Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation
Open accessAbstract
Background Research on the neural correlates associated with risk for suicidal ideation (SI) has been limited, particularly in one increasingly at-risk group-adolescents. Previous research with adolescents indicates that poor emotion regulation skills are linked with SI, but these studies have not previously examined neural activation in service of emotion regulation between those with and without SI histories. Methods Here we examine whether SI is associated with neural responses during an emotion regulation functional magnetic resonance imaging task in a group of adolescents (N = 49) 13 to 20 years of age (mean = 16.95). Results While there were no differences between youths with and without SI in self-reported emotional responses to negative pictures, youths with SI activated the dorsolateral prefrontal cortex more than youths without SI on trials in which they attempted to regulate their emotional responses compared with trials in which they passively viewed negative pictures. In contrast, during passive viewing of negative stimuli, youths with SI activated the dorsolateral prefrontal cortex, temporoparietal junction, and cerebellum less than same-age control subjects. Conclusions These findings were robust to control subjects for depression and adversity exposure and are consistent with the idea that youths with SI have disrupted emotion regulation, potentially related to differences in recruitment of top-down control regions. In contrast, youths without SI activated regions implicated in emotion regulation even when not directed to effortfully control their emotional response. This is the first study to examine neural function during emotion regulation as a potential neural correlate of risk for SI in adolescents.
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We replicated a similar pattern of results in a separate sample of adolescents and in a sample of emerging adults.
“We have replicated a similar pattern of results in a separate sample of adolescents and in a sample of emerging adults (Miller et al. 2018).”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Miller et al. 2018
The Methods (Participants; page unavailable) describe one sample of 49 adolescents, and the Discussion reports differences in neural activation associated with suicidal ideation in that sample. This supports the reference to a similar pattern in adolescents, but the paper does not report a separate sample of emerging adults. (LLM, conf=0.86)
Experimental — accuracy not yet measuredStudies have shown that emotion dysregulation eases the development of suicidal ideation and behavior.
“Accordingly, studies have shown that emotion dysregulation eases the development of suicidal ideation and behavior [15,16,17,18].”
From The Role of Emotion Dysregulation in Understanding Suicide Risk: A Systematic Review of the Literature (2024) · cites this paper as [16]
The paper states that emotion-regulation difficulties are associated with increased risk for suicidal ideation in youth (section labeled Abstract > Conclusions; page unavailable). Its Discussion links disrupted emotion regulation to adolescent ideation, but only suggests that improving regulation could help prevent suicidal behavior. It does not establish that dysregulation causes the development of ideation or behavior. (LLM, conf=0.84)
Experimental — accuracy not yet measuredIn our group's work, youths with a history of suicidal ideation showed decreased dorsolateral prefrontal cortex activation when passively viewing negative stimuli compared with controls.
“work from our group demonstrated that compared with controls, youths with a history of suicidal ideation show decreased dorsolateral PFC activation when passively viewing negative stimuli (Miller et al. 2018)”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Miller et al. 2018
Individuals with a history of suicidal ideation or behavior show altered neural activation and neural network connectivity in prefrontal cortex regions.
“An emerging line of research points to altered neural activation (Just et al. 2017, Miller et al. 2018, Pan et al. 2013, Quevedo et al. 2016) and neural network connectivity (Chase et al. 2017; Ordaz et al. 2018; Zhang et al. 2014, 2016) in PFC regions among individuals with a history of suicidal ideation or behavior.”
From Adolescent Suicide as a Failure of Acute Stress-Response Systems. (2019) · cites this paper as Miller et al. 2018
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Cites
Risk factors for suicidal thoughts and behaviors: A meta-analysis of 50 years of research
Franklin, J. C., Ribeiro, J. D., Fox, K. R., Bentley, K. H., Kleiman, E. M., Huang, X., Musacchio, K. M., Jaroszewski, A. C., Chang, B. P., & Nock, M. K. (2017) · Psychological Bulletin · doi:10.1037/bul0000084 · Cited by 3,784 · cited 1× · see citing works
“Unfortunately, despite years of research on risk factors for suicide, few reliable within-person predictors or successful interventions have been identified (8).”
SHAFFER, D., FISHER, P., LUCAS, C. P., DULCAN, M. K., & SCHWAB-STONE, M. E. (2000) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200001000-00014 · Cited by 3,505 · cited 4× · see citing works
“Past-year depressive symptoms were assessed using the DISC-IV (35).”
InfluentialAssessment of suicidal intention: The Scale for Suicide Ideation.
Beck, A. T., Kovacs, M., & Weissman, A. (1979) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.47.2.343 · Cited by 3,419 · cited 1× · see citing works
“SI was considered present (= 1) for any of the following: a score greater than zero on the Scale for Suicidal Ideation (self-report for past 2 weeks) (34), a response of “yes” to the SI question on the Diagnostic Interview Schedule for Children Version IV (DISC-IV) (past year questions) (35), or a response of “yes” to…”
People thinking about thinking peopleThe role of the temporo-parietal junction in “theory of mind”
Saxe, R., & Kanwisher, N. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00230-1 · Cited by 2,316 · cited 1× · see citing works
“A robust body of literature has linked the TPJ with deciphering others’ mental states or “theory of mind” (51).”
Nipype: A Flexible, Lightweight and Extensible Neuroimaging Data Processing Framework in Python
Gorgolewski, K. J., Burns, C. D., Madison, C. M., Clark, D., Halchenko, Y. O., Waskom, M., & Ghosh, S. (2011) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2011.00013 · Cited by 2,206 · cited 1× · see citing works
“Preprocessing and statistical analysis of functional magnetic resonance imaging data was performed in Nipype (45).”
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113 · cited 4× · see citing works
“Design and contrasts of this task were based on previous literature (30,31).”
InfluentialCognitive Reappraisal of Emotion: A Meta-Analysis of Human Neuroimaging Studies
Buhle, J. T., Silvers, J. A., Wager, T. D., Lopez, R., Onyemekwu, C., Kober, H., Weber, J., & Ochsner, K. N. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht154 · Cited by 1,896 · cited 8× · see citing works
“A recent meta-analysis of studies employing a cognitive reappraisal emotion regulation task (31) concluded that effortful regulation via cognitive reappraisal consistently activates prefrontal control regions including the dorsomedial PFC, dlPFC, and ventrolateral PFC (28).”
InfluentialOchsner, K. N., Silvers, J. A., & Buhle, J. T. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06751.x · Cited by 1,879 · cited 1× · see citing works
“In the context of emotion regulation, it is thought that activation in this region may reflect holding potential reappraisals in mind while examining stimuli (28,29).”
