Cited by 2,132Algal biology and biofuel productionSeaweed-derived Bioactive CompoundsMicrobial Metabolic Engineering and Bioproduction

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Valuable products from biotechnology of microalgae

Pulz, Otto, Gross, Wolfgang·2004·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-004-1647-x

Open this paper in CoChat — free account

Abstract

The biotechnology of microalgae has gained considerable importance in recent decades. Applications range from simple biomass production for food and feed to valuable products for ecological applications. For most of these applications, the market is still developing and the biotechnological use of microalgae will extend into new areas. Considering the enormous biodiversity of microalgae and recent developments in genetic engineering, this group of organisms represents one of the most promising sources for new products and applications. With the development of sophisticated culture and screening techniques, microalgal biotechnology can already meet the high demands of both the food and pharmaceutical industries.

Integrity signals

Registry

Crossref · 10.1007/s00253-004-1647-x

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Micro‐algal biotechnology
Rogers, L. J. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80268-0 · Cited by 1,289
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190
Modern approach to the classification system of Cyanophytes 4-Nostocales
Komárek, J., & Anagnostidis, K. (1989) · Cited by 1,152
Photobioreactors: Production systems for phototrophic microorganisms
O., P. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100702 · Cited by 987
Manual on the production and use of live food for aquaculture
Lavens, P., & Sorgeloos, P. (1996) · Medical Entomology and Zoology · Cited by 986
Handbook of Microalgal Culture: Biotechnology and Applied Phycology
(2003) · doi:10.1002/9780470995280 · Cited by 886
Biodiversity and application of microalgae
Metting, F. B. (1996) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01574779 · Cited by 600
Microalgal Biotechnology
Borowitzka, M. A., & Borowitzka, L. J. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839162473 · Cited by 568
Microalgae as sources of pharmaceuticals and other biologically active compounds
Borowitzka, M. A. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003544 · Cited by 520
Microalgae for aquaculture: Opportunities and constraints
Borowitzka, M. A. (1997) · Journal of Applied Phycology · doi:10.1023/a:1007921728300 · Cited by 478

Show all 40 references

Research works printed but not linked: 18

Anagnostidis K, Komárek JA (1985) Modern approach to the classification system of cyanophytes 1?introduction. Arch Hydrobiol Suppl 71:291?302
Anagnostidis K, Komárek JA (1988) Modern approach to the classification systems of cyanophytes 3?oscillatorales. Arch Hydrobiol Suppl 80:327?472
De Pauw N, Persoone G (1988) Micro-algae for aquaculture, micro-algal biotechnology. In: Borowitzka MA, Borowitzka LJ (eds) Cambridge University Press, Cambridge, pp 197?221
Gimmler H, Degenhardt B (2001) In: Rai LC, Gaur JP (eds) Alkaliphilic and alkali-tolerant algae, algal adaptation to environmental stresses. Springer, Berlin Heidelberg New York
Gross W, Schnarrenberger C (1995) Heterotrophic growth of two strains of the acidothermophilic red alga Galderia sulphuria. Plant Cell Physiol 4:633?638
Komárek JA, Anagnostidis K (1986) Modern approach to the classification systems of cyanophytes 2-Chroococales. Arch Hydrobiol Suppl 73:157?226
Kretschmer P, Pulz O, Gudin C, Semenenko V (1995). Biotechnology of Microalgae. (Proceedings of the second European workshop) IGV Institute for Cereal Processing, Potsdam-Rehbrücke
Laing I, Ayala F (1990) In: Akatsuka I (ed) Commercial mass culture techniques for producing microalgae, introduction to applied phycology. SPB, The Hague, pp 447?477
Muller-Feuga A, Moal J, Kaas R (2003) The microalgae for aquaculture. In: Stottrup JG, McEvoy LA (eds) Life feeds in marine aquaculture. Blackwell, Oxford
Musafarov AM, Taubayev TT (1974). Chlorella (in Russian). FAN, Tashkent
New MB (1999) Global aquaculture: current trends and challenges for 21st century. World Aquacult 3:8?14
Ördög V, Szigeti J, Pulz O (1996). Proceedings of the conference on progress in plant sciences from plant breeding to growth regulation. Pannon University, Mosonmagyarovar
Piccardi R, Materassi R, Tredici M (1999) Algae and human affairs in the 21st century. (Abstr Int Conf Appl Algol) Universita degli Studi di Firenze, Firenze
Richmond A (2004) Handbook of microalgal culture. Blackwell, Oxford
Schreckenbach K, Thürmer C, Loest K, Träger G, Hahlweg R (2001) Der Einfluss von Mikroalgen (Spirulina platensis) in Trockenmischfutter auf Karpfen (Cyprinus carpio). Fischer Teichwirt 1:10?13
Sivonen K, Jones G (1999) Cyanobacterial toxins. In: Chorus I, Bertram J (eds) Toxic cyanobacteria in water: a guide to public health significance, monitoring and management. Spon, London, pp 41?111
Spektorova L, Creswell RL, Vaughan D (1997) Closed tubular cultivators. World Aquacult 6:39?43
Weber M, Grimmer A (2001) Lohnt sich der Einsatz von Grünalgen im Ferkelfutter? Landwirtsch Wochenbl Rheinland 2001:34

