The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Bioreactor monitoring with spectroscopy and chemometrics: a review
Abstract
Biotechnological processes are crucial to the development of any economy striving to ensure a relevant position in future markets. The cultivation of microorganisms in bioreactors is one of the most important unit operations of biotechnological processes, and real-time monitoring of bioreactors is essential for effective bioprocess control. In this review, published material on the potential application of different spectroscopic techniques for bioreactor monitoring is critically discussed, with particular emphasis on optical fiber technology, reported for in situ bioprocess monitoring. Application examples are presented by spectroscopy type, specifically focusing on ultraviolet-visible, near-infrared, mid-infrared, Raman, and fluorescence spectroscopy. The spectra acquisition devices available and the major advantages and disadvantages of each spectroscopy are discussed. The type of information contained in the spectra and the available chemometric methods for extracting that information are also addressed, including wavelength selection, spectra pre-processing, principal component analysis, and partial least-squares. Sample handling techniques (flow and sequential injection analysis) that include transport to spectroscopic sensors for ex-situ on-line monitoring are not covered in this review.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the monitoring of intracellular and extracellular macromolecules in bioprocesses share many intrinsic similarities to yeast and bacteria bioprocesses, which have been extensively reviewed together due to these similarities [20,21,29].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“Currently, there are few reviews of vibrational spectroscopy as it pertains to the microalgae industry [9,17-19]; however, these reviews do not take into account the technological progress and development of on-line/in-line vibrational spectroscopy implemented in bioprocess, pharmaceutical, and liquid and solid food industries [20-28]”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“There are numerous cases of in situ MIR applications, all of which use ATR-FTIR probes to acquire quantitative MIR spectra of a multitude of media components and bioproducts [20,21].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“MIR spectra relevant to the microalgal industry obtained in situ in yeast and bacterial bioreaction suspensions in 5 L to 15 L reactors include optical density, ammonium, phosphates, acetate, glucose, fructose, organic acids as well as several bioproducts [20,21].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“However, a promising mode of MIR for wet applications is attenuated total reflectance Fourier transform infrared (ATR-FTR), which has had growing applications in pharmaceutical, agro-food, and environmental sectors and can be used on-line/in-line in liquid media (see reviews by [20] and [21]).”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“NIR in vivo analysis of microalgae has only yet investigated biomass, lipids, and carotenoids (Fig. 2) but the potential use of high-selectivity on-line/in-line NIR in microalgae bioreactions is evidenced by its prolific use in other bioprocesses [20,21].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“Most applications of vibrational spectroscopy PAT require calibration and validation of chemometric models [21, 48,102] with the exception of some analytes, for example carotenoids measured through Raman [94].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“Another drawback of ATR-FTIR is that fiber optic materials with sufficient MIR transmission are limited and costly [80] and require very short fiber optic cables and may not be suitable for multiplexing [21] to monitor inhomogeneities across large scale photobioreactors.”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
In the citing paper
“On the other hand, Raman and NIR are more likely to be multiplexed with fiber optic conduits, each which can be up to a few meters long [21].”