Nock, M. K., Green, J. G., Hwang, I., McLaughlin, K. A., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.55 · Cited by 1,666 · cited 3× · see citing works
“Because we felt it was important to determine whether our results held when controlling for well-known correlates of SI, including depression symptoms (46), age (4), and child maltreatment (47), we controlled for these variables.”
Self-citationValidity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population
BERNSTEIN, D. P., AHLUVALIA, T., POGGE, D., & HANDELSMAN, L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199703000-00012 · Cited by 1,574 · cited 2× · see citing works
“Table 1 presents comparisons between those with and without SI histories including gender, race, parental education, age, scores on the Childhood Trauma Questionnaire, and major depression symptoms.”
The neural basis of the central executive system of working memory
D’Esposito, M., Detre, J. A., Alsop, D. C., Shin, R. K., Atlas, S. W., & Grossman, M. (1995) · Nature · doi:10.1038/378279a0 · Cited by 1,468 · cited 1× · see citing works
“Historically, in this task the dlPFC is implicated in active emotion regulation (28), and in other studies activation of the dlPFC is associated with working memory (50).”
The Enigmatic temporal pole: a review of findings on social and emotional processing
Olson, I. R., Plotzker, A., & Ezzyat, Y. (2007) · Brain · doi:10.1093/brain/awm052 · Cited by 1,370 · see citing works
Nock, M. K., Holmberg, E. B., Photos, V. I., & Michel, B. D. (2007) · Psychological Assessment · doi:10.1037/1040-3590.19.3.309 · Cited by 1,352 · cited 1× · see citing works
“SI was considered present (= 1) for any of the following: a score greater than zero on the Scale for Suicidal Ideation (self-report for past 2 weeks) (34), a response of “yes” to the SI question on the Diagnostic Interview Schedule for Children Version IV (DISC-IV) (past year questions) (35), or a response of “yes” to…”
Ribeiro, J. D., Franklin, J. C., Fox, K. R., Bentley, K. H., Kleiman, E. M., Chang, B. P., & Nock, M. K. (2016) · Psychological Medicine · doi:10.1017/s0033291715001804 · Cited by 1,346 · cited 3× · see citing works
“All three measures have strong psychometric properties and have been used in numerous previous studies with adolescent SI (7,37).”
Mokdad, A. H., Forouzanfar, M. H., Daoud, F., Mokdad, A. A., El Bcheraoui, C., Moradi-Lakeh, M., Kyu, H. H., Barber, R. M., Wagner, J., Cercy, K., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00648-6 · Cited by 984 · see citing works
Youth Risk Behavior Surveillance - United States, 2015.
Kann, L., Mcmanus, T., Harris, W., Shanklin, S., Flint, K., Hawkins, J., Queen, B. E., Lowry, R., Olsen, E., Chyen, D., et al. (2016) · Morbidity and mortality weekly report. Surveillance summaries · doi:10.15585/mmwr.ss6506a1 · Cited by 829 · see citing works
McRae, K., Gross, J. J., Weber, J., Robertson, E. R., Sokol-Hessner, P., Ray, R. D., Gabrieli, J. D. E., & Ochsner, K. N. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr093 · Cited by 655 · cited 1× · see citing works
“These strategies have been used in previous studies (30,31,44).”
Nock, M. K., Wedig, M. M., Holmberg, E. B., & Hooley, J. M. (2007) · Behavior Therapy · doi:10.1016/j.beth.2007.05.005 · Cited by 622 · cited 2× · see citing works
“Given evidence that adolescents with SI exhibit greater self-reported emotional reactivity (9), we hypothesized that adolescents with versus without SI histories would show greater activity in limbic regions when viewing negative stimuli relative to neutral stimuli.”
Mehlum, L., Tørmoen, A. J., Ramberg, M., Haga, E., Diep, L. M., Laberg, S., Larsson, B. S., Stanley, B. H., Miller, A. L., Sund, A. M., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.07.003 · Cited by 616 · cited 1× · see citing works
“Indeed, research from the behavioral literature suggests that during emotional crises, youths with SI demonstrate limited access to emotion regulation (10) and problem-solving (53,54) strategies, but that explicit instruction in emotion regulation, in the form of dialectical behavioral therapy, can mitigate these defi…”
Self-citationSilvers, J. A., McRae, K., Gabrieli, J. D. E., Gross, J. J., Remy, K. A., & Ochsner, K. N. (2012) · Emotion · doi:10.1037/a0028297 · Cited by 522 · cited 3× · see citing works
“Design and contrasts of this task were based on previous literature (30,31).”
Costs of Health Care Use by Women HMO Members With a History of Childhood Abuse and Neglect
Walker, E. A., Unützer, J., Rutter, C. M., Gelfand, A. N., Saunders, K. W., VonKorff, M., Koss, M. P., & Katon, W. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.7.609 · Cited by 442 · cited 1× · see citing works
“Participants completed the Childhood Trauma Questionnaire (41) and were considered to have experienced lifetime maltreatment (= 1) or not (= 0) based on their total score using a validated threshold (42).”
Social and Interpersonal Factors Relating to Adolescent Suicidality: A Review of the Literature
King, C. A., & Merchant, C. R. (2008) · Archives of Suicide Research · doi:10.1080/13811110802101203 · Cited by 441 · cited 1× · see citing works
“Because we felt it was important to determine whether our results held when controlling for well-known correlates of SI, including depression symptoms (46), age (4), and child maltreatment (47), we controlled for these variables.”
Prinstein, M. J., Nock, M. K., Simon, V., Aikins, J. W., Cheah, C. S. L., & Spirito, A. (2008) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.76.1.92 · Cited by 435 · cited 1× · see citing works
“SI is frequently associated with suicidal behavior and suicide death (6,7) and places adolescents at serious risk for premature death.”
Violent Death Rates: The US Compared with Other High-income OECD Countries, 2010
Grinshteyn, E. G., & Hemenway, D. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.10.025 · Cited by 416 · see citing works
Miller, A. B., Esposito-Smythers, C. L., Weismoore, J. T., & Renshaw, K. D. (2013) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-013-0131-5 · Cited by 412 · cited 1× · see citing works
“All three measures have strong psychometric properties and have been used in numerous previous studies with adolescent SI (7,37).”
Self-citationChild Maltreatment and Neural Systems Underlying Emotion Regulation
McLaughlin, K. A., Peverill, M., Gold, A. L., Alves, S., & Sheridan, M. A. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.06.010 · Cited by 409 · cited 6× · see citing works
“Because we and many others observe differences in PFC activation for regulate versus look trials and a decrease in selfreported emotion for regulate relative to look trials across all subjects (28,32), it is unlikely that the observation that control youths activated the dlPFC and TPJ during look trials means that you…”
InfluentialSelf-citationSingle-item measurement of suicidal behaviors: Validity and consequences of misclassification
Millner, A. J., Lee, M. D., & Nock, M. K. (2015) · PLOS ONE · doi:10.1371/journal.pone.0141606 · Cited by 361 · cited 1× · see citing works
“Further, a larger sample of youths with SI will allow examination of differences between passive and active SI [see (57)].”
Emotion dysregulation and vulnerability to suicidal ideation and attempts
Rajappa, K., Gallagher, M., & Miranda, R. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-011-9419-2 · Cited by 251 · cited 4× · see citing works
“Indeed, research from the behavioral literature suggests that during emotional crises, youths with SI demonstrate limited access to emotion regulation (10) and problem-solving (53,54) strategies, but that explicit instruction in emotion regulation, in the form of dialectical behavioral therapy, can mitigate these defi…”
InfluentialJohnston, J. A. Y., Wang, F., Liu, J., Blond, B. N., Wallace, A., Liu, J., Spencer, L., Cox Lippard, E. T., Purves, K. L., Landeros-Weisenberger, A., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15050652 · Cited by 247 · cited 1× · see citing works
“(21) found that youths with a history of suicide attempts have decreased gray matter volume in the orbitofrontal cortex, hippocampus, and cerebellum as well as decreased functional connectivity between the amygdala and left ventral and right rostral prefrontal cortex (PFC) when viewing emotional faces.”
Predicting suicide attempts in young adults with histories of childhood abuse
Brezo, J., Paris, J., Vitaro, F., Hébert, M., Tremblay, R. E., & Turecki, G. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.037994 · Cited by 229 · cited 1× · see citing works
“, depression) and exposure to child adversity (39,40).”
Psychological processes and repeat suicidal behavior: a four-year prospective study
O'Connor, R. C., Smyth, R., Ferguson, E., Ryan, C., & Williams, J. M. G. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0033751 · Cited by 194 · cited 1× · see citing works
“Because we felt it was important to determine whether our results held when controlling for well-known correlates of SI, including depression symptoms (46), age (4), and child maltreatment (47), we controlled for these variables.”
Pisani, A. R., Wyman, P. A., Petrova, M., Schmeelk-Cone, K., Goldston, D. B., Xia, Y., & Gould, M. S. (2013) · Journal of Youth and Adolescence · doi:10.1007/s10964-012-9884-2 · Cited by 183 · see citing works
Pan, L. A., Hassel, S., Segreti, A. M., Nau, S. A., Brent, D. A., & Phillips, M. L. (2013) · Psychological Medicine · doi:10.1017/s0033291712002966 · Cited by 183 · cited 1× · see citing works
“negative relative to positive facial expressions during an emotion perception task (22).”
Association between abnormal default mode network activity and suicidality in depressed adolescents
Zhang, S., Chen, J.-M., Kuang, L., Cao, J., Zhang, H., Ai, M., Wang, W., Zhang, S.-D., Wang, S.-Y., Liu, S.-J., et al. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1047-7 · Cited by 163 · cited 1× · see citing works
“Interestingly, a recent study found increased resting-state connectivity between cerebellum and lingual gyrus of depressed youths with suicide attempt histories (52).”
Esposito, C., & Clum, G. (2002) · Journal of Traumatic Stress · doi:10.1023/a:1014860024980 · Cited by 154 · cited 1× · see citing works
“Indeed, research from the behavioral literature suggests that during emotional crises, youths with SI demonstrate limited access to emotion regulation (10) and problem-solving (53,54) strategies, but that explicit instruction in emotion regulation, in the form of dialectical behavioral therapy, can mitigate these defi…”
McLaughlin, K. A., Sheridan, M. A., Alves, S., & Mendes, W. B. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000098 · Cited by 149 · cited 1× · see citing works
“54; 59% girls) recruited in the context of a larger study examining the effects of childhood maltreatment on development (32,33).”
Self-citationAMYGDALA RESPONSE TO NEGATIVE STIMULI PREDICTS PTSD SYMPTOM ONSET FOLLOWING A TERRORIST ATTACK
McLaughlin, K. A., Busso, D. S., Duys, A., Green, J. G., Alves, S., Way, M., & Sheridan, M. A. (2014) · Depression and Anxiety · doi:10.1002/da.22284 · Cited by 146 · see citing works
Self-citationGrover, K. E., Green, K. L., Pettit, J. W., Monteith, L. L., Garza, M. J., & Venta, A. (2009) · Journal of Clinical Psychology · doi:10.1002/jclp.20632 · Cited by 135 · see citing works
Du, L., Zeng, J., Liu, H., Tang, D., Meng, H., Li, Y., & Fu, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.027 · Cited by 129 · see citing works
Pu, S., Nakagome, K., Yamada, T., Yokoyama, K., Matsumura, H., Yamada, S., Sugie, T., Miura, A., Mitani, H., Iwata, M., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.010 · Cited by 114 · see citing works
Myung, W., Han, C. E., Fava, M., Mischoulon, D., Papakostas, G. I., Heo, J.-Y., Kim, K. W., Kim, S. T., Kim, D. J. H., Kim, D. K., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.110 · Cited by 101 · see citing works
Further evidence of the reliability and validity of the body esteem scale
Franzoi, S. L. (1994) · Journal of Clinical Psychology · doi:10.1002/1097-4679(199403)50:2 · Cited by 99 · see citing works
Preserved hippocampal function during learning in the context of risk in adolescent suicide attempt
Pan, L., Segreti, A., Almeida, J., Jollant, F., Lawrence, N., Brent, D., & Phillips, M. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.07.008 · Cited by 82 · see citing works
Chase, H. W., Segreti, A. M., Keller, T. A., Cherkassky, V. L., Just, M. A., Pan, L. A., & Brent, D. A. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.01.013 · Cited by 78 · see citing works
Minzenberg, M. J., Lesh, T. A., Niendam, T. A., Yoon, J. H., Cheng, Y., Rhoades, R. N., & Carter, C. S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.049 · Cited by 72 · cited 1× · see citing works
“Although an extensive review of these studies is beyond the scope of this article given our focus on adolescent SI, results generally suggest that dysfunction of frontal control regions is commonly associated with histories of SI across samples of adults with recent-onset schizophrenia (11–13), recent-onset major depr…”
Frontal cortex control dysfunction related to long-term suicide risk in recent-onset schizophrenia
Minzenberg, M., Lesh, T. A., Niendam, T. A., Yoon, J. H., Rhoades, R. N., & Carter, C. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.039 · Cited by 52 · see citing works
Khurana, A., & Romer, D. (2012) · Prevention Science · doi:10.1007/s11121-012-0292-3 · Cited by 46 · cited 1× · see citing works
“Unmanageable emotional distress is a common antecedent to SI in youths (24–26) and individuals who report more emotion regulation difficulties are at increased risk for SI even after accounting for depression symptoms (27).”
