Cited by 2,132Algal biology and biofuel productionSeaweed-derived Bioactive CompoundsMicrobial Metabolic Engineering and Bioproduction

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Valuable products from biotechnology of microalgae

Pulz, Otto, Gross, Wolfgang·2004·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-004-1647-x

Open this paper in CoChat — free account

Abstract

The biotechnology of microalgae has gained considerable importance in recent decades. Applications range from simple biomass production for food and feed to valuable products for ecological applications. For most of these applications, the market is still developing and the biotechnological use of microalgae will extend into new areas. Considering the enormous biodiversity of microalgae and recent developments in genetic engineering, this group of organisms represents one of the most promising sources for new products and applications. With the development of sophisticated culture and screening techniques, microalgal biotechnology can already meet the high demands of both the food and pharmaceutical industries.

Integrity signals

Registry

Crossref · 10.1007/s00253-004-1647-x

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Micro‐algal biotechnology
Rogers, L. J. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80268-0 · Cited by 1,289
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190
Modern approach to the classification system of Cyanophytes 4-Nostocales
Komárek, J., & Anagnostidis, K. (1989) · Cited by 1,152
Photobioreactors: Production systems for phototrophic microorganisms
O., P. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100702 · Cited by 987
Manual on the production and use of live food for aquaculture
Lavens, P., & Sorgeloos, P. (1996) · Medical Entomology and Zoology · Cited by 986
Handbook of Microalgal Culture: Biotechnology and Applied Phycology
(2003) · doi:10.1002/9780470995280 · Cited by 886
Biodiversity and application of microalgae
Metting, F. B. (1996) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01574779 · Cited by 600
Microalgal Biotechnology
Borowitzka, M. A., & Borowitzka, L. J. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839162473 · Cited by 568
Microalgae as sources of pharmaceuticals and other biologically active compounds
Borowitzka, M. A. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003544 · Cited by 520
Microalgae for aquaculture: Opportunities and constraints
Borowitzka, M. A. (1997) · Journal of Applied Phycology · doi:10.1023/a:1007921728300 · Cited by 478

Flagged first, then by citations

Show all 40 references

1 of the 40 references couldn’t be matched to a known paper.

Research works printed but not linked: 18

Anagnostidis K, Komárek JA (1985) Modern approach to the classification system of cyanophytes 1?introduction. Arch Hydrobiol Suppl 71:291?302
Anagnostidis K, Komárek JA (1988) Modern approach to the classification systems of cyanophytes 3?oscillatorales. Arch Hydrobiol Suppl 80:327?472
De Pauw N, Persoone G (1988) Micro-algae for aquaculture, micro-algal biotechnology. In: Borowitzka MA, Borowitzka LJ (eds) Cambridge University Press, Cambridge, pp 197?221
Gimmler H, Degenhardt B (2001) In: Rai LC, Gaur JP (eds) Alkaliphilic and alkali-tolerant algae, algal adaptation to environmental stresses. Springer, Berlin Heidelberg New York
Gross W, Schnarrenberger C (1995) Heterotrophic growth of two strains of the acidothermophilic red alga Galderia sulphuria. Plant Cell Physiol 4:633?638
Komárek JA, Anagnostidis K (1986) Modern approach to the classification systems of cyanophytes 2-Chroococales. Arch Hydrobiol Suppl 73:157?226
Kretschmer P, Pulz O, Gudin C, Semenenko V (1995). Biotechnology of Microalgae. (Proceedings of the second European workshop) IGV Institute for Cereal Processing, Potsdam-Rehbrücke
Laing I, Ayala F (1990) In: Akatsuka I (ed) Commercial mass culture techniques for producing microalgae, introduction to applied phycology. SPB, The Hague, pp 447?477
Muller-Feuga A, Moal J, Kaas R (2003) The microalgae for aquaculture. In: Stottrup JG, McEvoy LA (eds) Life feeds in marine aquaculture. Blackwell, Oxford
Musafarov AM, Taubayev TT (1974). Chlorella (in Russian). FAN, Tashkent
New MB (1999) Global aquaculture: current trends and challenges for 21st century. World Aquacult 3:8?14
Ördög V, Szigeti J, Pulz O (1996). Proceedings of the conference on progress in plant sciences from plant breeding to growth regulation. Pannon University, Mosonmagyarovar
Piccardi R, Materassi R, Tredici M (1999) Algae and human affairs in the 21st century. (Abstr Int Conf Appl Algol) Universita degli Studi di Firenze, Firenze
Richmond A (2004) Handbook of microalgal culture. Blackwell, Oxford
Schreckenbach K, Thürmer C, Loest K, Träger G, Hahlweg R (2001) Der Einfluss von Mikroalgen (Spirulina platensis) in Trockenmischfutter auf Karpfen (Cyprinus carpio). Fischer Teichwirt 1:10?13
Sivonen K, Jones G (1999) Cyanobacterial toxins. In: Chorus I, Bertram J (eds) Toxic cyanobacteria in water: a guide to public health significance, monitoring and management. Spon, London, pp 41?111
Spektorova L, Creswell RL, Vaughan D (1997) Closed tubular cultivators. World Aquacult 6:39?43
Weber M, Grimmer A (2001) Lohnt sich der Einsatz von Grünalgen im Ferkelfutter? Landwirtsch Wochenbl Rheinland 2001:34

Sorted by citations

Items 601–700 of 1,012

Design of Closed Photobioreactors for Algal Cultivation
Koller, M. (2015) · Algal Biorefineries · doi:10.1007/978-3-319-20200-6_4 · Cited by 66
Differential Production of Phenolics, Lipids, Carbohydrates and Proteins in Stressed and Unstressed Aquatic Plants, Azolla filiculoides and Azolla pinnata
Tran, T. L. N., Miranda, A. F., Abeynayake, S. W., & Mouradov, A. (2020) · Biology · doi:10.3390/biology9100342 · Cited by 55
Antioxidant and Cytotoxic Effects on Tumor Cells of Exopolysaccharides from Tetraselmis suecica (Kylin) Butcher Grown Under Autotrophic and Heterotrophic Conditions
Parra-Ríofrio, G., García‐Márquez, J., Casas-Arrojo, V., Uribe-Tapia, E., & Abdala‐Díaz, R. (2020) · Marine Drugs · doi:10.3390/md18110534 · Cited by 51
“The increase in antioxidant activity is due to the fact that the photosystem II of the cells produces reactive oxygen species (ROS), caused by the photosynthetic process [45].”
Background
Life cycle assessment: Blazing a trail for bioresources management
Kumar, B., & Verma, P. (2020) · Energy Conversion and Management X · doi:10.1016/j.ecmx.2020.100063 · Cited by 52
Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging
Gupta, A., Singh, A. P., Singh, V. K., Singh, P. R., Jaiswal, J., Kumari, N., Upadhye, V. J., Singh, S. C., & Sinha, R. P. (2023) · Catalysts · doi:10.3390/catal13040745 · Cited by 51
Controls of microalgal biomass and lipid production in municipal wastewater‐fed bioreactors
Sturm, B., Peltier, E. F., Smith, V. H., & deNoyelles, F. J. (2011) · Environmental Progress & Sustainable Energy · doi:10.1002/ep.10586 · Cited by 51
“Nitrogen starvation has been shown to increase the total lipid content per dry weight of many algal species [5, 26, 31].”
Background
Scenedesmus dimorphus and Scenedesmus quadricauda : two potent indigenous microalgae strains for biomass production and CO2 mitigation - A study on their growth behavior and lipid productivity under different concentration of urea as nitrogen source.
Goswami, R. C. D., & Kalita, M. C. (2011) · Cited by 52
Façade integrated photobioreactors for building energy efficiency
Öncel, S. Ş., Köse, A., & Senyay-Oncel, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100546-0.00011-x · Cited by 55
The role of starch as transient energy buffer in synchronized microalgal growth in Acutodesmus obliquus
León-Saiki, G. M., Remmers, I. M., Martens, D. E., Lamers, P. P., Wijffels, R. H., & van der Veen, D. (2017) · Algal Research · doi:10.1016/j.algal.2017.05.018 · Cited by 53
Optimization of a raceway pond system for wastewater treatment: a review
Filali, R., Taidi, B., & Pareau, D. (2019) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2019.1571007 · Cited by 51
“These microorganisms can form a promising source of bioenergy feedstocks [1], lead to the production of high value compounds [2] in various fields such as cosmetics, pharmaceutical, nutraceutical, aquaculture [2–5] or play a role in the environmental field [6].”
Background
Chemical composition, antioxidant, anti-inflammatory and cytotoxic effects of Chondrus crispus species of red algae collected from the Red Sea along the shores of Jeddah city
Alkhalaf, M. I. (2020) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2020.10.007 · Cited by 51
Modelling of Scenedesmus obliquus; function of nutrients with modified Gompertz model
Çelekli̇, A., Balcı, M., & Bozkurt, H. (2008) · Bioresource Technology · doi:10.1016/j.biortech.2008.04.028 · Cited by 51
“Additionally, species of the genus have been worldwide used for industrial purpose because of the ease of cultivation and adaptation to the environmental conditions (Pulz and Gross, 2004; Li et al., 2005).”
Background
Purification and Characterization of a Corrinoid-Compound in an Edible Cyanobacterium Aphanizomenon flos-aquae as a Nutritional Supplementary Food
Miyamoto, E., Tanioka, Y., Nakao, T., Barla, F., Inui, H., Fujita, T., Watanabe, F., & Nakano, Y. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062300r · Cited by 49
Numerical investigation of a bubble-column photo-bioreactor design for microalgae cultivation
Seo, I.-H., Lee, I.-B., Hwang, H.-S., Hong, S.-W., Bitog, J. P., Kwon, K.-S., Lee, C., Kim, Z., & Cuello, J. L. (2012) · Biosystems Engineering · doi:10.1016/j.biosystemseng.2012.08.001 · Cited by 50
Flux balancing of light and nutrients in a biofilm photobioreactor for maximizing photosynthetic productivity
Murphy, T. E., & Berberoğlu, H. (2014) · Biotechnology Progress · doi:10.1002/btpr.1881 · Cited by 50
Label-Free Analysis and Sorting of Microalgae and Cyanobacteria in Microdroplets by Intrinsic Chlorophyll Fluorescence for the Identification of Fast Growing Strains
Best, R. J., Łyczakowski, J. J., Abalde‐Cela, S., Yu, Z., Abell, C., & Smith, A. G. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b02364 · Cited by 50
