Coupling factors involved in preserving bone balance

Kim, Beom-Jun; Koh, Jung-Min

doi:10.1007/s00018-018-2981-y

Cited by 111Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

Coupling factors involved in preserving bone balance

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Kim, Beom-Jun, Koh, Jung-Min·2019·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-018-2981-yPMC PMC11105749

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Abstract

Coupling during bone remodeling refers to the spatial and temporal coordination of bone resorption with bone formation. Studies have assessed the subtle interactions between osteoclasts and osteoblasts to preserve bone balance. Traditionally, coupling research related to osteoclast function has focused on bone resorption activity causing the release of growth factors embedded in the bone matrix. However, considerable evidence from in vitro, animal, and human studies indicates the importance of the osteoclasts themselves in coupling phenomena, and many osteoclast-derived coupling factors have been identified. These include sphingosine-1-phosphate, vesicular-receptor activator of nuclear factor-κB, collagen triple helix repeat containing 1, and cardiotrophin-1. Interestingly, neuronal guidance molecules, such as slit guidance ligand 3, semaphorin (SEMA) 3A, SEMA4D, and netrin-1, originally identified as instructive cues allowing the navigation of growing axons to their targets, have been shown to be involved in the intercellular cross-talk among bone cells. This review discusses osteoclast-osteoblast coupling signals, including recent advances and the potential roles of these signals as therapeutic targets for osteoporosis and as biomarkers predicting human bone health.

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SLIT3 production increases during osteoclast differentiation and SLIT3 is necessary for osteoblast precursor migration.
“SLIT3 contributes to the initial establishment of the osteogenic environment after resorption and meets the requirements to be considered a coupling factor, as i) SLIT3 production increases during osteoclast differentiation and ii) SLIT3 is necessary for osteoblast precursor migration.235”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [235]
Several osteoclast-derived compounds, including SLIT3, usherin, Fras-1, atrial natriuretic peptide, afamin, collagen α-1 chain, laminin β2, angiotensin-converting enzyme, and ADAMTS-like protein 4, stimulate osteoblast activity.
“Among others, slit guidance ligand 3 (SLIT3) usherin, Fraser syndrome 1 (Fras-1), atrial natriuretic peptide, afamin, collagen α-1 chain, laminin β2, angiotensin-converting enzyme, and ADAMTS-like protein 4 were identified in a screen as osteoclast-derived compounds that stimulate osteoblast activity.”
From Interactions between Muscle and Bone—Where Physics Meets Biology (2020) · cites this paper as [119]

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Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works
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Authors: Kim, B.-J., & Koh, J.-M.
Affiliations: Asan Medical Center (KR)
Corresponding author: Koh, Jung-Min
ORCID: Kim, Beom-Jun
Koh, Jung-Min
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2018-12-04
Volume: 76
Issue: 7
Pages: 1243-1253
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-018-2981-y
PMC: PMC11105749
OpenAlex: W2903038722
Cited by: 111
References: 114
Citations by year: 2026: 10 · 2025: 7 · 2024: 15 · 2023: 17 · 2022: 15 · 2021: 20 · 2020: 13 · 2019: 13
FWCI: 1.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Health and Welfare (HI15C2792, HI15C0377)
Korea National Research Foundation (2016M3A9E8941329)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords: bone remodeling, bone balance, osteoclasts, osteoblasts, sphingosine-1-phosphate, VEGFR2, CTNNB1, cardiotrophin-1, semaphorin 3A, Sema4D, netrin-1, osteoporosis, bone health biomarkers
MeSH terms: Bone and Bones, Bone Diseases, Metabolic, Humans, Lysophospholipids, Osteoblasts, Osteoclasts, Sphingosine, Biomarkers, Bone Remodeling, Semaphorins, RANK Ligand

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