Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

Jorenby, D. E.; Hatsukami, Dorothy K.; Smith, Stevens S.; Fiore, Michael C.; Allen, Sharon; Jensen, Joni; Baker, Timothy B.

doi:10.1007/s002130050118

Cited by 141Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesNicotinic Acetylcholine Receptors Study

Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

Jorenby, D. E., Hatsukami, Dorothy K., Smith, Stevens S., Fiore, Michael C., Allen, Sharon, Jensen, Joni, Baker, Timothy B.·1996·Psychopharmacology

DOI 10.1007/s002130050118

Open this paper in CoChat — free account

Abstract

The accurate assessment of both tobacco withdrawal and the impact of the nicotine patch on withdrawal may be compromised by attrition of subjects, or by subjects smoking during withdrawal. To reduce these occurrences, 211 participants were provided with intensive cessation counseling while trying to quit smoking with either nicotine (21 mg) or placebo transdermal patches. Subject attrition was low, with 80.5% of participants continuing through the 5-week study period. Abstinence rates were also high over this period (75% and 61% in active and placebo groups, respectively). In this multisite, double-blind trial, withdrawal severity was assessed using a nine-item daily self-report questionnaire, and abstinence was confirmed via CO monitoring. Abrupt smoking cessation increased multiple tobacco withdrawal symptoms/signs including craving for cigarettes, irritability, anxiety, appetite, sleep disruption, difficulty concentrating, restlessness, depression, and impatience. Treatment with transdermal nicotine reduced craving for cigarettes, anxiety, irritability, and appetite, as well as weight gain (1.85 versus 2.88 kg mean gain over 4 weeks in active and placebo groups, respectively).

Integrity signals

Registry

Crossref · 10.1007/s002130050118

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bupropion improves abstinence rates to 14-18% of subjects.
“Bupropion improves rates of abstinence to 14–18% of subjects [150, 233]”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [150]

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment
Fagerström, K.-O. (1978) · Addictive Behaviors · doi:10.1016/0306-4603(78)90024-2 · Cited by 2,221 · see citing works
Signs and Symptoms of Tobacco Withdrawal
Hughes, J. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800030107013 · Cited by 1,669 · see citing works
Symptoms of Tobacco Withdrawal: A Replication and Extension
Hughes, J. R. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810250054007 · Cited by 449 · see citing works
Untitled work
(1986) · PubMed · Cited by 439 · see citing works
Tobacco withdrawal symptoms: An experimental analysis
Hatsukami, D. K., Hughes, J. R., Pickens, R. W., & Svikis, D. S. (1984) · Psychopharmacology · doi:10.1007/bf00427451 · Cited by 217 · see citing works
CONTROLLED TRIAL OF TRANSDERMAL NICOTINE PATCH IN TOBACCO WITHDRAWAL
Abelin, T., Müller, P., Buehler, A., Vesanen, K., & Imhof, P. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91671-1 · Cited by 201 · see citing works
Effectiveness of a 16-hour transdermal nicotine patch in a medical practice setting, without intensive group counseling.
Sachs, D., Säwe, U., & Leischow, S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410160041003 · Cited by 155 · see citing works
Pre-abstinence smoke intake and smoking motivation as predictors of severity of cigarette withdrawal symptoms
West, R., & Russell, M. A. (1985) · Psychopharmacology · doi:10.1007/bf00432717 · Cited by 148 · see citing works
Factors associated with participation, attrition, and outcome in a smoking cessation program at the workplace.
Klesges, R. C., Brown, K., Pascale, R. W., Murphy, M., Williams, E., & Cigrang, J. A. (1988) · Health Psychology · doi:10.1037//0278-6133.7.6.575 · Cited by 146 · see citing works
Transdermal nicotine facilitates smoking cessation
Rose, J. E., Levin, E. D., Behm, F. M., Adivi, C., & Schur, C. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.35 · Cited by 131 · see citing works
The Smoking and Body Weight Relationship: Implications for Intervention and Postcessation Smoking Control
Gritz, E. R., Klesges, R. C., & Meyers, A. W. (1989) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm1104_4 · Cited by 84 · see citing works
The nicotine patch in smoking cessation. A randomized trial with telephone counseling
Westman, E. C. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.16.1917 · Cited by 79 · see citing works
Weight gain as a function of smoking cessation and 2-mg nicotine gum use among middle-aged smokers with mild lung impairment in the first 2 years of the Lung Health Study.
Nides, M. A., Rand, C. S., Dolce, J., Murray, R. A., O’Hara, P., Voelker, H. T., & Connett, J. E. (1994) · Health Psychology · doi:10.1037/0278-6133.13.4.354 · Cited by 76 · see citing works
Symptoms of tobacco withdrawal from total cigarette cessation versus partial cigarette reduction
Hatsukami, D. K., Dahlgren, L., Zimmerman, R., & Hughes, J. (1988) · Psychopharmacology · doi:10.1007/bf00176853 · Cited by 64 · see citing works
Weight gain following smoking cessation: a possible role for nicotine replacement in weight management
Emont, S. L., & Cummings, K. M. (1987) · Addictive Behaviors · doi:10.1016/0306-4603(87)90021-9 · Cited by 54 · see citing works