Sorted by citations

Items 501–600 of 1,012

Past, current, and future research on microalga-derived biodiesel: a critical review and bibliometric analysis
Ma, X., Gao, M., Gao, Z., Wang, J., Zhang, M., Ma, Y., & Wang, Q. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-1453-0 · Cited by 68
“Some microalgae, such asChlorella and Spirulina, are eaten because of their high protein content (Pulz and Gross 2004).”
Background
Natural astaxanthin encapsulation: Use of response surface methodology for the design of alginate beads
Niizawa, I., Espinaco, B. Y., Zorrilla, S. E., & Sihufe, G. A. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.10.044 · Cited by 68
Freshwater diatoms as a source of lipids for biofuels
Graham, J. M., Graham, L. E., Zulkifly, S., Pfleger, B. F., Hoover, S. W., & Yoshitani, J. (2011) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-011-1041-5 · Cited by 68
Biochemical composition and amino acid profiles of Nannochloropsis granulata algal biomass before and after supercritical fluid CO2 extraction at two processing temperatures
Tibbetts, S. M., Bjornsson, W. J., & McGinn, P. J. (2015) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2015.04.006 · Cited by 68
Bioactivity and Applications of Polysaccharides from Marine Microalgae
Raposo, M. F. D. J., Morais, A. M. M. B., & Morais, R. M. S. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-16298-0_47 · Cited by 66
“As photoautotrophs, microalgae are highly exposed to oxidative and radical stresses, therefore accumulating effective antioxidative scavenger complexes to protect their own cells from free radicals (Pulz and Gross 2004).”
Background
Effect of Carbon Content, Salinity and pH on Spirulina platensis for Phycocyanin, Allophycocyanin and Phycoerythrin Accumulation
Sharma, G. (2014) · Journal of Microbial & Biochemical Technology · doi:10.4172/1948-5948.1000144 · Cited by 73
“Carotenoids are structurally diverse lipid soluble pigment have many different biological functions, such as specific coloration, photoprotection, light harvesting and also serve as precursors for many hormones therefore an important medicinal and biotechnological class of natural pigments [28].”
Background
Advanced methods for genetic engineering of Haematococcus pluvialis (Chlorophyceae, Volvocales)
Sharon-Gojman, R., Maimon, E., Leu, S., Zarka, A., & Boussiba, S. (2015) · Algal Research · doi:10.1016/j.algal.2015.03.022 · Cited by 66
“Microalgae have high areal biomass productivity and can accumulate significant concentrations of high value products, or over 50% of dry weight as oil in the form of triacylglycerol (TAG) under adequate conditions [30,31,33,41].”
Background
Pilot-scale isolation of bioactive extracellular polymeric substances from cell-free media of mass microalgal cultures using tangential-flow ultrafiltration
Li, H., Li, Z., Xiong, S., Zhang, H., Li, N., Zhou, S., Liu, Y., & Huang, Z. (2011) · Process Biochemistry · doi:10.1016/j.procbio.2011.01.028 · Cited by 67
Irradiance optimization of outdoor microalgal cultures using solar tracked photobioreactors
Hindersin, S., Leupold, M., Kerner, M., & Hanelt, D. (2013) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-012-0790-5 · Cited by 70
“The demand of microalgal biomass as a possible source of fine and bulk chemicals, as a food or feed additive, as well as for renewable energy caused an increase in research and development in microalgae biotechnology during the last years [1–6].”
Background
Microalgal secondary metabolite productions as a component of biorefinery: A review
Park, Y. H., Han, S., Oh, B., Kim, H. S., Jeon, M. S., Kim, S., & Choi, Y.-E. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126206 · Cited by 67
The microalga Dunaliella and its applications: a review
Barbosa, M., Inácio, L. G., Afonso, C., & Maranhão, P. (2023) · Applied Phycology · doi:10.1080/26388081.2023.2222318 · Cited by 70
“These compounds are also applied in animal feeding to improve the colour manipulation of ornamental fish (Pulz & Gross, 2004) and eggs (Moulton & Burford, 1990).”
Background
Seaweeds: a sustainable feed source for livestock and aquaculture
Rajauria, G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418697-2.00015-5 · Cited by 66
Nitrogen-dependent coordination of cell cycle, quiescence and TAG accumulation in Chlamydomonas
Takeuchi, T., & Benning, C. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1635-0 · Cited by 66
Effects of growth phase and nitrogen limitation on biochemical composition of two strains of Tisochrysis lutea
da Costa, F., Le Grand, F., Quéré, C., Bougaran, G., Cadoret, J. P., Robert, R., & Soudant, P. (2017) · Algal Research · doi:10.1016/j.algal.2017.09.003 · Cited by 64