From Microalgal process-monitoring based on high-selectivity spectroscopy tools: status and future perspectives (2018) · cites this paper as [21]
Citations
Cites
The Nature of Statistical Learning Theory
Vapnik, V. N. (1995) · doi:10.1007/978-1-4757-2440-0 · Cited by 39,138
PLS-regression: a basic tool of chemometrics
Wold, S., Sjöström, M., & Eriksson, L. (2001) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/s0169-7439(01)00155-1 · Cited by 10,084
Encyclopedia of Analytical Chemistry
Grochocki, W., Markuszewski, M., & Quirino, J. P. (2006) · Wiley eBooks · doi:10.1002/9780470027318 · Cited by 7,503
Infrared Spectroscopy: Fundamentals and Applications
Stuart, B. H. (2004) · Analytical Techniques in the Sciences · doi:10.1002/0470011149 · Cited by 4,427
Fuzzy clustering with a fuzzy covariance matrix
Gustafson, D. E., & Kessel, W. (1978) · IEEE Conference on Decision and Control including the Symposium on Adaptive Processes (CDC) · doi:10.1109/cdc.1978.268028 · Cited by 1,981
Fiber-Optic Chemical Sensors and Biosensors
Wolfbeis, O. S. (2006) · Analytical Chemistry · doi:10.1021/ac060490z · Cited by 1,635
Handbook of Near-Infrared Analysis
Burns, D. A., & Ciurczak, E. W. (2001) · CRC Press eBooks · doi:10.1201/9781003042204 · Cited by 1,472
Multivariate SPC Charts for Monitoring Batch Processes
Nomikos, P., & MacGregor, J. F. (1995) · Technometrics · doi:10.1080/00401706.1995.10485888 · Cited by 1,430
A user-friendly guide to Multivariate Calibration and Classification
Næs, T., Isaksson, T., Fearn, T., & Davies, T. (2017) · doi:10.1255/978-1-906715-25-0 · Cited by 1,401
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies
Roggo, Y., Chalus, P., Maurer, L., Lema-Martinez, C., Edmond, A., & Jent, N. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.03.023 · Cited by 1,136
Fluorescence as a potential monitoring tool for recycled water systems: A review
Henderson, R. K., Baker, A., Murphy, K. R., Hambly, A. C., Stuetz, R. M., & Khan, S. J. (2008) · Water Research · doi:10.1016/j.watres.2008.11.027 · Cited by 991
NIR spectroscopy: a rapid-response analytical tool
Blanco, M., & Villarroya, I. (2002) · TrAC Trends in Analytical Chemistry · doi:10.1016/s0165-9936(02)00404-1 · Cited by 874
Near-infrared spectroscopy and imaging: Basic principles and pharmaceutical applications
Reich, G. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.020 · Cited by 852
Chemometrics: Statistics and Computer Application in Analytical Chemistry
(2001) · Microchemical Journal · doi:10.1016/s0026-265x(00)00156-9 · Cited by 753
Lwin, T., Martens, H., & Naes, T. (1991) · Biometrics · doi:10.2307/2532682 · Cited by 544
Chemometrics: statistics and computer application in analytical chemistry
(1999) · Choice Reviews Online · doi:10.5860/choice.37-0336 · Cited by 534
Martens, H., & Stark, E. (1991) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/0731-7085(91)80188-f · Cited by 515
Neural networks in multivariate calibration
Despagne, F., & Luc Massart, D. (1998) · The Analyst · doi:10.1039/a805562i · Cited by 462
Applications of Raman spectroscopy in pharmaceutical analysis
Vankeirsbilck, T., Vercauteren, A., Baeyens, W., Weken, G. V. D., Verpoort, F., Vergote, G. J., & Remon, J. P. (2002) · TrAC Trends in Analytical Chemistry · doi:10.1016/s0165-9936(02)01208-6 · Cited by 442
Near-infrared spectroscopy applications in pharmaceutical analysis
Luypaert, J., Massart, D. L., & Heyden, Y. V. (2006) · Talanta · doi:10.1016/j.talanta.2006.12.023 · Cited by 430
Chemometrics in Analytical Spectroscopy
