Retracted: Regional Differences in Brain-Derived Neurotrophic Factor Levels and Dendritic Spine Density Confer Resilience to Inescapable Stress

The rat brain in stereotaxic coordinates

Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works

The Rat Brain in Stereotaxic Coordinates

Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works

Physiology and neurobiology of stress and adaptation: central role of the brain

McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 3× · see citing works

The Neuroendocrinology of Stress: A Never Ending Story

Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works

The mesolimbic dopamine reward circuit in depression

Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression

Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works

Psychobiology and molecular genetics of resilience

Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272 · see citing works

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works

Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines

Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · cited 1× · see citing works

Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs

Karege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600 · see citing works

Critical Role of Brain-Derived Neurotrophic Factor in Mood Disorders

Hashimoto, K., Shimizu, E., & Iyo, M. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.02.003 · Cited by 522 · see citing works

Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions

Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388 · see citing works

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

Duman, R. S., & Li, N. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0357 · Cited by 362 · see citing works

Resilience to Chronic Stress Is Mediated by Hippocampal Brain-Derived Neurotrophic Factor

Taliaz, D., Loya, A., Gersner, R., Haramati, S., Chen, A., & Zangen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5725-10.2011 · Cited by 311 · see citing works

Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

Zhang, J.-C., Wu, J., Fujita, Y., Yao, W., Ren, Q., Yang, C., Li, S.-X., Shirayama, Y., & Hashimoto, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu077 · Cited by 289 · see citing works

Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats

Marmigère, F., Givalois, L., Rage, F., Arancibia, S., & Tapia‐Arancibia, L. (2003) · Hippocampus · doi:10.1002/hipo.10109 · Cited by 253 · see citing works

Effect of brain‐derived neurotrophic factor haploinsufficiency on stress‐induced remodeling of hippocampal neurons

Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232 · see citing works

Neurochemistry of the nucleus accumbens and its relevance to depression and antidepressant action in rodents

Shirayama, Y., & Chaki, S. (2006) · Current Neuropharmacology · doi:10.2174/157015906778520773 · Cited by 225 · see citing works

Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression

Hashimoto, K. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.09.001 · Cited by 208 · see citing works

Clinical role of brain-derived neurotropic factor in mood disorders

Hashimoto, K. (2004) · Medical Entomology and Zoology · Cited by 183 · see citing works

Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress

Naert, G., IXART, G., Maurice, T., Tapia‐Arancibia, L., & Givalois, L. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.08.006 · Cited by 154 · see citing works

Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

Lindholm, J. S. O., & Castrén, E. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00143 · Cited by 114 · see citing works

Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats

Shirayama, Y., Muneoka, K. T., Fukumoto, M., Tadokoro, S., Fukami, G., Hashimoto, K., & Iyo, M. (2010) · Hippocampus · doi:10.1002/hipo.20824 · Cited by 66 · see citing works

Differential levels of brain amino acids in rat models presenting learned helplessness or non-learned helplessness

Muneoka, K. T., Shirayama, Y., Horio, M., Iyo, M., & Hashimoto, K. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3080-2 · Cited by 17 · see citing works

Dopamine system dysregulation in major depressive disorders

Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., Yao, W., Ma, M., Dong, C., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.136 · Cited by 605 · see citing works

Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets

Zhang, J.-C., Yao, W., & Hashimoto, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094646 · Cited by 538 · see citing works

Brain–gut–microbiota axis in depression: A historical overview and future directions

Chang, L., Wei, Y., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.004 · Cited by 395 · see citing works

The molecular and cellular mechanisms of depression: a focus on reward circuitry

Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works

Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice

Yang, C., Fujita, Y., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2017) · Scientific Reports · doi:10.1038/srep45942 · Cited by 202 · see citing works

Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut–microbiota–brain axis

Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.112 · Cited by 182 · see citing works

Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis

Yang, B., Ren, Q., Zhang, J.-C., Chen, Q.-X., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.95 · Cited by 182 · see citing works

Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression

Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., & Hashimoto, K. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4062-3 · Cited by 183 · see citing works

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

Ren, Q., Ma, M., Ishima, T., Morisseau, C. H. P., Yang, J., Wagner, K. M., Zhang, J.-C., Yang, C., Yao, W., Dong, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601532113 · Cited by 161 · see citing works

Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice

Yao, W., Zhang, J.-C., Ishima, T., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, J., Suganuma, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30659 · Cited by 154 · see citing works

Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress model of depression

Liu, W., Wang, J., Xie, Z.-M., Xu, N., Zhang, G.-F., Jia, M., Zhou, Z., Hashimoto, K., & Yang, J. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4128-2 · Cited by 154 · see citing works

Individual differences in stress susceptibility and stress inhibitory mechanisms

Ebner, K., & Singewald, N. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.11.016 · Cited by 150 · see citing works

Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist

Shirayama, Y., Yang, C., Zhang, J.-C., Ren, Q., Yao, W., & Hashimoto, K. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.002 · Cited by 137 · see citing works

Modelling resilience in adolescence and adversity: a novel framework to inform research and practice

Malhi, G. S., Das, P., Bell, E., Mattingly, G. W., & Mannie, Z. N. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0651-y · Cited by 144 · see citing works

Rapid and Sustained Antidepressant Action of the mGlu2/3 Receptor Antagonist MGS0039 in the Social Defeat Stress Model: Comparison with Ketamine

Dong, C., Zhang, J.-C., Yao, W., Ren, Q., Ma, M., Yang, C., Chaki, S., & Hashimoto, K. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw089 · Cited by 116 · see citing works

Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience

Nowacka-Chmielewska, M. M., Grabowska, K., Grabowski, M., Meybohm, P., Burek, M., & Małecki, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113348 · Cited by 117 · see citing works

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

Yao, W., Lin, S., Su, J. Y., Cao, Q., Chen, Y., Chen, J., Zhang, Z., Hashimoto, K., Qi, Q., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01261-6 · Cited by 106 · see citing works

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse

Tang, J., Yu, W., Chen, S., Gao, Z., & Xiao, B. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2504-0 · Cited by 101 · see citing works

BDNF–TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms

Ren, Q., Ma, M., Yang, C., Zhang, J.-C., Yao, W., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.157 · Cited by 99 · see citing works

Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective

Hashimoto, K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01182 · Cited by 98 · see citing works

Abnormal composition of gut microbiota is associated with resilience versus susceptibility to inescapable electric stress

Zhang, K., Fujita, Y., Chang, L., Qu, Y., Pu, Y., Wang, S., Shirayama, Y., & Hashimoto, K. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0571-x · Cited by 98 · see citing works

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

Yang, B., Zhang, J.-C., Han, M., Yao, W., Yang, C., Ren, Q., Ma, M., Chen, Q.-X., & Hashimoto, K. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4399-2 · Cited by 91 · see citing works

Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood

Shirai, Y., Fujita, Y., Hashimoto, R., Ohi, K., Yamamori, H., Yasuda, Y., Ishima, T., Suganuma, H., Ushida, Y., Takeda, M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127244 · Cited by 88 · see citing works

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

Walker, C. K., & Herskowitz, J. H. (2021) · The Neuroscientist · doi:10.1177/1073858420945964 · Cited by 86 · see citing works

Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model

Sun, H.-L., Zhou, Z.-Q., Zhang, G.-F., Yang, C., Wang, X.-M., Shen, J.-C., Hashimoto, K., & Yang, J.-J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.21 · Cited by 84 · see citing works

Esketamine alleviates postoperative depression-like behavior through anti-inflammatory actions in mouse prefrontal cortex

Wang, T., Weng, H., Zhou, H., Yang, Z., Tian, Z., Xi, B., & Li, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.03.072 · Cited by 80 · see citing works

Effects of a single bilateral infusion of R-ketamine in the rat brain regions of a learned helplessness model of depression

Shirayama, Y., & Hashimoto, K. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0718-1 · Cited by 74 · see citing works

Alterations in the inflammatory cytokines and brain-derived neurotrophic factor contribute to depression-like phenotype after spared nerve injury: improvement by ketamine

Xie, Z.-M., Wang, X., Xu, N., Wang, J., Pan, W., Tang, X.-H., Zhou, Z., Hashimoto, K., & Yang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03590-3 · Cited by 72 · see citing works

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience

Yang, B., Yang, C., Ren, Q., Zhang, J.-C., Chen, Q., Shirayama, Y., & Hashimoto, K. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0693-6 · Cited by 69 · see citing works

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

Ma, M., Ren, Q., Yang, C., Zhang, J.-C., Yao, W., Dong, C., Ohgi, Y., Futamura, T., & Hashimoto, K. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4483-7 · Cited by 69 · see citing works

Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress

Zhang, J.-C., Yao, W., Dong, C., Han, M., Shirayama, Y., & Hashimoto, K. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0848-0 · Cited by 66 · see citing works

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

Qu, Y., Yang, C., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.16 · Cited by 68 · see citing works

Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens

Zhang, J.-C., Yao, W., Ren, Q., Yang, C., Dong, C., Ma, M., Wu, J., & Hashimoto, K. (2016) · Scientific Reports · doi:10.1038/srep36705 · Cited by 64 · see citing works

Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling

Ma, M., Ren, Q., Yang, C., Zhang, J.-C., Yao, W., Dong, C., Ohgi, Y., Futamura, T., & Hashimoto, K. (2016) · Scientific Reports · doi:10.1038/srep39209 · Cited by 58 · see citing works

The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications

Jaggar, M., Fanibunda, S. E., Ghosh, S. K., Duman, R. S., & Vaidya, V. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00006-8 · Cited by 58 · see citing works

Ketamine’s dose related multiple mechanisms of actions: Dissociative anesthetic to rapid antidepressant

Lavender, E., Hirasawa-Fujita, M., & Domino, E. F. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112631 · Cited by 56 · see citing works

How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders

Kaul, D., Schwab, S. G., Mechawar, N., & Matosin, N. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.025 · Cited by 56 · see citing works

Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress

Yang, C., Shirayama, Y., Zhang, J., Ren, Q., & Hashimoto, K. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.36 · Cited by 54 · see citing works

Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders

Singh, A. A., Katiyar, S., & Song, M. (2025) · Brain Sciences · doi:10.3390/brainsci15030252 · Cited by 53 · see citing works

Allostatic load and reduced cortical thickness in schizophrenia

Chiappelli, J., Kochunov, P. V., Savransky, A., Fisseha, F., Wisner, K., Du, X. M., Rowland, L. M., & Hong, L. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.021 · Cited by 51 · see citing works

BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis.

Matin, S., & Dadkhah, M. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110882 · Cited by 44 · see citing works

The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers

Larosa, A., & Wong, T. P. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110601 · Cited by 47 · see citing works

Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression

Su, C.-L., Su, C.-W., Hsiao, Y., & Gean, P. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.02.008 · Cited by 47 · see citing works

Ketamine Alleviates Postoperative Depression-Like Symptoms in Susceptible Mice: The Role of BDNF-TrkB Signaling

Li, S., Luo, X., Hua, D., Wang, Y., Zhan, G., Huang, N., Jiang, R., Yang, L., Zhu, B., Yuan, X., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01702 · Cited by 45 · see citing works

Rapid-acting and long-lasting antidepressant-like action of (R)-ketamine in Nrf2 knock-out mice: a role of TrkB signaling

Qu, Y., Shan, J., Wang, S., Chang, L., Pu, Y., Wang, X., Tan, Y., Yamamoto, M. P., & Hashimoto, K. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01208-w · Cited by 42 · see citing works

Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype

Zhang, J.-C., Yao, W., Qu, Y., Nakamura, M., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Shirayama, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07325-2 · Cited by 41 · see citing works

New insights on brain‐derived neurotrophic factor epigenetics: from depression to memory extinction

Poon, C. H., Heng, B. C., & Lim, L. W. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14458 · Cited by 40 · see citing works

A potential role for microglia in stress- and drug-induced plasticity in the nucleus accumbens: A mechanism for stress-induced vulnerability to substance use disorder

McGrath, A. G., & Briand, L. A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.007 · Cited by 37 · see citing works

Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression

Zhang, W., Wang, H., Lv, Y., Liu, C.-C., Sun, W.-Y., & Tian, L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.045 · Cited by 36 · see citing works

PGC-1α–FNDC5–BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat

Zhan, G., Huang, N., Li, S., Hua, D., Zhang, J., Fang, X., Yang, N., Luo, A., & Yang, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5041-2 · Cited by 32 · see citing works

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury

Fang, X., Yang, C., Li, S., Zhan, G., Zhang, J., Huang, N., Du, X., Xu, H., Hashimoto, K., & Luo, A. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0909-z · Cited by 32 · see citing works

What Are the Causes for Discrepancies of Antidepressant Actions of (2R,6R)-Hydroxynorketamine?

