The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Valuable products from biotechnology of microalgae
Abstract
The biotechnology of microalgae has gained considerable importance in recent decades. Applications range from simple biomass production for food and feed to valuable products for ecological applications. For most of these applications, the market is still developing and the biotechnological use of microalgae will extend into new areas. Considering the enormous biodiversity of microalgae and recent developments in genetic engineering, this group of organisms represents one of the most promising sources for new products and applications. With the development of sophisticated culture and screening techniques, microalgal biotechnology can already meet the high demands of both the food and pharmaceutical industries.
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“Due to their simple cultivation with high protein content and nutritional value, Chlorella and Arthrospira platensis are at the forefront of the microalgal market [63,78].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [63]
In the citing paper
“Algae are produced in quantity and sold directly as food and nutrient supplements, while their processed products or extracts are used in biopharmaceuticals and cosmetics [5–7].”
In the citing paper
“The world energy crisis in the 1970s led to the identification of algae as renewable and sustainable sources for biofuels production, prompting the exploration of microalgae as a new field of research for fuels and other valuable products [10, 140].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [140]
In the citing paper
“According to one estimate, about 5000 metric tons of dry algal biomass processed for bioproducts generates US$ 1.25 × 109 each year [140].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [140]
Citations
Cites
Rogers, L. J. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80268-0 · Cited by 1,289
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190
Modern approach to the classification system of Cyanophytes 4-Nostocales
Komárek, J., & Anagnostidis, K. (1989) · Cited by 1,152
Photobioreactors: Production systems for phototrophic microorganisms
O., P. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100702 · Cited by 987
Manual on the production and use of live food for aquaculture
Lavens, P., & Sorgeloos, P. (1996) · Medical Entomology and Zoology · Cited by 986
Handbook of Microalgal Culture: Biotechnology and Applied Phycology
(2003) · doi:10.1002/9780470995280 · Cited by 886
Biodiversity and application of microalgae
Metting, F. B. (1996) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/bf01574779 · Cited by 600
Borowitzka, M. A., & Borowitzka, L. J. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839162473 · Cited by 568
Microalgae as sources of pharmaceuticals and other biologically active compounds
Borowitzka, M. A. (1995) · Journal of Applied Phycology · doi:10.1007/bf00003544 · Cited by 520
Microalgae for aquaculture: Opportunities and constraints
Borowitzka, M. A. (1997) · Journal of Applied Phycology · doi:10.1023/a:1007921728300 · Cited by 478
Research works printed but not linked: 18
- Anagnostidis K, Komárek JA (1985) Modern approach to the classification system of cyanophytes 1?introduction. Arch Hydrobiol Suppl 71:291?302
- Anagnostidis K, Komárek JA (1988) Modern approach to the classification systems of cyanophytes 3?oscillatorales. Arch Hydrobiol Suppl 80:327?472
- De Pauw N, Persoone G (1988) Micro-algae for aquaculture, micro-algal biotechnology. In: Borowitzka MA, Borowitzka LJ (eds) Cambridge University Press, Cambridge, pp 197?221
- Gimmler H, Degenhardt B (2001) In: Rai LC, Gaur JP (eds) Alkaliphilic and alkali-tolerant algae, algal adaptation to environmental stresses. Springer, Berlin Heidelberg New York
- Gross W, Schnarrenberger C (1995) Heterotrophic growth of two strains of the acidothermophilic red alga Galderia sulphuria. Plant Cell Physiol 4:633?638
- Komárek JA, Anagnostidis K (1986) Modern approach to the classification systems of cyanophytes 2-Chroococales. Arch Hydrobiol Suppl 73:157?226
- Kretschmer P, Pulz O, Gudin C, Semenenko V (1995). Biotechnology of Microalgae. (Proceedings of the second European workshop) IGV Institute for Cereal Processing, Potsdam-Rehbrücke