Flagged first, then by citations

Sorted by citations

Addiction motivation reformulated: an affective processing model of negative reinforcement
Baker, T. B., Piper, M. E., McCarthy, D. E., Majeskie, M. R., & Fiore, M. C. (2004) · Psychological Review · doi:10.1037/0033-295x.111.1.33 · Cited by 2,162 · see citing works
A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation
Jorenby, D. E., Leischow, S. J., Nides, M. A., Rennard, S. I., Johnston, J. A., Hughes, A. R., Smith, S. S., Muramoto, M. L., Daughton, D. M., Doan, K., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400903 · Cited by 1,585 · see citing works
Imaginary Relish and Exquisite Torture: The Elaborated Intrusion Theory of Desire.
Kavanagh, D. J., Andrade, J., & May, J. (2005) · Psychological Review · doi:10.1037/0033-295x.112.2.446 · Cited by 956 · see citing works
Effects of abstinence from tobacco: Valid symptoms and time course
Hughes, J. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701188919 · Cited by 793 · see citing works
Exercise interventions for smoking cessation
USSHER, M. H., Taylor, A. H., & Faulkner, G. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002295.pub5 · Cited by 509 · see citing works
Smoking Cessation in Women
Perkins, K. A. (2001) · CNS Drugs · doi:10.2165/00023210-200115050-00005 · Cited by 403 · see citing works
Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers.
Jacobsen, L. K., Krystal, J. H., Mencl, W. E., Westerveld, M., Frost, S. J., & Pugh, K. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.022 · Cited by 393 · see citing works
Craving's place in addiction theory: Contributions of the major models
Skinner, M. D., & Aubin, H.-J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.024 · Cited by 372 · see citing works
Motivational Influences on Cigarette Smoking
Baker, T. B., Brandon, T. H., & Chassin, L. (2004) · Annual Review of Psychology · doi:10.1146/annurev.psych.55.090902.142054 · Cited by 352 · see citing works
Development and validation of the Wisconsin Smoking Withdrawal Scale.
Welsch, S. K., Smith, S. S., Wetter, D. W., Jorenby, D. E., Fiore, M. C., & Baker, T. B. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.7.4.354 · Cited by 308 · see citing works
Predicting relapse back to smoking: Contrasting affective and physical models of dependence.
Kenford, S. L., Smith, S. S., Wetter, D. W., Jorenby, D. E., Fiore, M. C., & Baker, T. B. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.1.216 · Cited by 279 · see citing works
Smoking withdrawal dynamics in unaided quitters.
Piasecki, T. M., Niaura, R., Shadel, W. G., Abrams, D., Goldstein, M., Fiore, M. C., & Baker, T. B. (2000) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.109.1.74 · Cited by 262 · see citing works
Effects of nicotine on sleep during consumption, withdrawal and replacement therapy
Jaehne, A., Loessl, B., Bárkai, Z., Riemann, D. W., & Hornyak, M. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.12.003 · Cited by 243 · see citing works
Phenotypic Characterization of an α<sub>4</sub> Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse
Ross, S. A., Wong, J. Y. F., Clifford, J. J., Kinsella, A., Massalas, J. S., Horne, M. K., Scheffer, I. E., Kola, I., Waddington, J. L., Berkovic, S. F., et al. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06431.2000 · Cited by 204 · see citing works
Measuring nicotine dependence among youth: a review of available approaches and instruments
Colby, S. M., Tiffany, S. T., Shiffman, S. S., & NIAURA, R. S. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00163-5 · Cited by 196 · see citing works
Effects of transdermal nicotine patches on abstinence-induced and cue-elicited craving in cigarette smokers.
Tiffany, S. T., Cox, L. S., & Elash, C. A. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.68.2.233 · Cited by 196 · see citing works
Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms.
Piasecki, T. M., Fiore, M. C., & Baker, T. B. (1998) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.107.2.238 · Cited by 189 · see citing works
Tobacco addiction and the dysregulation of brain stress systems
Bruijnzeel, A. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.015 · Cited by 172 · see citing works