Hashimoto, K., & Shirayama, Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.12.007 · Cited by 31 · see citing works

Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling

Wei, Y., Chang, L., & Hashimoto, K. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.04.010 · Cited by 30 · see citing works

Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders

Kaul, D., Smith, C. C., Stevens, J., Fröhlich, A. S., Binder, E. B., Mechawar, N., Schwab, S. G., & Matosin, N. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100270 · Cited by 30 · see citing works

Influence of gut microbiota on resilience and its possible mechanisms

Wang, J., Zhou, T., Liu, F., Huang, Y., Xiao, Z., Qian, Y., & Zhou, W. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82362 · Cited by 30 · see citing works

Comparison of rapid and long-lasting antidepressant effects of negative modulators of α5-containing GABAA receptors and (R)‑ketamine in a chronic social defeat stress model

Xiong, Z., Zhang, K., Ishima, T., Ren, Q., Chang, L., Chen, J., & Hashimoto, K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.10.005 · Cited by 29 · see citing works

Deletion of serine racemase confers D-serine –dependent resilience to chronic social defeat stress

Dong, C., Zhang, J., Ren, Q., Ma, M., Qu, Y., Zhang, K., Yao, W., Ishima, T., Mori, H., & Hashimoto, K. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.03.008 · Cited by 26 · see citing works

Longitudinal in vivo Diffusion Tensor Imaging Detects Differential Microstructural Alterations in the Hippocampus of Chronic Social Defeat Stress-Susceptible and Resilient Mice

Liu, X., Yuan, J., Guang, Y., Wang, X., & Feng, Z. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00613 · Cited by 25 · see citing works

Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function

Sun, W., Cheng, H., Yang, Y., Tang, D., Li, X., & An, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.678182 · Cited by 24 · see citing works

Diabetes mellitus, cognitive deficits and serum BDNF levels in chronic patients with schizophrenia: A case-control study

Li, S., Chen, D., Xiu, M., Li, J., & Zhang, X. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.035 · Cited by 24 · see citing works

Analysis of antidepressant-like effects and action mechanisms of GSB-106, a small molecule, affecting the TrkB signaling

Vakhitova, Y. V., Kalinina, T. S., Zainullina, L. F., Lusta, A. Y., Volkova, A. V., Kudryashov, N. V., Gudasheva, T. A., Shimshirt, A. A., Kadnikov, I. A., Voronin, M. V., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413381 · Cited by 21 · see citing works

Differential expression of serum biomarkers in hemodialysis patients with mild cognitive decline: A prospective single-center cohort study

Zhu, B., Jin, L., Shen, J., Liu, J., Jiang, R., Yang, L., Zhang, J., Luo, A., Miao, L., & Yang, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-29760-5 · Cited by 22 · see citing works

Sex-Dependent Ketamine Addiction-Like Behavior Profile Following Exposure to Chronic Mild Stress

Wright, K. N., Hagarty, D. P., Strong, C. E., Schoepfer, K. J., & Kabbaj, M. (2019) · Chronic Stress · doi:10.1177/2470547019832613 · Cited by 20 · see citing works

Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin

Hashimoto, K. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0682-9 · Cited by 20 · see citing works

mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice

Jing, X.-Y., Wang, Y., Zou, H.-W., Li, Z.-L., Liu, Y.-J., & Li, L. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174231 · Cited by 18 · see citing works

Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling

Khalifeh, M., Hobeika, R., Hayek, L. E., Saad, J., Eid, F., Khoury, R. E., Ghayad, L. M., Jabre, V., Nasrallah, P., Barmo, N., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112499 · Cited by 18 · see citing works

Post-weaning social isolation causes sex-specific alterations to dendritic spine density in subregions of the prefrontal cortex and nucleus accumbens of adult mice

McGrath, A. G., & Briand, L. A. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147755 · Cited by 17 · see citing works

Sustained antidepressant action of the N‑methyl‑D‑aspartate receptor antagonist MK‑801 in a chronic unpredictable mild stress model

Yang, B., Qin, J., Nie, Y., & Chen, J. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6876 · Cited by 17 · see citing works

Modulation of neuroplasticity-related targets following stress-induced acute escape deficit

Benatti, C., Radighieri, G., Alboni, S., Blom, J. M. C., Brunello, N., & Tascedda, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.023 · Cited by 17 · see citing works

Rapid Antidepressant Activity of Ketamine Beyond NMDA Receptor

Hashimoto, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-49795-2_4 · Cited by 16 · see citing works

Lack of rapid antidepressant effects of Kir4.1 channel inhibitors in a chronic social defeat stress model: Comparison with (R)-ketamine

Xiong, Z., Zhang, K., Ishima, T., Ren, Q., Ma, M., Pu, Y., Chang, L., Chen, J., & Hashimoto, K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.11.010 · Cited by 16 · see citing works

The correlation between perceived social support, cortisol and brain derived neurotrophic factor levels in healthy women

Yung, D., Chang, W. H., Chi, M. H., Tsai, H. C., Yang, Y. K., & Chen, P. S. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.03.019 · Cited by 16 · see citing works

The role of MeCP2 and the BDNF/TrkB signaling pathway in the stress resilience of mice subjected to CSDS

Huang, L., He, L., Ma, R., Ding, W., Zhou, C., Lin, S., Zhang, J., Chen, J., & Yao, W. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06176-8 · Cited by 13 · see citing works

Monoaminergic balances predict non-depression-like phenotype in Learned Helplessness Paradigm

Muneoka, K. T., Oda, Y., Iwata, M., Iyo, M., Hashimoto, K., & Shirayama, Y. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.033 · Cited by 11 · see citing works

Aberrant ventral dentate gyrus structure and function in trauma susceptible mice

Dirven, B. C. J., van der Geugten, D., Temporão, C., van Bodegom, M., Madder, L., van Agen, L., Homberg, J. R., Kozicz, T., & Henckens, M. J. A. G. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02264-7 · Cited by 11 · see citing works

The alterations of glutamate transporter 1 and glutamine synthetase in the rat brain of a learned helplessness model of depression

Yoshino, K., Oda, Y., Kimura, M., Kimura, H., Nangaku, M., Shirayama, Y., & Iyo, M. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05555-3 · Cited by 11 · see citing works

Increased BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescence

Dong, C., Tian, Z. R., Zhang, K., Chang, L., Qu, Y., Pu, Y., Ren, Q., Fujita, Y., Ohgi, Y., Futamura, T., et al. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.01.002 · Cited by 10 · see citing works

Prenatal cyanuric acid exposure depresses hippocampal synaptic plasticity and induces spatial learning and memory deficits

Sun, W., Yang, Y., Mei, Y., Wu, Y., Chen, X., & An, L. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.10.012 · Cited by 9 · see citing works

The Regulation of Glutamate Transporter 1 in the Rapid Antidepressant-Like Effect of Ketamine in Mice

Chen, Y., Shen, M., Liu, X., Xu, J., & Wang, C. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.789524 · Cited by 9 · see citing works

Maladaptation of dentate gyrus mossy cells mediates contextual discrimination deficit after traumatic stress

Jeong, M., Jang, J., Oh, S.-J., Park, J., Lee, J., Hwang, S., & Oh, Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114000 · Cited by 9 · see citing works

Learned Helplessness in Rodents

Silveira, K. M., & Joca, S. R. L. (2022) · Neuromethods · doi:10.1007/978-1-0716-2748-8_9 · Cited by 6 · see citing works

The interactive effects of ketamine and magnesium upon depressive-like pathology

Hayley, S. P., Razmjou, S., Litteljohn, D., Rudyk, C., Syed, S., Clarke, M., Pentz, R., & Dwyer, Z. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s111131 · Cited by 6 · see citing works

Resolving the contributions of anaesthesia, surgery, and nerve injury on brain derived neurotrophic factor expression in the medial prefrontal cortex of male rats in the CCI model of neuropathic pain

Kang, J. W. M., Keay, K. A., & Mor, D. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24095 · Cited by 6 · see citing works

Insights for the Next Generation of Ketamine for the Treatment of Depressive Disorder

Martins, A. C. F., Badenoch, B., & Gomes, R. D. S. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02467 · Cited by 4 · see citing works

The Role of Brain-Derived Neurotrophic Factor in Mediating the Action of Antidepressants in the Treatment of Depression

Иродионовна, В. Т., Ахапкин, Р. В., & Aleksandrovsky, Y. A. (2019) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn1107 · Cited by 4 · see citing works

Biomarkers of resilience and susceptibility in rodent models of stress

Magalhães, R. J. D. S., Ganz, E., Rodrigues, M., Barrière, D. A., Mériaux, S., Jay, T. M., & Sousa, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00020-3 · Cited by 4 · see citing works