“Microalgae are fast-growing organisms that produce a variety of compounds, such as polyunsaturated fatty acids (PUFA), sterols, pigments, antioxidants, and vitamins [1, 2].”
Background
Effect of Mild Salinity Stress on the Growth, Fatty Acid and Carotenoid Compositions, and Biological Activities of the Thermal Freshwater Microalgae Scenedesmus sp.
Elloumi, W., Jebali, A., Maalej, A., Chamkha, M., & Sayadi, S. (2020) · Biomolecules · doi:10.3390/biom10111515 · Cited by 64
Production of biomass and lipid by the microalgae Chlorella protothecoides with heterotrophic-Cu(II) stressed (HCuS) coupling cultivation
Li, Y., Mu, J., Chen, D., Han, F., Xu, H., Kong, F., Xie, F., & Feng, B. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.08.153 · Cited by 63
“35 g/L, which showed better values of yield than that of the microalgae mentioned above and other known extremophile microalgae (Pulz and Gross, 2004; Tittel et al., 2005).”
BackgroundInfluential
Time-resolved transcriptome analysis and lipid pathway reconstruction of the oleaginous green microalga Monoraphidium neglectum reveal a model for triacylglycerol and lipid hyperaccumulation
Jaeger, D., Winkler, A., Mussgnug, J. H., Kalinowski, J., Goesmann, A., & Kruse, O. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0882-1 · Cited by 65
Exploitation of Microalgae Species for Nutraceutical Purposes: Cultivation Aspects
Saha, S. K., & Murray, P. (2018) · Fermentation · doi:10.3390/fermentation4020046 · Cited by 65
Versatile Applications of Cyanobacteria in Biotechnology
Żymańczyk-Duda, E., Samson, S. O., Brzezińska-Rodak, M., & Klimek-Ochab, M. (2022) · Microorganisms · doi:10.3390/microorganisms10122318 · Cited by 64
Screening of antioxidant and cytotoxic activities of several microalgal extracts with pharmaceutical potential
Gürlek, C., Yarkent, Ç., Köse, A., Tuğcu, B., Gebologlu, I. K., Öncel, S. Ş., & Elibol, M. (2019) · Health and Technology · doi:10.1007/s12553-019-00388-3 · Cited by 63
Microalgae and Cyanobacteria: How Exploiting These Microbial Resources Can Address the Underlying Challenges Related to Food Sources and Sustainable Agriculture: A Review
Chanda, M. J., Sbabou, L., & Arroussi, H. E. (2022) · Journal of Plant Growth Regulation · doi:10.1007/s00344-021-10534-9 · Cited by 66
“2010), or incorporated into other food and dairy products, such as pasta, bread, soft drinks, yogurt or snacks (Gross 2004; Mohamed et al.”
Background
Bioprospecting microalgae as potential sources of “Green Energy”—challenges and perspectives (Review)
Ratha, S. K., & Prasanna, R. (2012) · Applied Biochemistry and Microbiology · doi:10.1134/s000368381202010x · Cited by 65
Selection of microalgal growth model for describing specific growth rate-light response using extended information criterion
Kurano, N., & Miyachi, S. (2005) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.100.403 · Cited by 63
Economics of Microalgae Biomass Production
Acién, F. G., Fernández, J. M., & Grima, E. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-444-59558-4.00014-0 · Cited by 64
Engineering the Unicellular Alga Phaeodactylum tricornutum for Enhancing Carotenoid Production
Manfellotto, F., Stella, G. R., Falciatore, A., Brunet, C., & Ferrante, M. I. (2020) · Antioxidants · doi:10.3390/antiox9080757 · Cited by 63
“Diatoms are rich in pharmaceutically active substances such as polyunsaturated fatty acids, vitamins, antioxidants, enzymes, polysaccharides and carotenoids [4].”
Background
Targeting photobioreactors: Immobilisation of cyanobacteria within porous silica gel using biocompatible methods
Rooke, J. C., Léonard, A. F., & Su, B. (2008) · Journal of Materials Chemistry · doi:10.1039/b717990a · Cited by 63
Chlorella in aquaculture: challenges, opportunities, and disease prevention for sustainable development
Aly, S. M., ElBanna, N. I., & Fathi, M. (2023) · Aquaculture International · doi:10.1007/s10499-023-01229-x · Cited by 72
“Moreover, microalgae-derived polysaccharides, such as carrageenan and agar, have applications in the food and cosmetic industries due to their gelling and thickening properties (Pulz and Gross 2004; Arenas et al. 2017).”
Induction of axenic culture of Arthrospira (Spirulina) platensis based on antibiotic sensitivity of contaminating bacteria
Choi, G., Bae, M.-S., Ahn, C., & Oh, H. (2007) · Biotechnology Letters · doi:10.1007/s10529-007-9523-2 · Cited by 62
“Arthrospira (Spirulina) platensis is a commercially important filamentous cyanobacterium, with an annual production estimated to be over 3,000 tons per year, the largest among microalgae ( Pulz and Gross 2004 ).”
Background