The clinical effectiveness and cost-effectiveness of bupropion and nicotine replacement therapy for smoking cessation: a systematic review and economic evaluation.
Woolacott, N., Jones, L., Forbes, C., Mather, L., Sowden, A., Song, F., Raftery, J., Aveyard, P., Hyde, C., & Barton, P. (2002) · Health Technology Assessment · doi:10.3310/hta6160 · Cited by 174 · see citing works
Smoking withdrawal dynamics: II. Improved tests of withdrawal-relapse relations
Piasecki, T. M., Jorenby, D. E., Smith, S. S., Fiore, M. C., & Baker, T. B. (2003) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.112.1.14 · Cited by 159 · see citing works
Smoking withdrawal dynamics: I. Abstinence distress in lapsers and abstainers
Piasecki, T. M., Jorenby, D. E., Smith, S. S., Fiore, M. C., & Baker, T. B. (2003) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.112.1.3 · Cited by 154 · see citing works
The efficacy of moderate-intensity exercise as an aid for smoking cessation in women: a randomized controlled trial.
Marcus, B., Lewis, B., Hogan, J. W., King, T., Albrecht, A. E., Bock, B., Parisi, A. F., Niaura, R., & Abrams, D. (2005) · Nicotine & Tobacco Research · doi:10.1080/14622200500266056 · Cited by 150 · see citing works
The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence
Bruijnzeel, A. W., & Gold, M. S. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.007 · Cited by 125 · see citing works
Sleep disturbances associated with cigarette smoking
McNamara, J. P. H., Wang, J., Holiday, D. B., Warren, J. Y., Paradoa, M., Balkhi, A. M., Fernandez-Baca, J., & McCrae, C. S. (2013) · Psychology Health & Medicine · doi:10.1080/13548506.2013.832782 · Cited by 123 · see citing works
Effect of oral nicotine dosing forms on cigarette withdrawal symptoms and craving: a systematic review
West, R., & Shiffman, S. (2001) · Psychopharmacology · doi:10.1007/s002130100712 · Cited by 115 · see citing works
Efficacy of exercise counselling as an aid for smoking cessation: a randomized controlled trial
USSHER, M. H., West, R., McEwen, A., Taylor, A. H., & Steptoe, A. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00346.x · Cited by 114 · see citing works
Confirmatory factor analysis of the Minnesota Nicotine Withdrawal Scale.
Toll, B. A., O’Malley, S. S., McKee, S. A., Salovey, P., & Krishnan‐Sarin, S. (2007) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.21.2.216 · Cited by 105 · see citing works
Smoking withdrawal dynamics: III. Correlates of withdrawal heterogeneity
Piasecki, T. M., Jorenby, D. E., Smith, S. S., Fiore, M. C., & Baker, T. B. (2003) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.11.4.276 · Cited by 104 · see citing works
Exercise interventions for smoking cessation
USSHER, M. H., Taylor, A. H., & Faulkner, G. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002295.pub4 · Cited by 104 · see citing works
Natural history of nicotine withdrawal
Shiffman, S., Patten, C., Gwaltney, C., Paty, J., Gnys, M., Kassel, J., Hickcox, M., Waters, A., & Balabanis, M. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01635.x · Cited by 104 · see citing works
Relationships of Psychiatric Disorders with Overweight and Obesity in an Adult General Population**
John, U., Meyer, C., Rumpf, H., & Hapke, U. (2005) · Obesity Research · doi:10.1038/oby.2005.13 · Cited by 95 · see citing works
Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal
De Biasi, M., & Salas, R. (2008) · Experimental Biology and Medicine · doi:10.3181/0712-mr-355 · Cited by 95 · see citing works
Effects of naltrexone with nicotine replacement on smoking cue reactivity: preliminary results
Hutchison, K. E., Monti, P. M., Rohsenow, D. J., Swift, R. M., Colby, S. M., Gnys, M., NIAURA, R. S., & Sirota, A. D. (1999) · Psychopharmacology · doi:10.1007/s002130050872 · Cited by 92 · see citing works
Identifying effective intervention components for smoking cessation: a factorial screening experiment
Piper, M. E., Fiore, M. C., Smith, S. S., Fraser, D. L., Bolt, D. M., Collins, L. M., Mermelstein, R. J., Schlam, T. R., Cook, J. W., Jorenby, D. E., et al. (2015) · Addiction · doi:10.1111/add.13162 · Cited by 89 · see citing works
