Cited by 222Genetically Modified Organisms ResearchAgricultural safety and regulationsCarcinogens and Genotoxicity Assessment

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New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity

Séralini, Gilles-Eric, Cellier, Dominique, de Vendomois, Joël Spiroux·2007·Archives of Environmental Contamination and Toxicology

DOI 10.1007/s00244-006-0149-5

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Abstract

Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological findings, and the results remained controversial. An Appeal Court action in Germany (Münster) allowed public access in June 2005 to all the crude data from this 90-day rat-feeding study. We independently re-analyzed these data. Appropriate statistics were added, such as a multivariate analysis of the growth curves, and for biochemical parameters comparisons between GMO-treated rats and the controls fed with an equivalent normal diet, and separately with six reference diets with different compositions. We observed that after the consumption of MON863, rats showed slight but dose-related significant variations in growth for both sexes, resulting in 3.3% decrease in weight for males and 3.7% increase for females. Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24-40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31-35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested. Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product.

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Authors: Séralini, G.-E., Cellier, D., & de Vendomois, J. S.
Affiliations: Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes (FR)
Venue: Archives of Environmental Contamination and Toxicology
Publisher: Springer Science and Business Media LLC
Published: 2007-03-13
Volume: 52
Issue: 4
Pages: 596-602
ISSN: 0090-4341 (ISSN-L)
1432-0703
DOI: 10.1007/s00244-006-0149-5
OpenAlex: W2128203876
Cited by: 222
References: 21
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 18 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 3 · 2015: 20 · 2014: 16 · 2013: 22 · 2012: 25
FWCI: 19.85
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Environmental Contamination and Toxicology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Innovative Research Group Project of the National Natural Science Foundation of China
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: transgenic maize, MON863, rat feeding study, hepatorenal toxicity, kidney pathology, growth retardation, sex differences, triglycerides, urinary sodium, health risk assessment, data reanalysis
MeSH terms: Animals, Body Weight, Zea mays, Diet, Female, Kidney, Liver, Male, Sex Factors, Rats, Sprague-Dawley, Plants, Genetically Modified, Rats

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New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity

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