- Laing I, Ayala F (1990) In: Akatsuka I (ed) Commercial mass culture techniques for producing microalgae, introduction to applied phycology. SPB, The Hague, pp 447?477
- Muller-Feuga A, Moal J, Kaas R (2003) The microalgae for aquaculture. In: Stottrup JG, McEvoy LA (eds) Life feeds in marine aquaculture. Blackwell, Oxford
- Musafarov AM, Taubayev TT (1974). Chlorella (in Russian). FAN, Tashkent
- New MB (1999) Global aquaculture: current trends and challenges for 21st century. World Aquacult 3:8?14
- Ördög V, Szigeti J, Pulz O (1996). Proceedings of the conference on progress in plant sciences from plant breeding to growth regulation. Pannon University, Mosonmagyarovar
- Piccardi R, Materassi R, Tredici M (1999) Algae and human affairs in the 21st century. (Abstr Int Conf Appl Algol) Universita degli Studi di Firenze, Firenze
- Richmond A (2004) Handbook of microalgal culture. Blackwell, Oxford
- Schreckenbach K, Thürmer C, Loest K, Träger G, Hahlweg R (2001) Der Einfluss von Mikroalgen (Spirulina platensis) in Trockenmischfutter auf Karpfen (Cyprinus carpio). Fischer Teichwirt 1:10?13
- Sivonen K, Jones G (1999) Cyanobacterial toxins. In: Chorus I, Bertram J (eds) Toxic cyanobacteria in water: a guide to public health significance, monitoring and management. Spon, London, pp 41?111
- Spektorova L, Creswell RL, Vaughan D (1997) Closed tubular cultivators. World Aquacult 6:39?43
- Weber M, Grimmer A (2001) Lohnt sich der Einsatz von Grünalgen im Ferkelfutter? Landwirtsch Wochenbl Rheinland 2001:34
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Huerlimann, R., & Heimann, K. (2012) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2012.668671 · Cited by 115
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BackgroundKalra, R., Gaur, S., & Goel, M. (2021) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2020.101794 · Cited by 140
Sustainable production of biologically active molecules of marine based origin
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“The high initial investment and operating costs of enclosed photobioreactors present the greatest barrier to the development of phototrophic cultivation systems [3].”
BackgroundMontemezzani, V., Duggan, I. C., Hogg, I. D., & Craggs, R. J. (2015) · Algal Research · doi:10.1016/j.algal.2015.06.024 · Cited by 114
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Tan, I. S., Lam, M. K., Foo, H. C. Y., Lim, S., & Lee, K. T. (2019) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2019.05.012 · Cited by 118
Li, S., Ji, L., Shi, Q., Wu, H., & Fan, J. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122048 · Cited by 120
Li, S., Zhao, S., Yan, S., Qiu, Y., Song, C., Li, Y., & Kitamura, Y. (2019) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2019.03.028 · Cited by 115
Lomartire, S., Cotas, J., Pacheco, D., Marques, J. C., Pereira, L., & Gonçalves, A. M. M. (2021) · Marine Drugs · doi:10.3390/md19050245 · Cited by 122
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BackgroundWondraczek, L., Tyystjärvi, E., Méndez‐Ramos, J., Müller, F. A., & Zhang, Q. (2015) · Advanced Science · doi:10.1002/advs.201500218 · Cited by 113
Henríquez, V., Escobar, C., Galarza, J. I., & Gimpel, J. A. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-39126-7_8 · Cited by 112
Perspectives on Future Protein Production
Colgrave, M. L., Dominik, S., Tobin, A. B., Stockmann, R., Simon, C. J., Howitt, C. A., Belobrajdic, D. P., Paull, C., & Vanhercke, T. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05989 · Cited by 123
“27 Other components, such as polyphenols (e.g., catechins, fl avonols, and phlorotannins) can also impart bitter fl avors and, although undesirable, can impart health bene fi ts.”
Tallentire, C. W., Mackenzie, S. G., & Kyriazakis, I. (2018) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.03.212 · Cited by 112
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BackgroundTaelman, S. E., Meester, S. D., van Dijk, W., da Silva, V., & Dewulf, J. P. (2015) · Resources Conservation and Recycling · doi:10.1016/j.resconrec.2015.05.013 · Cited by 123
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Salih, F. M. (2011) · Journal of Environmental Protection · doi:10.4236/jep.2011.25074 · Cited by 115
“oxygen renewal along with the recycling of carbon into potentially beneficial biomass [3,4].”
