Adverse pregnancy conditions, infertility, and future cardiovascular risk: implications for mother and child
Open accessAbstract
Adverse pregnancy conditions in women are common and have been associated with adverse cardiovascular and metabolic outcomes such as myocardial infarction and stroke. As risk stratification in women is often suboptimal, recognition of non-traditional risk factors such as hypertensive disorders of pregnancy and premature delivery has become increasingly important. Additionally, such conditions may also increase the risk of cardiovascular disease in the children of afflicted women. In this review, we aim to highlight these conditions, along with infertility, and the association between such conditions and various cardiovascular outcomes and related maternal risk along with potential translation of risk to offspring. We will also discuss proposed mechanisms driving these associations as well as potential opportunities for screening and risk modification.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fertility therapy may confer unintended health risks to women.
“Although fertility therapy represents a safe and feasible option for many couples with infertility, these treatments may confer unintended health risks to women.”
From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [19]
Recent observational data indicate double the risk of severe maternal morbidity in fertility-treated pregnancy when compared with naturally conceived pregnancy.
“For example, recent observational data indicate double the risk of severe maternal morbidity (13,18,19) in fertility-treated pregnancy when compared with naturally conceived pregnancy.”
From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [19]
Fertility therapy is associated with short-term maternal complications.
“This question is increasingly relevant because fertility therapy is widely used to achieve pregnancy among older women, is associated with short-term maternal complications (13,18,19), and its long-term CV safety is unknown.”
From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [19]
Fertility therapy is widely used to achieve pregnancy among older women.
“This question is increasingly relevant because fertility therapy is widely used to achieve pregnancy among older women, is associated with short-term maternal complications (13,18,19), and its long-term CV safety is unknown.”
From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Epidemiology and causes of preterm birth
Goldenberg, R. L., Culhane, J. F., Iams, J. D., & Romero, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60074-4 · Cited by 7,801 · see citing works
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491 · see citing works
2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.005 · Cited by 4,945 · see citing works
(2013) · doi:10.1097/01.aog.0000437382.03963.88 · Cited by 3,961 · see citing works
Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis
Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60731-5 · Cited by 3,253 · see citing works
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715 · see citing works
Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. J. (2007) · BMJ · doi:10.1136/bmj.39335.385301.be · Cited by 2,552 · see citing works
Mosca, L., Benjamin, E. J., Berra, K., Bezanson, J. L., Dolor, R. J., Lloyd-Jones, D. M., Newby, L. K., Piña, I. L., Roger, V. L., Shaw, L. J., et al. (2011) · Circulation · doi:10.1161/cir.0b013e31820faaf8 · Cited by 2,143 · see citing works
Buchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123 · see citing works
Onuegbu, A. J., Olisekodiaka, J. M., Udo, J., Umeononihu, O. S., Amah, U. K., Okwara, J. E., & Atuegbu, C. (2015) · Medical Principles and Practice · doi:10.1159/000381778 · Cited by 2,057 · see citing works
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967 · see citing works
ESC Guidelines on the management of cardiovascular diseases during pregnancy
Endorsed by the European Society of Gynecology (ESG), T. A. F. E. P. C. (., Authors/Task Force Members, Regitz-Zagrosek, V., Blomstrom Lundqvist, C., Borghi, C., Cifkova, R., Ferreira, R., Foidart, J.-M., Gibbs, J. S. R., Gohlke-Baerwolf, C., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr218 · Cited by 1,924 · see citing works
Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919 · see citing works
Metzger, B. E., Buchanan, T. A., Coustan, D. R., de Leiva, A., Dunger, D. B., Hadden, D. R., Hod, M., Kitzmiller, J. L., Kjos, S. L., Oats, J. N., et al. (2007) · Diabetes Care · doi:10.2337/dc07-s225 · Cited by 1,908 · see citing works
Ridker, P. M., Buring, J. E., Rifai, N., & Cook, N. R. (2007) · JAMA · doi:10.1001/jama.297.6.611 · Cited by 1,814 · see citing works
Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
Ehrmann, D. A., Barnes, R. B., Rosenfield, R. L., Cavaghan, M. K., & Imperial, J. (1999) · Diabetes Care · doi:10.2337/diacare.22.1.141 · Cited by 1,257 · cited 1× · see citing works
“In patients with this condition, there is some degree of insulin resistance, and this is independent of obesity in women [76, 77] and ranges from impaired glucose tolerance to overt type-2 diabetes with increased risk in women with a family history of diabetes [78–82].”
BackgroundIrgens, H. U., Roberts, J. M., Reisæter, L., Irgens, L. M., & Lie, R. T. (2001) · BMJ · doi:10.1136/bmj.323.7323.1213 · Cited by 1,040 · see citing works
Napoli, C., D'Armiento, F. P., Mancini, F. P., Postiglione, A., Witztum, J. L., Palumbo, G., & Palinski, W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119813 · Cited by 1,014 · see citing works
Wild, S., Pierpoint, T., McKeigue, P., & Jacobs, H. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01000.x · Cited by 970 · see citing works
Prevalence and Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome
Apridonidze, T., Essah, P. A., Iuorno, M. J., & Nestler, J. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1045 · Cited by 931 · see citing works
Cardiovascular sequelae of preeclampsia/eclampsia: A systematic review and meta-analyses
McDonald, S. D., Malinowski, A., Zhou, Q., Yusuf, S., & Devereaux, P. J. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.06.042 · Cited by 924 · see citing works
Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes
Ben‐Haroush, A., Yogev, Y., & Hod, M. (2004) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.00985.x · Cited by 856 · see citing works
Ridker, P. M., Paynter, N. P., Rifai, N., Gaziano, J. M., & Cook, N. R. (2008) · Circulation · doi:10.1161/circulationaha.108.814251 · Cited by 841 · see citing works
Serial study of factors influencing changes in cardiac output during human pregnancy
Robson, S. C., Hunter, S. K., Boys, R. J., & Dunlop, W. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.4.h1060 · Cited by 837 · see citing works
Coronary microvascular dysfunction: an update
Crea, F., Camici, P. G., & Merz, C. N. B. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht513 · Cited by 784 · see citing works
Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women—2011 Update
Mosca, L. J., Benjamin, E. J., Berra, K. A., Bezanson, J. L., Dolor, R. J., Lloyd‐Jones, D. M., Newby, L. K., Piña, I. L., Roger, V. L., Shaw, L. J., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.005 · Cited by 783 · see citing works
Wallis, A. B., Saftlas, A. F., Hsia, J., & Atrash, H. K. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.20 · Cited by 766 · see citing works
Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome
Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1329 · Cited by 703 · see citing works
Lykke, J. A., Langhoff‐Roos, J., Sibai, B. M., Funai, E. F., Triche, E. W., & Paidas, M. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.130765 · Cited by 673 · see citing works
Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome
Legro, R. S., Kunselman, A. R., & Dunaif, A. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00948-2 · Cited by 622 · see citing works
DeUgarte, C. M., Bartolucci, A. A., & Azziz, R. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.11.070 · Cited by 589 · see citing works
(2013) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000433006.09219.f1 · Cited by 583 · see citing works
Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study
Hernández–Dı́az, S., Toh, S., & Cnattingius, S. (2009) · BMJ · doi:10.1136/bmj.b2255 · Cited by 568 · see citing works
Gilbert, J. S., Ryan, M. J., LaMarca, B. B., Sedeek, M. H., Murphy, S., & Granger, J. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01113.2007 · Cited by 553 · see citing works
Association of Maternal Endothelial Dysfunction With Preeclampsia
Chambers, J. C. (2001) · JAMA · doi:10.1001/jama.285.12.1607 · Cited by 539 · see citing works
Menstrual cycle irregularity and risk for future cardiovascular disease
Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J. E., Stampfer, M. J., Willett, W. C., Speizer, F. E., & Manson, J. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8471 · Cited by 528 · see citing works
Glucose Regulation in Young Adults with Very Low Birth Weight
Hovi, P., ANDERSSON, S. M., Eriksson, J. G., Järvenpää, A., Strang‐Karlsson, S., Mäkitie, O., & Kajantie, E. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067187 · Cited by 524 · see citing works
Davis, E., Lazdam, M., Lewandowski, A. J., Worton, S. A., Kelly, B., Kenworthy, Y., Adwani, S., Wilkinson, A. R., McCormick, K. P., Sargent, I. L., et al. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3093 · Cited by 522 · see citing works
Intrauterine Programming of Physiological Systems: Causes and Consequences
Fowden, A. L., Giussani, D. A., & Forhead, A. J. (2006) · Physiology · doi:10.1152/physiol.00050.2005 · Cited by 511 · see citing works
Talbott, E. O., Guzick, D. S., Sutton-Tyrrell, K., McHugh-Pemu, K. P., Zborowski, J. V., Remsberg, K. E., & Kuller, L. H. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.11.2414 · Cited by 511 · see citing works
Mortality of Women with Polycystic Ovary Syndrome at Long-term Follow-up
Pierpoint, T., McKeigue, P. M., Isaacs, A. J., Wild, S. H., & Jacobs, H. S. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00035-3 · Cited by 504 · see citing works
(2013) · PubMed · Cited by 462 · see citing works
Jaddoe, V. W. V., de Jonge, L. L., Hofman, A., Franco, O. H., Steegers, E. A. P., & Gaillard, R. (2014) · BMJ · doi:10.1136/bmj.g14 · Cited by 443 · see citing works
Preeclampsia and Cardiovascular Disease Death
Mongraw‐Chaffin, M., Cirillo, P. M., & Cohn, B. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150078 · Cited by 436 · see citing works
Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring
Kajantie, E., Eriksson, J. G., Osmond, C., Thornburg, K. L. R., & Barker, D. J. P. (2009) · Stroke · doi:10.1161/strokeaha.108.538025 · Cited by 434 · see citing works
Ehrmann, D. A., Sturis, J., Byrne, M. M., Karrison, T., Rosenfield, R. L., & Polonsky, K. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118064 · Cited by 426 · see citing works
Martin, J. A., Hamilton, B. E., Sutton, P. D., Ventura, S. J., Mathews, T. J., Kirmeyer, S., & Osterman, M. J. K. (2010) · PubMed · Cited by 419 · see citing works
Rich-Edwards, J. W., Fraser, A., Lawlor, D. A., & Catov, J. M. (2014) · Epidemiologic Reviews · doi:10.1093/epirev/mxt006 · Cited by 417 · see citing works
Epidemiology and Adverse Cardiovascular Risk Profile of Diagnosed Polycystic Ovary Syndrome
Lo, J. C.-M., Feigenbaum, S. L., Yang, J., Pressman, A. R., Selby, J. V., & Go, A. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2430 · Cited by 414 · see citing works
Fraser, A., Nelson, S. M., Macdonald-Wallis, C., Cherry, L., Butler, E., Sattar, N., & Lawlor, D. A. (2012) · Circulation · doi:10.1161/circulationaha.111.044784 · Cited by 401 · see citing works
Prevalence and Predictors of Coronary Artery Calcification in Women with Polycystic Ovary Syndrome
Christian, R. C., Dumesic, D. A., Behrenbeck, T. R., Oberg, A. L., Sheedy, P. F., & Fitzpatrick, L. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030334 · Cited by 396 · see citing works
de Groot, P. C. M., Dekkers, O. M., Romijn, J. A., Dieben, S. W. M., & Helmerhorst, F. M. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr001 · Cited by 394 · see citing works
The risk of adverse pregnancy outcomes in women who are overweight or obese
Athukorala, C., Rumbold, A. R., Willson, K. J., & Crowther, C. A. (2010) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-10-56 · Cited by 390 · see citing works
Cardiometabolic Differences in Children Born After in Vitro Fertilization: Follow-Up Study
Ceelen, M., van Weissenbruch, M. M., Vermeiden, J. P. W., van Leeuwen, F. E., & de Waal, H. A. D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2432 · Cited by 383 · see citing works
Annual Summary of Vital Statistics: 2010–2011
Hamilton, B. E., Hoyert, D. L., Martin, J. A., Strobino, D. M., & Guyer, B. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3769 · Cited by 374 · see citing works
Hypertension in Pregnancy and Later Cardiovascular Risk
Romundstad, P., Magnussen, E. B., Smith, G. D., & VATTEN, L. J. (2010) · Circulation · doi:10.1161/circulationaha.110.943407 · Cited by 372 · see citing works
Vgontzas, A. N., Legro, R. S., Bixler, E. O., Grayev, A., Kales, A., & Chrousos, G. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7185 · Cited by 371 · see citing works
Screening Women With Polycystic Ovary Syndrome for Metabolic Syndrome
Dokras, A., Bochner, M., Hollinrake, E., Markham, S. M., Voorhis, B. J. V., & Jagasia, D. H. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000167408.30893.6b · Cited by 353 · see citing works
Carr, D. B., Utzschneider, K. M., Hull, R. L., Tong, J., Wallace, T. M., Kodama, K., Shofer, J. B., Heckbert, S. R., Boyko, E. J., Fujimoto, W. Y., et al. (2006) · Diabetes Care · doi:10.2337/dc05-2482 · Cited by 350 · see citing works
Katz, R. J., Karliner, J. S., & Resnik, R. R. (1978) · Circulation · doi:10.1161/01.cir.58.3.434 · Cited by 348 · see citing works
Boulman, N., Levy, Y., Leiba, R., Shachar, S. S., Linn, R., Zinder, O., & Blumenfeld, Z. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031096 · Cited by 332 · see citing works
Birdsall, M. A., Farquhar, C. M., & White, H. D. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-1-199701010-00005 · Cited by 327 · cited 1× · see citing works
“These women also tend to have more extensive coronary disease by angiography and computed tomography and increase in intima-media thickness on carotid imaging [90–92].”
BackgroundNumber of Pregnancies and the Subsequent Risk of Cardiovascular Disease
Ness, R. B., Harris, T. B., Cobb, J. L., Flegal, K. M., Kelsey, J. L., Balanger, A., Stunkard, A. J., & D’Agostino, R. B. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305273282104 · Cited by 317 · see citing works
Haemodynamic changes during the puerperium: a Doppler and M‐mode echocardiographic study
Robson, S. C., Dunlop, W., MOORE, M., et al. (1987) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1987.tb02286.x · Cited by 304 · see citing works
Flow-Mediated Dilation in 9- to 11-Year-Old Children
Leeson, C. P. M., Whincup, P. H., Cook, D. G., Donald, A. E., Papacosta, O., Lucas, A., & Deanfield, J. E. (1997) · Circulation · doi:10.1161/01.cir.96.7.2233 · Cited by 304 · see citing works
Lawlor, D. A., Emberson, J., Ebrahim, S. B. J., Whincup, P. H., Wannamethee, S. G., Walker, M., & Smith, G. D. (2003) · Circulation · doi:10.1161/01.cir.0000053441.43495.1a · Cited by 302 · see citing works
Trends in Death Rates Among U.S. Adults With and Without Diabetes Between 1997 and 2006
Gregg, E. W., Cheng, Y. J., Saydah, S., Cowie, C. C., GARFIELD, S. A., Geiss, L. S., & Barker, L. E. (2012) · Diabetes Care · doi:10.2337/dc11-1162 · Cited by 299 · see citing works
Risk of High Blood Pressure Among Young Men Increases With the Degree of Immaturity at Birth
Johansson, S., Iliadou, A. N., Bergvall, N., Tuvemo, T., Norman, M., & Cnattingius, S. (2005) · Circulation · doi:10.1161/circulationaha.105.540906 · Cited by 298 · see citing works
Scherrer, U., Rimoldi, S. F., Rexhaj, E., Stüber, T., Duplain, H., Garcin, S., de Marchi, S. F., NICOD, P. H., Germond, M., Allemann, Y., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.071183 · Cited by 295 · see citing works
Pulmonary and Systemic Vascular Dysfunction in Young Offspring of Mothers With Preeclampsia
Jayet, P., Rimoldi, S. F., Stüber, T., Salmón, C. S., Hutter, D., Rexhaj, E., Thalmann, S., Schwab, M., Turini, P., Sartori-Cucchia, C., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.941203 · Cited by 285 · see citing works
Cardiovascular changes in early phase of pregnancy
Capeless, E. L., & Clapp, J. F. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90902-2 · Cited by 276 · see citing works
Wiznitzer, A., Mayer, A., Novack, V., Sheiner, E., Gilutz, H., Malhotra, A., & Novack, L. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.05.032 · Cited by 275 · see citing works
Fogel, R. B., Malhotra, A., Pillar, G., Pittman, S. D., Dunaif, A., & White, D. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7316 · Cited by 274 · see citing works
Infertility, Assisted Reproductive Technology, and Adverse Pregnancy Outcomes
Reddy, U. M., Wapner, R. J., Rebar, R. W., & Tasca, R. J. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000259316.04136.30 · Cited by 256 · see citing works
Lipoprotein metabolism during normal pregnancy
Brizzi, P., Tonolo, G., Esposito, F., Puddu, L., Dessole, S., Maioli, M., & Milia, S. (1999) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(99)70574-0 · Cited by 236 · see citing works
Parity and risk of later-life maternal cardiovascular disease
Parikh, N. I., Cnattingius, S., Dickman, P. W., Mittleman, M. A., Ludvigsson, J. F., & Ingelsson, E. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.11.017 · Cited by 234 · see citing works
Ovarian hyperstimulation syndrome: pathophysiology and prevention
Nastri, C. O., Ferriani, R. A., Rocha, I. A., & Martins, W. P. (2010) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-010-9387-6 · Cited by 233 · see citing works
Sex and gender differences in symptoms of myocardial ischaemia
Regitz‐Zagrosek, V. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr272 · Cited by 232 · see citing works
Geelhoed, J. J. M., Fraser, A., Tilling, K. M., Benfield, L., Smith, G. D., Sattar, N. A., Nelson, S. M., & Lawlor, D. A. (2010) · Circulation · doi:10.1161/circulationaha.110.936674 · Cited by 213 · see citing works
Cardiac output in normal pregnancy: A critical review
VANOPPEN, A., Stigter, R. H., & Bruinse, H. W. (1996) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00348-7 · Cited by 207 · see citing works
Ehrmann, D. A., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0229 · Cited by 205 · see citing works
Elevated Blood Pressure in Offspring Born Premature to Hypertensive Pregnancy
Lazdam, M., de la Horra, A., Pitcher, A., Mannie, Z. N., Diesch, J., Trevitt, C., Kylintireas, I., Contractor, H., Singhal, A., Lucas, A., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150235 · Cited by 197 · see citing works
Bonamy, A. E., Bendito, A., Martin, H., Andolf, E. G., Sedin, G., & Norman, M. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000181373.29290.80 · Cited by 194 · see citing works
The long-term renal and cardiovascular consequences of prematurity
Abitbol, C. L., & Rodriguez, M. M. (2012) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.38 · Cited by 194 · see citing works
Sharaf, B. L., Wood, T., Shaw, L. J., Johnson, B. D., Kelsey, S. F., Anderson, R. D., Pepine, C. J., & Merz, C. N. B. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.04.002 · Cited by 188 · see citing works
Self-citationEarly origins of adult disease: Low birth weight and vascular remodeling
Visentin, S., Grumolato, F., Nardelli, G. B., Camillo, B. D., Grisan, E., & Cosmi, E. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.09.027 · Cited by 187 · see citing works
Perinatal Risk Factors for Ischemic Heart Disease
Kaijser, M., Bonamy, A. E., Akre, O., Cnattingius, S., Granath, F. N., Norman, M., & Ekbom, A. (2008) · Circulation · doi:10.1161/circulationaha.107.710715 · Cited by 186 · see citing works
Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies
Davis, E., Newton, L., Lewandowski, A. J., Lazdam, M., Kelly, B., Kyriakou, T., & Leeson, P. (2012) · Clinical Science · doi:10.1042/cs20110627 · Cited by 183 · see citing works
Gunderson, E. P., Chiang, V., Pletcher, M. J., Jacobs, D. R., Quesenberry, C. P., Sidney, S., & Lewis, C. E. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000490 · Cited by 182 · see citing works
Relation of arterial stiffness with gestational age and birth weight
Cheung, Y. (2004) · Archives of Disease in Childhood · doi:10.1136/adc.2003.025999 · Cited by 167 · see citing works
Valenzuela‐Alcaráz, B., Crispi, F., Bijnens, B. H., Cruz-Lemini, M., Creus, M. T., Sitges, M., Bartrons, J., Cı́vico, S., Balasch, J., & Gratacós, E. (2013) · Circulation · doi:10.1161/circulationaha.113.002428 · Cited by 161 · see citing works
Reference ranges of lipids and apolipoproteins in pregnancy
Piechota, W., & Staszewski, A. (1992) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(92)90190-a · Cited by 160 · see citing works
Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis
Messerlian, C., Maclagan, L. C., & Basso, O. (2012) · Human Reproduction · doi:10.1093/humrep/des347 · Cited by 160 · see citing works
Hypertensive Disorders of Pregnancy and Cardiometabolic Health in Adolescent Offspring
Fraser, A., Nelson, S. M., Macdonald-Wallis, C. M., Sattar, N. A., & Lawlor, D. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01513 · Cited by 157 · see citing works
In vitro fertilisation in Sweden: obstetric characteristics, maternal morbidity and mortality
Källén, B. A. J., Finnström, O., Nygren, K. G., Olausson, P. O., & Wennerholm, U. (2005) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00745.x · Cited by 155 · see citing works
Low birth weight and the developing vascular tree: a systematic review
Norman, M. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00904.x · Cited by 154 · see citing works
Birth dimensions of offspring, premature birth, and the mortality of mothers
Smith, G. D., Whitley, E., Gissler, M., & Hemminki, E. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03406-1 · Cited by 150 · see citing works
Smith, G. D., Hart, C., Ferrell, C., Upton, M. N., Hole, D. J., Hawthorne, V. M., & Watt, G. C. M. (1997) · BMJ · doi:10.1136/bmj.315.7117.1189 · Cited by 145 · see citing works
Claudio Napoli, A., Witztum, J. L., de Nigris, F., Palumbo, G. A., D’Armiento, F. P., & Palinski, W. (1999) · Circulation · doi:10.1161/01.cir.99.15.2003 · Cited by 145 · see citing works
Kharazmi, E., Dossus, L., Rohrmann, S., & Kaaks, R. (2010) · Heart · doi:10.1136/hrt.2010.202226 · Cited by 143 · see citing works
Sprung, V. S., Atkinson, G., Cuthbertson, D. J., Pugh, C. J. A., Aziz, N., GREEN, D. J., Cable, N. T., & Jones, H. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04490.x · Cited by 142 · see citing works
Seidman, D. S., Laor, A., Gale, R., Stevenson, D. K., Mashiach, S., & Danon, Y. L. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb15339.x · Cited by 135 · see citing works
Relationships between Sleep Disordered Breathing and Glucose Metabolism in Polycystic Ovary Syndrome
Tasali, E., Cauter, E. V., & Ehrmann, D. A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1084 · Cited by 135 · see citing works
Reproductive Factors and Risk of Myocardial Infarction
Palmer, J. R., Rosenberg, L. A., & Shapiro, S. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116513 · Cited by 133 · see citing works
Colilla, S., Cox, N. J., & Ehrmann, D. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7518 · Cited by 130 · see citing works
Fuel Metabolism During Pregnancy
Homko, C. J., Sivan, E., Reece, E. A., & Boden, G. H. (1999) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-1016219 · Cited by 125 · see citing works
Early or Recurrent Preterm Birth and Maternal Cardiovascular Disease Risk
Catov, J. M., Wu, C. S., Olsen, J., Sutton-Tyrrell, K., Li, J., & Nohr, E. A. (2010) · Annals of Epidemiology · doi:10.1016/j.annepidem.2010.05.007 · Cited by 124 · see citing works
Bonamy, A. K. E., Martin, H., Jörneskog, G., et al. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01868.x · Cited by 120 · see citing works
Tenhola, S., Rahiala, E., Halonen, P., Vanninen, E., & Voutilainen, R. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000196734.54473.e3 · Cited by 118 · see citing works
Ueda, P., Cnattingius, S., Stephansson, O., Ingelsson, E., Ludvigsson, J. F., & Bonamy, A. E. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9892-5 · Cited by 111 · see citing works
Menstrual irregularity and cardiovascular mortality.
Wang, E., Cirillo, P. M., Vittinghoff, E., Bibbins-Domingo, K., Cohn, B., & Cedars, M. (2011) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2010-1709 · Cited by 109 · see citing works
Offspring Birth Weight and Parental Mortality: Prospective Observational Study and Meta-Analysis
Smith, G. D., Hyppönen, E., Power, C., & Lawlor, D. A. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm054 · Cited by 107 · see citing works
Parity and Carotid Artery Atherosclerosis in Elderly Women
Humphries, K. H., Westendorp, I. C. D., Bots, M. L., Spinelli, J. J., Carere, R. G., Albert Hofman, D., & Witteman, J. C. M. (2001) · Stroke · doi:10.1161/hs1001.097224 · Cited by 106 · see citing works
An association between preterm delivery and long-term maternal cardiovascular morbidity
Kessous, R., Shoham-Vardi, I., Pariente, G., Holcberg, G., & Sheiner, E. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.05.041 · Cited by 104 · see citing works
Maternal Recall of Hypertensive Disorders in Pregnancy: A Systematic Review
Stuart, J. J., Merz, C. N. B., Berga, S. L., Miller, V. M., Ouyang, P., SHUFELT, C. L., Steiner, M. S., WENGER, N. K., & Rich-Edwards, J. W. (2012) · Journal of Women s Health · doi:10.1089/jwh.2012.3740 · Cited by 100 · see citing works
Subfertility and risk of later life maternal cardiovascular disease
Parikh, N. I., Cnattingius, S., Mittleman, M. A., Ludvigsson, J. F., & Ingelsson, E. (2011) · Human Reproduction · doi:10.1093/humrep/der400 · Cited by 97 · see citing works
Oren, A. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03151-5 · Cited by 91 · see citing works
Long term cardiovascular risk in women prescribed fertility therapy
Udell, J. A., Lu, H., & Redelmeier, D. A. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.085 · Cited by 90 · see citing works
Diagnosis of hyperandrogenism: Biochemical criteria
Stanczyk, F. Z. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.03.007 · Cited by 90 · see citing works
HIGGINS, M. W., Keller, J., Moore, F. E., et al. (1980) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112882 · Cited by 86 · see citing works
Characteristics of Arterial Stiffness in Very Low Birth Weight Premature Infants
Tauzin, L., Rossi, P. M., Giusano, B., Gaudart, J., Boussuges, A., Fraisse, A., & Siméoni, U. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000242264.68586.28 · Cited by 86 · see citing works
High Blood Pressure in 2.5-Year-Old Children Born Extremely Preterm
Bonamy, A. E., Källén, K., & Norman, M. (2012) · PEDIATRICS · doi:10.1542/peds.2011-3177 · Cited by 83 · see citing works
Hastie, C. E., Smith, G. C. S., Mackay, D., & Pell, J. P. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyq270 · Cited by 82 · see citing works
Preterm delivery and risk of subsequent cardiovascular morbidity and type‐II diabetes in the mother
Lykke, J. A., Paidas, M., Damm, P., Triche, E. W., Kuczynski, E., & Langhoff‐Roos, J. (2010) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02448.x · Cited by 81 · see citing works
Vgontzas, A. N., Legro, R. S., Bixler, E. O., Grayev, A. M., Kales, A., & Chrousos, G. P. (2001) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200107000-00017 · Cited by 80 · see citing works
Mortality in a cohort of IVF patients
Venn, A., Hemminki, E., Watson, L., et al. (2001) · Human Reproduction · doi:10.1093/humrep/16.12.2691 · Cited by 79 · see citing works
Catov, J. M., Newman, A. B., Sutton-Tyrrell, K., Harris, T. B., Tylavsky, F., Visser, M., Ayonayon, H. N., & Ness, R. B. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.09.009 · Cited by 77 · see citing works
Oxidative stress and inflammation in pregnancy
Fialová, L., Malbohan, I., Kalousová, M., Soukupová, J., Krofta, L., Štípek, S., & Zima, T. (2006) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510500375230 · Cited by 76 · see citing works
Not all women diagnosed with PCOS share the same cardiovascular risk profiles
Jovanovic, V. P., Carmina, E., & Løbo, R. A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.04.021 · Cited by 68 · see citing works
Palti, H., & Rothschild, E. (1989) · Early Human Development · doi:10.1016/0378-3782(89)90061-3 · Cited by 62 · see citing works
Legro, R. S., Azziz, R., Ehrmann, D. A., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030044 · Cited by 60 · see citing works
Xu, G., Zhang, J., Pan, H., Tian, S., Liu, M., Yu, T., Li, J., Ying, W.-W., Yao, W., Lin, X.-H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2349 · Cited by 60 · see citing works
Maternal-foetal epigenetic interactions in the beginning of cardiovascular damage
Claudio Napoli, A., Infante, T., & Casamassimi, A. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr201 · Cited by 57 · see citing works
Prior Preterm Birth and Maternal Subclinical Cardiovascular Disease 4 to 12 Years After Pregnancy
Catov, J. M., Dodge, R., Barinas‐Mitchell, E., Sutton-Tyrrell, K., Yamal, J., Piller, L. B., & Ness, R. B. (2013) · Journal of Women s Health · doi:10.1089/jwh.2013.4248 · Cited by 54 · see citing works
Prior Preterm or Small-for-Gestational-Age Birth Related to Maternal Metabolic Syndrome
Catov, J. M., Dodge, R., Yamal, J., Roberts, J. M., Piller, L. B., & Ness, R. B. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3182075626 · Cited by 53 · see citing works
Torrens, C., Snelling, T. H., Chau, R., Shanmuganathan, M., Cleal, J. K., Poore, K. R., Noakes, D. E., Poston, L., Hanson, M. A., & Green, L. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.047340 · Cited by 51 · see citing works
Preterm birth and long-term maternal cardiovascular health
Perng, W., Stuart, J. J., Rifas‐Shiman, S. L., Rich-Edwards, J. W., Stuebe, A. M., & Oken, E. (2014) · Annals of Epidemiology · doi:10.1016/j.annepidem.2014.10.012 · Cited by 50 · see citing works
Delivery of a Small for Gestational Age Infant and Greater Maternal Risk of Ischemic Heart Disease
Bukowski, R. K., Davis, K. E., & Wilson, P. W. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033047 · Cited by 48 · see citing works
(2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.006 · Cited by 48 · see citing works
Göbl, C. S., Bozkurt, L., Yarragudi, R., Prikoszovich, T., Tura, A., Pacini, G., Koppensteiner, R., & Kautzky‐Willer, A. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0138-3 · Cited by 41 · see citing works
Langford, H. G., & Watson, R. L. (1980) · Hypertension · doi:10.1161/01.hyp.2.4_pt_2.i130 · Cited by 39 · see citing works
Protein metabolism in insulin-treated gestational diabetes.
Butte, N. F., Hsu, H. W., Thotathuchery, M., et al. (1999) · Diabetes Care · doi:10.2337/diacare.22.5.806 · Cited by 36 · see citing works
Metabolic syndrome and the risk for recurrent pre‐eclampsia: a retrospective cohort study
Stekkinger, E., Scholten, R. R., van der Vlugt, M. J., van Dijk, A., Janssen, M., & Spaanderman, M. E. A. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12189 · Cited by 36 · see citing works
Multiple Causes for Ischemia Without Obstructive Coronary Artery Disease
Pepine, C. J. (2015) · Circulation · doi:10.1161/circulationaha.115.015553 · Cited by 33 · see citing works
Self-citationLangford, H. G., & Rl, W. (1980) · Hypertension · doi:10.1161/01.hyp.2.4.130 · Cited by 32 · see citing works
Washburn, L. K., Brosnihan, K. B., Chappell, M. C., Diz, D. I., Gwathmey, T. M., Nixon, P. A., Russell, G. B., Snively, B. M., & O’Shea, T. M. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320314526940 · Cited by 29 · see citing works
Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study
Hastie, C. E., Smith, G. C. S., Mackay, D., & Pell, J. P. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.06.080 · Cited by 25 · see citing works
Yeh, J. S., Cheng, H., Hsu, P., Sung, S., Liu, W.-L., Fang, H., & Chuang, S. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001008 · Cited by 20 · see citing works
Association of Lipid Levels During Gestation With Preeclampsia and Gestational Diabetes Mellitus
Wiznitzer, A., Mayer, A., Novack, V., et al. (2011) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000393165.62909.3b · Cited by 20 · see citing works
Xu, J., Barinas‐Mitchell, E., Kuller, L. H., Youk, A. O., & Catov, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104149 · Cited by 16 · see citing works
Preterm Delivery and Risk of Subsequent Cardiovascular Morbidity and Type II Diabetes in the Mother
Lykke, J. A., Paidas, M. J., Damm, P., et al. (2011) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000397122.12461.07 · Cited by 15 · see citing works
Preeclampsia: effect on newborn blood pressure in the 3 days following preterm birth: a cohort study
Reveret, M., Boivin, A., Guigonnis, V., Audibert, F., & Nuyt, A. M. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2014.50 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wu, P., Gulati, M., Kwok, C. S., Wong, C. W., Narain, A., O'Brien, S., Chew‐Graham, C. A., Verma, G., Kadam, U. T., & Mamas, M. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007809 · Cited by 204 · see citing works
Cardiovascular Risk Following Fertility Therapy
Dayan, N., Filion, K. B., Okano, M., Kilmartin, C., Reinblatt, S., Landry, T., Basso, O., & Udell, J. A. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.753 · Cited by 94 · see citing works
- Authors
- Park, K., Wei, J., Minissian, M., Bairey Merz, C. N., & Pepine, C. J.
- Affiliations
- University of Florida (US)
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Pepine, Carl J.
- Venue
- Cardiovascular Drugs and Therapy
- Published
- 2015-06-03
- Volume
- 29
- Issue
- 4
- Pages
- 391-401
- ISSN
- 0920-3206 (ISSN-L)
- 1573-7241
- PMC
- PMC4758514
- OpenAlex
- W605094320
- Cited by
- 40
- References
- 152
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 10 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cardiovascular Drugs and Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001427, n01hv068164-006, n01hv068162-009, n01hv068161-005, UL1TR000124, n01hv068163-006, UL1TR000064)
- U.S. Public Health Service (U0164829)
- National Institute on Aging (R03AG032631)
- National Heart, Lung, and Blood Institute (N01-HV68162, U01HL649141, N01 HV068162, T32HL069751, N01HV68163, N01 HV068164, N01- HV-068161, U01 HL649241, N01 HV068163, T32HL69751, R01HL090957, K23HL105787, T32HL116273)
- National Institute of Nursing Research (F31NR015725)
- National Center for Research Resources (MO1-RR00425, M01RR000425)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- adverse pregnancy outcomes, infertility, cardiovascular risk, hypertensive disorders of pregnancy, preterm birth, maternal cardiovascular disease, offspring cardiovascular risk, risk stratification, risk factor control, screening, pathophysiological mechanisms
- MeSH terms
- Cardiovascular Diseases, Child, Female, Humans, Infertility, Mothers, Pregnancy, Pregnancy Complications, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