Cyanobacteria immobilised in porous silica gels: exploring biocompatible synthesis routes for the development of photobioreactors
Léonard, A. F., Rooke, J. C., Meunier, C. F., Sarmento, H., Descy, J., & Su, B. (2010) · Energy & Environmental Science · doi:10.1039/b923859j · Cited by 62
Towards protein production and application by using Chlorella species as circular economy
Lai, Y.-C., Chang, C., Chen, C., Chang, J., & Ng, I. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121625 · Cited by 62
Microalgae: from staple foodstuff to avant-garde cuisine
Pérez-Lloréns, J. L. (2020) · International Journal of Gastronomy and Food Science · doi:10.1016/j.ijgfs.2020.100221 · Cited by 61
Multiplexed Knockouts in the Model Diatom Phaeodactylum by Episomal Delivery of a Selectable Cas9
Moosburner, M., Gholami, P., McCarthy, J. K., Tan, M. H., Bielinski, V. A., & Allen, A. E. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00005 · Cited by 61
“TAGs), polyunsaturated fatty acids (PUFAs), and photosynthetic pigments (Pulz and Gross, 2004; Vinayak et al., 2015).”
Background
Multiproduct biorefinery from marine thraustochytrids towards a circular bioeconomy
Gupta, A., Barrow, C. J., & Puri, M. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.09.003 · Cited by 63
Performance of CO2 concentrations on nutrient removal and biogas upgrading by integrating microalgal strains cultivation with activated sludge
Sun, S., Ge, Z., Zhao, Y., Hu, C., Zhang, H., & Ping, L. (2016) · Energy · doi:10.1016/j.energy.2015.12.126 · Cited by 61
Use of Palm Oil Mill Effluent as Medium for Cultivation of Chlorella sorokiniana
Nwuche, C. O. (2014) · British Biotechnology Journal · doi:10.9734/bbj/2014/6921 · Cited by 60
“Apart from biofuel, microalgae can be processed into dietary proteins [5], vitamins, carotenoids, antioxidants [6], fatty acids, enzymes, polymers, toxins and sterols [7].”
Background
Machine learning for algal biofuels: a critical review and perspective for the future
Çoşgun, A., Günay, M. E., & Yıldırım, R. (2023) · Green Chemistry · doi:10.1039/d3gc00389b · Cited by 61
Effect of abiotic stress on the production of lutein and β-carotene by Chlamydomonas acidophila
Garbayo, I., Cuaresma, M., Vı́lchez, C., & Vega, J. M. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.06.012 · Cited by 60
“[2] Pulz O, Gross W (2004) Valuable products from biotechnology of microalgae.”
Background
Ettlia sp. YC001 showing high growth rate and lipid content under high CO2
Yoo, C., Choi, G., Kim, S., & Oh, H. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.09.046 · Cited by 60
Fish oil replacement by different microalgal products in microdiets for early weaning of gilthead sea bream (Sparus aurata, L.)
Eryalçın, K. M., Roo, J., Saleh, R., Atalah, E., Benítez-Santana, T., Betancor, M. B., Cruz, M. C. H., & Izquierdo, M. S. (2012) · Aquaculture Research · doi:10.1111/j.1365-2109.2012.03237.x · Cited by 65
Environmental sustainability of emerging algal biofuels: A comparative life cycle evaluation of algal biodiesel and renewable diesel
Zaimes, G. G., & Khanna, V. (2013) · Environmental Progress & Sustainable Energy · doi:10.1002/ep.11810 · Cited by 62
Cyanobacterial Polyhydroxyalkanoate Production: Status Quo and Quo Vadis?
Koller, M. (2015) · Current Biotechnology · doi:10.2174/2211550104666150917010849 · Cited by 60
Microalga Scenedesmus bajacalifornicus BBKLP-07, a new source of bioactive compounds with in vitro pharmacological applications
Patil, L., & KALIWAL, B. B. (2019) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-019-02099-5 · Cited by 60
Development of a Green Downstream Process for the Valorization of Porphyridium cruentum Biomass
Gallego, R., Martínez, M., Cifuentes, A., Ibáñez, E., & Herrero, M. (2019) · Molecules · doi:10.3390/molecules24081564 · Cited by 62
“A notable example is the use of Dunaliella salina to produce β-carotene [2].”
Background
Microalgae as a Potential Source of Proteins
Matos, Â. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816695-6.00003-9 · Cited by 62
Thermochemical Conversion of Microalgae: Challenges and Opportunities
Chiaramonti, D., Prussi, M., Buffi, M., Casini, D., & Rizzo, A. M. (2015) · Energy Procedia · doi:10.1016/j.egypro.2015.07.142 · Cited by 59
Photosynthetic aspects and lipid profiles in the mixotrophic alga Neochloris oleoabundans as useful parameters for biodiesel production
Baldisserotto, C., Popovich, C. A., Giovanardi, M., Sabia, A., Ferroni, L., Constenla, D. T., Leonardi, P. I., & Pancaldi, S. (2016) · Algal Research · doi:10.1016/j.algal.2016.03.022 · Cited by 61
Optimum lipid production using agro-industrial wastewater treated microalgae as biofuel substrate
