Cited by 439Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorHistorical and Modern Theater Studies

The neuropsychology of ventral prefrontal cortex: Decision-making and reversal learning

Clark, L., Cools, R., Robbins, T.W.·2004·Brain and Cognition

Abstract

Converging evidence from human lesion, animal lesion, and human functional neuroimaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning.

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Crossref · 10.1016/s0278-2626(03)00284-7

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112 of 112 references verified0 citation errors · 0 not checkable

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  • Serotonin and striatal dopamine neurotransmitter systems have a modulatory role in reversal learning, as shown by human and animal lesion, stimulation, and neuroimaging studies.

    “Serotonin and striatal dopamine neurotransmitter systems have a modulatory role in reversal learning, as evidenced by human and animal lesion, stimulation and neuroimaging studies106.”
  • Spatial reversal learning is not exclusively associated with hippocampal function but also with the prefrontal cortex, namely the prelimbic and infralimbic, and orbitalfrontal regions.

    “This particular cognitive task is not exclusively associated with hippocampal function but also the prefrontal cortex,42 namely the prelimbic and infralimbic, and orbitalfrontal regions;43”

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Authors
Clark, L., Cools, R., & Robbins, T. W.
Affiliations
University of Cambridge (GB)
Corresponding author
Clark, L.
Venue
Brain and Cognition
Publisher
Elsevier BV
Published
2004-06
Volume
55
Issue
1
Pages
41-53
ISSN
0278-2626 (ISSN-L)
OpenAlex
W2160601359
Cited by
439
References
112
Citations by year
2026: 2 · 2025: 9 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 24 · 2020: 11 · 2019: 15 · 2018: 13 · 2017: 22 · 2016: 23 · 2015: 29 · 2014: 28 · 2013: 35 · 2012: 25
FWCI
2.08
Type
journal article
Language
en
Open access
closed
Locations
  • Brain and Cognition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
ventral prefrontal cortex, decision-making, reversal learning, serotonin, dopamine, neural circuits, mental illness, neurological disorders, functional markers, behavioral adaptation
MeSH terms
Animals, Brain Damage, Chronic, Brain Mapping, Cognition, Decision Making, Humans, Neuropsychology, Reversal Learning, Serotonin, Tomography, Emission-Computed, Prefrontal Cortex

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