Gender differences in response to nicotine replacement therapy: Objective and subjective indexes of tobacco withdrawal.
Wetter, D. W., Fiore, M. C., Young, T. B., McClure, J. B., de Moor, C. A., & Baker, T. B. (1999) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.7.2.135 · Cited by 89 · see citing works
The effects of exercise and nicotine replacement therapy on smoking rates in women
Harry Prapavessis, A., Cameron, L. D., Baldi, J. C., Robinson, S. M., Borrie, K., Harper, T., & Grove, B. (2006) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.10.005 · Cited by 89 · see citing works
Effects of three doses of transdermal nicotine on post-cessation eating, hunger and weight
Hughes, J. R., & Hatsukami, D. K. (1997) · Journal of Substance Abuse · doi:10.1016/s0899-3289(97)90013-4 · Cited by 86 · see citing works
Effects of gender on relapse prevention in smokers treated with bupropion SR
Gonzales, D. H. (2002) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(02)00419-1 · Cited by 85 · see citing works
Exercise interventions for smoking cessation
USSHER, M. H., Taylor, A. H., & Faulkner, G. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002295.pub3 · Cited by 85 · see citing works
Epidemiological profiles of patients with chronic migraine and chronic tension-type headache
Schramm, S. H., Obermann, M., Katsarava, Z., Diener, H., Moebus, S., & Yoon, M. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-40 · Cited by 82 · see citing works
Smokers deprived of cigarettes for 72 h: effect of nicotine patches on craving and withdrawal
Teneggi, V., Tiffany, S. T., Squassante, L., Milleri, S., Ziviani, L., & Bye, A. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1176-1 · Cited by 81 · see citing works
Self-reported abstinence effects in the first month after smoking cessation
Ward, M. M., Swan, G. E., & Jack, L. M. (2001) · Addictive Behaviors · doi:10.1016/s0306-4603(00)00107-6 · Cited by 78 · see citing works
Measurement of the effects of abstinence from tobacco: A qualitative review.
Hughes, J. R. (2007) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.21.2.127 · Cited by 76 · see citing works
Revealing the multidimensional framework of the Minnesota nicotine withdrawal scale
Cappelleri, J. C., Bushmakin, A. G., Baker, C. L., Merikle, E. P., Olufade, A. O., & Gilbert, D. G. (2005) · Current Medical Research and Opinion · doi:10.1185/030079905x43712 · Cited by 75 · see citing works
Delirium from nicotine withdrawal in neuro-ICU patients
Mayer, S. A., Chong, J. Y., Ridgway, E., Min, K. C., Commichau, C., & Bernardini, G. L. (2001) · Neurology · doi:10.1212/wnl.57.3.551 · Cited by 74 · see citing works
Mechanistic insights into nicotine withdrawal
Paolini, M., & De Biasi, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.075 · Cited by 66 · see citing works
Manipulating smoking motivation: Impact on an electrophysiological index of approach motivation.
Zinser, M. C., Fiore, M. C., Davidson, R. J., & Baker, T. B. (1999) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.108.2.240 · Cited by 65 · see citing works
Consenso sobre o tratamento da dependência de nicotina
Marques, A. C. P. R., Campana, A., Gigliotti, A. D. P., Lourenço, M. T. C., Ferreira, M. P., & Laranjeira, R. (2001) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462001000400007 · Cited by 59 · see citing works
An Experimental Examination of the Initial Weeks of Abstinence in Cigarette Smokers.
Alessi, S. M., Badger, G. J., & Higgins, S. T. (2004) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.12.4.276 · Cited by 62 · see citing works
Transdermal nicotine-induced tobacco abstinence symptom suppression: Nicotine dose and smokers' gender.
Evans, S. E., Blank, M. D., Sams, C., Weaver, M. F., & Eissenberg, T. (2006) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.14.2.121 · Cited by 62 · see citing works
Stress and Addiction: When a Robust Stress Response Indicates Resiliency
Al’Absi, M. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000520 · Cited by 63 · see citing works
Maternal smoking during pregnancy and appetite control in offspring
