Cited by 1,073Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

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Dopamine: Functions, Signaling, and Association with Neurological Diseases

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Klein, Marianne O., Battagello, Daniella S., Cardoso, Ariel R., Hauser, David N., Bittencourt, Jackson C., Correa, Ricardo G.·2019·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-018-0632-3PMC PMC11469830

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Abstract

The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery, that exerts its actions upon binding to G protein-coupled receptors. Dopamine receptors are widely expressed in the body and function in both the peripheral and the central nervous systems. Dopaminergic signaling pathways are crucial to the maintenance of physiological processes and an unbalanced activity may lead to dysfunctions that are related to neurodegenerative diseases. Unveiling the neurobiology and the molecular mechanisms that underlie these illnesses may contribute to the development of new therapies that could promote a better quality of life for patients worldwide. In this review, we summarize the aspects of dopamine as a catecholaminergic neurotransmitter and discuss dopamine signaling pathways elicited through dopamine receptor activation in normal brain function. Furthermore, we describe the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system, such as Parkinson's, Schizophrenia, Huntington's, Attention Deficit and Hyperactivity Disorder, and Addiction. A brief description of new dopaminergic drugs recently approved and under development treatments for these ailments is also provided.

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Authors: Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G.
Affiliations: Universidade de São Paulo (BR)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Bittencourt, Jackson C.
Correa, Ricardo G.
ORCID: Klein, Marianne O.
Battagello, Daniella S.
Cardoso, Ariel R.
Hauser, David N.
Bittencourt, Jackson C.
Correa, Ricardo G.
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2018-11-16
Volume: 39
Issue: 1
Pages: 31-59
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-018-0632-3
PMC: PMC11469830
OpenAlex: W2901208536
Cited by: 1,073
References: 472
Citations by year: 2026: 141 · 2025: 174 · 2024: 214 · 2023: 199 · 2022: 148 · 2021: 105 · 2020: 64 · 2019: 27
FWCI: 6.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine, dopaminergic signaling, dopamine receptors, G protein-coupled receptors, catecholamine neurotransmitters, neuromodulation, neurodegenerative diseases, Parkinson's disease, schizophrenia, Huntington's disease, attention deficit hyperactivity disorder, addiction, dopaminergic therapy, reward and motivation
MeSH terms: Animals, Brain, Dopamine, Humans, Models, Biological, Nervous System Diseases, Signal Transduction

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Dopamine: Functions, Signaling, and Association with Neurological Diseases

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