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Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment

Tahmasebi, Fatemeh, Asl, Elmira Roshani, Vahidinia, Zeinab, Barati, Shirin·2024·Cellular and Molecular Neurobiology
DOI 10.1007/s10571-024-01478-1PMC PMC11076329
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Abstract

Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by inflammation and demyelination of CNS neurons. Up to now, there are many therapeutic strategies for MS but they are only being able to reduce progression of diseases and have not got any effect on repair and remyelination. Stem cell therapy is an appropriate method for regeneration but has limitations and problems. So recently, researches were used of exosomes that facilitate intercellular communication and transfer cell-to-cell biological information. MicroRNAs (miRNAs) are a class of short non-coding RNAs that we can used to their dysregulation in order to diseases diagnosis. The miRNAs of microvesicles obtained stem cells may change the fate of transplanted cells based on received signals of injured regions. The miRNAs existing in MSCs may be displayed the cell type and their biological activities. Current studies show also that the miRNAs create communication between stem cells and tissue-injured cells. In the present review, firstly we discuss the role of miRNAs dysregulation in MS patients and miRNAs expression by stem cells. Finally, in this study was confirmed the relationship of microRNAs involved in MS and miRNAs expressed by stem cells and interaction between them in order to find appropriate treatment methods in future for limit to disability progression. Graphical Abstract The effect of miRNAs in transplanted MSC derived exosomes for MS patient treatment. The role of different miRNAs on proliferation, reprogramming, migration and differentiation have been shown.

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Fig. 1 Glial cells related miRNA expression in Multiple Sclerosis. MicroRNA are upregulated (red) and downregulated (blue) in microglia, astrocytes, and oligodendrocytes in the nervous system of MS patients
Fig. 1 Glial cells related miRNA expression in Multiple Sclerosis. MicroRNA are upregulated (red) and downregulated (blue) in microglia, astrocytes, and oligodendrocytes in the nervous system of MS patientsCC BY · PubMed Central
Fig. 2 Immune system related miRNA expression in Multiple Sclerosis. MicroRNAs are upregulated (red) and downregulated (blue) in CD4+ T cells, CD8+ T cells, Treg cells, and B cells in the immune cells of MS patients
Fig. 2 Immune system related miRNA expression in Multiple Sclerosis. MicroRNAs are upregulated (red) and downregulated (blue) in CD4+ T cells, CD8+ T cells, Treg cells, and B cells in the immune cells of MS patientsCC BY · PubMed Central
Fig. 3 The effect of miRNAs in transplanted MSC-derived exosomes for MS patient treatment. These extracellular vesicles contain microRNAs and proteins. The role of different miRNAs on proliferation, reprogramming, migration, and differentiation has been shown
Fig. 3 The effect of miRNAs in transplanted MSC-derived exosomes for MS patient treatment. These extracellular vesicles contain microRNAs and proteins. The role of different miRNAs on proliferation, reprogramming, migration, and differentiation has been shownCC BY · PubMed Central

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Metadata

Authors
Tahmasebi, F., Asl, E. R., Vahidinia, Z., & Barati, S.
Venue
Cellular and Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2024-05-07
Volume
44
Issue
1
ISSN
  • 0272-4340
  • 1573-6830
DOI
10.1007/s10571-024-01478-1
PMC
PMC11076329
Cited by
6
References
12
Language
en
Licence
Funders
saveh university of medical sciences

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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