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Mechanisms and consequences of entosis
Open accessAbstract
Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
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“Entosis is a form of cell cannibalism that occurs in healthy and malignant mammalian tissues, involving the engulfment of viable cells by non-phagocytic cells of the same (homotypic) or a different (heterotypic) type [691, 692].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [691]
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“Often (but not always), internalization is followed by the demise of internalized cells (which are commonly referred to as “entotic cells”) [691–693].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [691]
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“The current model proposes that the internalization of entotic cells occurs through cell invasion rather than by phagocytosis [691].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [691]
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Metadata
- Authors
- Krishna, S., & Overholtzer, M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Overholtzer, Michael
- ORCID
- Overholtzer, Michael
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-04-05
- Volume
- 73
- Issue
- 11-12
- Pages
- 2379-2386
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC4889469
- OpenAlex
- W2331432060
- Cited by
- 118
- References
- 65
- Citations by year
- 2026: 2 · 2025: 19 · 2024: 13 · 2023: 17 · 2022: 6 · 2021: 13 · 2020: 13 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Cancer Institute (R01CA154649)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- entosis, cell-in-cell structures, cell engulfment, carcinogenesis, development (biology), cell population dynamics
- MeSH terms
- Autophagy, Humans, Neoplasms, Phagocytosis, Apoptosis, Entosis, Carcinogenesis
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