The DOI matches its Crossref record, with a small difference in title or year; 40 of the 40 references it cites were found in a registry or an index.
Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
Open accessAbstract
Purpose Dietary flavonoids, including anthocyanins, may positively influence cognition and may be beneficial for the prevention and treatment of dementia. We aimed to assess whether daily consumption of anthocyanin-rich cherry juice changed cognitive function in older adults with dementia. Blood pressure and anti-inflammatory effects were examined as secondary outcomes.Methods A 12-week randomised controlled trial assessed cognitive outcomes in older adults (+70 year) with mild-to-moderate dementia (n = 49) after consumption of 200 ml/day of either a cherry juice or a control juice with negligible anthocyanin content. Blood pressure and inflammatory markers (CRP and IL-6) were measured at 6 and 12 weeks. ANCOVA controlling for baseline and RMANOVA assessed change in cognition and blood pressure.Results Improvements in verbal fluency (p = 0.014), short-term memory (p = 0.014) and long-term memory (p ≤ 0.001) were found in the cherry juice group. A significant reduction in systolic (p = 0.038) blood pressure and a trend for diastolic (p = 0.160) blood pressure reduction was evident in the intervention group. Markers of inflammation (CRP and IL-6) were not altered.Conclusion Inclusion of an anthocyanin-rich beverage may be a practical and feasible way to improve total anthocyanin consumption in older adults with mild-to-moderate dementia, with potential to improve specific cognitive outcomes.
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“In these patients, the dietary introduction of a daily anthocyanin-rich fruit juice significantly improved verbal fluency, as well as short-term and long-term memory, over a 12-week period [119], which is consistent with other reports [120,121].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [119]
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Engelhart, M. J. (2002) · JAMA · doi:10.1001/jama.287.24.3223 · Cited by 1,080 · cited 1×
“A growing body of evidence has shown that phytochemicals, non-nutritive bioactive compounds, contribute to the antioxidant activity of individual fruits and vegetables and are consequently credited with the observed health benefits (2).”
BackgroundPolyphenols and Human Health: Prevention of Disease and Mechanisms of Action
Vauzour, D., Rodriguez‐Mateos, A., Corona, G., Oruña-Concha, M. J., & Spencer, J. P. E. (2010) · Nutrients · doi:10.3390/nu2111106 · Cited by 885
The Lawton instrumental activities of daily living scale
Graf, C. (2008) · AJN, American Journal of Nursing · doi:10.1097/01.naj.0000314810.46029.74 · Cited by 832 · cited 2×
“Lawton’s Instrumental Activities of Daily Living Scale (IADL) (21) determined functional impairment and hand grip strength was assessed using a digital Jamar handgrip dynamometer (Lafayette”
MethodBlueberry supplementation improves memory in older adults
Krikorian, R., Shidler, M. D., Nash, T. A., Kalt, W., Vinqvist-Tymchuk, M. R., Shukitt-Hale, B., & Joseph, J. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9029332 · Cited by 582 · cited 4×
“4 Preliminary dietary supplementation studies have shown that blueberries (11) and concord grapes (12, 13) improve aspects of memory in older adults over a 12 and 16 week intervention.”
BackgroundMethodResultInfluentialThe neuroprotective potential of flavonoids: a multiplicity of effects
Vauzour, D., Vafeiadou, K., Rodriguez‐Mateos, A., Rendeiro, C., & Spencer, J. P. E. (2008) · Genes & Nutrition · doi:10.1007/s12263-008-0091-4 · Cited by 561 · cited 1×
“Their antioxidant actions assist to scavenge free radicals in the brain (8), while their neuro-protective effects include protection of vulnerable neurons against inflammation, enhancement of existing neuronal function, increased blood flow to the brain and neurogenesis initiation in areas of the brain that are associ…”
BackgroundValidação da escala de depressão geriátrica em um ambulatório geral
Paradela, E. M. P., Lourenço, R. A., & Veras, R. P. (2005) · Revista de Saúde Pública · doi:10.1590/s0034-89102005000600008 · Cited by 450 · cited 1×
“The geriatric depression scale (GDS) (29) assessed mood state.”
BackgroundWilliams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448 · cited 2×
“The ability of flavonoids to modulate Alzheimer’s disease progression is still poorly understood (17).”
BackgroundFlavonoids: modulators of brain function?
Spencer, J. P. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508965776 · Cited by 385
The impact of fruit flavonoids on memory and cognition
Spencer, J. P. E. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003934 · Cited by 369
Cereda, E. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834d7647 · Cited by 359
Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509992364 · Cited by 353 · cited 5×
“Previous intervention trials have hypothesised that the mechanisms relating to the improvements seen in cognitive performance after anthocyanin-rich food supplementation are due to a reduction in inflammatory markers, resulting in a blood pressure-lowering effect (13).”
BackgroundMethodResultInfluentialDietary Antioxidants and Long-term Risk of Dementia
Devore, E. E., Grodstein, F., van Rooij, F. J. A., Albert Hofman, D., Stampfer, M. J., Witteman, J. C. M., & Breteler, M. M. B. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.144 · Cited by 286 · cited 1×
“Additionally, as Alzheimer’s disease is associated with progressive and chronic inflammation (38), the disease pathology may mask any potential anti-inflammatory effects provided by the cherry juice.”
BackgroundFruit polyphenols and CVD risk: a review of human intervention studies
Chong, M. F., Macdonald, R., & Lovegrove, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003922 · Cited by 273
Concord Grape Juice Supplementation and Neurocognitive Function in Human Aging
Krikorian, R., Boespflug, E. L., Fleck, D. E., Stein, A. L., Wightman, J. D., Shidler, M. D., & Sadat-Hossieny, S. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300277g · Cited by 255 · cited 3×
“4 Preliminary dietary supplementation studies have shown that blueberries (11) and concord grapes (12, 13) improve aspects of memory in older adults over a 12 and 16 week intervention.”
BackgroundResultFlavonoids and cognition: The molecular mechanisms underlying their behavioural effects
Spencer, J. P. E., Vauzour, D., & Rendeiro, C. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.10.003 · Cited by 235
Schoenberg, M. R., Dawson, K., Duff, K. M., Patton, D. A., SCOTT, J., & ADAMS, R. (2006) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2006.06.010 · Cited by 222 · cited 6×
“15 Table 3: Mean scores for cognitive performance and mood by group a Control group Intervention group Baseline n=25 12 weeks n=21 Mean Difference Baseline n=24 12 weeks n=21 Mean Difference Letter Verbal Fluency (executive function) 13.1 ± 7.5 13.1 ± 7.9 0.015 ± 0.4 18.9 ± 11.0 19.0 ± 10.3 0.13 ± 0.7 Category Verbal…”
MethodInfluentialWhich Sources of Flavonoids: Complex Diets or Dietary Supplements?
Egert, S., & Rimbach, G. H. (2011) · Advances in Nutrition · doi:10.3945/an.110.000026 · Cited by 212
Fruit Polyphenolics and Brain Aging
Galli, R. L., Shukitt‐Hale, B., Youdim, K. A., & Joseph, J. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02089.x · Cited by 199
Effects of Concord grape juice on cognitive and motor deficits in aging
Shukitt‐Hale, B., Carey, A. N., Simon, L., Mark, D. A., & Joseph, J. A. (2006) · Nutrition · doi:10.1016/j.nut.2005.07.016 · Cited by 197
Polyphenols and cancer cell growth
Kampa, M., Nifli, A., Notas, G., & Castanas, E. (2007) · Springer eBooks · doi:10.1007/112_2006_0702 · Cited by 193
Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
Williamson, G., & Holst, B. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508006867 · Cited by 185 · cited 1×
“In the absence of a Nutrient Reference Value (NRV) for flavonoids (37), this magnitude of increase in consumption can be considered to be a significant increase above habitual intake levels for this age group.”
BackgroundDietary Flavonoid Sources in Australian Adults
Somerset, S. M., & Johannot, L. (2008) · Nutrition and Cancer · doi:10.1080/01635580802143836 · Cited by 177 · cited 14×
“Total intake and major sources of flavonoids of participants at baseline was similar to that reported for Australians aged 65+ years (510 vs 575 vs 683mg/day respectively) (4, 35, 36).”
BackgroundResultInfluentialEffects of blackberries on motor and cognitive function in aged rats
Shukitt‐Hale, B., Cheng, V., & Joseph, J. A. (2009) · Nutritional Neuroscience · doi:10.1179/147683009x423292 · Cited by 166 · cited 1×
“These findings are consistent with those of recent human and animal studies showing improvement in cognitive performance in these domains with dietary supplementation with other anthocyanin-rich food sources (11-13, 31-33).”
ResultVerbal fluency in dementia of frontal lobe type and dementia of alzheimer type
Pasquier, F., Lebert, F., Grymonprez, L., & Petit, H. (1995) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.58.1.81 · Cited by 156
Mulabagal, V., Lang, G. A., DeWitt, D. L., Dalavoy, S. S., & Nair, M. G. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8032039 · Cited by 142
Age-related variations in flavonoid intake and sources in the Australian population
Johannot, L., & Somerset, S. (2006) · Public Health Nutrition · doi:10.1017/phn2006971 · Cited by 128 · cited 1×
“Total intake and major sources of flavonoids of participants at baseline was similar to that reported for Australians aged 65+ years (510 vs 575 vs 683mg/day respectively) (4, 35, 36).”
ResultAge-related variations in flavonoid intake and sources in the Australian population
Johannot, L., & Somerset, S. M. (2006) · Public Health Nutrition · doi:10.1017/s1368980006009712 · Cited by 109
Effects of Age and Dementia on the Trail Making Test
Rasmusson, X., Zonderman, A. B., Kawas, C. H., & Resnick, S. M. (1998) · The Clinical Neuropsychologist · doi:10.1076/clin.12.2.169.2005 · Cited by 105 · cited 3×
“Outcome assessment Cognitive function was assessed using a battery of seven cognitive tests, including the Rey Auditory Verbal Learning Test (RAVLT) (22, 23) , the self-ordered pointing task (SOPT)(24), the Boston naming test (25), the trail making test (TMT) (26), digit span backwards task (27) and category and lette…”
MethodRecent advances in berry supplementation and age-related cognitive decline
Willis, L., Shukitt‐Hale, B., & Joseph, J. A. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831b9c6e · Cited by 100 · cited 1×
“However, preclinical studies indicate that flavonoids from berry fruits may require only several weeks to accumulate in brain regions associated with cognition (40).”
BackgroundProjections of Future Numbers of Dementia Cases in Australia with and Without Prevention
Jorm, A. F., Dear, K. B. G., & Burgess, N. M. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1111/j.1440-1614.2005.01713.x · Cited by 88 · cited 1×
“In light of projections indicating rapid increases in the prevalence of the dementia (18) and in the absence of successful treatments, alternative measures to slow the development and”
BackgroundCalero, M. D., Arnedo, M. L., Navarro, E., Ruiz-Pedrosa, M., & Pardo, C. C. (2002) · The Journals of Gerontology Series B · doi:10.1093/geronb/57.2.p187 · Cited by 83
Iland, P. G., Cynkar, W. U., Francis, I. L., et al. (1996) · Australian Journal of Grape and Wine Research · doi:10.1111/j.1755-0238.1996.tb00105.x · Cited by 79 · cited 4×
“The high antioxidant activity and anthocyanin content of cherries is well retained in the juice which had a high Oxygen Radical Absorbance Capacity (3200 µmol Trolox Equivalents/g) and contained 69 mg red pigments (anthocyanins) per 100g of juice as determined by HPLC (19) (Table 2).”
BackgroundInfluentialThe reliability and validity of the self-ordered pointing task
ROSS, T., HANOUSKOVA, E., Giarla, K., CALHOUN, E., & Tucker, M. (2007) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2007.01.023 · Cited by 75
Tierney, M. C., Nores, A., Snow, W. G., Fisher, R. H., Zorzitto, M. L., & Reid, D. W. (1994) · Psychological Assessment · doi:10.1037/1040-3590.6.2.129 · Cited by 65
Bondonno, C. P., Downey, L. A., Croft, K. D., Scholey, A. B., Stough, C. K. K., Yang, X., Considine, M. J., Ward, N. C., Puddey, I. B., Swinny, E. E., et al. (2014) · Food & Function · doi:10.1039/c3fo60590f · Cited by 63
Leather, S. (1995) · British Food Journal · doi:10.1108/00070709510095403 · Cited by 42
Anthocyanin-rich cherry juice does not improve acute cognitive performance on RAVLT
Caldwell, K., Charlton, K. E., Roodenrys, S. J., & Jenner, A. M. (2015) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000005 · Cited by 25
Validity of Digit Span as a test for memory in dementia
Gliko, B. (2000) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(00)80162-6 · Cited by 4 · cited 1×
“Outcome assessment Cognitive function was assessed using a battery of seven cognitive tests, including the Rey Auditory Verbal Learning Test (RAVLT) (22, 23) , the self-ordered pointing task (SOPT)(24), the Boston naming test (25), the trail making test (TMT) (26), digit span backwards task (27) and category and lette…”
Method
Research works printed but not linked: 1
- USDA (2013) United States Department of Agriculture Database for the flavonoid content of selected foods. Release 3:1
Cited by
Sorted by citations
Mattioli, R., Francioso, A., Mosca, L., & Silva, P. (2020) · Molecules · doi:10.3390/molecules25173809 · Cited by 1,145
“Inflammatory markers (CRP and IL-6) were not altered by this intervention [267].”
BackgroundPhenolic compounds: Current industrial applications, limitations and future challenges
Albuquerque, B. R., Heleno, S. A., Oliveira, M. B. P. P., Barros, L., & Ferreira, I. C. F. R. (2021) · Food & Function · doi:10.1039/d0fo02324h · Cited by 716
Cosme, P., Rodríguez, A. B., Espino, J., & Garrido, M. (2020) · Antioxidants · doi:10.3390/antiox9121263 · Cited by 420
“Besides, both systolic and diastolic blood pressure was lower in these patients [92].”
BackgroundFlavonoids and their role in oxidative stress, inflammation, and human diseases
Jomová, K., Alomar, S. Y., Valko, R., Líška, J., Nepovimová, E., Kuča, K., & Valko, M. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111489 · Cited by 449
Qi, Q., Chu, M., Yu, X., et al. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2029479 · Cited by 281
Metadata
- Authors
- Kent, K., Charlton, K., Roodenrys, S., Batterham, M., Potter, J., Traynor, V., Gilbert, H., Morgan, O., & Richards, R.
- Affiliations
- University of Wollongong (AU)
- Wollongong Hospital (AU)
- Corresponding author
- Kent, Katherine
- Venue
- European Journal of Nutrition
- Published
- 2015-10-19
- Volume
- 56
- Issue
- 1
- Pages
- 333-341
- ISSN
- 0044-264X (ISSN-L)
- 1436-6207
- 1435-1293
- OpenAlex
- W1786564295
- Cited by
- 214
- References
- 39
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 25 · 2023: 19 · 2022: 24 · 2021: 24 · 2020: 31 · 2019: 30 · 2018: 19 · 2017: 7 · 2016: 6
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Zeitschrift für Ernährungswissenschaft (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- anthocyanins, cherry juice, dementia, cognitive function, memory, older adults, dietary flavonoids, blood pressure, inflammation, C-reactive protein, interleukin-6, verbal fluency
- MeSH terms
- Fruit and Vegetable Juices, Prunus avium, Aged, Anthocyanins, Ascorbic Acid, Blood Pressure, C-Reactive Protein, Cognition, Dementia, Female, Follow-Up Studies, Fruit, Humans, Male, Memory, Biomarkers, Nutrition Assessment, Interleukin-6, Body Mass Index, Hand Strength
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