Wyman, P. A., Gaudieri, P. A., Schmeelk-Cone, K., Cross, W., Brown, C. H., Sworts, L., West, J., Burke, K. C., & Nathan, J. (2009) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-009-9330-4 · Cited by 43 · see citing works
Giletta, M., Hastings, P. D., Rudolph, K. D., Bauer, D. J., Nock, M. K., & Prinstein, M. J. (2016) · Development and Psychopathology · doi:10.1017/s0954579416001218 · Cited by 37 · see citing works
Minzenberg, M., Lesh, T. A., Niendam, T. A., Yoon, J. H., Cheng, Y., Rhoades, R. N., & Carter, C. S. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.002 · Cited by 36 · see citing works
Millner, A. J., Ursano, R. J., Hwang, I. H., King, A. J., Naifeh, J. A., Sampson, N. A., Zaslavsky, A. M., Stein, M. B., Kessler, R. C., Nock, M. K., et al. (2017) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.12363 · Cited by 36 · cited 1× · see citing works
“Given that the transition from thinking about suicide to acting on suicidal thoughts tends to be quite rapid (56), treatment targeting access to automatic emotion regulation strategies could be beneficial in preventing suicidal behavior.”
Minzenberg, M. J., Lesh, T. A., Niendam, T. A., Cheng, Y., & Carter, C. S. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15120422 · Cited by 28 · cited 1× · see citing works
“Although an extensive review of these studies is beyond the scope of this article given our focus on adolescent SI, results generally suggest that dysfunction of frontal control regions is commonly associated with histories of SI across samples of adults with recent-onset schizophrenia (11–13), recent-onset major depr…”
Marchand, W. R. (2011) · Depression Research and Treatment · doi:10.1155/2012/246725 · Cited by 25 · see citing works
Minzenberg, M., Lesh, T. A., Niendam, T. A., Yoon, J. H., Cheng, Y., Rhoades, R. N., & Carter, C. S. (2015) · Crisis · doi:10.1027/0227-5910/a000335 · Cited by 20 · see citing works
Flagged first, then by citations
3 of the 57 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [38]Kaplan ML Asnis GM Sanderson WC Keswani L de Lecuona JM Joseph S 1994 Suicide assessment: Clinical interview vs. self-report J Clin Psychol 50 294 298 8014256
Cited by
Sorted by citations
Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies
Schmaal, L., van Harmelen, A.-L., Chatzi, V., Lippard, E. T. C., Toenders, Y. J., Averill, L. A., Mazure, C. M., & Blumberg, H. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0587-x · Cited by 373 · see citing works
Adolescent Suicide as a Failure of Acute Stress-Response Systems.
Miller, A. B., & Prinstein, M. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095625 · Cited by 235 · see citing works
“An emerging line of research points to altered neural activation (Just et al. 2017, Miller et al. 2018, Pan et al. 2013, Quevedo et al. 2016) and neural network connectivity (Chase et al. 2017; Ordaz et al. 2018; Zhang et al. 2014, 2016) in PFC regions among individuals with a history of suicidal…”
BackgroundResultSelf-citationNeural correlates associated with suicide and nonsuicidal self-injury in youth
Auerbach, R. P., Pagliaccio, D., Allison, G. O., Alqueza, K. L., & Alonso, M. F. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.002 · Cited by 204 · see citing works
“There is, however, reduced activation among ideators during passive viewing of negative stimuli within the right thalamus, left cerebellum/lateral occipital region, right DLPFC, and the right temporal parietal junction (85).”
BackgroundDifficulties in emotion regulation and suicide ideation and attempt in adolescent inpatients
Hatkevich, C., Penner, F., & Sharp, C. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.038 · Cited by 139 · see citing works
“While multimethod research has investigated other markers of emotion regulation (e.g., neural correlates of emotion regulation; Miller et al., 2018) and adolescent suicide-related experiences, no studies have concurrently investigated difficulties in perceived abilities to identify, accept, and regulate affect (as put…”
BackgroundRodman, A. M., Jenness, J. L., Weissman, D. G., Pine, D. S., & McLaughlin, K. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.033 · Cited by 147 · see citing works
“Some studies find affected relative to unaffected individuals to show greater recruitment of frontoparietal regions and heightened amygdala activity during cognitive reappraisal (48,69,73,76), whereas others find affected individuals to show reduced recruitment across prefrontal regions (77,78) or no amygdala differen…”
Self-citationJenness, J. L., Peverill, M., Miller, A. B., Heleniak, C. M., Robertson, M. M., Sambrook, K., Sheridan, M. A., & McLaughlin, K. A. (2020) · Psychological Medicine · doi:10.1017/s0033291720000641 · Cited by 108 · see citing works
“, 2012) and greater dorsolateral PFC recruitment during effortful regulation was found among adolescents reporting suicidal ideation (Miller et al., 2018).”
BackgroundSelf-citationConner, C. M., Golt, J., Righi, G., Shaffer, R., Siegel, M., & Mazefsky, C. A. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04370-1 · Cited by 77 · see citing works
“Given the prevalence of suicidal ideation across diagnoses, it is imperative to identify transdiagnostic risk factors (Miller et al. 2018).”
BackgroundAlarcón, G., Sauder, M., Teoh, J. Y., Forbes, E. E., & Quevedo, K. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.06.036 · Cited by 66 · see citing works
Oppenheimer, C. W., Silk, J. S., Lee, K. H., Dahl, R. E., Forbes, E., Ryan, N., & Ladouceur, C. D. (2020) · Child Psychiatry & Human Development · doi:10.1007/s10578-019-00920-6 · Cited by 55 · see citing works
“Previous studies within the suicide risk literature have focused either on brain function [22, 24], or social factors [32, 59].”
BackgroundCao, J., Ai, M., Chen, X., Chen, J., Wang, W., & Kuang, L. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2019.112713 · Cited by 48 · see citing works
Reduced dorsal striatal gray matter volume predicts implicit suicidal ideation in adolescents
Ho, T. C., Cichocki, A. C., Gifuni, A. J., Catalina Camacho, M., Ordaz, S. J., Singh, M. K., & Gotlib, I. H. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy089 · Cited by 48 · see citing works
Schwartz, J., Ordaz, S. J., Ho, T. C., & Gotlib, I. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.009 · Cited by 46 · see citing works
“For example, focusing on single regions of interest (ROIs), Miller et al. (2018) found that adolescents with SI had less activation in the dorsolateral prefrontal cortex while passively viewing negative emotional stimuli than did adolescents without SI, possibly reflecting a diminished ability to…”
BackgroundVidal-Ribas, P., Janiri, D., Doucet, G. E., Pornpattananangkul, N., Nielson, D. M., Frangou, S., & Stringaris, A. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20020120 · Cited by 45 · see citing works
Li, X., Yu, R., Huang, Q., Chen, X.-L., Ai, M., Zhou, Y., Dai, L., Qin, X., & Kuang, L. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.762343 · Cited by 45 · see citing works
Rogante, E., Cifrodelli, M., Sarubbi, S., Costanza, A., Erbuto, D., Berardelli, I., & Pompili, M. (2024) · Healthcare · doi:10.3390/healthcare12020169 · Cited by 39 · see citing works
Dai, Z., Shao, J., Zhou, H., Chen, Z., Zhang, S., Wang, H., Jiang, H., Yao, Z., & Lü, Q. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110475 · Cited by 38 · see citing works
Flores-Kanter, P. E., García-Batista, Z. E., Moretti, L. S., & Medrano, L. A. (2019) · The Spanish Journal of Psychology · doi:10.1017/sjp.2019.45 · Cited by 40 · see citing works
Swee, G., Shochet, I. M., Cockshaw, W. D., & Hides, L. (2020) · Journal of Youth and Adolescence · doi:10.1007/s10964-020-01301-2 · Cited by 36 · see citing works
Chen, C.-F., Chen, W.-N., & Zhang, B. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00503-x · Cited by 35 · see citing works
Raschle, N. M., Fehlbaum, L. V., Menks, W. M., Martinelli, A., Prätzlich, M., Bernhard, A., Ackermann, K., Freitag, C. M., Brito, S. A. D., Fairchild, G. F., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.003 · Cited by 32 · see citing works
Vieira, R., Faria, A. R., Ribeiro, D., Picó‐Pérez, M., & Bessa, J. M. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110799 · Cited by 34 · see citing works
Dobbertin, M. D., Blair, K. S., Carollo, E., Blair, J., Dominguez, A. J., & Bajaj, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1083244 · Cited by 31 · see citing works
“found that adolescents with suicidal ideation (SUI) showed increased activation in the dorsolateral prefrontal cortex (dlPFC) compared to healthy controls (21).”
BackgroundEffects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review.
Serafini, G., Canepa, G., Aguglia, A., Amerio, A., Bianchi, D., Magnani, L., Dell'Osso, B., Pompili, M., Fitzgerald, P., & Amore, M. (2020) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109981 · Cited by 32 · see citing works
“magnetic resonance imaging task (Miller et al., 2018) in depressed patients.”
BackgroundHo, T. C., Teresi, G. I., Ojha, A., Walker, J. C., Kirshenbaum, J. S., Singh, M. K., & Gotlib, I. H. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.046 · Cited by 30 · see citing works
Ji, X., Zhao, J., Li, H.-H., Pizzagalli, D., Law, S., Lin, P., Fan, L., Zhang, P., Fang, S., Wang, X., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.007 · Cited by 29 · see citing works
Cao, J., Chen, X., Chen, J., Ai, M., Gan, Y., He, J., & Kuang, L. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.567976 · Cited by 29 · see citing works
“Our results are in agreement with several results from previous studies in depressed patients with and without suicide behaviour (25, 30, 44).”
BackgroundResultConnectome-based functional connectivity markers of suicide attempt
Stumps, A. D., Jagger-Rickels, A. C., Rothlein, D., Amick, M. M., Park, H., Evans, T. C., Fortenbaugh, F. C., Fortier, C. B., Fonda, J. R., Lee, D. J., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.061 · Cited by 24 · see citing works
Hatkevich, C. E., Sumlin, E. D., & Sharp, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.630697 · Cited by 27 · see citing works
Li, X., Chen, X., Zhou, Y., Dai, L., Cui, L., Yu, R., Ai, M., Huang, Q., Tian, Y., Mei, M., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12091121 · Cited by 22 · see citing works
“SI is defined as “thoughts about death, dying, plans for suicide, or desire for death” [5,6], it is strongly predictive of death by suicide [7].”
BackgroundEmotion Regulation, Effort and Fatigue: Complex Issues Worth Investigating
Lewczuk, K., Wizła, M., Oleksy, T., & Wyczesany, M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.742557 · Cited by 23 · see citing works
Morese, R., & Longobardi, C. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00713 · Cited by 24 · see citing works
“SI is defined as “thoughts about death, dying, plans for suicide, or desire for death” (Miller et al., 2018; Levi-Belz et al., 2019).”
BackgroundLi, W., Wang, C., Lan, X., Fu, L., Zhang, F., Ye, Y., Liu, H., Zhou, Y., & Ning, Y. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.07.001 · Cited by 23 · see citing works
Translating Interventional Neuroscience to Suicide: It’s About Time
Barredo, J., Bozzay, M. L., Primack, J. M., Schatten, H. T., Armey, M. F., Carpenter, L. L., & Philip, N. S. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.013 · Cited by 19 · see citing works
“DLPFC recruitment also distinguishes depressed adol escents with/without STBs during explicit regulation (80), but not passive tasks (80, 81).”
BackgroundCalcium-binding proteins are altered in the cerebellum in schizophrenia
Vidal-Domènech, F., Alacid, G. R., Pinacho, R., Rodríguez‐Mias, R. A., Vera-Montecinos, A., Monje, A., Ferrer, I., Callado, L. F., Meana, J. J., Villén, J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230400 · Cited by 22 · see citing works
“Some reports have also linked reduced cerebellar activity and reduced grey matter with the ideation of suicide or suicide attempt, respectively [53,54].”
BackgroundEmotion Reactivity and Regulation in Adolescent Girls Following an Interpersonal Rejection
Miller, A. B., Prinstein, M. J., Munier, E., Machlin, L., & Sheridan, M. A. (2018) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01351 · Cited by 23 · see citing works
“, 2017; Ochsner & Gross, 2005) and that adolescent girls are able to successfully engage in this emotion reactivity and regulation task (Miller et al., 2018; Silvers et al., 2015), even when a temporary negative state is introduced via targeted rejection.”
Self-citationTymofiyeva, O., Reeves, K. W., Shaw, C., Lopez, E., Aziz, S., Max, J. E., & Yang, T. T. (2023) · Behavioural Neurology · doi:10.1155/2023/7254574 · Cited by 19 · see citing works
“Among the studies reviewed here, aberrant cerebellum activity during emotion processing tasks has been linked to adolescent suicidal ideation (e.g., [43]) and attempts [19 – 22].”
Lee, K. H., Lee, H. Y., Park, I., Jeon, J. E., Kim, N., Oh, S. M., Jeon, S., Kim, S., Lee, Y. J., & Kim, S. J. (2021) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674211025729 · Cited by 19 · see citing works
“Empirical studies have provided evidence that stress is linked to both physical (e.g. somatic symptoms) and mental health problems (e.g. depressive symptoms) through sleep disturbance (Chang et al., 2019; Mohr et al., 2003).”
BackgroundA Computational Model of Hopelessness and Active-Escape Bias in Suicidality
Karvelis, P., & Diaconescu, A. O. (2022) · Computational Psychiatry · doi:10.5334/cpsy.80 · Cited by 21 · see citing works
Westrupp, E., Macdonald, J., Bennett, C., Havighurst, S., Kehoe, C., Foley, D., Berkowitz, T. S., King, G., & Youssef, G. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038124 · Cited by 15 · see citing works
Bajaj, S., Blair, K., Dobbertin, M., Patil, K., Tyler, P. M., Ringle, J., Bashford-Largo, J., Mathur, A., Elowsky, J., Dominguez, A., et al. (2023) · Discover Mental Health · doi:10.1007/s44192-023-00033-6 · Cited by 14 · see citing works
“…mood regulation (e.g., dorsal-and ventral-lateral prefrontal cortices, orbito-frontal cortex, superior frontal gyrus, and anterior cingulate cortex [9–11]); (b) reduced functional hemodynamic response within the left precentral gyrus during a verbal fluency task [12]; and (c) functional…”
BackgroundDetecting Suicide Ideation in the Era of Social Media: The Population Neuroscience Perspective
Morese, R., Gruebner, O., Sykora, M. D., Elayan, S., Fadda, M., & Albanese, E. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.652167 · Cited by 16 · see citing works
Miller, A. B., Jenness, J. L., Elton, A., Pelletier‐Baldelli, A., Patel, K. K., Bonar, A. S., Martin, S., Dichter, G. S., Giletta, M., Slavich, G. M., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.10.015 · Cited by 20 · see citing works
“We hypothesized that girls with versus without STBs would demonstrate greater activation in the dorsolateral PFC during effortful emotion regulation before the rejection, potentially re fl ecting increased effort to engage explicit cognitive reap-praisal skills (41).”
BackgroundMethodInfluentialSelf-citationFang, S., Law, S., Ji, X., Liu, Q., Zhang, P., Zhong, R., Li, H., Wang, X., Yao, S., & Wang, X. (2023) · European psychiatry · doi:10.1192/j.eurpsy.2023.2444 · Cited by 13 · see citing works
“…research has also found higher DLPFC activation during active regulation of negative emotional scenes in adolescents with suicidal ideation [64], suggesting that suicide ideators may require more top-down emotional regulation from the DLPFC to regulate their negative emotions – such as…”
BackgroundAdvances in Research on Adolescent Suicide and a High Priority Agenda for Future Research
Clayton, M. G., Pollak, O. H., Owens, S., Miller, A. B., & Prinstein, M. J. (2021) · Journal of Research on Adolescence · doi:10.1111/jora.12614 · Cited by 11 · see citing works
“A recent fMRI study of adolescents (n = 49) demonstrated that youth with (vs. without) suicidal ideation histories showed reduced activation in the dorsolateral PFC when passively viewing negative stimuli (Miller et al., 2018).”
Self-citationJanackovski, A., Deane, F. P., & Hains, A. R. (2020) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2536 · Cited by 15 · see citing works
Ehlers, C., Wills, D., Karriker-Jaffe, K., Gilder, D., Phillips, E., & Bernert, R. (2020) · Behavioral Science · doi:10.3390/bs10100154 · Cited by 12 · see citing works
“Activated dorsolateral prefrontal cortex has been demonstrated in fMRI studies of youth that attempted to regulate their emotional responses to negative pictures [143] as well.”
BackgroundLi, X., Chen, X.-L., Yu, R.-Q., Dai, L., Ai, M., Huang, Q., Zhou, Y., Chen, W., Guo, J.-M., Zheng, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.944520 · Cited by 11 · see citing works
“SI is defined as “thoughts of death, dying, plans for suicide, or desire for death” (7, 8), and it is thought to be the first step leading to suicide (3).”
BackgroundAthanassiou, M., Dumais, A., Iammatteo, V., Benedictis, L. D., Dubreucq, J.-L., & Potvin, S. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110253 · Cited by 13 · see citing works
Miller, A. B., & Eisenlohr-Moul, T. A. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00185-2 · Cited by 12 · see citing works
Self-citationShen, Y., Chen, D., Ying, J., Wang, C., & You, J. (2023) · Current Psychology · doi:10.1007/s12144-023-05133-8 · Cited by 8 · see citing works
“Suicidal ideation, defined as thoughts about suicide-related behavior and death (Hatkevich et al., 2019; Nock et al., 2008), is one of the main predictors of suicide (Miller et al., 2018).”
Dhami, P., Lee, J. C., Schwartzmann, B., Knyahnytska, Y., Atluri, S., Christie, G. J., Croarkin, P. E., Blumberger, D. M., Daskalakis, Z. J., Moreno, S., et al. (2022) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2022.100439 · Cited by 6 · see citing works
Oppenheimer, C. W., Bertocci, M. A., Greenberg, T., Chase, H. W., Stiffler, R. S., Aslam, H. A., Lockovich, J., Graur, S., Bebko, G. M., & Phillips, M. L. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111386 · Cited by 11 · see citing works
Dobbertin, M. D., Blair, K. S., Aloi, J. M., Bajaj, S., Bashford‐Largo, J., Mathur, A., Zhang, R., Carollo, E., Schwartz, A., Elowsky, J., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-023-02723-9 · Cited by 7 · see citing works
Berger-Cardoso, J., Brabeck, K. M., Chen, T. A., Bjugstad, A., Mytelka, C., Capps, R., & Crea, T. (2023) · Applied Developmental Science · doi:10.1080/10888691.2023.2251383 · Cited by 8 · see citing works
“Deprivation—the absence of expected inputs from the environment, such as emotional, social, and cognitive stimulation—is the core feature of neglect, institutionalization, and the lack of psychosocial stimulation that often occurs in poverty (Miller et al., 2018).”
InfluentialThe Role of Frontolimbic Network in Suicide: A Descriptive Literature Review of Neuroimaging Studies
Shen, Y., Zhu, J., & Yu, Y. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.10.035 · Cited by 7 · see citing works
Saavedra, C. S. F., Guillén, V., Huenupán, F., Vallejos, C., Henríquez, E., Urrutia, F., Sanhueza, F., & Acuña, E. F. A. (2024) · Journal of Voice · doi:10.1016/j.jvoice.2024.08.006 · Cited by 6 · see citing works
Farfan, C. H. V., & Tafet, G. E. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101002 · Cited by 4 · see citing works
“The precuneus and cuneus, regions crucial for integrating self-referential and emotional information, exhibit greater engagement, implying elevated neural resource demands during self-relevant tasks (Miller et al., 2018; Sugiura, 2015).”
InfluentialJeong, H., Luo, T., Kang, M., Garvey, W. F., Blankenau, G., Suk, J.-W., Tarzaben, M., & Hwang, S. (2024) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2024.111917 · Cited by 6 · see citing works
“Suicidality represents one of the most serious clinical concerns in adolescent depression, with suicide ranking as the second leading cause of death among Americans aged 10 to 24 (Rihmer, 2007; Miller et al., 2018).”
Multimodal neuroimaging and suicidality in a US population-based sample of school-aged childrenPreprint
Vidal‐Ribas, P., Janiri, D., Doucet, G. E., Pornpattananangkul, N., Nielson, D. M., Frangou, S., & Stringaris, A. K. (2019) · medRxiv · doi:10.1101/19013193 · Cited by 5 · see citing works
Liu, S.-J., Qi, Q., Zeng, Z.-H., & Hu, Y.-Q. (2024) · Child and Youth Care Forum · doi:10.1007/s10566-024-09817-5 · Cited by 4 · see citing works
“Suicidal ideation refers to the cognitive emergence of plans, thoughts, or desires related to suicide and death (Miller et al., 2018 ), and it serves as a significant predictor of suicidal behavior(O’Connor, 2011).”
Chase, H. W., Segreti, A. M., Fournier, J. C. J., Phillips, M. L., Brent, D. A., & Pan, L. A. (2019) · Journal of Medical Psychology · doi:10.3233/jmp-180018 · Cited by 4 · see citing works
“In addition, our findings are somewhat consistent with a recent study of emotion regulation in suicidal adolescents [36] in which heightened DLPFC activity was observed in suicidal ideators compared to controls during expli it emotion regulation, but less DLPFC activity was observed during passive viewing.”
Seah, T. H. S., Eckstrand, K., Gupta, T., Marshal, M. P., & Forbes, E. E. (2025) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-025-01296-y · Cited by 3 · see citing works
“Relatedly, dampened TPJ response during viewing of negative emotional pictures has also been observed in a small sample of adolescents 7 with SI and history of victimization (Miller et al., 2018).”
Herber, C. C. L. M., Lott-Sandkamp, L. L., Straub, E., & Tuschen‐Caffier, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-72336-9 · Cited by 4 · see citing works
Schreiner, M. W., Dillahunt, A., Frandsen, S. B., DelDonno, S. R., Schubert, B., Pocius, S. L., Jenkins, L., Kassel, M., Bessette, K. L., Thomas, L. R., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.06.025 · Cited by 3 · see citing works
Emotion Regulation in Daily Life Among Adults With Suicidal Thoughts
Millgram, Y., Coppersmith, D. D. L., Sheppes, G., Fortgang, R. G., Goldenberg, A., & Nock, M. K. (2025) · Clinical Psychological Science · doi:10.1177/21677026251349809 · Cited by 1 · see citing works
“However, based on previous findings (see Jenkins et al., 2025; Kudinova et al., 2016; Miller et al., 2018; Rogier et al., 2024), we expected that people with current suicidal thoughts would experience difficulties in the selection stage of regulation such that they would report using strategies…”
InfluentialFeng, L., Li, S., & Li, C.-R. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119730 · Cited by 2 · see citing works
Dickey, L., Murch, G. B., Pegg, S. L., Dao, A., Venanzi, L., Politte-Corn, M., Abitante, G., & Kujawa, A. (2025) · JAACAP Open · doi:10.1016/j.jaacop.2025.04.008 · Cited by 2 · see citing works
“15,19 The high temporal precision at the scale of milliseconds makes EEG methods particularly bene fi cial for studying SI risk, enabling the ability to capture rapid changes in initial reactivity and subsequent regulation of responses to emotional stimuli.”
Karimi, F., & Zargarshirazi, F. (2024) · Research on Addiction · doi:10.61186/etiadpajohi.17.70.175 · Cited by 2 · see citing works
Euzebio, L. D. C., & Mosmann, C. P. (2023) · Ciencias Psicológicas · doi:10.22235/cp.v17i1.2583 · Cited by 1 · see citing works
“…em adolescentes estão sendo relacionadas com fatores de proteção de saúde mental (Antunes et al., 2018) se forem adaptativas e com ansiedade (Young et al., 2019), depressão (Young et al., 2019) e ideação suicida (Miller et al., 2018), nos casos de déficits na regulação emocional de adolescentes.”
Wang, C., Yang, Y., Jiang, Z., Niu, X., Liu, Y., Jia, X., Lin, L., & Zhang, Y. (2022) · The Journal of Early Adolescence · doi:10.1177/02724316221088754 · Cited by 2 · see citing works
“…with suicidal ideation were not considered in the current study, such as family environment (Low, 2021), school bullying (Wright, 2016), and emotion dysregulation (Miller et al., 2018), limiting the ability to investigate the impact factors of suicidal ideation in adolescents from a broader view.”
BackgroundNeural mechanism of NSSI and comparative study with comorbidities
Deng, X., Chen, N., Wang, D., Zhao, H.-H., & He, W. (2022) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2022.01561 · Cited by 2 · see citing works
“00 00 1v 1 自杀(自杀意念和自杀尝试) Miller et al., 2018 自杀意念组 14 人 对照组 35 人 13~20 fMR; 情绪调节任务 自杀意念组控制脑区异常，背 外侧前额叶激活更强。 Alarcón et al., 2019 自杀尝试组 24 人 自杀意念组 58 人 对照组 38 人 11~18 MRI; 情绪面孔识别 任务 自杀尝试组情绪脑区异常，杏 仁核与前扣带回的连接性更 强。 Iznak et al., 2021 自伤组 21 人 自伤+自杀意念组 24 人 M=18 ERP; Go/Nogo 任务 有自杀意念的被试大脑左半球…”
Walker, J. C., Parker, A. J., Hernandez, B. N., & Wiggins, J. L. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.122091 · Cited by 1 · see citing works
Chen, L., Feng, Y., Wang, Y., Xiong, N.-N., Li, L., & Li, X. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1776388 · Cited by 1 · see citing works
“A large body of theoretical (Law et al., 2015; Heffer and Willoughby, 2018) and empirical research (Miller et al., 2018; Brausch and Woods, 2019) indicates that both general emotion dysregulation and specific emotion regulation problems are linked to increased risk of suicidal ideation.”
Neuroanatomical signatures of suicide attempts in major depressive disorder
Kim, A., Kang, Y., Kang, J. C., & Ham, B. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112192 · Cited by 1 · see citing works
Yin, Q.-L., Tong, S., Chen, Z.-Y., Xu, H.-J., Qian, J., Liang, M., & Liu, T.-S. (2025) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-025-00325-z · Cited by 1 · see citing works
Min, J., Zhu, T., Liu, M., Zhang, J., Yan, T., Zhu, S., Yang, Y., Zhu, X., Yu, R., Huang, Y., et al. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116845 · Cited by 1 · see citing works
Li, S. M., Kobrinsky, V., Irani, K., Sangani, A. N., & Liu, Q. (2025) · Archives of Suicide Research · doi:10.1080/13811118.2025.2560362 · Cited by 1 · see citing works
“Specifically, four studies focused on SI (Dobbertin et al., 2024; Herzog et al., 2025; Miller et al., 2018; Toleson et al., 2024), three focused on SA (Athanassiou et al., 2021; Michel et al., 2024; Silvers et al., 2016), two examined both SI and SA separately (Albanese et al., 2019; Miller et al.,…”
InfluentialBrain network-driven predictive neural markers for suicide risk
Lee, Y., Gilbert, J. R., Fatt, C. C., Stout, J. D., Waldman, L. R., Lamontagne, S. J., Zarate, C. A., & Ballard, E. D. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1950068
Liu, S.-J., Yang, Q., Zeng, Z.-H., & Hu, Y.-Q. (2026) · European Journal of Developmental Psychology · doi:10.1080/17405629.2026.2720636
“Suicidal ideation refers to thoughts, plans, or desires related to suicide (Miller et al., 2018) and has been widely recognized as a robust predictor of suicidal behaviours (O’Connor, 2011).”
Luan, Y., Wang, S., Gao, Y., Kong, Q., Ma, Z., & Luan, C. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1915122
Xu, V. E., Fang, K. K., & Shao, R. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04293-y
“The results were fully replicated after excluding the one study which involved non-clinical samples with and without suicidal ideation [37].”
Differential neural activation during reward processing in preadolescent suicidal ideation.
Parker, A. J., Quam, A. J., Walker, J., Wiggins, J. L., & Dougherty, L. (2026) · Child Psychiatry and Human Development · doi:10.1007/s10578-026-02055-x
Kong, L., Zheng, J.-J., Wu, Y., Zhao, P.-F., Zhou, J., Yu, Y., Zhang, R., Wang, F., & Zhu, R.-X. (2026) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111829
House, A., Toleson, S., Jenkins, K. C., Kreutzer, K. A., Allan, N. P., Phan, K. L., & Gorka, S. (2026) · Journal of Clinical Psychology · doi:10.1002/jclp.70169
“…in emotion‐regulation strategies given explicit instruction, there appear to be autonomic emotion‐regulation deficits that have implications for youth with SI during emotional crises that may impact the transition from thinking about suicide to acting on suicidal thoughts (Miller et al. 2018).”
Chen, X., Chen, J., Ai, M., Hong, S. L., Dai, L., Shen, X., & Kuang, L. (2026) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2026.1811399
“Specifically, SI is defined as “thoughts regarding death, dying, suicide plans, or a desire for death (Miller et al., 2018; Levi-Belz et al., 2019),” and it serves as a robust predictor of death by suicide.”
Ma, Y., Zhou, Y., Fu, H., Lin, X., Huang, M., Zhang, Y., Li, Y., Liu, Y., Zhou, W., Chen, R., et al. (2026) · Annals of General Psychiatry · doi:10.1186/s12991-026-00655-4
“These regions are also implicated in self-harm behaviors [17, 18], suggesting potential shared neurobiological pathways.”
Wang, Y., & Xia, Q. (2026) · Psychology Research and Behavior Management · doi:10.2147/prbm.s602767
“8 The relative imbalance between a more reactive limbic system and a still-developing prefrontal cortex may increase vulnerability to maladaptive cognitive patterns such as rumination, while also making regulatory capacities such as mindfulness particularly salient during this stage.”
Burhunduli, P., Fang, Z., Vandeloo, K. L., Sharmin, F., Blier, P., & Phillips, J. L. (2026) · NeuroImage: Clinical · doi:10.1016/j.nicl.2026.103961
“These associations may reflect the involvement of limbic circuits in processing emotionally salient or autobiographical material influencing suicidal thinking (Miller et al., 2018).”
Zhang, Y., Suo, X., Xu, J., Li, W., Wang, X., Xu, W., Pan, L., Wang, J., & Gao, J. (2026) · BMC Psychology · doi:10.1186/s40359-026-04027-1
“Moreover, these symptoms impair emotional regulation capacity by damaging the function of the prefrontal-limbic circuit, thereby exacer-bating the severity of SI [61, 62].”
Huang, M., Sun, Q., Ma, L., Tian, J., Gao, M., Jiang, Y., Zhou, Y., Cheng, Z., Liu, J., Zhang, Y., et al. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115852
Ma, S., Hu, Y.-Y., Wu, R., Zhou, Y., Liu, X., & Jiang, H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120351
Yuan, Y., Kaiser, S., Patel, K., Brock, P., Parker, A. J., & Wiggins, J. L. (2025) · Developmental Psychobiology · doi:10.1002/dev.70055
- Authors
- Miller, A. B., McLaughlin, K. A., Busso, D. S., Brueck, S., Peverill, M., & Sheridan, M. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Washington (US)
- Harvard University (US)
- Boston College (US)
- Corresponding author
- Miller, Adam Bryant
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 3
- Issue
- 2
- Pages
- 125-132
- ISSN
- 2451-9022 (ISSN-L)
- PMC
- PMC5851479
- OpenAlex
- W2753033900
- Cited by
- 96
- References
- 57
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 8 · 2023: 9 · 2022: 13 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 5
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Charles H. Hood Foundation
- National Institute of Mental Health (F32MH108238, MH103291, MH-092526, L40 MH111017, K01MH092526, R01MH103291, R01MH106482)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- suicidal ideation, adolescents, emotion regulation, neural correlates, dorsolateral prefrontal cortex, top-down control, negative emotional stimuli, temporoparietal junction, cerebellum, passive viewing
- MeSH terms
- Adolescent, Brain, Brain Mapping, Depression, Emotions, Evoked Potentials, Female, Humans, Magnetic Resonance Imaging, Male, Photic Stimulation, Young Adult, Suicidal Ideation
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