Kamyab, H., Din, M. F. M., Hosseini, S. E., Ghoshal, S. K., Ashokkumar, V., Keyvanfar, A., Shafaghat, A., Lee, C. T., Bavafa, A. A., & Majid, M. Z. A. (2016) · Clean Technologies and Environmental Policy · doi:10.1007/s10098-016-1212-1 · Cited by 60
“Pulz and Gross (2004) acknowledged that microalgal can serve as a successful source for biofuel depending on the right choice of & Muhd Zaimi Abd Majid mzaimi@utm.my 1 Department of Environmental Engineering, Centre for Environmental Sustainability and Water Security (IPASA), Research Institute for…”
Background
Algae for biofuels: The third generation of feedstock
Chowdhury, H., Loganathan, B., Mustary, I., Alam, F., & Mobin, S. M. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815162-4.00012-4 · Cited by 58
A two‐enzyme constituted mixture to improve the degradation of Arthrospira platensis microalga cell wall for monogastric diets
Coelho, D., Lopes, P. A., Cardoso, V., Ponte, P. I. P., Brás, J. L. A., Madeira, M. S. M. D. S., Alfaia, C. M., Bandarra, N. M., Fontes, C. M. G. A., & Prates, J. A. M. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13239 · Cited by 59
“The starch in cyanobacteria is a highly branched α‐1,4‐polyglucan, denominated as cyanophycean starch (Pulz & Gross, 2004), deeply located in the cyanobacterial cell wall with an irregular whitish spherical form (Lang, 1968; Pyo et al., 2013).”
Background
Kinetic modeling of microalgae growth and CO2 bio-fixation using central composite design statistical approach
Almomani, F. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137594 · Cited by 59
Polar lipidomic profile shows Chlorococcum amblystomatis as a promising source of value-added lipids
Conde, T. A., Couto, D., Melo, T., Costa, M., Silva, J., Domingues, M. R., & Domingues, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-83455-y · Cited by 58
“(9) Relative quantification of ω−3/ω−6 polar lipids = ∑”
Use of algae in poultry production: a review
Coudert, E., Baéza, É., & Berri, C. (2020) · World s Poultry Science Journal · doi:10.1080/00439339.2020.1830012 · Cited by 64
Acid Tolerant and Acidophilic Microalgae: An Underexplored World of Biotechnological Opportunities
Abiusi, F., Trompetter, E., Pollio, A., Wijffels, R. H., & Janssen, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.820907 · Cited by 63
“Spirulina is cultivated in alkaline media (pH 8.5–10.5), Dunaliella at high NaCl concentrations (35–300 g/L; Oren, 2014) and also Haematococcus can tolerate high salinity, which is used to promote accumulation of the red pigment astaxanthin within the cells (Oslan et al., 2021).”
BackgroundInfluential
Morphophysiological analyses of Neochloris oleoabundans (Chlorophyta) grown mixotrophically in a carbon-rich waste product
Giovanardi, M., Ferroni, L., Baldisserotto, C., Tedeschi, P., Maietti, A., Pantaleoni, L., & Pancaldi, S. (2012) · PROTOPLASMA · doi:10.1007/s00709-012-0390-x · Cited by 58
“well-known not only for their use as a natural feeding or as a food colorant but also for their employment in biotechnological processes, such as the production of high value compounds like polyunsaturated fatty acids, pigments, polysaccharides, other fine chemicals and biomass (Borowitzka 1998; Pulz and Gross 2004; S…”
Background
Comparative Life Cycle Assessment of Conventional and Novel Microalgae Production Systems and Environmental Impact Mitigation in Urban-Industrial Symbiosis
Pechsiri, J. S., Thomas, J.-B., Bahraoui, N. E., Acién, F. G., Chaouki, J., Chidami, S., Rivera-Tinoco, R., Martin, J. P., Gómez-Serrano, C., Combe, M., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158445 · Cited by 57
Biodiversity and biogeography of microalgae: progress and pitfalls
Sharma, N. K., & Rai, A. K. (2011) · Environmental Reviews · doi:10.1139/a10-020 · Cited by 57
“25 109/year (Pulz and Gross 2004).”
Background
The development of microalgal biotechnology in the Czech Republic
Masojídek, J., & Prášil, O. (2010) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-010-0802-x · Cited by 57
“Japan, and brown algae were already processed for iodine and soda in the 18th century [62].”
Background
Arthrospira (Spirulina) platensis cultivation in tubular photobioreactor: Use of no-cost CO2 from ethanol fermentation
Ferreira, L. S., Rodrigues, M. S., Converti, A., Sato, S., & de Carvalho, J. C. M. (2011) · Applied Energy · doi:10.1016/j.apenergy.2011.11.019 · Cited by 57
Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells
Sun, Z., Liu, J., Zeng, X., Huangfu, J., Jiang, Y., Wang, M., & Chen, F. (2011) · Food & Function · doi:10.1039/c1fo10021a · Cited by 57
High-added value products from microalgae and prospects of aquaculture wastewaters as microalgae growth media