Toschke, A. M., Ehlin, A., von Kries, R., Ekbom, A., & Montgomery, S. (2003) · Journal of Perinatal Medicine · doi:10.1515/jpm.2003.034 · Cited by 59 · see citing works
Moderate intensity exercise as an adjunct to standard smoking cessation treatment for women: A pilot study.
Williams, D. M., Whiteley, J. A., DUNSIGER, S. I., Jennings, E., Albrecht, A. E., USSHER, M. H., Ciccolo, J. T., Parisi, A. F., & Marcus, B. H. (2010) · Psychology of Addictive Behaviors · doi:10.1037/a0018332 · Cited by 59 · see citing works
High-dose transdermal nicotine and naltrexone: Effects on nicotine withdrawal, urges, smoking, and effects of smoking.
Rohsenow, D. J., Monti, P. M., Hutchison, K. E., Swift, R. M., MacKinnon, S. V., Sirota, A. D., & Kaplan, G. B. (2007) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.15.1.81 · Cited by 50 · see citing works
Decreased anxiety-like behavior in beta3 nicotinic receptor subunit knockout mice
Booker, T. K., Butt, C. M., Wehner, J. M., Heinemann, S. F., & Collins, A. C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.04.011 · Cited by 49 · see citing works
Effect of Varenicline on Individual Nicotine Withdrawal Symptoms: A Combined Analysis of Eight Randomized, Placebo-Controlled Trials
Foulds, J., Russ, C., Yu, C.-R., Zou, K. H., Galaznik, A., Franzon, M., Berg, A. S., & Hughes, J. R. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntt066 · Cited by 48 · see citing works
Exercise interventions for smoking cessation
USSHER, M. H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002295.pub2 · Cited by 46 · see citing works
Effects of topiramate on cue-induced cigarette craving and the response to a smoked cigarette in briefly abstinent smokers
Reid, M. S., Palamar, J. J., Raghavan, S. S., & Flammino, F. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0755-6 · Cited by 45 · see citing works
The relationship between level of cigarette consumption and latency to the onset of retrospectively reported withdrawal symptoms
Fernando, W. W. S. A., Wellman, R. J., & DiFranza, J. R. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0497-x · Cited by 45 · see citing works
Sleep Disturbance During Smoking Cessation: Withdrawal or Side Effect of Treatment?
Ashare, R. L., Lerman, C., Tyndale, R. F., Hawk, L. W., George, T. P., Cinciripini, P., & Schnoll, R. A. (2017) · Journal of Smoking Cessation · doi:10.1017/jsc.2016.11 · Cited by 42 · see citing works
The influence of smoking and smokeless tobacco use on weight amongst men
Rodu, B., Stegmayr, B. G., Nasic, S., Cole, P. T., & Asplund, K. (2003) · Journal of Internal Medicine · doi:10.1046/j.0954-6820.2003.01244.x · Cited by 40 · see citing works
Consideration of sex in clinical trials of transdermal nicotine patch: A systematic review.
Weinberger, A. H., Smith, P. H., Kaufman, M., & McKee, S. A. (2014) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0037692 · Cited by 38 · see citing works
Association of smoking status and health-related quality of life: difference among young, middle-aged, and older adults in Shandong, China
Jing, Z., Li, J., Wang, Y., Yuan, Y., Zhao, D., Hao, W., Yu, C., & Zhou, C. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02645-9 · Cited by 37 · see citing works
Prevalence and risk factors of migraine and non-migraine headache in older people – results of the Heinz Nixdorf Recall study
Schramm, S. H., Tenhagen, I., Schmidt, B., Holle, D., Naegel, S., Katsarava, Z., Jöckel, K., & Moebus, S. (2020) · Cephalalgia · doi:10.1177/0333102420977183 · Cited by 37 · see citing works
Subjective sleep disturbance during a smoking cessation program: Associations with relapse
Okun, M. L., Levine, M. D., Houck, P. R., Perkins, K. A., & Marcus, M. D. (2011) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.03.001 · Cited by 37 · see citing works
One year effectiveness of an individualised smoking cessation intervention at the workplace: a randomised controlled trial
Rodríguez‐Artalejo, F., Urdinguio, P. J. L., Guallar‐Castillón, P., Dublang, P. G., Martínez, O. S., Azcárate, J. I. D., Alemán, M. F., & Banegas, J. R. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.5.358 · Cited by 37 · see citing works
No beneficial effects of transdermal nicotine in patients with primary sclerosing cholangitis: results of a randomized double-blind placebo-controlled cross-over study
Vleggaar, F. P., van Buuren, H. R., Henegouwen, G. P. V. B., Hop, W. C. J., & van Erpecum, K. J. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200102000-00013 · Cited by 37 · see citing works
A placebo controlled randomized trial of the effects of phenylpropanolamine and nicotine gum on cessation rates and postcessation weight gain in women
Cooper, T. V., Klesges, R. C., DeBon, M. W., Zbikowski, S. M., Johnson, K., & Clemens, L. H. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.04.013 · Cited by 36 · see citing works
Evaluation of the Chinese versions of the Minnesota Nicotine Withdrawal Scale and the Questionnaire on Smoking Urges-Brief
Yu, X., Xiao, D., Li, B., Liu, Y., Wang, G., Chen, J., Bai, C., Pan, J., Wan, H., Li, Q. Y., et al. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq063 · Cited by 34 · see citing works
Dynamic effects of craving and negative affect on adolescent smoking relapse.
Zundert, R. M. P. V., Ferguson, S. G., Shiffman, S. M., & Engels, R. C. M. E. (2011) · Health Psychology · doi:10.1037/a0025204 · Cited by 33 · see citing works
Does Smoking Affect OSA? What about Smoking Cessation?
Pataka, A., Kotoulas, S., Kalamaras, G., Tzinas, A., Grigoriou, I., Kasnaki, N., & Argyropoulou, P. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175164 · Cited by 35 · see citing works
Activation of PPARγ Attenuates the Expression of Physical and Affective Nicotine Withdrawal Symptoms through Mechanisms Involving Amygdala and Hippocampus Neurotransmission
Domi, E., Caputi, F. F., Romualdi, P., Domi, A., Scuppa, G., Candeletti, S., Atkins, A. L., Heilig, M. A., Demopulos, G. A., Gaitanaris, G., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1922-19.2019 · Cited by 32 · see citing works
Nicotine withdrawal symptoms following a quit attempt: An ecological momentary assessment study among adolescents
Zundert, R. M. P. V., Boogerd, E. A., Vermulst, A. A., & Engels, R. C. M. E. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp055 · Cited by 31 · see citing works
Combined behavioral and pharmacological treatments for smoking cessation
Stitzer, M. L. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050012041 · Cited by 30 · see citing works
Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta‐analysis
Hsieh, M., Tseng, P., Wu, Y., Tu, Y., Wu, H., Hsu, C., Lei, W., Stubbs, B., Carvalho, A. F., Liang, C., et al. (2019) · Obesity Reviews · doi:10.1111/obr.12835 · Cited by 29 · see citing works
Cessation of Smoking and Body Weight
Ward, K. D., Klesges, R. C., & Weg, M. W. V. (2001) · doi:10.1002/0470846739.ch22 · Cited by 29 · see citing works
Long-term effects of nicotine gum on weight gain after smoking cessation
Nordstrom, B. L., Kinnunen, T., Utman, C. H., & Garvey, A. J. (1999) · Nicotine & Tobacco Research · doi:10.1080/14622299050011381 · Cited by 26 · see citing works
Tobacco Dependence Treatment for Korean Americans: Preliminary Findings
Kim, S. S., Kim, S.-H., & Ziedonis, D. M. (2011) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-011-9507-0 · Cited by 26 · see citing works
Nicotine lowers the body-weight set-point in male rats
Frankham, P., & Cabanac, M. (2003) · Appetite · doi:10.1016/s0195-6663(03)00024-2 · Cited by 25 · see citing works
Treating depressed and anxious smokers in smoking cessation programs.
Richards, C. S., Cohen, L. M., Morrell, H. E. R., Watson, N. L., & Low, B. E. (2012) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0027793 · Cited by 25 · see citing works
Effect of nicotine replacement therapy on post-cessation weight gain and nutrient intake: A randomized controlled trial of postmenopausal female smokers
ALLEN, S. S., Hatsukami, D. K., Brintnell, D. M., & Bade, T. (2005) · Addictive Behaviors · doi:10.1016/j.addbeh.2005.01.003 · Cited by 23 · see citing works
Effects of the Transdermal Nicotine Patch on Normalization of HDL-C and Its Subfractions
Moffatt, R. J., Biggerstaff, K. D., & STAMFORD, B. A. (2000) · Preventive Medicine · doi:10.1006/pmed.2000.0694 · Cited by 23 · see citing works
The influence of sleep quality on smoking cessation in socioeconomically disadvantaged adults
