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Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD

Karlsen, Anette, Paur, Ingvild, Bøhn, Siv K., Sakhi, Amrit K., Borge, Grethe I., Serafini, Mauro, Erlund, Iris, Laake, Petter, Tonstad, Serena, Blomhoff, Rune·2010·European Journal of Nutrition

DOI 10.1007/s00394-010-0092-0

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Abstract

Purpose Bilberries are abundant in polyphenols. Dietary polyphenols have been associated with strategies for prevention and treatment of chronic inflammatory diseases. We investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).Methods In a randomized controlled trial, participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.Results Supplementation with bilberry juice resulted in significant decreases in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG). Unexpectedly, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) was observed in the bilberry group. CRP, IL-6, IL15, MIG, and TNF-alpha are all target genes of nuclear factor- kappa B (NF-kappaB), -a transcription factor that is crucial in orchestrating inflammatory responses. Plasma quercetin and p-coumaric acid increased in the bilberry group, otherwise no differences were observed for clinical parameters, oxidative stress or antioxidant status. Furthermore, we studied the effect of polyphenols from bilberries on lipopolysaccharide (LPS)-induced NF-kappaB activation in a monocytic cell line. We observed that quercetin, epicatechin, and resveratrol inhibited NF-kappaB activation.Conclusions These findings suggest that supplementation with bilberry polyphenols may modulate the inflammation processes. Further testing of bilberry supplementation as a potential strategy in prevention and treatment of chronic inflammatory diseases is warranted.

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Authors: Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., & Blomhoff, R.
Affiliations: University of Oslo (NO)
Nofima (NO)
Institut National de la Recherche Agronomique du Niger (NE)
Finnish Institute for Health and Welfare (FI)
Oslo University Hospital (NO)
Corresponding author: Blomhoff, Rune
ORCID: Paur, Ingvild
Bøhn, Siv K.
Sakhi, Amrit K.
Borge, Grethe I.
Serafini, Mauro
Erlund, Iris
Tonstad, Serena
Blomhoff, Rune
Venue: European Journal of Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2010-02-02
Volume: 49
Issue: 6
Pages: 345-355
ISSN: 1436-6207 (ISSN-L)
1436-6215
DOI: 10.1007/s00394-010-0092-0
OpenAlex: W2102160308
Cited by: 216
References: 56
Citations by year: 2026: 4 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 18 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 23 · 2012: 12
FWCI: 10.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders: Norges Forskningsråd
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords: dietary polyphenols, NF-κB signaling, inflammatory markers, cardiovascular risk, C-reactive protein, interleukin-6, IL-15, monokine induced by interferon-gamma, TNF-α, quercetin, p-coumaric acid, epicatechin, resveratrol, antioxidant status, oxidative stress, functional food supplementation
MeSH terms: Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Beverages, C-Reactive Protein, Cardiovascular Diseases, Female, Flavonoids, Fruit, Humans, Lipopolysaccharides, Male, Middle Aged, Monocytes, Phenols, Risk Factors, Biomarkers, Cytokines, NF-kappa B, Inflammation Mediators, Dietary Supplements, U937 Cells, Vaccinium myrtillus, Polyphenols

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Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD

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