Dourou, M., Dritsas, P., Baeshen, M. N., Elazzazy, A. M., AL-Farga, A. M., & Aggelis, G. (2020) · FEMS Microbiology Letters · doi:10.1093/femsle/fnaa081 · Cited by 57
Integrated marine microalgae biorefineries for improved bioactive compounds: A review
Cheng, P., Li, Y., Wang, C., Guo, J., Zhou, C., Zhang, R., Ma, Y., Ma, X., Wang, L., Cheng, Y., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.152895 · Cited by 59
First Principles Model of a Tubular Photobioreactor for Microalgal Production
Fernández, I., Acién, F. G., Berenguel, M., & Guzmán, J. L. (2014) · Industrial & Engineering Chemistry Research · doi:10.1021/ie501438r · Cited by 57
The green alga Dictyosphaerium chlorelloides biomass and polysaccharides production determined using cultivation in crossed gradients of temperature and light
Kumar, D., Kvíderová, J., Kaštánek, P., & Lukavský, J. (2017) · Engineering in Life Sciences · doi:10.1002/elsc.201700014 · Cited by 56
“The EPS from microbial sources are used in many biotechnological applications, for instance, in food production as various jelly compounds, in pharmaceutical industry for capsule covering or novel anti-tumor/viral drugs, for pigments suspension for textile making, as emulsifier and detergents in cosmetics, and so on […”
Background
Perspective: Multiomics and machine learning help unleash the alternative food potential of microalgae
Helmy, M., Elhalis, H., Liu, Y., Chow, Y., & Selvarajoo, K. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2022.11.002 · Cited by 57
A review of alternative proteins for vegan diets: Sources, physico-chemical properties, nutritional equivalency, and consumer acceptance
Ulhas, R. S., Ravindran, R., Malaviya, A., Priyadarshini, A., Tiwari, B. K., & Rajauria, G. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113479 · Cited by 59
“These algal proteins can be processed into a variety of food and non-food products, including protein powders, dietary supplements, and even added to functional foods such as noodles, bread, biscuits, drinks, sweets, beer and vegetarian burgers (Pulz & Gross, 2004).”
Applications of Bioactive Compounds from Marine Microalgae in Health, Cosmetics, and Functional Foods
Prates, J. A. M. (2025) · Applied Sciences · doi:10.3390/app15116144 · Cited by 70
Cyanobacteria and eukaryotic microalgae as potential sources of antibiotics
Senhorinho, G. N. A., Ross, G. M., & Scott, J. A. (2015) · Phycologia · doi:10.2216/14-092.1 · Cited by 55
“This is likely due in part to the paucity of information regarding activity and toxicity in vivo (Borowitzka 1995), as well as the challenges of controlled large-scale production (Skulberg 2000; Olaizola 2003; Pulz & Gross 2004; Wijffels 2008; Skjånes et al. 2013).”
Background
Synthesis of Antioxidant Carotenoids in Microalgae in Response to Physiological Stress
Faraloni, C., & Torzillo, G. (2017) · InTech eBooks · doi:10.5772/67843 · Cited by 56
“Microalgae and cyanobacteria are photoautotrophic organisms that are exposed to high oxygen and radical stress in their natural environment, and consequently have developed several efficient protective systems against reactive oxygen species and free radicals [1].”
Background
Isolation and characterization of anti-inflammatory peptides derived from trypsin hydrolysis of microalgae protein ( Synechococcus sp. VDW)
Suttisuwan, R., Phunpruch, S., Saisavoey, T., Sangtanoo, P., Thongchul, N., & Karnchanatat, A. (2019) · Food Biotechnology · doi:10.1080/08905436.2019.1673171 · Cited by 56
“Microalgae possess >50% protein in their biomass and are predominantly used as animal feed (Pulz and Gross 2004).”
Background
Resourceful treatment of harsh high-nitrogen rare earth element tailings (REEs) wastewater by carbonate activated Chlorococcum sp. microalgae
Geng, Y., Cui, D., Yang, L., Xiong, Z., Pavlostathis, S. G., Shao, P., Zhang, Y., Luo, X., & Luo, S. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127000 · Cited by 55
Effect of biomass concentration on the productivity of Tetraselmis suecica in a pilot-scale tubular photobioreactor using natural sunlight
Michels, M. H. A., Slegers, P. M., Vermuë, M. H., & Wijffels, R. H. (2013) · Algal Research · doi:10.1016/j.algal.2013.11.011 · Cited by 62
Properties of microalgal enzymatic protein hydrolysates: Biochemical composition, protein distribution and FTIR characteristics
Köse, A., & Öncel, S. Ş. (2015) · Biotechnology Reports · doi:10.1016/j.btre.2015.02.005 · Cited by 56
“They are composed of proteins, essential amino acids, fatty acids, antioxidant pigments, vitamins and other bioactive compounds that express unique features for the development of pharmaceutials, nutraceuticals, cosmetics and biofuel industry [33,30].”
Background
La production de biocarburant lipidique avec des microalgues : promesses et défis
Cadoret, J., & Olivier Bernard, A. (2008) · Journal de la Société de Biologie · doi:10.1051/jbio:2008022 · Cited by 80
A Review on Potential Biotechnological applications of Microalgae
Sigamani, S., Ramamurthy, D., & Hemalatha, N. (2016) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2016.60829 · Cited by 56
“…active compounds present in the microalgal biomass is responsible for distinct biological activities, such as cytotoxic, antibiotic, antioxidant, antifungal, antiinflammatory and antihelminthic compounds (Pulz and Gross, 2004; Gouveia et al., 2008; Plaza et al., 2009 and Patil et al., 2011).”
Background
Microalgal food supplements from the perspective of Polish consumers: patterns of use, adverse events, and beneficial effects
Rzymski, P., & Jaśkiewicz, M. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1079-5 · Cited by 55
Heterotrophic microalgae production on food waste and by-products
Ende, S. S. W., & Noke, A. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1697-6 · Cited by 55
Mexican Microalgae Biodiversity and State-Of-The-Art Extraction Strategies to Meet Sustainable Circular Economy Challenges: High-Value Compounds and Their Applied Perspectives
Sosa‐Hernández, J. E., Romero‐Castillo, K. D., Parra-Arroyo, L., Aguilar-Aguila-Isaías, M. A., García-Reyes, I. E., Ahmed, I., Parra‐Saldívar, R., Bilal, M., & Iqbal, H. M. N. (2019) · Marine Drugs · doi:10.3390/md17030174 · Cited by 56
“Also, in this area, microalga biomass price along with its valued compound depend on where the product is located and the market status [15].”
Background
Utilization of phenolic compounds by microalgae
Lindner, A. V., & Pleißner, D. (2019) · Algal Research · doi:10.1016/j.algal.2019.101602 · Cited by 55
Fatty acids and proteins from marine cold adapted microalgae for biotechnology
Schulze, P. S. C., Hulatt, C. J., Morales‐Sánchez, D., Wijffels, R. H., & Kiron, V. (2019) · Algal Research · doi:10.1016/j.algal.2019.101604 · Cited by 59
A sustainable perspective of microalgal biorefinery for co‐production and recovery of high‐value carotenoid and biofuel with CO2 valorization
Dineshkumar, R., & Sen, R. (2020) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.2107 · Cited by 56
Microalgal biomass production through phycoremediation of fresh market wastewater and potential applications as aquaculture feeds
Apandi, N. M., Mohamed, R. M. S. R., Al-Gheethi, A., & Kassim, A. H. M. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3937-3 · Cited by 54
Cu-mediated biomass productivity enhancement and lutein enrichment of the novel microalga Coccomyxa onubensis
Vaquero, I., Ruiz‐Domínguez, M. C., Márquez, M., & Vı́lchez, C. (2012) · Process Biochemistry · doi:10.1016/j.procbio.2012.01.016 · Cited by 54
“Several studies [2,3] showed such Coccomyxa microalga has a retty good growth rate, higher than many acidophile algae [4–6] nd pretty similar to other common microalgae, having the advanage of growing in a low pH media with an inorganic carbon ource which prevents cultures from bacterial contamination.”
Background
UV-A Mediated Modulation of Photosynthetic Efficiency, Xanthophyll Cycle and Fatty Acid Production of Nannochloropsis
Forján, E., Garbayo, I., Henriques, M., Rocha, J. M. S., Vega, J. M., & Vı́lchez, C. (2010) · Marine Biotechnology · doi:10.1007/s10126-010-9306-y · Cited by 54
“UV-A Effect on PUFAs Accumulation In order to assess whether the enhanced carotenoid production in UV-A exposed cultures of Nannochloropsis is part of a more general effect consisting of an enhanced lipid production in UV-A exposed algal cultures, the time-course content of some saturated and unsaturated fatty acids w…”
BackgroundInfluential
Algae Biotechnology – Green Cell-Factories on the Rise
Hallmann, A. (2015) · Current Biotechnology · doi:10.2174/2211550105666151107001338 · Cited by 58
Microalgae a Superior Source of Folates: Quantification of Folates in Halophile Microalgae by Stable Isotope Dilution Assay
Woortman, D. V., Fuchs, T., Striegel, L., Fuchs, M., Weber, N., Brück, T., & Rychlik, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00481 · Cited by 55
The potential of nuclear magnetic resonance (NMR) in metabolomics and lipidomics of microalgae- a review
Bisht, B., Kumar, V., Gururani, P., Tomar, M. S., Nanda, M., Vlaskin, M. S., Kumar, S., & KURBATOVA, A. I. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108987 · Cited by 53
Impacts of Fortifying Nile Tilapia (Oreochromis niloticus) Diet with Different Strains of Microalgae on Its Performance, Fillet Quality and Disease Resistance to Aeromonas hydrophila Considering the Interplay between Antioxidant and Inflammatory Response