De novo transcriptomic analysis of Chlorella sorokiniana reveals differential genes expression in photosynthetic carbon fixation and lipid production
Li, L., Zhang, G., & Wang, Q. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0839-8 · Cited by 50
“Due to its various and robust metabolic capacities, Chlorella has received increasingly attention as promising microalgae to produce biomass [4], biodiesel [5] as well as high additional-value products [6].”
Background
Nanodroplets of Docosahexaenoic Acid-Enriched Algae Oil Encapsulated within Microparticles of Hydrocolloids by Emulsion Electrospraying Assisted by Pressurized Gas
Prieto, C., & Lagaron, J. M. (2020) · Nanomaterials · doi:10.3390/nano10020270 · Cited by 50
“The use of algae and krill oils, which are the primary source of PUFAs, present the advantage of the absence of pollutants as well as the lack of unpleasant odor [6,7].”
Background
Food allergen detection by mass spectrometry: From common to novel protein ingredients
Bianco, M., Ventura, G., Calvano, C. D., Losito, I., & Cataldi, T. R. I. (2023) · PROTEOMICS · doi:10.1002/pmic.202200427 · Cited by 56
Productivity and selective accumulation of carotenoids of the novel extremophile microalga Chlamydomonas acidophila grown with different carbon sources in batch systems
Cuaresma, M., Casal, C., Forján, E., & Vı́lchez, C. (2010) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-010-0841-3 · Cited by 49
“, lipid synthesis and carotenoid accumulation [5, 41].”
Background
Combined Effects of Nitrogen Concentration and Seasonal Changes on the Production of Lipids in Nannochloropsis oculata
Olofsson, M., Lamela, T., Nilsson, E., Bergé, J.-P., Pino, V. D., Uronen, P., & Legrand, C. (2014) · Marine Drugs · doi:10.3390/md12041891 · Cited by 49
“EPA can serve as a marine drug since it has a well documented positive effect on human health [14].”
Background
Investigation on novel raceway pond with inclined paddle wheels through simulation and microalgae culture experiments
Zeng, F., Huang, J., Chen, M., Zhu, F., Chen, J., & Li, Y. (2015) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-015-1501-9 · Cited by 49
The role of light and nitrogen in growth and carotenoid accumulation in Scenedesmus sp.
Přibyl, P., Pilný, J., Cepák, V., & Kaštánek, P. (2016) · Algal Research · doi:10.1016/j.algal.2016.02.028 · Cited by 49
A rapid, modular and marker-free chloroplast expression system for the green alga Chlamydomonas reinhardtii
Bertalan, I., Munder, M. C., Weiß, C., Kopf, J., Fischer, D., & Johanningmeier, U. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2014.12.017 · Cited by 49
Biphasic short time heat degradation of the blue microalgae protein phycocyanin from Arthrospira platensis
Böcker, L., Ortmann, S., Surber, J., Leeb, E., Reineke, K., & Mathys, A. (2019) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2018.11.007 · Cited by 46
Phytoplankton community succession in relation to water quality changes in the indoor industrial aquaculture system for Litopenaeus vannamei
Qiao, L., Chang, Z., Li, J., & Chen, Z. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735441 · Cited by 52
Effects of nutritional conditions on lipid production by cyanobacteria
CORDEIRO, R. S., VAZ, I. C. D., MAGALHÃES, S. M. S., & BARBOSA, F. A. R. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720150707 · Cited by 48
Adaptation of Livestock to New Diets Using Feed Components without Competition with Human Edible Protein Sources—A Review of the Possibilities and Recommendations
PAS, M. F. W. T., Veldkamp, T., de Haas, Y., Bannink, A., & Ellen, E. D. (2021) · Animals · doi:10.3390/ani11082293 · Cited by 57
“The BW gain of weaned piglets fed diets with Spirulina was higher compared to the control fed pigs, but this result was not consistent over all experiments [33].”
Result
Realization process of microalgal biorefinery: The optional approach toward carbon net-zero emission
Wang, Y., Yang, S., Liu, J., Wang, J., Xiao, M., Liang, Q., Ren, X., Wang, Y., Mou, H., & Sun, H. (2023) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165546 · Cited by 50
Outdoor pilot-scale production of Botryococcus braunii in panel reactors
Bazaes, J., Sepulveda, C., Acién, F. G., Morales, J., Gonzales, L., Rivas, M., & Riquelme, C. E. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9787-3 · Cited by 48
“However, currently the microalgae biomass market produces only 5 kt year−1 at mean production costs of US $25,000 t−1 (Pulz and Gross 2004), from US $5 to over US $1,000 kg−1 (Borowitzka 1999).”
Background
Effect of magnesium ion concentration in autotrophic cultures of Chlorella vulgaris
Ayed, H. B. A.-B., Taidi, B., Ayadi, H., Pareau, D., & Stambouli, M. (2015) · Algal Research · doi:10.1016/j.algal.2015.03.021 · Cited by 48