Peltier, M. R., LEE, J., Ma, P., Businelle, M. S., & Kendzor, D. E. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.11.004 · Cited by 22 · see citing works
The effects of oral nicotine administration and abstinence on sleep in male C57BL/6J mice
Mathews, H. L., & Stitzel, J. A. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5139-6 · Cited by 22 · see citing works
Olanzapine reduces urge to smoke and nicotine withdrawal symptoms in community smokers.
Rohsenow, D. J., Tidey, J. W., Miranda, R., McGeary, J. E., Swift, R. M., Hutchison, K. E., Sirota, A. D., & Monti, P. M. (2008) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.16.3.215 · Cited by 22 · see citing works
Using quadratic inference functions to determine the factors associated with obesity: findings from the STEPS Survey in Iran
Asgari, F., Biglarian, A., Seifi, B., Bakhshi, A., Miri, H. H., & Bakhshi, E. (2013) · Annals of Epidemiology · doi:10.1016/j.annepidem.2013.07.006 · Cited by 19 · see citing works
Psychometric Properties of the Minnesota Nicotine Withdrawal Scale: A Korean Version
Kim, S. S., Gulick, E. E., Kim, S.-H., & Seo, H.-G. (2007) · Journal of Nursing Measurement · doi:10.1891/106137407782156354 · Cited by 19 · see citing works
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal
Varani, A. P., Pedrón, V. T., Moutinho, L. M., Antonelli, M. C., Bettler, B., & Balerio, G. N. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.013 · Cited by 17 · see citing works
Does combination pharmacological intervention for smoking cessation prevent post-cessation weight gain? A systemic review
Yang, M., Bhowmik, D., Wang, X., & Abughosh, S. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.11.007 · Cited by 17 · see citing works
A tutorial on principal stratification-based sensitivity analysis: application to smoking cessation studies
Egleston, B. L., Cropsey, K. L., Lazev, A. B., & Heckman, C. J. (2010) · Clinical Trials · doi:10.1177/1740774510367811 · Cited by 17 · see citing works
Is Impulsivity a Symptom of Initial Tobacco Withdrawal? A Meta-Analysis and Qualitative Systematic Review
Hughes, J. R., Dash, M., & CALLAS, P. W. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntu220 · Cited by 16 · see citing works
Predictors of Increased Body Mass Index Following Cessation of Smoking
John, U., Meyer, C., Rumpf, H., Hapke, H., & Schümann, A. (2006) · American Journal on Addictions · doi:10.1080/10550490500528738 · Cited by 15 · see citing works
Cross-Cultural Validation of a Smoking Abstinence Self-Efficacy Scale in Korean American Men
Kim, S. S., Kim, S., & Gulick, E. (2009) · Issues in Mental Health Nursing · doi:10.1080/01612840802370582 · Cited by 16 · see citing works
The dark side of compulsive eating and food addiction
Zorrilla, E. P., & Koob, G. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816207-1.00006-8 · Cited by 14 · see citing works
Imagery and Cravings
Kemps, E., & Tiggemann, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5879-1_20 · Cited by 11 · see citing works
Effect of nicotine lozenge use prior to smoking cue presentation on craving and withdrawal symptom severity
Kotlyar, M., Vogel, R. I., Dufresne, S. R., Mills, A. M., & Vuchetich, J. P. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107706 · Cited by 11 · see citing works
The effect of nicotine patches on craving in the brain
Liberman, K., Schuerbeek, P. V., Herremans, S. C., Meysman, M., Mey, J. D., & Buls, N. (2018) · Medicine · doi:10.1097/md.0000000000012415 · Cited by 11 · see citing works
Conditions of sleep restoration after smoking cessation: A systematic review
Mauries, S., Rolland, B., Mallevays, M., Catoire, S., Zehani, F., Sauvage, K., Davido, G., Lejoyeux, M., & Geoffroy, P. A. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.102041 · Cited by 10 · see citing works
Tobacco use cessation for adolescents.
Adelman, W. P. (2006) · PubMed · doi:10.1016/j.admecli.2006.06.013 · Cited by 10 · see citing works
Smoking, Obesity, and Post-Cessation Weight Gain: Neurobiological Intersection and Treatment Recommendations
Golden, A. K., & Davis, J. M. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s509971 · Cited by 10 · see citing works

Transdermal nicotine facilitates smoking cessation
Rose, J. E., Levin, E. D., Behm, F. M., Adivi, C., & Schur, C. (1990) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1990.35 · Cited by 131 · see citing works
CONTROLLED TRIAL OF TRANSDERMAL NICOTINE PATCH IN TOBACCO WITHDRAWAL
Abelin, T., Müller, P., Buehler, A., Vesanen, K., & Imhof, P. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91671-1 · Cited by 201 · see citing works
[Effects of transdermal nicotine as an adjunct in smoking cessation therapy. A double-blind randomized study controlled with placebo].
Daughton, D. M., Heatley, S. A., Prendergast, J. J., Causey, D., Knowles, M., Rolf, C. N., Cheney, R. A., Hatlelid, K., Thompson, A., & Blasio, F. D. (1992) · PubMed · Cited by 7 · see citing works
Effects of transdermal nicotine delivery on measures of acute nicotine withdrawal.
Pickworth, W. B., Fant, R. V., Butschky, M. F., & Henningfield, J. E. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21150-8 · Cited by 38 · see citing works
Effect of transdermal nicotine delivery as an adjunct to low-intervention smoking cessation therapy. A randomized, placebo-controlled, double-blind study
Daughton, D. M. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.4.749 · Cited by 127 · see citing works

Authors: Jorenby, D. E., Hatsukami, D. K., Smith, S. S., Fiore, M. C., Allen, S., Jensen, J., & Baker, T. B.
Affiliations: University of Wisconsin–Madison (US)
University of Minnesota (US)
ORCID: Jorenby, D. E.
Hatsukami, Dorothy K.
Smith, Stevens S.
Fiore, Michael C.
Allen, Sharon
Jensen, Joni
Baker, Timothy B.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 1996-11-14
Volume: 128
Issue: 2
Pages: 130-138
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s002130050118
OpenAlex: W1980782104
Cited by: 141
References: 16
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 9 · 2012: 5
FWCI: 2.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Minnesota
Topics: Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: tobacco withdrawal symptoms, transdermal nicotine, nicotine patch, smoking cessation, craving, appetite, weight gain, irritability, anxiety, sleep disruption, abstinence
MeSH terms: Administration, Cutaneous, Adult, Double-Blind Method, Erythema, Female, Headache, Humans, Hunger, Male, Minnesota, Nicotine, Smoking, Substance Withdrawal Syndrome, Tobacco Use Disorder, Wisconsin, Weight Gain, Smoking Cessation, Nicotinic Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks