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Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
Open accessAbstract
Purpose Dietary flavonoids, including anthocyanins, may positively influence cognition and may be beneficial for the prevention and treatment of dementia. We aimed to assess whether daily consumption of anthocyanin-rich cherry juice changed cognitive function in older adults with dementia. Blood pressure and anti-inflammatory effects were examined as secondary outcomes.Methods A 12-week randomised controlled trial assessed cognitive outcomes in older adults (+70 year) with mild-to-moderate dementia (n = 49) after consumption of 200 ml/day of either a cherry juice or a control juice with negligible anthocyanin content. Blood pressure and inflammatory markers (CRP and IL-6) were measured at 6 and 12 weeks. ANCOVA controlling for baseline and RMANOVA assessed change in cognition and blood pressure.Results Improvements in verbal fluency (p = 0.014), short-term memory (p = 0.014) and long-term memory (p ≤ 0.001) were found in the cherry juice group. A significant reduction in systolic (p = 0.038) blood pressure and a trend for diastolic (p = 0.160) blood pressure reduction was evident in the intervention group. Markers of inflammation (CRP and IL-6) were not altered.Conclusion Inclusion of an anthocyanin-rich beverage may be a practical and feasible way to improve total anthocyanin consumption in older adults with mild-to-moderate dementia, with potential to improve specific cognitive outcomes.
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“In these patients, the dietary introduction of a daily anthocyanin-rich fruit juice significantly improved verbal fluency, as well as short-term and long-term memory, over a 12-week period [119], which is consistent with other reports [120,121].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [119]
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Casati, C. B., Baeza, R. I., & Sánchez, V. (2019) · Journal of Berry Research · doi:10.3233/jbr-190409 · Cited by 33
“In par-∗ ticular, anthocyanins are compounds associated to health promoting properties such as anti-inflammatory and antimicrobial actions and also involved in reducing the risk of having heart diseases, neurodegenerative disorders and cancer [5–8].”
Brain, K., Burrows, T. L., Rollo, M. E., Hayes, C., Hodson, F. J., & Collins, C. E. (2019) · Nutrients · doi:10.3390/nu11010181 · Cited by 32
Morris, G., Gamage, E., Travica, N., Berk, M., Jacka, F. N., O'Neil, A. E., Puri, B. K., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.036 · Cited by 31
Neuroinflammation: The Role of Anthocyanins as Neuroprotectants
Banji, O. J. F., Banji, D., Makeen, H. A., Alqahtani, S. S., & Alshahrani, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220119140835 · Cited by 31
“It is perceived that cherry juice mediates its action through signaling cascades; however, the levels of IL-6 were not significantly altered [125].”
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Neurocognitive Effects of Cocoa and Red-Berries Consumption in Healthy Adults
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“(13) found significant improvements on all three measures of EM after 3 months, with moderate to large effect sizes (13).”
BackgroundInfluentialKimble, R., Keane, K. M., Lodge, J. K., Cheung, W., Haskell-Ramsay, C. F., & Howatson, G. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522000460 · Cited by 35
“Moreover, both aforementioned studies (29; 31) were predicated by reductions in systolic blood pressure, suggesting that the vasodilatory properties of the”
BackgroundRampogu, S. D., Park, C., Ravinder, D., Son, M., Baek, A., Zeb, A., Bavi, R., Kumar, R., Lee, G., Parate, S., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5189490 · Cited by 31
Krishna, G., Ying, Z., & Gómez‐Pinilla, F. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801055 · Cited by 30
Cook, M. D., Sandu, B. A. K., & Joyce, J. (2020) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2019.1707740 · Cited by 30
Health effects of 100% fruit and vegetable juices: evidence from human subject intervention studies
Rossi, I., Mignogna, C., Rio, D. D., & Mena, P. R. (2023) · Nutrition Research Reviews · doi:10.1017/s095442242300015x · Cited by 33
N-of-1 Clinical Trials in Nutritional Interventions Directed at Improving Cognitive Function
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Chen, H., Chen, J., Cao, Y., Sun, Y., Huang, L., Ji, J. S., Voortman, T., Vernooij, M. W., Shen, J., Zheng, Y., et al. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.01.015 · Cited by 29
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Desai, T., Roberts, M. G., & Bottoms, L. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.04.005 · Cited by 27
Laudani, S., Godos, J., Domenico, F. M. D., Barbagallo, I. A., Randazzo, C. L., Leggio, G. M., Galvano, F., & Grosso, G. (2023) · Antioxidants · doi:10.3390/antiox12091773 · Cited by 34
“Kent, 2017, Australia [47] Controlled, RCT 42 older adults with mild-to moderate dementia (Alzheimer’s type) (+70 y) 12 wk 200 mL/day cherry juice 138 mg red pigment (anthocyanin) 200 mL/day commercially prepared apple juice Cherry juice consumption determined a significant reduction in SBP (p = 0.”
MethodInfluentialBergland, A. K., Soennesyn, H., Dalen, I., Rodriguez‐Mateos, A., Berge, R. K., Giil, L. M., Rajendran, L., Siow, R. C. M., Tassotti, M., Larsen, A. I., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00536 · Cited by 25
“Other studies did not report a reduction of pro-inflammatory mediators after anthocyanin supplementation (Hassellund et al., 2013; Kent et al., 2015).”
Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort
Bondonno, C. P., Bondonno, N. P., Dalgaard, F., Murray, K., Gardener, S. L., Martins, R. N., Rainey‐Smith, S. R., Cassidy, A., Lewis, J. R., Croft, K. D., et al. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12175 · Cited by 27
Arbizu, S., Mertens‐Talcott, S. U., Talcott, S. T., & Noratto, G. D. (2023) · Nutrients · doi:10.3390/nu15030681 · Cited by 26
“Likewise, a study conducted with older individuals with mild-to-moderate dementia demonstrated that serum IL-6 was not altered after a 12-week sweet cherry juice (200 mL) consumption [36].”
BackgroundEffects of nutrient and bioactive food components on Alzheimer's disease and epigenetic
Celik, E., & Şanlıer, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1359488 · Cited by 25
“It is stated that short-term and long-term memory develops in cherry juice containing anthocyanin at 200 mL/day, 12 weeks of intervention, 70 years of age or older, and moderate dementia (Kent et al., 2015).”
BackgroundWen, H., Tian, H., Liu, C., Zhang, X., Peng, Y., Yang, X., Chen, F., & Li, J. (2021) · Food & Function · doi:10.1039/d1fo02122b · Cited by 25
Effects of Anthocyanins on Cognition and Vascular Function: A Systematic Review
Ellis, L. R., Boesch, C., & Dye, L. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300502 · Cited by 23
Suominen, M. H., Laaksonen, M. M. L., Salmenius-Suominen, H., Kautiainen, H., Hongisto, S.-M., Tuukkanen, K., Jyväkorpi, S. K., & Pitkälä, K. H. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110933 · Cited by 23
Rosli, H., Shahar, S., Rajab, N. F., Din, N. C., & Haron, H. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1880312 · Cited by 24
Metadata
- Authors
- Kent, K., Charlton, K., Roodenrys, S., Batterham, M., Potter, J., Traynor, V., Gilbert, H., Morgan, O., & Richards, R.
- Affiliations
- University of Wollongong (AU)
- Wollongong Hospital (AU)
- Corresponding author
- Kent, Katherine
- Venue
- European Journal of Nutrition
- Published
- 2015-10-19
- Volume
- 56
- Issue
- 1
- Pages
- 333-341
- ISSN
- 0044-264X (ISSN-L)
- 1436-6207
- 1435-1293
- OpenAlex
- W1786564295
- Cited by
- 214
- References
- 39
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 25 · 2023: 19 · 2022: 24 · 2021: 24 · 2020: 31 · 2019: 30 · 2018: 19 · 2017: 7 · 2016: 6
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Zeitschrift für Ernährungswissenschaft (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- anthocyanins, cherry juice, dementia, cognitive function, memory, older adults, dietary flavonoids, blood pressure, inflammation, C-reactive protein, interleukin-6, verbal fluency
- MeSH terms
- Fruit and Vegetable Juices, Prunus avium, Aged, Anthocyanins, Ascorbic Acid, Blood Pressure, C-Reactive Protein, Cognition, Dementia, Female, Follow-Up Studies, Fruit, Humans, Male, Memory, Biomarkers, Nutrition Assessment, Interleukin-6, Body Mass Index, Hand Strength
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