BackgroundAustic, R. E., Mustafa, A., Jung, B., Gatrell, S. K., & Lei, X. G. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf401957z · Cited by 110
Ramos, A., Polle, J. E. W., Tran, D., Cushman, J. C., Jin, E., & Varela, J. C. S. (2011) · ALGAE · doi:10.4490/algae.2011.26.1.003 · Cited by 116
“…as bioreactors have been reviewed extensively (Chapin 1991, Dunahay et al. 1996, Geng et al. 2003, Hejazi and Wijffels 2004, León-Bañares et al. 2004, Pulz and Gross 2004, Rochaix 2004, Walker et al. 2005c, Chisti 2008, Raja et al. 2008, Rosenberg et al. 2008, Wijffels 2008, Potvin and Zhang 2010).”
BackgroundOptimization of culture conditions and comparison of biomass productivity of three green algae
Kim, W., Park, J. M., Gim, G. H., Jeong, S.-H., Kang, C. M., Kim, D., & Kim, S. W. (2011) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-011-0612-1 · Cited by 110
“antioxidants, medicine and healthy food [5].”
Morris, H. J., Carrillo-Farnés, O., Almarales, Á., Bermúdez, R. C., Lebeque, Y., Fontaine, R., Maury, G. L., & Beltrán, Y. (2006) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2006.07.021 · Cited by 109
Microalgae for the prevention of cardiovascular disease and stroke
Raposo, M. F. D. J., & Morais, A. M. M. B. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.09.018 · Cited by 111
Rahaman, M. S. A., Cheng, L.-H., Xu, X., Zhang, L., & Chen, H.-L. (2011) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2011.07.031 · Cited by 117
Abomohra, A., El-Sheekh, M. M., & Hanelt, D. (2014) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2014.03.049 · Cited by 107
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Arenas, E., Rodríguez-Palacio, M. C., Juantorena, A. U., Santis-Espinosa, L. F., & Sebastian, P. J. (2016) · International Journal of Energy Research · doi:10.1002/er.3663 · Cited by 116
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BackgroundHamidi, M., Kozani, P. S., Kozani, P. S., Pierre, G., Michaud, P., & Delattre, C. (2019) · Marine Drugs · doi:10.3390/md18010028 · Cited by 110
Das, S., Das, S., Das, I., & Ghangrekar, M. M. (2019) · Materials Science for Energy Technologies · doi:10.1016/j.mset.2019.08.003 · Cited by 106
Wu, C., Xiong, W., Dai, J., & Wu, Q. (2015) · Plant Physiology · doi:10.1104/pp.114.250688 · Cited by 108
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BackgroundKhatoon, H., Leong, L. K., Rahman, N. A., Mian, S., Begum, H., Banerjee, S., & Endut, A. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.10.052 · Cited by 109
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Zhang, S., Merino, N., Okamoto, A., & Gedalanga, P. B. (2018) · Microbial Biotechnology · doi:10.1111/1751-7915.13300 · Cited by 115
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BackgroundApplications of microalgal paste and powder as food and feed: An update using text mining tool
Raja, R., Coelho, A., Hemaiswarya, S., Kumar, P., Carvalho, I. S., & Arun, A. (2018) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1016/j.bjbas.2018.10.004 · Cited by 109
Chen, G., Jiang, Y., & Chen, F. (2008) · Journal of Phycology · doi:10.1111/j.1529-8817.2008.00565.x · Cited by 105
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BackgroundAlgae for Aquaculture and Animal Feeds
Shields, R., & Lupatsch, I. (2012) · TATuP Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis · doi:10.14512/tatup.21.1.23 · Cited by 104
Yamada, K., Suzuki, H., Takeuchi, T., Kazama, Y., Mitra, S., Abe, T., Goda, K., Suzuki, K., & Iwata, O. (2016) · Scientific Reports · doi:10.1038/srep26327 · Cited by 103
Tibbetts, S. M., Mann, J., & Dumas, A. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.08.018 · Cited by 105
“80 Annual production of Chlorella remains small (~2,000 t) and this is related to high production costs 81 and technological challenges associated with current cultivation systems (Brennan and Owende 2010; Liu 82 and Hu 2013; Priyadarshani and Rath 2012; Pulz and Gross 2004; Walker 2009).”
BackgroundRasheed, R. N., Pourbakhtiar, A., Allaf, M. M., Baharlooeian, M., Rafiei, N., Aratboni, H. A., Morones‐Ramírez, J. R., & Winck, F. V. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1193424 · Cited by 114
“, 2019), as well as biodegradable plastics, bioflocculants, bioactive compounds, cosmetics, and polysaccharides (Olaizola, 2003; Pulz and Gross, 2004).”
Abdelaziz, A. E. M., Leite, G. B., & Hallenbeck, P. C. (2013) · Environmental Technology · doi:10.1080/09593330.2013.831487 · Cited by 107
“), nutritional products, organic fertilizers, biodegradable plastics, medicines and animal feed.[135,136] Algal biomass can be processed in different ways to yield biofuels or biofuel-related products either by using the whole algal biomass, algal biomass extracts or the wastes after extraction.”
BackgroundZhang, X., Rong, J., Chen, H., He, C., & Wang, Q. (2014) · Frontiers in Energy Research · doi:10.3389/fenrg.2014.00032 · Cited by 102
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BackgroundMethodInfluentialFernandes, T., & Cordeiro, N. (2021) · Marine Drugs · doi:10.3390/md19100573 · Cited by 95
“Microalgal biotechnological historical data go back to the Aztec population, who harvested Arthrospira from lake Texcoco for food purposes [2,3].”
BackgroundMoheimani, N. R., Vadiveloo, A., Ayre, J. M., & Pluske, J. R. (2018) · Algal Research · doi:10.1016/j.algal.2018.09.007 · Cited by 100
Eilam, Y., Khattib, H., Pintel, N., & Avni, D. (2023) · Global Challenges · doi:10.1002/gch2.202200177 · Cited by 101
Herrero, M., & Ibáñez, E. (2014) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2014.09.006 · Cited by 101
Selvarajan, R., Felföldi, T., Tauber, T., Sanniyasi, E., Sibanda, T., & Tekere, M. (2015) · Energies · doi:10.3390/en8077502 · Cited by 100
“Chlorella strains are also used for medicinal purposes, since they have role in improved immune response, protection against renal failure, improved fertility, better weight control, healthier skin and growth promotion of intestinal lactobacillus [34,43].”
BackgroundPieber, S. M., Schober, S., & Mittelbach, M. (2012) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2012.10.019 · Cited by 101
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“…have been principally developed as an important source of many products, such as aquaculture feeds, human food supplements and pharmaceutics (Pulz and Grass 2001; Apt and Behrens 1999), and algae have been suggested as a very good candidate for fuel production (Borowitzka and Moheimani…”
BackgroundGuedes, A. C., Amaro, H. M., Pereira, R., & Malcata, F. X. (2011) · Biotechnology Progress · doi:10.1002/btpr.649 · Cited by 101
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BackgroundMicroalgae as source of biofuel, food, fodder, and medicines
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Sastre, R. R., Csőgör, Z., Perner-Nochta, I., Fleck-Schneider, P., & Posten, C. H. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2007.04.022 · Cited by 98
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Zhou, W., Li, Y., Gao, Y., & Zhao, H. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.08.160 · Cited by 100
Dahman, Y., Syed, K., Begum, S., Roy, P., & Mohtasebi, B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102426-3.00014-x · Cited by 103
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Gonçalves, A. L., Pires, J. C. M., & Simões, M. V. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.10.023 · Cited by 100
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“Phycoerythrin Biotechnology Red algae Pulz and Gross (2004)”
BackgroundMicroalgae culture enhancement through key microbial approaches
Tandon, P., & Jin, Q. (2017) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2017.05.260 · Cited by 101
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Olivier Bernard, A., Mairet, F., & Chachuat, B. (2015) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2014_287 · Cited by 102
“Industrial exploitation of microalgae is just starting, motivated by their huge potential, and by the diversity of innovative applications [86, 100].”
BackgroundImprovement in microalgae lipid extraction using a sonication-assisted method
Neto, A. M. P., de Souza, R. A. S., Leon-Nino, A. D., da Costa, J. D. A., Tiburcio, R. S., Nunes, T. A., de Mello, T. C. S., Kanemoto, F. T., Saldanha‐Corrêa, F. M. P., & Gianesella, S. M. F. (2013) · Renewable Energy · doi:10.1016/j.renene.2013.01.019 · Cited by 102
Recent advances in CO2 uptake and fixation mechanism of cyanobacteria and microalgae
Singh, S., Sundaram, S., Sinha, S., Rahman, M., & Kapur, S. (2016) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2016.1217911 · Cited by 84
“Recently, many articles have been published to investigate the carbon fixation potential of different algal species (Jacob-Lopes et al., 2009a; Yoo et al., 2010, Farrelly et al., 2014; Singh et al., 2016) and sustainable use of produced algal biomass (Pulz and Gross, 2004; Skjanes et al., 2007).”
BackgroundAdvances in cyanobacterial polyhydroxyalkanoates production
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Slegers, P. M., Olivieri, G., Breitmayer, E., Sijtsma, L., Eppink, M. H. M., Wijffels, R. H., & Reith, J. H. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.550758 · Cited by 101
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Masi, A., Leonelli, F., Scognamiglio, V., Gasperuzzo, G., Antonacci, A., & Terzidis, M. A. (2023) · Molecules · doi:10.3390/molecules28031185 · Cited by 97
Barra, L., Chandrasekaran, R., Corato, F., & Brunet, C. (2014) · Marine Drugs · doi:10.3390/md12031641 · Cited by 100
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BackgroundSustainable production of liquid biofuels from renewable microalgae biomass
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Afify, A. E.-M. M. R., Baroty, G. S. E., Baz, F. K. E., El‐Baky, H. H. A., & Murad, S. A. (2018) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2018.01.002 · Cited by 97
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BackgroundDarwish, R., Gedi, M. A., Akepach, P., Assaye, H., Zaky, A. S., & Gray, D. A. (2020) · Applied Sciences · doi:10.3390/app10196736 · Cited by 97
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BackgroundInfluentialThe Biochemistry and Effectiveness of Antioxidants in Food, Fruits, and Marine Algae
Pruteanu, L.-L., Bailey, D. S., Grădinaru, A. C., & Jäntschi, L. (2023) · Antioxidants · doi:10.3390/antiox12040860 · Cited by 124
Sönmez, M. E., Eczacıoğlu, N., Gümüş, N. E., Aslan, M. F., Sabancı, K., & Aşıkkutlu, B. (2021) · Algal Research · doi:10.1016/j.algal.2021.102568 · Cited by 96
Guedes, A. C., Barbosa, C. R., Amaro, H. M., Pereira, C. I., & Malcata, F. X. (2011) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2011.02567.x · Cited by 96
Marine Algae: a Source of Biomass for Biotechnological Applications
Stengel, D. B., & Connan, S. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2684-8_1 · Cited by 99
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“Microalgae display a high degree of biodiversity and are considered as one of the most promising sources for new products and applications (Pulz and Gross 2004).”
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BackgroundRazeghifard, R. (2013) · Photosynthesis Research · doi:10.1007/s11120-013-9828-z · Cited by 89
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BackgroundChen, G., JIANG, Y., & Chen, F. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.03.008 · Cited by 86
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“Most acidophile microalgae are slow growth strains, as reported in the literature [5,17].”
Background
Metadata
- Authors
- Pulz, O., & Gross, W.
- Affiliations
- Institut für Getreideverarbeitung (Germany) (DE)
- Freie Universität Berlin (DE)
- Corresponding author
- Pulz, Otto
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2004-08-06
- Volume
- 65
- Issue
- 6
- Pages
- 635-648
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2044809902
- Cited by
- 2,132
- References
- 40
- Citations by year
- 2026: 56 · 2025: 82 · 2024: 119 · 2023: 104 · 2022: 109 · 2021: 150 · 2020: 169 · 2019: 152 · 2018: 124 · 2017: 127 · 2016: 134 · 2015: 162 · 2014: 152 · 2013: 132 · 2012: 107
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Applied Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- microalgae, microalgal biotechnology, microalgal biomass, food and feed, genetic engineering of microalgae, pharmaceutical applications, ecological applications, screening method
- MeSH terms
- Biotechnology, Drug Industry, Food Industry, Eukaryota
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