The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers
Open accessAbstract
OBJECTIVES: Perfluorooctanoic acid (PFOA) results in peroxisome proliferator mediated effects in rats and mice resulting in hypolipidemia but not in monkeys. Counterintuitive modestly positive associations between PFOA and cholesterol levels in production workers have been inconsistently reported. The purpose of this assessment was to examine this association in male workers who manufactured or used PFOA at three facilities. METHODS: Subjects were male employee voluntary participants of a fluorochemical medical surveillance program who provided blood samples for serum measurement of PFOA (perfluorooctanoate) and various lipid, hepatic, and thyroid parameters. Statistical analyses included multiple and logistic regression and analysis of covariance. RESULTS: A total of 506 employees, who did not take cholesterol-lowering medications (93% of all male participants), were analyzed. Serum PFOA concentrations ranged from 0.007 to 92.03 microg/ml [arithmetic mean 2.21 microg/ml (95% confidence interval 1.66-2.77), median 1.10 microg/ml]. Adjusted for age, body mass index, and alcohol usage in regression analyses, PFOA was not statistically significantly (P>0.05) associated with total cholesterol or low-density lipoproteins (LDL). High-density lipoproteins (HDL) were significantly negatively (P<0.01) associated with PFOA for the three facilities combined but not by individual sites, indicating the overall result was likely a consequence of residual confounding due to different demographic profiles at these sites. Serum triglycerides were significantly positively associated with PFOA but not consistently by locations. There were no statistically significant associations observed between PFOA and hepatic enzymes for the three facilities combined although some modest positive associations were observed between PFOA and hepatic enzymes at one of the three facilities. Analyses of all locations showed no associations with TSH or T4 and PFOA. A negative association was observed for free T4 and positive association for T3; however, the findings were well within these assays' normal reference ranges. CONCLUSION: There was no evidence that employees' serum PFOA concentrations were associated with total cholesterol or LDL. A negative association with HDL was explained by demographic differences across the three locations. Several explanations are offered for the inconsistent triglyceride associations with PFOA including both methodological as well as biological possibilities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hernan, M. A. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.2.176 · Cited by 1,445
Compound-specific, quantitative characterization of organic fluorochemicals in biological matrices
Hansen, K. J., Clemen, L. A., Ellefson, M. E., & Johnson, H. O. (2001) · Environmental Science & Technology · doi:10.1021/es001489z · Cited by 923
Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol
Brousseau, M. E., Schaefer, E. J., Wolfe, M. L., Bloedon, L. T., Digenio, A. G., Clark, R. W., Mancuso, J. P., & Rader, D. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031766 · Cited by 774
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742
Self-citationSubchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
Seacat, A. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/68.1.249 · Cited by 564 · cited 2×
“This prior association with PFOS is inconsistent with the well-established hypolipidemia reported in PFOS-related toxicological studies with concentrations much higher than in the present study (Seacat et al. 2002, 2003).”
ResultAl-Naimi, S., Hampton, S. M., Richard, P., Tzung, C., & Morgan, L. M. (2004) · Chronobiology International · doi:10.1081/cbi-200037171 · Cited by 134
Effects of the endogenous clock and sleep time on melatonin, insulin, glucose and lipid metabolism
Morgan, L., Arendt, J., Owens, D., Folkard, S., Hampton, S., Deacon, S., English, J., Ribeiro, D., & Taylor, K. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1570443 · Cited by 124
Cited by
Endocrine Disruptors: From Endocrine to Metabolic Disruption
Casals-Casas, C., & Desvergne, B. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142200 · Cited by 902
De Silva, A. O., Armitage, J. M., Bruton, T. A., Dassuncao, C., Heiger-Bernays, W., Hu, X. C., Kärrman, A., Kelly, B., Ng, C., Robuck, A., et al. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4935 · Cited by 835
Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)
Steenland, K., Fletcher, T., & Savitz, D. A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901827 · Cited by 660
Post, G. B., Cohn, P. D., & Cooper, K. R. (2012) · Environmental Research · doi:10.1016/j.envres.2012.03.007 · Cited by 639
Nelson, J. W., Hatch, E. E., & Webster, T. F. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901165 · Cited by 538
Melzer, D., Rice, N., Depledge, M. H., Henley, W. E., & Galloway, T. S. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901584 · Cited by 496
Jian, J.-M., Chen, D., Han, F.-J., Guo, Y., Zeng, L., Lu, X., & Wang, F. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.04.380 · Cited by 429
Toxicology of perfluorinated compounds
Stahl, T., Mattern, D., & Brunn, H. (2011) · Environmental Sciences Europe · doi:10.1186/2190-4715-23-38 · Cited by 432
Costello, E., Rock, S., Stratakis, N., Eckel, S. P., Walker, D. I., Valvi, D., Cserbik, D., Jenkins, T., Xanthakos, S. A., Kohli, R., et al. (2022) · Environmental Health Perspectives · doi:10.1289/ehp10092 · Cited by 420
Halldorsson, T. I., Rytter, D., Haug, L. S., Bech, B. H., Danielsen, I., Becher, G., Henriksen, T. B., & Olsen, S. F. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104034 · Cited by 353
Frisbee, S. J., Shankar, A., Knox, S. S., Steenland, K., Savitz, D. A., Fletcher, T., & Ducatman, A. M. (2010) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2010.163 · Cited by 274
Worley, R. R., Moore, S. M., Tierney, B. C., Ye, X., Calafat, A. M., Campbell, S., Woudneh, M. B., & Fisher, J. (2017) · Environment International · doi:10.1016/j.envint.2017.06.007 · Cited by 272
Meegoda, J. N., Kewalramani, J. A., Li, B., & Marsh, R. W. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218117 · Cited by 256
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
Bonato, M., Corrà, F., Bellio, M., Guidolin, L., Tallandini, L., Irato, P., & Santovito, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218020 · Cited by 243
Thirty years of medical surveillance in perfluooctanoic acid production workers
Costa, G., Sartori, S., & Consonni, D. (2009) · Journal of Occupational & Environmental Medicine · doi:10.1097/jom.0b013e3181965d80 · Cited by 238
Blake, B. E., Pinney, S. M., Hines, E. P., Fenton, S. E., & Ferguson, K. K. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.07.042 · Cited by 236
Activation of Human Nuclear Receptors by Perfluoroalkylated Substances (PFAS)
Behr, A.-C., Plinsch, C., Braeuning, A., & Buhrke, T. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104700 · Cited by 235
Steenland, K., Tinker, S., Shankar, A., & Ducatman, A. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0900940 · Cited by 224
Beesoon, S., & Martin, J. W. (2015) · Environmental Science & Technology · doi:10.1021/es505399w · Cited by 223
Chang, E. T., Adami, H.-O., Boffetta, P., Cole, P., Starr, T. B., & Mandel, J. S. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.905767 · Cited by 180
Perfluoroalkyl Chemicals and Chronic Kidney Disease in US Adults
Shankar, A., Xiao, J., & Ducatman, A. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr171 · Cited by 166
Ammonium Perfluorooctanoate Production and Occupational Mortality
Lundin, J. I., Alexander, B. H., Olsen, G. W., & Church, T. R. (2009) · Epidemiology · doi:10.1097/ede.0b013e3181b5f395 · Cited by 156
Self-citationWebster, G. M., Venners, S. A., Mattman, A., & Martin, J. W. (2014) · Environmental Research · doi:10.1016/j.envres.2014.06.012 · Cited by 145
Zhang, C., Sundaram, R., Maisog, J., Calafat, A. M., Barr, D. B., & Buck Louis, G. M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.10.001 · Cited by 135
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
India-Aldana, S., Yao, M., Midya, V., Colicino, E., Chatzi, L., Chu, J., Gennings, C., Jones, D. P., Loos, R. J. F., Setiawan, V. W., et al. (2023) · Current Pollution Reports · doi:10.1007/s40726-023-00269-4 · Cited by 114
Yan, S., Zhang, H., Zheng, F., Sheng, N., Guo, X., & Dai, J. (2015) · Scientific Reports · doi:10.1038/srep11029 · Cited by 110
Perfluorocarbon exposure, gender and thyroid function in the C8 Health Project
S. Knox, S., Jackson, T., J. Frisbee, S., Javins, B., & M. Ducatman, A. (2011) · The Journal of Toxicological Sciences · doi:10.2131/jts.36.403 · Cited by 95
Gomis, M. I., Vestergren, R., MacLeod, M., Mueller, J. F., & Cousins, I. T. (2017) · Environment International · doi:10.1016/j.envint.2017.08.002 · Cited by 85
Li, H., Dong, Q., Zhang, M., Gong, T., Zan, R., & Wang, W. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121579 · Cited by 80
Perfluoroalkyl substances and thyroid function in older adults
Shrestha, S., Bloom, M. S., Yucel, R., Seegal, R. F., Wu, Q., Kannan, K., Rej, R., & Fitzgerald, E. F. (2015) · Environment International · doi:10.1016/j.envint.2014.11.018 · Cited by 76
Perfluoroalkyl Chemicals in Neurological Health and Disease: Human Concerns and Animal Models
Piekarski, D., Diaz, K., & McNerney, M. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.01.001 · Cited by 76
Han, X., Meng, L., Zhang, G., Li, Y., Shi, Y., Zhang, Q., & Jiang, G. (2021) · Environment International · doi:10.1016/j.envint.2021.106637 · Cited by 74
Wang, J., Wang, X., Sheng, N., Zhou, X., Cui, R., Zhang, H., & Dai, J. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3376 · Cited by 73
Rebholz, S. L., Jones, T., Herrick, R. L., Xie, C., Calafat, A. M., Pinney, S. M., & Woollett, L. A. (2016) · Toxicology Reports · doi:10.1016/j.toxrep.2015.11.004 · Cited by 69
Yuan, Z., Shao, X., Miao, Z., Zhao, B., Zheng, Z., & Zhang, J. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.05.011 · Cited by 64
Nakamura, T., Ito, Y., Yanagiba, Y., Ramdhan, D. H., Kono, Y., Naito, H., Hayashi, Y., Li, Y., Aoyama, T., Gonzalez, F. J., et al. (2009) · Toxicology · doi:10.1016/j.tox.2009.09.004 · Cited by 57
Gribble, M. O., Bartell, S. M., Kannan, K., Wu, Q., Fair, P. A., & Kamen, D. L. (2015) · Environmental Research · doi:10.1016/j.envres.2015.03.012 · Cited by 43
“…Frisbee et al., 2009; Gump et al., 2011; Guruge et al., 2005; Holzer et al., 2008; Kannan et al., 2004; Kato et al., 2014; Maisonet et al., 2012; Olsen and Zobel, 2007; Pinney et al., 2014; Schecter et al., 2012; Shaw et al., 2013; Tao et al., 2008a; Tao et al., 2008b; Tao et al., 2008c; von…”
Fang, X., Gao, G., Xue, H., Zhang, X., & Wang, H. (2012) · Toxicology · doi:10.1016/j.tox.2012.02.008 · Cited by 43
Du, X., Xu, X., Dong, X.-X., Liang, X., Wu, Y., Du, Z., Pan, C.-W., Liang, G., Li, Y.-Z., Zheng, Y.-J., et al. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c01138 · Cited by 24
Qazi, M. R., Hassan, M., Nelson, B. D., DePierre, J. W., & Abedi-Valugerdi, M. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2012.12.001 · Cited by 21
McAdoo, M. A., Connock, G. T., & Messinger, T. (2022) · Scientific Investigations Report · doi:10.3133/sir20225067 · Cited by 15
Metadata
- Authors
- Olsen, G. W., & Zobel, L. R.
- Venue
- International Archives of Occupational and Environmental Health
- Published
- 2007-06-29
- Volume
- 81
- Issue
- 2
- Pages
- 231-246
- ISSN
- 0340-0131 (ISSN-L)
- 1432-1246
- OpenAlex
- W2074020914
- Cited by
- 301
- References
- 7
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