“vulgaris belongs to the Chlorophyceae family of green algae [10], it is an eukaryotic organism [10] that reproduces asexually [11] by formation of autospores within the parent cell.”
Background
Improving the feasibility of producing biofuels from microalgae using wastewater
Rawat, I., Bhola, V., Kumar, R. R., & Bux, F. (2013) · Environmental Technology · doi:10.1080/09593330.2013.826287 · Cited by 50
“[7,8,13,14] Microalgae can yield multiple energy sources (Figure 1): value-added resources and other renewable fuels such as biodiesel, biomethane, bioethanol,[4] biohydrogen [15] as well as pigments: chlorophyll,[16] chemicals, fine chemicals,[17] metabolites (protein and carbohydrates), animal feed, organic fertiliz…”
Background
Upscale of a laboratory rotating disk biofilm reactor and evaluation of its performance over a half-year operation period in outdoor conditions
Sebestyén, P., Blanken, W., Bacsa, I., Tóth, G. J., Martin, A., Bhaiji, T., Dergez, Á., Kesserű, P., Koós, Á., & Kiss, I. (2016) · Algal Research · doi:10.1016/j.algal.2016.06.024 · Cited by 48
Biosystems Engineering: Biofactories for Food Production in the Century XXI
Guevara-González, R. G., & Torres‐Pacheco, I. (2014) · Springer eBooks · doi:10.1007/978-3-319-03880-3 · Cited by 50
Integrity of the microalgal cell plays a major role in the lipolytic stability during wet storage
Balduyck, L., Stock, T., Bijttebier, S., Bruneel, C., Jacobs, G., Voorspoels, S., Muylaert, K., & Foubert, I. (2017) · Algal Research · doi:10.1016/j.algal.2017.06.013 · Cited by 49
Algal spent biomass—A pool of applications
Guedes, A. C., Amaro, H. M., Sousa‐Pinto, I., & Malcata, F. X. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64192-2.00016-0 · Cited by 49
Electroporation as a Solvent-Free Green Technique for Non-Destructive Extraction of Proteins and Lipids From Chlorella vulgaris
Eleršek, T., Flisar, K., Likozar, B., Klemenčič, M., Golob, J., Kotnik, T., & Damijan Miklavčič, A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00443 · Cited by 48
High‐value Recombinant Protein Production in Microalgae
Barrera, D. J., & Mayfield, S. P. (2013) · doi:10.1002/9781118567166.ch27 · Cited by 48
Methyladeninylcobamide functions as the cofactor of methionine synthase in a Cyanobacterium, Spirulina platensis NIES‐39
Tanioka, Y., Miyamoto, E., Yabuta, Y., Ohnishi, K., Fujita, T., Yamaji, R., Misono, H., Shigeoka, S., Nakano, Y., Inui, H., et al. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.013 · Cited by 40
“Among these edible cyanobacteria, Spirulina platensis is most important in both the food and pharmaceutical industries, since substantial amounts of Spirulina cells (3000 t/year) are produced worldwide to meet the high demands of these industries [8]; Spirulina cells contain various nutrients and therapeutic compounds…”
Background
Effect of Spirulina (Arthrospira platensis) microencapsulated in alginate and whey protein concentrate addition on physicochemical and organoleptic properties of functional stirred yogurt
Nourmohammadi, N., Soleimanian‐Zad, S., & Shekarchizadeh, H. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10576 · Cited by 47
Emerging prospects of microbial production of omega fatty acids: Recent updates
Patel, A. K., Chauhan, A. S., Kumar, P., Michaud, P., Gupta, V. K., Chang, J., Chen, C., Dong, C., & Singhania, R. R. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.127534 · Cited by 47
Biological and Nutritional Applications of Microalgae
Sarıtaş, S., Kalkan, A. E., Yılmaz, K., Gürdal, S., Göksan, T., Witkowska, A. M., Lombardo, M., & Karav, S. (2024) · Nutrients · doi:10.3390/nu17010093 · Cited by 63
A process design and productivity evaluation for oil production by indoor mass cultivation of a marine diatom, Fistulifera sp. JPCC DA0580
Satoh, A., Ichii, K., Matsumoto, M., Kubota, C., Nemoto, M., Tanaka, M., Yoshino, T., Matsunaga, T., & Tanaka, T. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.03.087 · Cited by 47
“Microalgal cultivation technology encompassing its biomass and products have received much attention in the last 5–6 decades owing to their potential as possible commodities and numerous other industrial applications (Becker, 2004; Borowitzka, 1995; Cardozo et al., 2007; Eriksen, 2008; Pulz and Gross, 2004; Spolaore e…”
Background
A methodology for screening of microalgae as a decision making tool for energy and green chemical process applications
Picardo, M. C., de Medeiros, J. L., Monteiro, J. G. M., Chaloub, R. M., Giordano, M., & Araújo, O. D. Q. F. (2012) · Clean Technologies and Environmental Policy · doi:10.1007/s10098-012-0508-z · Cited by 48
“1) as follows: Step 1: Literature collection of types I or II biomass compositions and growth data Successful algal biotechnology mainly depends on choosing the right alga with relevant properties for specific culture conditions and products (Pulz and Gross 2004).”