Adams, M. J. (2004) · Royal Society of Chemistry eBooks · doi:10.1039/9781847550484 · Cited by 423
(2010) · Wiley eBooks · doi:10.1002/9780470689592 · Cited by 401
Use of FTIR for Rapid Authentication and Detection of Adulteration of Food
RODRIGUEZ‐SAONA, L. E., & Allendorf, M. E. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133750 · Cited by 347
Analysis, monitoring and fault diagnosis of batch processes using multiblock and multiway PLS
Kourti, T., Nomikos, P., & MacGregor, J. F. (1995) · Journal of Process Control · doi:10.1016/0959-1524(95)00019-m · Cited by 342
Comprehensive chemometrics: chemical and biochemical data analysis
McLachlan, G. J., Rathnayake, S., & Lee, S.-H. (2020) · Cited by 335
Fiber-Optic Chemical Sensors and Biosensors
Wolfbeis, O. S. (2002) · Analytical Chemistry · doi:10.1021/ac020176e · Cited by 325
Pharmaceutical applications of Mid-IR and Raman spectroscopy
Wartewig, S., & Neubert, R. H. H. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.022 · Cited by 317
Application of flow cytometry to industrial microbial bioprocesses
Dı́az, M., Herrero, M., García, L. A., & Quirós, C. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.07.013 · Cited by 292
Progress in monitoring, modeling and control of bioprocesses during the last 20 years
Schügerl, K. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00361-8 · Cited by 278
Mulvaney, S. P., & Keating, C. D. (2000) · Analytical Chemistry · doi:10.1021/a10000155 · Cited by 244
Bioprocess control: Advances and challenges
Alford, J. S. (2006) · Computers & Chemical Engineering · doi:10.1016/j.compchemeng.2006.05.039 · Cited by 235
Real-time bioprocess monitoring
Vojinovic, V., Cabral, J. M. S., & Fonseca, L. P. (2005) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2005.07.059 · Cited by 224
Workman, J., Koch, M. V., & Veltkamp, D. (2005) · Analytical Chemistry · doi:10.1021/ac050620o · Cited by 204
Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative
Teixeira, A. P., Oliveira, R., Alves, P. M., & Carrondo, M. J. T. (2009) · Biotechnology Advances · doi:10.1016/j.biotechadv.2009.05.003 · Cited by 204
Recent progress and novel applications of photonic crystal fibers
Arismar Cerqueira, S. (2010) · Reports on Progress in Physics · doi:10.1088/0034-4885/73/2/024401 · Cited by 201
Two-Dimensional Fluorescence Spectroscopy: A New Tool for On-Line Bioprocess Monitoring
Marose, S., Lindemann, C., & Scheper, T. (1998) · Biotechnology Progress · doi:10.1021/bp970124o · Cited by 190
Recent development in derivative ultraviolet/visible absorption spectrophotometry: 2004–2008
Rojas, F. S., & Ojeda, C. B. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.12.039 · Cited by 186
UV-Visible Spectrophotometry of Water and Wastewater
(2007) · Techniques and instrumentation in analytical chemistry · doi:10.1016/s0167-9244(07)x8002-8 · Cited by 175
Spectral analysis and fingerprinting for biomedia characterisation
Pons, M., Bonté, S. L., & Potier, O. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.03.028 · Cited by 168
Near-Infrared Analysis of Fat, Protein, and Casein in Cow's Milk
Laporte, M.-F., & Paquin, P. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980929r · Cited by 166
Comprehensive Chemometrics: Set: Chemical and Biochemical Data Analysis
Brown, S. D., Ferré, R. T., & Walczak, B. (2009) · Cited by 159
Cavinato, A. G., Mayes, D. M., Ge, Z., & Callis, J. B. (1990) · Analytical Chemistry · doi:10.1021/ac00217a015 · Cited by 158
Better Quality Food and Beverages: The Role of near Infrared Spectroscopy
