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Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD
Abstract
Purpose Bilberries are abundant in polyphenols. Dietary polyphenols have been associated with strategies for prevention and treatment of chronic inflammatory diseases. We investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).Methods In a randomized controlled trial, participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.Results Supplementation with bilberry juice resulted in significant decreases in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG). Unexpectedly, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) was observed in the bilberry group. CRP, IL-6, IL15, MIG, and TNF-alpha are all target genes of nuclear factor- kappa B (NF-kappaB), -a transcription factor that is crucial in orchestrating inflammatory responses. Plasma quercetin and p-coumaric acid increased in the bilberry group, otherwise no differences were observed for clinical parameters, oxidative stress or antioxidant status. Furthermore, we studied the effect of polyphenols from bilberries on lipopolysaccharide (LPS)-induced NF-kappaB activation in a monocytic cell line. We observed that quercetin, epicatechin, and resveratrol inhibited NF-kappaB activation.Conclusions These findings suggest that supplementation with bilberry polyphenols may modulate the inflammation processes. Further testing of bilberry supplementation as a potential strategy in prevention and treatment of chronic inflammatory diseases is warranted.
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“FoxO proteins are transcription factors which regulate the expression of genes involved in energy homeostasis, cell survival and inflammatory responses including NF-kB (274 -278) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [274]
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“As a consequence, metabolic efficiency is improved, cell defences against stress are strengthened and inflammatory activities are dampened, notably by decreasing the activation of NF-kB (271 -274) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [274]
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Metadata
- Authors
- Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., & Blomhoff, R.
- Affiliations
- University of Oslo (NO)
- Nofima (NO)
- Institut National de la Recherche Agronomique du Niger (NE)
- Finnish Institute for Health and Welfare (FI)
- Oslo University Hospital (NO)
- Corresponding author
- Blomhoff, Rune
- ORCID
- Venue
- European Journal of Nutrition
- Published
- 2010-02-02
- Volume
- 49
- Issue
- 6
- Pages
- 345-355
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- OpenAlex
- W2102160308
- Cited by
- 216
- References
- 56
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 18 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 23 · 2012: 12
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Norges Forskningsråd
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- dietary polyphenols, NF-κB signaling, inflammatory markers, cardiovascular risk, C-reactive protein, interleukin-6, IL-15, monokine induced by interferon-gamma, TNF-α, quercetin, p-coumaric acid, epicatechin, resveratrol, antioxidant status, oxidative stress, functional food supplementation
- MeSH terms
- Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Beverages, C-Reactive Protein, Cardiovascular Diseases, Female, Flavonoids, Fruit, Humans, Lipopolysaccharides, Male, Middle Aged, Monocytes, Phenols, Risk Factors, Biomarkers, Cytokines, NF-kappa B, Inflammation Mediators, Dietary Supplements, U937 Cells, Vaccinium myrtillus, Polyphenols
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