Suicidal ideation among anxious youth: a preliminary investigation of the role of neural processing of social rejection in interaction with real world negative social experiences
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Suicidal ideation increases in adolescence, especially for anxious youth, and is a frequent precursor to suicide. This study examined whether neural processing of social rejection interacted with negative social experiences to predict suicidal ideation. Thus, to our knowledge this is the first study to examine how brain function may interact with the environment to contribute to suicidal ideation in youth, consistent with a developmental psychopathology perspective. Thirty-six anxious youth (ages 11 to 16) completed diagnostic interviews and questionnaires, an ecological momentary assessment (EMA) protocol, and a functional magnetic resonance imaging paradigm. Results showed that youth experienced greater severity of suicidal ideation when they exhibited heightened activation to social rejection in the right anterior insula and also experienced high levels of peer victimization or EMA-measured daily negative social experiences. Findings provide preliminary evidence that alterations in neural processing of social rejection interacts with exposure to negative social experiences to contribute to suicidal ideation.
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Greater suicidal ideation in adolescents is associated with heightened insula activation to social rejection during an ecological momentary assessment protocol.
“Greater SI in adolescents has also been found to be associated with heightened insula activation to social rejection during an EMA protocol (79).”
From New methods for assessing rapid changes in suicide risk (2021) · cites this paper as [79]
Peer victimization moderates the relationship between right anterior insula activation (rejection versus acceptance) and suicide ideation.
“Experience of peer victimization moderates the relationship between right anterior insula activation (rejection versus acceptance) and suicide ideation (80).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [80]
Collectively, neuroimaging studies demonstrate consistent evidence of engagement in subgenual ACC, vlPFC, posterior midline regions, and ventral striatum during social exclusion; paradigms looking at anticipation/receipt of social evaluative feedback additionally elicit responses in amygdala and medial orbitofrontal cortex.
“Collectively, these studies demonstrate consistent evidence of engagement in subgenual ACC (sgACC), vlPFC, posterior midline regions, and ventral striatum (for a meta-analysis, see (124)); the paradigms that look at anticipation/receipt of social evaluative feedback additionally elicit responses in amygdala and medial orbitofrontal cortex.(39,122,123,125)”
From Puberty Initiates Cascading Relationships Between Neurodevelopmental, Social, and Internalizing Processes Across Adolescence (2021) · cites this paper as [124]
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- Authors
- Oppenheimer, C. W., Silk, J. S., Lee, K. H., Dahl, R. E., Forbes, E., Ryan, N., & Ladouceur, C. D.
- Affiliations
- University of Pittsburgh (US)
- Seoul National University (KR)
- University of California, Berkeley (US)
- Corresponding author
- Oppenheimer, Caroline W.
- ORCID
- Venue
- Child Psychiatry & Human Development
- Published
- 2019-08-16
- Volume
- 51
- Issue
- 2
- Pages
- 163-173
- ISSN
- 0009-398X (ISSN-L)
- 1573-3327
- PMC
- PMC7024007
- OpenAlex
- W2967531853
- Cited by
- 55
- References
- 56
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 13 · 2021: 10 · 2020: 9
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Child Psychiatry & Human Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Foundation for the National Institutes of Health (MH091327)
- National Institute of Mental Health (K23MH109850)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Keywords
- suicidal ideation, social rejection, anxiety, adolescents, anterior insula, neural processing, peer victimization, developmental psychopathology, ecological momentary assessment, functional MRI
- MeSH terms
- Ecological Momentary Assessment, Adolescent, Anxiety, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Peer Group, Surveys and Questionnaires, Risk Factors, Psychological Distance, Crime Victims, Bullying, Suicidal Ideation
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