Woodcock, T., Downey, G., & O’Donnell, C. P. (2008) · Journal of Near Infrared Spectroscopy · doi:10.1255/jnirs.758 · Cited by 153
In‐situ near infrared spectroscopy to monitor key analytes in mammalian cell cultivation
Arnold, S. A., Crowley, J. N., Woods, N., Harvey, L. M., & McNeil, B. W. J. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10738 · Cited by 152
Estimation of Fermentation Biomass Concentration by Measuring Culture Fluorescence
Zabriskie, D. W., & Humphrey, A. E. (1978) · Applied and Environmental Microbiology · doi:10.1128/aem.35.2.337-343.1978 · Cited by 144
Chemometrics in bioprocess engineering: Process analytical technology (PAT) applications
Lopes, J. A., Costa, P. F., Alves, T. P., & Menezes, J. C. (2004) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2004.07.006 · Cited by 137
Self-citationHarrison, D. E. F., & Chance, B. (1970) · Applied Microbiology · doi:10.1128/am.19.3.446-450.1970 · Cited by 136
UV Resonance Raman Spectroscopic Detection of Nitrate and Nitrite in Wastewater Treatment Processes
Ianoul, A. I., Coleman, T., & Asher, S. A. (2002) · Analytical Chemistry · doi:10.1021/ac010863q · Cited by 136
Optical Spectroscopy: Methods and Instrumentations
Tkachenko, N. V. (2011) · Cited by 133
Arnold, S. A., ., R. G., Harvey, L. M., & McNeil, B. W. J. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10383 · Cited by 126
Near Infrared Spectroscopy for Bioprocess Monitoring and Control: Current Status and Future Trends
Scarff, M., Arnold, S. A., Harvey, L. M., & McNeil, B. (2006) · Critical Reviews in Biotechnology · doi:10.1080/07388550500513677 · Cited by 124
Picard, A., Daniel, I., Montagnac, G., & Oger, P. (2006) · Extremophiles · doi:10.1007/s00792-006-0054-x · Cited by 123
Holm‐Nielsen, J. B., Lomborg, C. J., Oleśkowicz-Popiel, P., & Esbensen, K. H. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21571 · Cited by 114
Raman spectroscopy in bioanalysis
Pappas, D. (2000) · Talanta · doi:10.1016/s0039-9140(99)00254-4 · Cited by 113
Eliasson, C., Macleod, N. A., Jayes, L., Clarke, F. C., Hammond, S. V., Smith, M. R., & Matousek, P. (2008) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2008.01.013 · Cited by 107
In situ bioprocess monitoring of Escherichia coli bioreactions using Raman spectroscopy
Lee, H., Boccazzi, P., Gorret, N., Ram, R. J., & Sinskey, A. J. (2004) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2003.12.015 · Cited by 106
Perspectives in the use of spectroscopy to characterise pharmaceutical solids
Aaltonen, J., Gordon, K. C., Strachan, C. J., & Rades, T. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.04.043 · Cited by 102
Data understanding with PCA: Structural and Variance Information plots
Camacho, J., Picó, J., & Ferrer, A. (2009) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2009.10.005 · Cited by 102
Ödman, P., Johansen, C. L., Lisbeth Olsson, A., Gernaey, K. V., & Lantz, A. E. (2009) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2009.08.018 · Cited by 100
Rudnitskaya, A. M., & Legin, A. V. (2008) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-007-0298-1 · Cited by 91
Monitoring of a paper mill wastewater treatment plant using UV/VIS spectroscopy
Langergraber, G., Fleischmann, N., Hofstädter, F., & Weingärtner, A. (2004) · Water Science & Technology · doi:10.2166/wst.2004.0004 · Cited by 90
Preisner, O., Lopes, J. A., Guiomar, R., Machado, J., & de Menezes, J. C. (2006) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-006-0851-1 · Cited by 89
Self-citationTerahertz spectroscopy: The renaissance of far infrared spectroscopy
