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Plasma levels of miR-137 and miR-124 are associated with Parkinson’s disease but not with Parkinson’s disease with depression

Li, Na, Pan, Xudong, Zhang, Jingli, Ma, Aijun, Yang, Shaonan, Ma, Juanjuan, Xie, Anmu·2017·Neurological Sciences
DOI 10.1007/s10072-017-2841-9
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Abstract

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Recently, it was reported that miR-137, miR-124, and miR-184 were widely expressed in the central nervous system and were vital to neuronal regulation. In this study, we detected the circulating levels of miR-137, miR-124, and miR-184 in PD patients, and explored the potential role of miR-124, miR-137, and miR-184 in the diagnosis of PD. We further described the relationship between these miRNAs and PD with depression (PD-Dep). The study recruited 60 controls and 60 PD patients, which were further divided into two subgroups, PD with depression (PD-Dep, n = 24) and non-depressed group (PD-NDep, n = 36) according to Hamilton Rating Scale for Depression. Plasma levels of miR-137, miR-124, and miR-184 were detected by qRT-PCR. Receiver-operating characteristic (ROC) curve was used to evaluate miR-124 and miR-137 levels as potential diagnostic biomarkers for PD. The results demonstrated that there were no significant differences in levels of miR-184 between PD patients and controls (p > 0.05). However, miR-137 levels were increased significantly for PD patients compared to controls (p 0.05). Thus, plasma levels of miR-137 and miR-124 are associated with Parkinson's disease and might be potential biomarkers of the diagnosis of PD. There were no associations of plasma miR-137 and miR-124 with the severity of PD motor symptoms or PD-Dep.

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Metadata

Authors
Li, N., Pan, X., Zhang, J., Ma, A., Yang, S., Ma, J., & Xie, A.
Venue
Neurological Sciences
Publisher
Springer Science and Business Media LLC
Published
2017-02-08
Volume
38
Issue
5
Pages
761-767
ISSN
  • 1590-1874
  • 1590-3478
DOI
10.1007/s10072-017-2841-9
Cited by
97
References
4
Language
en
Licence
www.springer.com/tdm (unspecified)
Funders
  • Qingdao Science and Technology Program (11-2-4-2-(19)-jch)
  • Shandong Science and Technology Program (2012G0021842)

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