The facilitating effect of unfavorable lactation on the potentiation of electrocorticogram after spreading depression in awake and anesthetized adult rats

de Souza, T. K. M., Silva-Gondim, M. B. E., Rodrigues, M. C. A., & Guedes, R. C. A. (2016) · Nutritional Neuroscience · doi:10.1080/1028415x.2016.1210878 · Cited by 4 · see citing works

A study of limbic brain derived neurotrophic factor gene expression in male Sprague-Dawley rats trained on a learned helplessness task

Storace, A., Daniels, S., Zhou, Y., Kalisch, B. E., Parker, L. A., Rock, E. M., Limebeer, C. L., Lapointe, T., & Leri, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112174 · Cited by 3 · see citing works

Subjective arousal and perceived control clarify heterogeneity in inflammatory and affective outcomes

Ghane, M., Sullivan‐Toole, H., Giacco, A. C. D., & Richey, J. A. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100341 · Cited by 3 · see citing works

Sex differences in resilience at puberty depend upon divergent effects of a stress steroid at α4βδ GABAA receptors

Kenney, L. A., Tekin, M., de Leon, D. M., Marshall, S., & Smith, S. S. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149874

Role of BDNF-TrkB Signaling in Regulating Anxiety and Depression-Like Behavior in Diverse Brain Regions

Shi, Y., Mu, C., & Xin, Y. (2023) · Clinical Neurology and Neuroscience · doi:10.11648/j.cnn.20230702.11 · Cited by 1 · see citing works

Early protein restriction in rats induces anhedonia in adult offspring: A key role of BDNF-TrkB signaling in the nucleus accumbens shell

Gutiérrez, M. C., Perondi, M. C., Tortoni, G. L., Cragnolini, A. B., Cuadra, G. R., & Valdomero, A. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110099 · Cited by 1 · see citing works

[Anatomo-echocardiographic correlation of scimitar syndrome in adults].

Espinola-Zavaleta, N. G., Muñoz‐Castellanos, L., Játiva-Chávez, S., & Zamora-González, C. (2005) · PubMed · Cited by 4 · see citing works

Development of a Novel Method to Assess the Effects of Predictability and Chronic Stress on Neuronal Morphology and Decision-Making in Rats

Kassem, M. S. (2017) · The Sydney eScholarship Repository (The University of Sydney)

Role of TrkB-signaling in taste development and function.

Rios-Pilier, J. (2018) · doi:10.18297/etd/3128

Aberrant ventral dentate gyrus structure and function in individuals susceptible to post-traumatic stress disorderPreprint

Dirven, B. C. J., van der Geugten, D., van Bodegom, M., Madder, L., van Agen, L., Homberg, J. R., Kozicz, T., & Henckens, M. J. A. G. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.01.321893

Sulforaphane Activates Brain-Derived Neurotrophic Factor (BDNF) Transcription by NF-E2-Related factor-2 (Nrf2), Showing Prevention Effects on the Microglial of Stressed MicePreprint

Tang, R., Cao, Q., He, L., Du, P., Chen, G., Fu, R., Xiao, F., Sun, Y., & Zhang, J.-C. (2020) · doi:10.21203/rs.3.rs-100350/v1

The Link Between Early Life Stress and Depressive Illness: The Mediating Role of Coping, Cognitive Flexibility, and Resilience

Santoni, S. (2017) · doi:10.22215/etd/2017-11964

Faculty Opinions recommendation of Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression.

Duman, R. S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726609768.793546111

Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience

Yang, B., Yang, C., Ren, Q., Zhang, J.-C., Chen, Q., Shirayama, Y., & Hashimoto, K. (2016) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-016-0693-6 · Cited by 69 · see citing works

A study of brain-derived neurotrophic factor in Sprague-Dawley rats trained on a learned helplessness procedure.

Storace, A., & Leri, F. (2018) · The Atrium (University of Guelph)

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

Qu, Y., Yang, C., Ren, Q., Ma, M., Dong, C., & Hashimoto, K. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.16 · Cited by 68 · see citing works

Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus

Greenwood, B. N., Strong, P. V., Foley, T. E., Thompson, R. S., & Fleshner, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.007 · Cited by 61 · see citing works

A study of limbic brain derived neurotrophic factor gene expression in male Sprague-Dawley rats trained on a learned helplessness task

Storace, A., Daniels, S., Zhou, Y., Kalisch, B. E., Parker, L. A., Rock, E. M., Limebeer, C. L., Lapointe, T., & Leri, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112174 · Cited by 3 · see citing works