Background
Algae as a feedstock for bioethanol production: new entrance in biofuel world.
Chaudhary, L. C., Pradhan, P., Soni, N., Singh, P., & Tiwari, A. (2014) · International Journal of ChemTech Research · Cited by 47
Cell Disruption and Pressurized Liquid Extraction of Carotenoids from Microalgae
Taucher, J., & Baer, S. (2016) · Journal of Thermodynamics & Catalysis · doi:10.4172/2157-7544.1000158 · Cited by 48
“Microalgae, including cyanobacteria, play an increasing role in science and industry, due to their wide range of commercial and potential novel products [1-3].”
Background
Hydrothermal Carbonization of Biomass
Titirici, M., Funke, A., & Kruse, A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-444-63289-0.00012-0 · Cited by 50
A multidomain enzyme, with glycerol‐3‐phosphate dehydrogenase and phosphatase activities, is involved in a chloroplastic pathway for glycerol synthesis in Chlamydomonas reinhardtii
Morales‐Sánchez, D., Kim, Y., Terng, E. L., Peterson, L., & Cerutti, H. D. (2017) · The Plant Journal · doi:10.1111/tpj.13530 · Cited by 46
“Microalgae, photosynthetic eukaryotic microorganisms, can convert CO2 to a variety of products, including high value chemicals, pharmaceuticals, and biofuel precursors (Borowitzka, 1998; Pulz and Gross, 2004; Spolaore et al., 2006; Giovanardi et al., 2013).”
Background
Dynamics of lipids and metabolites during the cell cycle of Chlamydomonas reinhardtii
Jüppner, J., Mubeen, U., Andrea Leisse, A., Caldana, C., Brust, H., Steup, M., Herrmann, M., Steinhauser, D., & Giavalisco, P. (2017) · The Plant Journal · doi:10.1111/tpj.13642 · Cited by 47
“Accordingly, numerous research efforts have been made to improve microalgal systems for the production of high-value products (Pulz and Gross, 2004; Spolaore et al., 2006; Georgianna and Mayfield, 2012).”
Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea
Pozharitskaya, O. N., Shikov, A. N., Laakso, I., Seppänen‐Laakso, T., Макаренко, И. Е., Фаустова, Н. М., Макарова, М. Н., & Makarov, V. G. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.030 · Cited by 47
‘Suitability of different photosynthetic organisms for an extraterrestrial biological life support system’.
Lehto, K. M., Lehto, H. J., & Kanervo, E. A. (2006) · Research in Microbiology · doi:10.1016/j.resmic.2005.07.011 · Cited by 43
Heterotrophic and Photoautotrophic Media Optimization Using Response Surface Methodology for the Novel Microalga Chlorococcum amblystomatis
Correia, N., Pereira, H., Schulze, P. S. C., Costa, M. M., Santo, G. E., Guerra, I., Trovão, M., Barros, A. I. R. N. A., Cardoso, H., Silva, J., et al. (2023) · Applied Sciences · doi:10.3390/app13042089 · Cited by 46
Investigating the Effects of Several Parameters on the Growth of Chlorella vulgaris Using Taguchi's Experimental Approach
Barghbani, R., Rezaei, K., & Javanshir, A. (2012) · Cited by 46
Technologies for extracting lipids from oleaginous microorganisms for biodiesel production
Wang, C., Chen, L., Bajpai, R. K., Qin, Y.-H., & Lv, R. (2012) · Frontiers in Energy · doi:10.1007/s11708-012-0193-y · Cited by 46
Microalgae Applications in Wastewater Treatment
Rawat, I., Gupta, S. K., Shriwastav, A., Singh, P., Kumari, S., & Bux, F. (2016) · Green energy and technology · doi:10.1007/978-3-319-12334-9_13 · Cited by 46
Lipid productivity and fatty acid composition in Chlorella and Scenepdesmus strains grown in nitrogen-stressed conditions
Ördög, V., Stirk, W. A., Bálint, P., Lovász, C., Pulz, O., & van Staden, J. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9857-6 · Cited by 49
“The first step in successful microalgae biotechnology depends on choosing the most suitable algae strain with the best characteristics for the culture conditions (Pulz and Gross 2004).”
Background
Microalgae Biodiesel as a Valuable Alternative to Fossil Fuels
Rahpeyma, S. S., & Raheb, J. (2019) · BioEnergy Research · doi:10.1007/s12155-019-10033-6 · Cited by 47
Energy from photobioreactors: Bioencapsulation of photosynthetically active molecules, organelles, and whole cells within biologically inert matrices
Rooke, J. C., Meunier, C., Léonard, A. F., & Su, B. (2008) · Pure and Applied Chemistry · doi:10.1351/pac200880112345 · Cited by 46
Biomass and Extracts of Algae as Material for Cosmetics
Fabrowska, J., Łęska, B., Schroeder, G., Messyasz, B., & Pikosz, M. (2015) · doi:10.1002/9783527679577.ch38 · Cited by 46
Nutritional characterization of traditional and improved dihe, alimentary blue-green algae from the lake Chad region in Africa
Carcea, M., Sorto, M., Batello, C., Narducci, V., Aguzzi, A., Azzini, E., Fantauzzi, P., Finotti, E., Gabrielli, P., Galli, V., et al. (2015) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2014.10.039 · Cited by 45
Impact of harvesting method on total lipid content and extraction efficiency for Phaeodactylum tricornutum
Vandamme, D., Gheysen, L., Muylaert, K., & Foubert, I. (2017) · Separation and Purification Technology · doi:10.1016/j.seppur.2017.10.035 · Cited by 45
Optical trapping of microalgae at 735–1064 nm: Photodamage assessment
Pilát, Z., Ježek, J., Šerý, M., Trtílek, M., Nedbal, L., & Zemánek, P. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.02.006 · Cited by 45
“However, photoautotrophic organisms have lately become a focus of enormous interest because of their ability to utilize solar energy for production of biofuels, high-value compounds and for assimilation of atmospheric CO2 [5,6].”
Background
Heterotrophic Cultivation of Cyanobacteria: Study of Effect of Exogenous Sources of Organic Carbon, Absolute Amount of Nutrients, and Stirring Speed on Biomass and Lipid Productivity
dos Santos, A. M., Vieira, K. R., Sartori, R. B., dos Santos, A. M., Queiroz, M. I., Zepka, L. Q., & Lopes, E. J. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00012 · Cited by 45
“…to agriculture, aquaculture, human and animal nutrition, bulk and fine chemicals, cosmetics, and biofuels (Becker, 1994; de-Bashan et al., 2002; Pulz and Gross, 2004; Harun et al., 2 Meireles dos Santos et al. Heterotrophic Cultivation of Cyanobacteria Frontiers in Bioengineering and…”
Background
Application of phototrophic biofilms: from fundamentals to processes
Strieth, D., Ulber, R., & Muffler, K. (2017) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-017-1870-3 · Cited by 46
Influence of long term nitrogen limitation on lipid, protein and pigment production of Euglena gracilis in photoheterotrophic cultures
Tossavainen, M., Ilyass, U., Ollilainen, V., Valkonen, K., Ojala, A., & Romantschuk, M. (2019) · PeerJ · doi:10.7717/peerj.6624 · Cited by 53
In vitro selenium bioaccessibility combined with in vivo bioavailability and bioactivity in Se-enriched microalga (Chlorella sorokiniana) to be used as functional food
Gómez-Jacinto, V., Navarro, F., Garbayo, I., Vı́lchez, C., Arias‐Borrego, A., & García‐Barrera, T. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103817 · Cited by 45
“…and animals after the consumption of this chlorophyll-containing organism (Becker, 2007), mainly due to the presence of minerals, dietary fiber and a wide range of antioxidants substances (Pulz & Gross, 2004; Spolaore, Joannis-Cassan, Duran, & Isambert, 2006; Stengel, Connan, & Popper, 2011).”
Background
Biotechnology applied to Haematococcus pluvialis Fotow: challenges and prospects for the enhancement of astaxanthin accumulation
Le-Feuvre, R., Moraga-Suazo, P., Gonzalez, J., Martin, S. S., Henríquez, V., Donoso, A., & Agurto-Muñoz, C. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-020-02231-z · Cited by 45
“…acids (PUFAs, like DHA and EPA), proteins, vitamins, polysaccharides, and carotenoids with high biotechnological impact, mainly in food products (Pulz and Gross 2004; Sousa et al. 2008), biodiesel production (Dickinson et al. 2017), bioremediation (Muñoz and Guieysse 2006), and cosmetics…”
Background
Analysis of interspecific variation in relative fatty acid composition: use of flow cytometry to estimate unsaturation index and relative polyunsaturated fatty acid content in microalgae
Mendoza Guzmán, H., de la Jara Valido, A., Carmona Duarte, L., & Freijanes Presmanes, K. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9526-6 · Cited by 44
“Little more than 30 species are currently in production in the aquaculture sector (Wikfors and Ohno 2001; Pulz and Cross 2004).”
Background
Stable transformation of Spirulina (Arthrospira) platensis: A promising microalga for production of edible vaccines
Dehghani, J., Adibkia, K., Movafeghi, A., Barzegari, A., Pourseif, M. M., Maleki Kakelar, H., Golchin, A., & Omidi, Y. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9296-7 · Cited by 43
Surveying techno-economic indicators of microalgae biofuel technologies
Ribeiro, L. A., & Silva, P. P. D. (2013) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2013.03.032 · Cited by 44
Evaluating the effect of various environmental factors on the growth of the marine microalgae, Chlorella vulgaris
Josephine, A., Sivasankarasubbiah, K. T., Surendran, B., Rajakumar, S., Kirubagaran, R., & Dharani, G. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.954622 · Cited by 52
Feedback-controlled LED photobioreactor for photophysiological studies of cyanobacteria
Melnicki, M. R., Pinchuk, G. E., Hill, E. A., Kucek, L. A., Stolyar, S. M., Fredrickson, J. K., Konopka, A. E., & Beliaev, A. S. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.01.079 · Cited by 47
Integration in microalgal bioprocess development: Design of efficient, sustainable, and economic processes
Fresewinkel, M., Rosello, R., Wilhelm, C., Kruse, O., Hankamer, B. D., & Posten, C. H. (2014) · Engineering in Life Sciences · doi:10.1002/elsc.201300153 · Cited by 46
A comparative analysis of lipid and carotenoid composition of the gonads of Anthocidaris crassispina, Diadema setosum and Salmacis sphaeroides
Chen, G., Xiang, W.-Z., Lau, C.-C., Peng, J., Qiu, J., Chen, F., & Jiang, Y. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.11.034 · Cited by 44
Quantification and characterisation of fatty acid methyl esters in microalgae: Comparison of pretreatment and purification methods
Lage, S., & Gentili, F. G. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.01.153 · Cited by 43
Co-cultivation of fungal-microalgal strains in biogas slurry and biogas purification under different initial CO2 concentrations
Zhou, K., Zhang, Y., & Jia, X. (2018) · Scientific Reports · doi:10.1038/s41598-018-26141-w · Cited by 44
Microalgae in Biotechnological Application: A Commercial Approach
Khatoon, N., & Pal, R. (2015) · Springer eBooks · doi:10.1007/978-81-322-2283-5_2 · Cited by 47
“7 Present state of microalgal production (Pulz and Gross 2004 ; Ratledge 2004 ; Hejazi 2004)”
Background
Algal Photosynthesis as the Primary Driver for a Sustainable Development in Energy, Feed, and Food Production
Anemaet, I. G., Bekker, M., & Hellingwerf, K. J. (2010) · Marine Biotechnology · doi:10.1007/s10126-010-9311-1 · Cited by 48
“In 2004, the worldwide annual production of algal biomass was estimated to be 5,000 t of dry biomass (Pulz and Gross 2004).”
Characterization of marine diatom-infecting virus promoters in the model diatom Phaeodactylum tricornutum
Kadono, T., Miyagawa‐Yamaguchi, A., Kira, N., Tomaru, Y., Okami, T., Yoshimatsu, T., Hou, L., Ohama, T., Fukunaga, K., Okauchi, M., et al. (2015) · Scientific Reports · doi:10.1038/srep18708 · Cited by 44
Latest avenues and approaches for biohydrogen generation from algal towards sustainable energy optimization: Recent innovations, artificial intelligence, challenges, and future perspectives
Zhang, G., Liu, J., Pan, X., Abed, A. M., Le, B. N., Ali, H. E., & Ge, Y. (2023) · International Journal of Hydrogen Energy · doi:10.1016/j.ijhydene.2022.10.224 · Cited by 43
Algal Lipids as Modulators of Skin Disease: A Critical Review
Conde, T., Lopes, D., Łuczaj, W., Neves, B. M., Pinto, B., Maurício, T., Domingues, P. M., Skrzydlewska, E., & Domingues, M. R. (2022) · Metabolites · doi:10.3390/metabo12020096 · Cited by 45
“, docosahexaenoic acid, DHA) in skin products [14].”
Background
Assessment of Antioxidant and Anticancer Activities of Microgreen Alga Chlorella vulgaris and Its Blend with Different Vitamins
Hamouda, R. A., Latif, A. A. E., Elkaw, E. M., Alotaibi, A. S., Alenzi, A. M., & Hamza, H. A. (2022) · Molecules · doi:10.3390/molecules27051602 · Cited by 43
“It is widely used in popular food additives and it is considered a potential source for healthy food in many countries and is effective in improving overall health and well-being [13,14].”
Background
Managing carbon dioxide mass transfer in photobioreactors for enhancing microalgal biomass productivity
Hajinajaf, N., Fallahi, A., Eustance, E., Sarnaik, A. P., Askari, A., Najafi, M., Davis, R. W., Rittmann, B. E., & Varman, A. M. (2024) · Algal Research · doi:10.1016/j.algal.2024.103506 · Cited by 45
The microalgal sector in Europe: Towards a sustainable bioeconomy
Gallego, I., Medić, N., Pedersen, J. S., Ramasamy, P. K., Robbens, J., Vereecke, E., & Romeis, J. (2025) · New Biotechnology · doi:10.1016/j.nbt.2025.01.002 · Cited by 48
Magnetically modified microalgae and their applications
Šafařı́k, I., Prochazková, G., Pospíšková, K., & Brányik, T. (2015) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2015.1064085 · Cited by 43
“Microalgae are also an essential part in many environmental applications where they can act as biofertilizers/soil N2-fixators (Pulz & Gross, 2004), biocatalysts in bioaccumulation and biodegradation of organic pollutants (Semple et al., 1999), materials for wastewater treatment (Abdel-Raouf et…”
Background
Development of a New Method for Genetic Transformation of the Green Alga Chlorella ellipsoidea
Liu, L., Wang, Y., Zhang, Y., Chen, X., Zhang, P., & Ma, S. (2012) · Molecular Biotechnology · doi:10.1007/s12033-012-9554-3 · Cited by 43
Effect of Sea Tangle (Laminaria japonica) and Charcoal Supplementation as Alternatives to Antibiotics on Growth Performance and Meat Quality of Ducks
Islam, M. M., Ahmed, S. T., Kim, Y. J., Mun, H., Kim, Y. J., & Yang, C. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13314 · Cited by 43
“5C, and thiobarbituric acid reactive substances (TBARS) of meat were assayed for fresh meat as well as on day 7 according to the method of Sarker and Yang (2011). TBARS values were expressed as micromoles of malondialdehyde (MDA) per 100 g of meat sample.”
Method
Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research
Castro, M., Preto, M., Vasconcelos, V. M., & Urbatzka, R. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160415155644 · Cited by 44
“Some strains of cyanobacteria are commercially available for consumption due to their beneficial properties to human health, e.g. Arthrospira, Nostoc and Aphanizomenon [146].”
An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity
Somasekharan, S. P., El-Naggar, A. M., Sorensen, P. H. B., Wang, Y. Z., & Cheng, H. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/9730654 · Cited by 43
“Among the marine plants, marine algae (phytoplankton) constitute a substantial part of the ocean flora as the largest body for oxygen production and form the basis of the marine food chain [7].”
Background
Transcriptome analysis of the cyanobacterium Synechocystis sp. PCC 6803 and mechanisms of photoinhibition tolerance under extreme high light conditions
Ogawa, K., Yoshikawa, K., Matsuda, F., Toya, Y., & Shimizu, H. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2018.05.015 · Cited by 42
The Biotechnology of Cyanobacteria
Grewe, C. B., & Pulz, O. (2012) · Springer eBooks · doi:10.1007/978-94-007-3855-3_26 · Cited by 46
Algal Biomass: Potential Renewable Feedstock for Biofuels Production – Part I
Agrawal, K., Bhatt, A., Bhardwaj, N., Kumar, B., & Verma, P. (2020) · Clean Energy Production Technologies · doi:10.1007/978-981-13-8637-4_8 · Cited by 42
Life cycle costs for the optimized production of hydrogen and biogas from microalgae
Meyer, M. A., & Weiß, A. (2014) · Energy · doi:10.1016/j.energy.2014.08.069 · Cited by 42
Enhancement of protein production by microalgae Dunaliella salina under mixotrophic conditions using response surface methodology
Kadkhodaei, S., Abbasiliasi, S., Shun, T., Masoumi, H. R. F., Mohamed, M. S., Movahedi, A., Rahim, R. A., & Ariff, A. (2015) · RSC Advances · doi:10.1039/c5ra04546k · Cited by 42
Growth, morphology and photosynthetic responses of Neochloris oleoabundans during cultivation in a mixotrophic brackish medium and subsequent starvation
Baldisserotto, C., Giovanardi, M., Ferroni, L., & Pancaldi, S. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1426-3 · Cited by 42
Potential of spectroscopic techniques and chemometric analysis for rapid measurement of docosahexaenoic acid and eicosapentaenoic acid in algal oil
Wu, D., & He, Y. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.02.109 · Cited by 42
Optimization of biomass production in outdoor tubular photobioreactors
de Andrade, G. A., Berenguel, M., Guzmán, J. L., Pagano, D. J., & Acién, F. G. (2015) · Journal of Process Control · doi:10.1016/j.jprocont.2015.10.001 · Cited by 42
Using spray-dried microalgae as a natural coloring agent in chewing gum: effects on color, sensory, and textural properties
Palabıyık, İ., Durmaz, Y., Öner, B., Toker, Ö. S., Çoksarı, G., Konar, N., & Tamtürk, F. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1324-y · Cited by 44
“Eicosapentaenoic acid (EPA, 20:5(n–3)) and docosahexaenoic acid (DHA, 22:6(n–3)) have also been reported to have beneficial effects such as reducing coronary heart disease risk and blood cholesterol, thus reducing the risk of arteriosclerosis, inflammation and several carcinomas (Gizberg et al. 2000; Guil-Guerrero et…”
Background
Effect of ammonium and high light intensity on the accumulation of lipids in Nannochloropsis oceanica (CCAP 849/10) and Phaeodactylum tricornutum (CCAP 1055/1)
Huete‐Ortega, M., Okurowska, K., Kapoore, R. V., Johnson, M. P., Gilmour, D. J., & Vaidyanathan, S. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1061-8 · Cited by 42
Promotion of microalgal biomass production and efficient use of CO2 from flue gas by monoethanolamine
Sun, Z., Zhang, D., Yan, C., Cong, W., & Lu, Y. (2014) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4367 · Cited by 42

Authors: Pulz, O., & Gross, W.
Affiliations: Institut für Getreideverarbeitung (Germany) (DE)
Freie Universität Berlin (DE)
Corresponding author: Pulz, Otto
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-08-06
Volume: 65
Issue: 6
Pages: 635-648
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-004-1647-x
OpenAlex: W2044809902
Cited by: 2,132
References: 40
Citations by year: 2026: 56 · 2025: 82 · 2024: 119 · 2023: 104 · 2022: 109 · 2021: 150 · 2020: 169 · 2019: 152 · 2018: 124 · 2017: 127 · 2016: 134 · 2015: 162 · 2014: 152 · 2013: 132 · 2012: 107
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: microalgae, microalgal biotechnology, microalgal biomass, food and feed, genetic engineering of microalgae, pharmaceutical applications, ecological applications, screening method
MeSH terms: Biotechnology, Drug Industry, Food Industry, Eukaryota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Valuable products from biotechnology of microalgae

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks