, and nociception, while avoiding impaired energy metabolism, oxidative stress, and inflammatory processes.
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“Exerciseinduced elevations of endocannabinoid levels have been proposed to account partially for anxiolytic (Tantimonaco et al., 2014;Fuss et al., 2015), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of exercise, which are all responses that instead are affected in a negative direction by sleep loss (e.g.Roy-Byrne et al., 1986;Schuh-Hofer et al., 2013;”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Tantimonaco et al., 2014
In the citing paper
“The increase of circulating levels of endocannabinoids following exercise has been proposed to partially account for the anxiolytic (Tantimonaco et al., 2014), anti-nociceptive (Galdino et al., 2014) and neuroprotective (Hill et al., 2010a) properties of physical exercise.”
From Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans (2016) · cites this paper as Tantimonaco et al., 2014
In the citing paper
“For example, PA has been shown to up-regulate circulating endocannabinoids such as anandamide, which can produce anxiolytic effects by regulating other neurotransmitters, such as dopamine [84].”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [84]
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Metadata
- Authors
- Tantimonaco, M., Ceci, R., Sabatini, S., Catani, M. V., Rossi, A., Gasperi, V., & Maccarrone, M.
- Affiliations
- Foro Italico University of Rome (IT)
- University of Rome Tor Vergata (IT)
- Università Campus Bio-Medico (IT)
- Corresponding author
- Gasperi, Valeria
- Maccarrone, Mauro
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2014-02-14
- Volume
- 71
- Issue
- 14
- Pages
- 2681-2698
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11113821
- OpenAlex
- W2063762175
- Cited by
- 112
- References
- 201
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 7 · 2023: 7 · 2022: 14 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 6 · 2017: 11 · 2016: 7 · 2015: 5 · 2014: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- physical activity, endocannabinoid system, endocannabinoid receptors, endocannabinoid metabolism, exercise-induced neuroplasticity, mood, cognition, nociception, energy metabolism, oxidative stress, inflammation
- MeSH terms
- Animals, Energy Intake, Central Nervous System, Energy Metabolism, Exercise Therapy, Humans, Models, Biological, Motor Activity, Mice, Endocannabinoids
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