Cited by 122Neural and Behavioral Psychology StudiesChild and Adolescent Psychosocial and Emotional DevelopmentNeurotransmitter Receptor Influence on Behavior

Social reward in youth at risk for depression: a preliminary investigation of subjective and neural differences

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Olino, Thomas M., Silk, Jennifer S., Osterritter, Catherine, Forbes, Erika E.·2015·Journal of Child and Adolescent Psychopharmacology

Abstract

OBJECTIVE: Offspring of depressed parents are at risk for developing depression at rates higher than the general population. One potential mechanism linking parent and offspring depression involves attenuated reward function. Despite the importance of social incentives for adolescents, no previous studies have relied on active social incentive reward paradigms in youth at risk for depression. The present study examined differences in youth self- and parent-report measures of and neural response to social reward between youth of mothers with and those of mothers without a history of depression. METHODS: Imaging data were collected on 10 youth with a depressed parent and 23 youth without depressed parent, which included a task examining neural response to social rewards. Youth and parents also completed self-report measures of social reward. RESULTS: Offspring of depressed parents had lower levels of parent-reported affiliation and reduced neural response to social reward in the ventral striatum and anterior cingulate cortex than offspring of parents without a history of depression. Higher parent-reported affiliation was associated with greater ventral striatal response to social reward. Data suggest that risk status differences in ventral striatal response to social acceptance may be accounted for by affiliation. No differences were found in youth self-reports of behavior. CONCLUSIONS: The results suggest that attenuated response to social reward, assessed through neurobiology and behavior, may be mechanistically linked to the etiology and pathophysiology of depression. Targeting social interest and engagement may be a new direction in preventing the onset of depressive disorders in youth.

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Crossref · 10.1089/cap.2014.0165

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  • Adolescents with or at high risk for depression show attenuated neural response in the striatum and amygdala to passive social rewards such as happy faces.

    “adolescents with or at high risk for depression show attenuated neural response in the striatum and amygdala to passive social rewards, such as happy faces (Monk et al., 2008; Olino et al., 2015)”

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Authors
Olino, T. M., Silk, J. S., Osterritter, C., & Forbes, E. E.
Affiliations
University of Pittsburgh Medical Center (US)
Corresponding author
Olino, Thomas M.
Venue
Journal of Child and Adolescent Psychopharmacology
Published
2015-11
Volume
25
Issue
9
Pages
711-721
ISSN
  • 1044-5463 (ISSN-L)
  • 1557-8992
OpenAlex
W2122350204
Cited by
122
References
41
Citations by year
2026: 7 · 2025: 3 · 2024: 9 · 2023: 14 · 2022: 13 · 2021: 30 · 2020: 10 · 2019: 13 · 2018: 7 · 2017: 10 · 2016: 6
FWCI
4.60
Type
journal article
Language
en
Open access
Locations
  • Journal of Child and Adolescent Psychopharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (UL1TR000005)
  • National Institute of Mental Health (K01MH092603)
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
social reward, depression risk, offspring of depressed parents, maternal depression, ventral striatum, anterior cingulate cortex, social affiliation, adolescent depression, depression prevention
MeSH terms
Adolescent, Child, Depression, Female, Gyrus Cinguli, Humans, Male, Reward, Social Behavior, Case-Control Studies, Child of Impaired Parents, Ventral Striatum

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