Cited by 2,132Algal biology and biofuel productionSeaweed-derived Bioactive CompoundsMicrobial Metabolic Engineering and Bioproduction

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Valuable products from biotechnology of microalgae

Pulz, Otto, Gross, Wolfgang·2004·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-004-1647-x

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Abstract

The biotechnology of microalgae has gained considerable importance in recent decades. Applications range from simple biomass production for food and feed to valuable products for ecological applications. For most of these applications, the market is still developing and the biotechnological use of microalgae will extend into new areas. Considering the enormous biodiversity of microalgae and recent developments in genetic engineering, this group of organisms represents one of the most promising sources for new products and applications. With the development of sophisticated culture and screening techniques, microalgal biotechnology can already meet the high demands of both the food and pharmaceutical industries.

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“Recent studies have shown that cyanobacteria, such as Arthrospira platensis (Nordstedt) Gomont, also positively influence the physiology of animals, improving their immune response and fertility and maintaining better weight control when incorporated in the feed [22,23].”
Result
Comparison of two different pneumatically mixed column photobioreactors for the cultivation of Artrospira platensis (Spirulina platensis)
Öncel, S. Ş., & Sukan, F. V. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.09.068 · Cited by 80
Variation of lipid class composition in Nitzschia laevis as a response to growth temperature change
Chen, G., Jiang, Y., & Chen, F. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.12.022 · Cited by 74
Optimizing conditions for the continuous culture of Isochrysis affinis galbana relevant to commercial hatcheries
Marchetti, J., Bougaran, G., Déan, L. L., Mégrier, C., Lukomska, E., Kaas, R., Olivo, E. A. J., Baron, R., Robert, R., & Cadoret, J. (2011) · Aquaculture · doi:10.1016/j.aquaculture.2011.11.020 · Cited by 74
“Due to their biodiversity, microalgae have many potential application, particularly in the areas of pharmaceuticals, cosmetics and energy (Pulz and Gross, 2004; Spolaore et al., 2006; Rosenberg et al., 2008).”
Background
Effects of magnetic field on the antioxidant defense system of recirculation‐cultured Chlorella vulgaris
Wang, H., Zeng, X., Guo, S., & Li, Z. (2007) · Bioelectromagnetics · doi:10.1002/bem.20360 · Cited by 74
“Biomass of C. vulgaris provided by industrial cultivation has been consumed as health food for years [Kittaka-Katsura et al., 2002; Pulz and Gross, 2004].”
Method
Effects of light and nitrogen availability on photosynthetic efficiency and fatty acid content of three original benthic diatom strains
Cointet, E., Wielgosz‐Collin, G., Bougaran, G., Rabesaotra, V., Gonçalves, O., & Méléder, V. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224701 · Cited by 78
“rheumatism, skin diseases, and inflammation of the mucosa of the gastrointestinal tract) [9].”
Background
Microalgae cultivation in raceway ponds: advances, challenges, and hydrodynamic considerations
Skifa, I., Chauchat, N., Cocquet, P.-H., & Guer, Y. L. (2025) · EFB Bioeconomy Journal · doi:10.1016/j.bioeco.2024.100073 · Cited by 73
Pigments from microalgae
Pagels, F., Salvaterra, D., Amaro, H. M., & Guedes, A. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818536-0.00018-x · Cited by 80
Microalgae: A green eco-friendly agents for bioremediation of tannery wastewater with simultaneous production of value-added products
Devi, A., Verma, M., Saratale, G. D., Saratale, R. G., Ferreira, L. F. R., Mulla, S. I., & Bharagava, R. N. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139192 · Cited by 77
Composition of carotenoids and identification of aerial microalgae isolated from the surface of rocks in mountainous districts of Japan
Aburai, N., Ohkubo, S., Miyashita, H., & Abe, K. (2013) · Algal Research · doi:10.1016/j.algal.2013.03.001 · Cited by 73
A novel photobioreactor with transparent rectangular chambers for cultivation of microalgae
Hsieh, C.-H., & Wu, W. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.06.004 · Cited by 73
Pão Sem Glúten Enriquecido Com a Microalga Spirulina platensis
Silva FIGUEIRA, F. D., Moraes CRIZEL, T. D., Rubira SILVA, C., & las Mercedes SALAS-MELLADO, M. D. (2011) · Brazilian Journal of Food Technology · doi:10.4260/bjft2011140400037 · Cited by 71
Screening of microalgae and cyanobacteria strains for α-tocopherol content at different growth phases and the influence of nitrate reduction on α-tocopherol production
Mudimu, O., Koopmann, I. K., Rybalka, N., Friedl, T., Schulz, R., & Bilger, W. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1188-1 · Cited by 72
The colors of biotechnology: general overview and developments of white, green and blue areas
Barcelos, M. C. S., Lupki, F. B., Campolina, G. A., Nelson, D. L., & Molina, G. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny239 · Cited by 72
Pharmaceutical aptitude of Cladophora: A comprehensive review
Munir, M., Qureshi, R., Bibi, M., & Khan, A. M. (2019) · Algal Research · doi:10.1016/j.algal.2019.101476 · Cited by 78
Salinity tolerance of four freshwater microalgal species and the effects of salinity and nutrient limitation on biochemical profiles
von Alvensleben, N., Magnusson, M. E., & Heimann, K. (2015) · Journal of Applied Phycology · doi:10.1007/s10811-015-0666-6 · Cited by 74
“In parallel, the resulting biomass can be used for production of commodities and high-value compounds such as protein or fatty acids (Mata et al. 2010; Pulz and Gross 2004; Stephens et al. 2010).”
Background
Development of a process for efficient use of CO 2 from flue gases in the production of photosynthetic microorganisms
González–López, C. V., Acién, F. G., Fernández-Sevilla, J. M., Fernández, J. F. S., & Grima, E. M. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24446 · Cited by 71
“This organic matter can be afterwards transformed into more valuable products such as bioethanol, biodiesel, hydrogen, aminoacids, etc. (Pulz and Gross, 2004; Skjånes et al., 2007).”
Background
Microalgae cultivation in urban wastewater: Coelastrum cf. pseudomicroporum as a novel carotenoid source and a potential microalgae harvesting tool
Úbeda, B., Gálvez, J. A., Michel-Rodriguez, M., & Bartual, A. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.12.095 · Cited by 71
“Their large variety makes this group a potentially rich source of a vast array of chemical products, representing one of the most promising sources for new bioactive molecules and applications (Olaizola, 2003; Pulz and Gross, 2004).”
Background
Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea
Pereira, H., Custódio, L. M. B., Rodrigues, M. J., de Sousa, C. B., Oliveira, M., Barreira, L. A., Neng, N. R., Nogueira, J. M. F., Alrokayan, S., Mouffouk, F., et al. (2015) · Marine Drugs · doi:10.3390/md13063531 · Cited by 72
“specific compounds [5].”
Recent advances in the integrated biorefinery concept for the valorization of algal biomass through sustainable routes
Katiyar, R., Banerjee, S., & Arora, A. (2021) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.2187 · Cited by 71
Advances in microalgal culture for aquaculture feed and other uses
Tredici, M. R., Biondi, N., Ponis, E., Rodolfi, L., & Zittelli, G. C. (2009) · Elsevier eBooks · doi:10.1533/9781845696474.3.610 · Cited by 75
Estimation of CO2 stripping/CO2 microalgae consumption ratios in a bubble column photobioreactor using the analysis of the pH profiles. Application to Nannochloropsis oculata microalgae culture
Valdés, F., Hernández, M. R., Catalá, L., & Marcilla, A. F. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.05.120 · Cited by 70
“…important source of many products, such as aquaculture feeds, human food supplements, and pharmaceuticals (Apt and Behrens, 1999; Borowitzka, 1995; Pulz and Gross, 2004; Rebolloso et al., 2001), and they have also been suggested as a very good candidate for fuel production (Schenk et al., 2008;…”
Background
UV radiation-induced accumulation of photoprotective compounds in the green alga Tetraspora sp. CU2551
Rastogi, R. P., & Incharoensakdi, A. (2013) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2013.04.021 · Cited by 70
A droplet microfluidics platform for rapid microalgal growth and oil production analysis
Kim, H. S., Guzman, A. R., Thapa, H. R., Devarenne, T. P., & Han, A. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.25930 · Cited by 70
“Microalgae are considered a promising future renewable source of chemicals as they can utilize sunlight and atmospheric CO2 to produce a variety of biomolecules, including a wide range of oil types for biofuel feedstocks (Chisti, 2007, 2013; Georgianna and Mayfield, 2012; Mata et al., 2010; Pulz and Gross, 2004; Scott…”
Background
Biotechnological production of value-added carotenoids from microalgae: Emerging technology and prospects
Wichuk, K., Brynjólfsson, S., & Fu, W. (2014) · Bioengineered · doi:10.4161/bioe.28720 · Cited by 70
Microbial fuel cells (MFC) and microalgae; photo microbial fuel cell (PMFC) as complete recycling machines
Greenman, J., Gajda, I., & Ieropoulos, I. A. (2019) · Sustainable Energy & Fuels · doi:10.1039/c9se00354a · Cited by 70
Pharmacognostical Botany: Classification of Medicinal and Aromatic Plants (MAPs), Botanical Taxonomy, Morphology, and Anatomy of Drug Plants
Alamgir, A. N. M. (2017) · Progress in drug research · doi:10.1007/978-3-319-63862-1_6 · Cited by 75
Improved DNA/protein delivery in microalgae – A simple and reliable method for the prediction of optimal electroporation settings
Muñoz, C. F., de Jaeger, L., Sturme, M. H. J., Lip, K. Y. F., Olijslager, J. W. J., Springer, J., Wolbert, E. J. H., Martens, D. E., Eggink, G., Weusthuis, R. A., et al. (2018) · Algal Research · doi:10.1016/j.algal.2018.06.021 · Cited by 69
Chlorella vulgaris extract ameliorates carbon tetrachloride-induced acute hepatic injury in mice
Li, L., Li, W., Kim, Y. H., & Lee, Y. W. (2011) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2011.06.003 · Cited by 69
Biotechnological Screening of Microalgal and Cyanobacterial Strains for Biogas Production and Antibacterial and Antifungal Effects
Mudimu, O., Rybalka, N., Bauersachs, T., Born, J., Friedl, T., & Schulz, R. (2014) · Metabolites · doi:10.3390/metabo4020373 · Cited by 68
“Microalgae and cyanobacteria offer numerous advantages for such investigations because of their enormous biodiversity, fast growth rate [19] and occurring in a variety of habitats [20–23].”
Background
Effect of different media on exopolysaccharide and biomass production by the green microalga Botryococcus braunii
Bayona, K. C. D., & Atehortúa, L. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0242-5 · Cited by 69
“, biofuels production), other metabolites from this microalga should be also commercially exploited (Cardozo et al. 2007; Pulz and Gross 2004; Ranga Rao et al. 2006; Mata et al. 2010; Yen et al. 2013).”
Background
High-Value Coproducts from Algae—An Innovational Way to Deal with Advance Algal Industry
Mehta, P., Singh, D., Saxena, R., Rani, R., Gupta, R. P., Puri, S. K., & Mathur, A. S. (2017) · Energy, environment, and sustainability · doi:10.1007/978-981-10-7431-8_15 · Cited by 71
Enhanced biogas production of red microalgae via enzymatic pretreatment and preliminary economic assessment
Cakmak, E. K., & Uğurlu, A. (2020) · Algal Research · doi:10.1016/j.algal.2020.101979 · Cited by 73
Plant-cyanobacteria interactions: Beneficial and harmful effects of cyanobacterial bioactive compounds on soil-plant systems and subsequent risk to animal and human health
Nowruzi, B., Bouaı̈cha, N., Metcalf, J. S., Porzani, S. J., & Konur, O. (2021) · Phytochemistry · doi:10.1016/j.phytochem.2021.112959 · Cited by 66
Bioactive Molecules from Marine Diatoms and Their Value for the Nutraceutical Industry
Nieri, P., Carpi, S., Esposito, R., Costantini, M., & Zupo, V. (2023) · Nutrients · doi:10.3390/nu15020464 · Cited by 72
“In fact, in many countries, food companies have already started to market functional foods containing microalgae and cyanobacteria [16,17].”
Background
Adhesion of Chlorella vulgaris to solid surfaces, as mediated by physicochemical interactions
Širmerová, M., Prochazková, G., Siristova, L., Kolská, Z., & Brányik, T. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-0015-6 · Cited by 68
“Due to the wide range of biotechnological applications of microalgae (Pulz and Gross 2004; Raja et al. 2008), the methods of their culturing and processing are receiving particular attention.”
Background
A low-cost culture medium for the production of Nannochloropsis gaditana biomass optimized for aquaculture
Camacho-Rodríguez, J., Cerón-García, M. C., González–López, C. V., Fernández-Sevilla, J. M., Contreras‐Gómez, A., & Grima, E. M. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.06.083 · Cited by 71
“The most common species are Nannochloropsis, Isochrysis, Scenedesmus, Dunaliella, Spirulina, 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 4 Phaeodactylum, Pavlova, Tetraselmis, Skel…”
A flow-lane incubator for studying freshwater and marine phototrophic biofilms
Zippel, B., Rijstenbil, J. W., & Neu, T. R. (2007) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2007.05.013 · Cited by 68
“Phototrophic organisms like microalgae have an interesting and yet not fully realized potential for biotechnological exploitation (Csögör et al., 2001; Pulz and Gross, 2004).”
Background
Algal bioactive compounds in the cosmeceutical industry: a review
Jahan, A., Ahmad, I. Z., Fatima, N., Ansari, V. A., & Akhtar, J. (2017) · Phycologia · doi:10.2216/15.58.1 · Cited by 68
“Tocopherols are the products of microalgal biotechnology and different compositions and concentrations of tocopherols have been reported in marine microalgae Nannochloropsis oculata and Tetraselmis suecica (Kylin) Butcher (Pulz & Gross 2004; O’Sullivan et al. 2011; Bong & Loh 2013).”
Background

Authors: Pulz, O., & Gross, W.
Affiliations: Institut für Getreideverarbeitung (Germany) (DE)
Freie Universität Berlin (DE)
Corresponding author: Pulz, Otto
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-08-06
Volume: 65
Issue: 6
Pages: 635-648
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-004-1647-x
OpenAlex: W2044809902
Cited by: 2,132
References: 40
Citations by year: 2026: 56 · 2025: 82 · 2024: 119 · 2023: 104 · 2022: 109 · 2021: 150 · 2020: 169 · 2019: 152 · 2018: 124 · 2017: 127 · 2016: 134 · 2015: 162 · 2014: 152 · 2013: 132 · 2012: 107
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: microalgae, microalgal biotechnology, microalgal biomass, food and feed, genetic engineering of microalgae, pharmaceutical applications, ecological applications, screening method
MeSH terms: Biotechnology, Drug Industry, Food Industry, Eukaryota

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