Social reward in youth at risk for depression: a preliminary investigation of subjective and neural differences
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OBJECTIVE: Offspring of depressed parents are at risk for developing depression at rates higher than the general population. One potential mechanism linking parent and offspring depression involves attenuated reward function. Despite the importance of social incentives for adolescents, no previous studies have relied on active social incentive reward paradigms in youth at risk for depression. The present study examined differences in youth self- and parent-report measures of and neural response to social reward between youth of mothers with and those of mothers without a history of depression. METHODS: Imaging data were collected on 10 youth with a depressed parent and 23 youth without depressed parent, which included a task examining neural response to social rewards. Youth and parents also completed self-report measures of social reward. RESULTS: Offspring of depressed parents had lower levels of parent-reported affiliation and reduced neural response to social reward in the ventral striatum and anterior cingulate cortex than offspring of parents without a history of depression. Higher parent-reported affiliation was associated with greater ventral striatal response to social reward. Data suggest that risk status differences in ventral striatal response to social acceptance may be accounted for by affiliation. No differences were found in youth self-reports of behavior. CONCLUSIONS: The results suggest that attenuated response to social reward, assessed through neurobiology and behavior, may be mechanistically linked to the etiology and pathophysiology of depression. Targeting social interest and engagement may be a new direction in preventing the onset of depressive disorders in youth.
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Adolescents with or at high risk for depression show attenuated neural response in the striatum and amygdala to passive social rewards such as happy faces.
“adolescents with or at high risk for depression show attenuated neural response in the striatum and amygdala to passive social rewards, such as happy faces (Monk et al., 2008; Olino et al., 2015)”
From Neural Activation to Parental Praise Interacts With Social Context to Predict Adolescent Depressive Symptoms (2019) · cites this paper as Olino et al., 2015
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Behavioral and psychiatric correlates of brain responses to social feedback
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Understanding the benefits of extrinsic emotion regulation in depression
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An Overview of Machine Learning Applications in Mood Disorders
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Neuroimaging Studies of Effects of Psychotherapy in Depression
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Electrophysiological Biomarkers for Mood Disorders
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Capturing individual differences in social motivation using a novel interactive task
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Targeting Neurodevelopmental Mechanisms in Emotional Disorders Through Intervention
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Neural response to social feedback and internalizing dimensions
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Brain Imaging and the Mechanisms of Antidepressant Action
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Effects of Lithium on Brain Structure in Bipolar Disorder
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Functional Connectome in Bipolar Disorder
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Reward Processing and Risk for Depression Across
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Imaging Genetic and Epigenetic Markers in Mood Disorders
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Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
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Resting-State Functional Connectivity in Unipolar Depression
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- Authors
- Olino, T. M., Silk, J. S., Osterritter, C., & Forbes, E. E.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Corresponding author
- Olino, Thomas M.
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2015-11
- Volume
- 25
- Issue
- 9
- Pages
- 711-721
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- PMC
- PMC4653819
- OpenAlex
- W2122350204
- Cited by
- 122
- References
- 41
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 9 · 2023: 14 · 2022: 13 · 2021: 30 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 10 · 2016: 6
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute of Mental Health (K01MH092603)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- social reward, depression risk, offspring of depressed parents, maternal depression, ventral striatum, anterior cingulate cortex, social affiliation, adolescent depression, depression prevention
- MeSH terms
- Adolescent, Child, Depression, Female, Gyrus Cinguli, Humans, Male, Reward, Social Behavior, Case-Control Studies, Child of Impaired Parents, Ventral Striatum
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