Mantsch, H. H., & Naumann, D. (2009) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2009.12.022 · Cited by 88
Navrátil, M., Norberg, A., Lembrén, L., & Mandenius, C. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.07.013 · Cited by 86
Vaccari, G., Dosi, E., Campi, A. L., Mantovani, G., Antonio González‐Vara y, R., & Matteuzzi, D. (1994) · Biotechnology and Bioengineering · doi:10.1002/bit.260431003 · Cited by 84
Rhiel, M. H., Ducommun, P., Bolzonella, I., Marison, I. W., & von Stockar, U. (2001) · Biotechnology and Bioengineering · doi:10.1002/bit.10134 · Cited by 83
Noninvasive Spectroscopy for Monitoring Cell Density in a Fermentation Process
Ge, Z., Cavinato, A. G., & Callis, J. B. (1994) · Analytical Chemistry · doi:10.1021/ac00080a023 · Cited by 81
Two-dimensional fluorescence spectroscopy: A novel approach for controlling fed-batch cultivations
Hantelmann, K., Kollecker, M., Hüll, D., Hitzmann, B., & Scheper, T. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.07.016 · Cited by 80
Retro-review of flow-injection analysis
Růžička, J., & Hansen, E. H. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.03.004 · Cited by 78
Roychoudhury, P., O’Kennedy, R. D., McNeil, B. W. J., & Harvey, L. M. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.03.011 · Cited by 77
Tosi, S., Rossi, M., Tamburini, E., Vaccari, G., Amaretti, A., & Matteuzzi, D. (2003) · Biotechnology Progress · doi:10.1021/bp034101n · Cited by 77
Bioreactor state estimation and control
Komives, C., & Parker, R. S. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.09.001 · Cited by 74
2-Dimensional fluorescence spectroscopy for on-line bioprocess monitoring
Lindemann, C., Marose, S., Nielsen, H. O., & Scheper, T. H. (1998) · Sensors and Actuators B Chemical · doi:10.1016/s0925-4005(98)00195-6 · Cited by 74
Harrison, D. E. F., & Chance, B. (1970) · Applied Microbiology · doi:10.1128/aem.19.3.446-450.1970 · Cited by 72
Use of near infrared spectroscopy in monitoring of volatile fatty acids in anaerobic digestion
Jacobi, H., Moschner, C. R., & Hartung, E. (2009) · Water Science & Technology · doi:10.2166/wst.2009.345 · Cited by 71
On‐line monitoring of Phaffia rhodozyma fed‐batch process with in situ dispersive raman spectroscopy
Cannizzaro, C., Rhiel, M., Marison, I., & von Stockar, U. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10698 · Cited by 70
Wolf, G., Almeida, J. S., Pinheiro, C., Correia, V., Rodrigues, C., Reis, M. A. M., & Crespo, J. G. (2000) · Biotechnology and Bioengineering · doi:10.1002/1097-0290(20010205)72:3 · Cited by 70
Workman, J., Koch, M. V., & Veltkamp, D. J. (2003) · Analytical Chemistry · doi:10.1021/ac0301393 · Cited by 69
Schenk, J., Marison, I. W., & VONSTOCKAR, U. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.09.015 · Cited by 67
Sarraguça, M. C., Paulo, A. M. S., Alves, M. M., Dias, A. M. A., Lopes, J. A., & Ferreira, E. C. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-3042-z · Cited by 67
Self-citationClementschitsch, F., Jürgen, K., Pötschacher, F., & Karl, B. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.05.030 · Cited by 66
On-line biomass measurements in bioreactor cultivations: comparison study of two on-line probes
Kiviharju, K., Salonen, K., Moilanen, U., Meskanen, E., LEISOLA, M. S. A., & Eerikäinen, T. (2007) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-007-0233-5 · Cited by 66
Acha, V., Meurens, M., Naveau, H. P., & Agathos, S. N. (2000) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(20000605)68:5 · Cited by 64
Haack, M. B., Lantz, A. E., & Lisbeth Olsson, A. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.05.009 · Cited by 63
Boehl, D. (2003) · Journal of Biotechnology · doi:10.1016/s0168-1656(03)00189-5 · Cited by 62
An On‐Line Approach To Monitor Ethanol Fermentation Using FTIR Spectroscopy
Veale, E. L., Irudayaraj, J., & Demırcı, A. (2007) · Biotechnology Progress · doi:10.1021/bp060306v · Cited by 61
Surribas, A., Geißler, D., Gierse, A., Scheper, T. H., Hitzmann, B., Montesinos, J. L. G., & Valero, F. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.01.002 · Cited by 60
Monitoring of batch processes using spectroscopy
Gurden, S. P., Westerhuis, J. A., & Smilde, A. K. (2002) · AIChE Journal · doi:10.1002/aic.690481018 · Cited by 56
Tamburini, E., Vaccari, G., Tosi, S., & Trilli, A. (2003) · Applied Spectroscopy · doi:10.1366/000370203321535024 · Cited by 53
Rhee, J. I., & Kang, T.-H. (2007) · Process Biochemistry · doi:10.1016/j.procbio.2007.05.007 · Cited by 52
Kinetic and fluorometric behavior of a phenol fermentation
Li, J., & Humphrey, A. E. (1989) · Biotechnology Letters · doi:10.1007/bf01026052 · Cited by 51
Langergraber, G., Gupta, J. K., Pressl, A., Hofstädter, F., Lettl, W., Weingärtner, A., & Fleischmann, N. (2004) · Water Science & Technology · doi:10.2166/wst.2004.0613 · Cited by 48
Wechselberger, P., Seifert, A. H., & Herwig, C. (2010) · Chemical Engineering Science · doi:10.1016/j.ces.2010.05.002 · Cited by 47
Kornmann, H., Valentinotti, S., Duboc, P., Marison, I. W., & von Stockar, U. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.03.029 · Cited by 45
Monitoring of a biogas process using electronic gas sensors and near-infrared spectroscopy (NIR)
Nordberg, Å., Hansson, M., Sundh, I., Nordkvist, E., Carlsson, H., & Mathisen, B. (2000) · Water Science & Technology · doi:10.2166/wst.2000.0049 · Cited by 44
On-line monitoring of fermentation processes by a new remote dispersive middle-infrared spectrometer
Fayolle, P., Picque, D., & Corrieu, G. (2000) · Food Control · doi:10.1016/s0956-7135(99)00105-x · Cited by 44
Cimander, C., Bachinger, T., & Mandenius, C. (2003) · Journal of Biotechnology · doi:10.1016/s0168-1656(03)00121-4 · Cited by 44
UV spectra analysis for water quality monitoring in a fuel park wastewater treatment plant
Lourenço, N. D., Chaves, C. L., Novais, J. M., de Menezes, J. C., Pinheiro, H. M., & Diniz, D. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.03.041 · Cited by 44
Self-citationApplication of multi-wavelength fluorometry for monitoring wastewater treatment process dynamics
Tartakovsky, B., Lishman, L. A., & Legge, R. L. (1996) · Water Research · doi:10.1016/s0043-1354(96)00196-0 · Cited by 44
Application of multi-wavelength fluorometry for on-line monitoring of an anaerobic digestion process
Morel, E., Santamaría, K. V. V., Perrier, M., Guiot, S. R., & Tartakovsky, B. (2004) · Water Research · doi:10.1016/j.watres.2004.05.003 · Cited by 42
Ojeda, C. B., & Rojas, F. S. (2009) · Applied Spectroscopy Reviews · doi:10.1080/05704920902717898 · Cited by 42
Real‐Time compensation of the inner filter effect in high‐density bioluminescent cultures
Konstantinov, K. B., Dhurjati, P., Dyk, T. K. V., Majarian, W. R., & LaRossa, R. A. (1993) · Biotechnology and Bioengineering · doi:10.1002/bit.260421009 · Cited by 40
On-line NIR monitoring during anaerobic treatment of municipal solid waste
Hansson, M., Nordberg, Å., & Mathisen, B. (2003) · Water Science & Technology · doi:10.2166/wst.2003.0208 · Cited by 38
Downstream Processing Biosurfactants Carotenoids
Fiechter, A. (1996) · Advances in biochemical engineering, biotechnology · doi:10.1007/bfb0102322 · Cited by 37
Early warning of disturbances in a laboratory-scale MSW biogas process
Hannsson, M., Nordberg, Å., Sundh, I., & Mathisen, B. (2002) · Water Science & Technology · doi:10.2166/wst.2002.0346 · Cited by 37
Software sensors are a real alternative to true sensors
Cecil, D., & Kozlowska, M. (2009) · Environmental Modelling & Software · doi:10.1016/j.envsoft.2009.05.004 · Cited by 34
Rodrigues, L. M., VIEIRA, L., CARDOSO, J., & de Menezes, J. C. (2008) · Talanta · doi:10.1016/j.talanta.2008.01.048 · Cited by 34
Dabros, M., Amrhein, M., Bonvin, D., Marison, I. W., & von Stockar, U. (2009) · Biotechnology Progress · doi:10.1002/btpr.143 · Cited by 34
On-line parallel factor analysis. A step forward in the monitoring of bioprocesses in real time
Amigo, J. M., Surribas, A., Coello, J., Montesinos, J. L. G., Maspoch, S., & Valero, F. (2008) · Chemometrics and Intelligent Laboratory Systems · doi:10.1016/j.chemolab.2007.12.001 · Cited by 33
In situ monitoring of the seed stage of a fermentation process using non-invasive NIR spectrometry
Nordon, A., Littlejohn, D., Dann, A. S., Jeffkins, P. A., Richardson, M. D., & Stimpson, S. L. (2008) · The Analyst · doi:10.1039/b719318a · Cited by 26
Schenk, J., Marison, I. W., & von Stockar, U. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.03.056 · Cited by 25
An improved method for two-dimensional fluorescence monitoring of complex bioreactors
Wolf, G., Almeida, J. S., Crespo, J. G., & Reis, M. A. M. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.12.029 · Cited by 24
Activated sludge process monitoring through in situ near-infrared spectral analysis
Dias, A. M. A., Moita, I., Alves, M. M., Ferreira, E. C., Páscoa, R. N. M. J., & Lopes, J. A. (2008) · Water Science & Technology · doi:10.2166/wst.2008.147 · Cited by 24
Self-citationLourenço, N. D., de Menezes, J. C., Pinheiro, H. M., & Diniz, D. (2008) · Environmental Technology · doi:10.1080/09593330802015581 · Cited by 23
Self-citationMonitoring aerobic sludge digestion by online scanning fluorometry
Arunachalam, R., Shah, H. K., & Ju, L. (2005) · Water Research · doi:10.1016/j.watres.2004.11.028 · Cited by 22
On-line and in-situ UV/vis spectroscopy for multi-parameter a brief review
van den Broeke, J., Langergraber, G., & Weingärtner, A. (2006) · Cited by 22
In situ near Infrared Monitoring of Activated Dairy Sludge Wastewater Treatment Processes
Páscoa, R. N. M. J., Lopes, J. A., & Lima, J. L. F. C. (2008) · Journal of Near Infrared Spectroscopy · doi:10.1255/jnirs.803 · Cited by 21
Self-citationReal-time detection of possible harmful events using UV/vis spectrometry
Langergraber, G., van den Broeke, J., Lettl, W., & Weingärtner, A. (2006) · Cited by 19
Engelhard, S., Kumke, M. U., & Löhmannsröben, H. (2005) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-005-3364-4 · Cited by 18
Babiak, P., & Ulber, R. (2007) · Advances in biochemical engineering, biotechnology · doi:10.1007/978-3-540-45696-4 · Cited by 18
Emerging tools and sustainability of water-quality monitoring
Gagnon, B., Marcoux, G., Leduc, R., Pouët, M.-F., & Thomas, O. P. (2007) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2006.11.009 · Cited by 14
Kinetics and performance of a co-immobilised system of amyloglucosidase andZymomonas mobilis
Hellendoorn, L., Ottengraf, S. P. P., van den Heuvel, J. C., Pennings, J. A. M. M., dos Santos, V. A. P. M., & Wijffels, R. H. (1999) · Biotechnology and Bioengineering · doi:10.1002/(sici)1097-0290(19990620)63:6 · Cited by 6
Spectroscopy in heterogenous media and applications for bioprocess and environmental monitoring
Schael, F., Reich, O., & Engelhard, S. (2002) · International Journal of Photoenergy · doi:10.1155/s1110662x02000041 · Cited by 5
Mid-infrared spectroscopy as a tool for pH prediction and control in bioprocesses
Schenk, J., Marison, I. W., & von Stockar, U. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2007.07.836 · Cited by 2
Flagged first, then by citations
Research works printed but not linked: 6
- Morris R (2010) How optical advances helped deliver the promise of miniature spectrometers. Spectroscopy 25:30–35
- Mark H (2000) In: Meyers RA (ed) Encyclopedia of analytical chemistry. John Wiley and Sons, Chichester
- Kourti T (2004) Process analytical technology and multivariate statistical process control. PAT J Proc Anal Technol 1:13–19
- Baylor LC, O’Rourke PE (2005) In: Bakeev KA (ed) Process analytical technology – spectroscopic tools and implementation strategies for the chemical and pharmaceutical industries. Blackwell, Oxford
- Bakeev KA (ed) (2005) Process analytical technology – spectroscopy tools and implementation strategies for the chemical and pharmaceutical industries. Blackwell, Oxford
- Hart JR, Golumbic C, Norris KH (1962) Determination of moisture content if seeds by near-infrared spectrophotometry of their methanol extracts. Cereal Chem 39:94–99
Cited by
Sorted by citations
Esmonde-White, K. A., Cuellar, M., Uerpmann, C., Lenain, B., & Lewis, I. R. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-9824-1 · Cited by 332
Sensor systems for bioprocess monitoring
Biechele, P., Busse, C., Solle, D., Scheper, T., & Reardon, K. (2015) · Engineering in Life Sciences · doi:10.1002/elsc.201500014 · Cited by 224
Wang, K., Sun, D., & Pu, H. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.06.001 · Cited by 206
Process Analytical Technologies – Advances in bioprocess integration and future perspectives
Gerzon, G., Sheng, Y., & Kirkitadze, M. D. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114379 · Cited by 179
Claßen, J., Aupert, F., Reardon, K. F., Solle, D., & Scheper, T. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0068-x · Cited by 176
Metadata
- Authors
- Lourenço, N. D., Lopes, J. A., Almeida, C. F., Sarraguça, M. C., & Pinheiro, H. M.
- Affiliations
- Institute for Biotechnology and Bioengineering (PT)
- Universidade do Porto (PT)
- Corresponding author
- Lourenço, N. D.
- Venue
- Analytical and Bioanalytical Chemistry
- Published
- 2012-05-30
- Volume
- 404
- Issue
- 4
- Pages
- 1211-1237
- ISSN
- 1618-2642 (ISSN-L)
- 1618-2650
- OpenAlex
- W2057328981
- Cited by
- 275
- References
- 123
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 23 · 2023: 13 · 2022: 20 · 2021: 23 · 2020: 22 · 2019: 23 · 2018: 21 · 2017: 29 · 2016: 28 · 2015: 17 · 2014: 16 · 2013: 10
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Analytical and Bioanalytical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Environmental Science › Waste Management and Disposal › Water Quality Monitoring and Analysis
- Keywords
- bioreactor monitoring, bioprocess monitoring, in situ monitoring, fiber optic sensors, UV-Vis spectroscopy, near-infrared spectroscopy, mid-infrared spectroscopy, Raman spectroscopy, fluorescence spectroscopy, chemometrics, principal component analysis, partial least squares, wavelength selection, microbial cultivation, real-time process control
- MeSH terms
- Bacteria, Biotechnology, Spectrum Analysis, Bioreactors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