Ibrahim, D., El-Hamid, M. I. A., Al-Zaban, M. I., ElHady, M., El-Azzouny, M. M., Feky, T. M. E., Sadik, G. M. A., Samy, O. M., Hamed, T. A., Albalwe, F. M., et al. (2022) · Antioxidants · doi:10.3390/antiox11112181 · Cited by 55
Prospects of using microalgae for biofuels production: Results of a Delphi study
Ribeiro, L. A., da Silva, P. P., Mata, T. M., & Martins, A. A. (2014) · Renewable Energy · doi:10.1016/j.renene.2014.10.065 · Cited by 53
Light-mediated lutein enrichment of an acid environment microalga
Vaquero, I., Mogedas, B., Ruiz‐Domínguez, M. C., Vega, J. M., & Vı́lchez, C. (2014) · Algal Research · doi:10.1016/j.algal.2014.09.005 · Cited by 53
Quality of Novel Healthy Processed Cheese Analogue Enhanced with Marine Microalgae Chlorella vulgaris Biomass
Shalaby, S. M. (2013) · Cited by 53
Dissolved inorganic carbon speciation in aquatic environments and its application to monitor algal carbon uptake
Chen, Y., Zhang, L., Xu, C., & Vaidyanathan, S. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.10.025 · Cited by 53
Algae in food and feed
Dajana, J. K., Jelica, B. S., Olivera, B., Aleksandra, Č. M., & Lj., M. I. (2013) · SCIndeks · Cited by 52
Mixotrophy in the phototrophic dinoflagellate Takayama helix (family Kareniaceae): Predator of diverse toxic and harmful dinoflagellates.
Jeong, H., Jin, H.-O., Lim, A., Kwon, J. E., Kim, S. J., & Lee, S.-Y.-O. (2016) · Harmful Algae · doi:10.1016/j.hal.2016.10.008 · Cited by 49
Meeting Sustainable Development Goals: Alternative Extraction Processes for Fucoxanthin in Algae
Foo, S. C., Khoo, K. S., Ooi, C. W., Show, P. L., Khong, N. M. H., & Yusoff, F. M. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.546067 · Cited by 56
“, 1996), as compared to only about 250,000 species in higher plants (Pulz and Gross, 2004).”
Background
Characterization of ash in algae and other materials by determination of wet acid indigestible ash and microscopic examination
Liu, K. (2017) · Algal Research · doi:10.1016/j.algal.2017.04.014 · Cited by 55
Investigation of growth limitation by CO2 mass transfer and inorganic carbon source for the microalga Chlorella vulgaris in a dedicated photobioreactor
Gouic, B. L., Marec, H., Pruvost, J., & Cornet, J. (2021) · Chemical Engineering Science · doi:10.1016/j.ces.2020.116388 · Cited by 54
Effects of dietary fish oil replacement by microalgae raw materials on growth performance, body composition and fatty acid profile of juvenile olive flounder, Paralichthys olivaceus
Qiao, H., Wang, H., Song, Z., Ma, J., Li, B., Liu, X., Zhang, S., Wang, J., & Zhang, L. (2014) · Aquaculture Nutrition · doi:10.1111/anu.12127 · Cited by 53
Light Harvesting Proteins for Solar Fuel Generation in Bioengineered Photoelectrochemical Cells
Ihssen, J., Braun, A., Faccio, G., Gajda‐Schrantz, K., & Thöny‐Meyer, L. (2014) · Current Protein and Peptide Science · doi:10.2174/1389203715666140327105530 · Cited by 54
Screening for Biologically Annotated Drugs That Trigger Triacylglycerol Accumulation in the Diatom Phaeodactylum
Conte, M., Lupette, J., Seddiki, K., Meï, C., Dolch, L.-J., Gros, V., Barette, C., Rébeillé, F., Jouhet, J., & Maréchal, É. (2018) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.01804 · Cited by 53
Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum
Yi, Z., Su, Y., Xu, M., Bergmann, A., Ingþórsson, S., Rolfsson, Ó., Salehi‐Ashtiani, K., Brynjólfsson, S., & Fu, W. (2018) · Marine Drugs · doi:10.3390/md16080272 · Cited by 52
“To date, there are still gaps between diatom research development and its fully commercial applications [8,25].”
Background

Authors: Pulz, O., & Gross, W.
Affiliations: Institut für Getreideverarbeitung (Germany) (DE)
Freie Universität Berlin (DE)
Corresponding author: Pulz, Otto
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-08-06
Volume: 65
Issue: 6
Pages: 635-648
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-004-1647-x
OpenAlex: W2044809902
Cited by: 2,132
References: 40
Citations by year: 2026: 56 · 2025: 82 · 2024: 119 · 2023: 104 · 2022: 109 · 2021: 150 · 2020: 169 · 2019: 152 · 2018: 124 · 2017: 127 · 2016: 134 · 2015: 162 · 2014: 152 · 2013: 132 · 2012: 107
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: microalgae, microalgal biotechnology, microalgal biomass, food and feed, genetic engineering of microalgae, pharmaceutical applications, ecological applications, screening method
MeSH terms: Biotechnology, Drug Industry, Food Industry, Eukaryota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Valuable products from biotechnology of microalgae

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks