Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment
Open accessAbstract
Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have indicated improvement in memory and motor function with grape juice supplementation, suggesting potential for cognitive benefit in ageing humans. In this initial investigation of neurocognitive effects, we enrolled twelve older adults with memory decline but not dementia in a randomised, placebo-controlled, double-blind trial with Concord grape juice supplementation for 12 weeks. We observed significant improvement in a measure of verbal learning and non-significant enhancement of verbal and spatial recall. There was no appreciable effect of the intervention on depressive symptoms and no effect on weight or waist circumference. A small increase in fasting insulin was observed for those consuming grape juice. These preliminary findings suggest that supplementation with Concord grape juice may enhance cognitive function for older adults with early memory decline and establish a basis for more comprehensive investigations to evaluate potential benefit and assess mechanisms of action.
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In elderly individuals with mild cognitive impairment, daily dietary introduction of an anthocyanin-rich fruit juice significantly improved verbal fluency, short-term memory, and long-term memory over a 12-week period.
“In these patients, the dietary introduction of a daily anthocyanin-rich fruit juice significantly improved verbal fluency, as well as short-term and long-term memory, over a 12-week period [119], which is consistent with other reports [120,121].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [120]
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“In these patients, the dietary introduction of a daily anthocyanin-rich fruit juice significantly improved verbal fluency, as well as short-term and long-term memory, over a 12-week period [119], which is consistent with other reports [120,121].”
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- Authors
- Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A.
- Affiliations
- University of Cincinnati Medical Center (US)
- Tufts University (US)
- Corresponding author
- Krikorian, Robert
- ORCID
- Joseph, James A.
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-12-23
- Volume
- 103
- Issue
- 5
- Pages
- 730-734
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2034960280
- Cited by
- 353
- References
- 58
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 18 · 2023: 20 · 2022: 17 · 2021: 28 · 2020: 22 · 2019: 30 · 2018: 22 · 2017: 20 · 2016: 29 · 2015: 22 · 2014: 28 · 2013: 29 · 2012: 26
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Concord grape juice, dietary supplementation, memory function, mild cognitive impairment, older adults, verbal learning, word recall, spatial recall, polyphenols, flavonoids, cognitive aging, insulin, depressive symptoms
- MeSH terms
- Aged, Aged, 80 and over, Anti-Inflammatory Agents, Antioxidants, Cardiovascular Diseases, Cognition Disorders, Double-Blind Method, Female, Flavonoids, Fruit, Humans, Insulin, Learning, Male, Phytotherapy, Memory, Memory Disorders, Phenols, Dietary Supplements, Vitis, Plant Preparations
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