Cited by 37Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentNeurotransmitter Receptor Influence on Behavior

Prediction of Preschool Aggression from DRD4 Risk, Parental ADHD Symptoms, and Home Chaos

Farbiash, Tali, Berger, Andrea, Atzaba-Poria, Naama, Auerbach, Judith G.·2014·Journal of Abnormal Child Psychology

Abstract

This study investigated the influence of a child's DRD4 risk, parental levels of ADHD symptoms, and the interactive influence of these factors on the development of preschool aggression. Additionally, the study investigated the role of home chaos as a mediator between parental ADHD symptoms and child aggression. The sample consisted of 84 4.5-year-old children and their parents. Children were genotyped for the DRD4 polymorphism. ADHD symptoms were self-reported by parents when the child was 2 to 6 months old. Parental reports of home chaos and the child's aggression were collected 4 years later. Child's DRD4 risk and parental ADHD symptoms significantly contributed to the prediction of preschool aggression. However, contrary to our hypotheses, no interactions were found between the child's DRD4 risk and the levels of parental ADHD symptoms. Home chaos played a mediating role in the relation between paternal ADHD symptoms and the child's aggression. The relation between maternal ADHD symptoms and the child's aggression was not significantly mediated through the level of home chaos. The current study emphasizes the importance of longitudinally investigating the contribution of parental ADHD symptoms to child aggression, while also exploring the differential contribution of maternal/paternal inattention and hyperactivity-impulsivity symptoms. Moreover, home chaos was found to be a significant environmental mechanism through which paternal ADHD symptoms affect children's aggression in the preschool years.

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Crossref · 10.1007/s10802-013-9791-3

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  • DRD4 7 R was associated with significantly higher aggression than those without 7 R allele (beta=0.21, p < 0.05).

    “DRD4 7 R associated with significantly higher aggression than those without 7 R allele (beta=0.21, p < 0.05)”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Farbiash [79]

  • The larger repeat (7 R or 6-8 R) DRD4 alleles were associated with high aggression in an Italian sample, the Mannheim Study of Children at Risk, and the Ben-Gurion University Infant Developmental Study.

    “The larger repeat (7 R or 6-8 R) alleles were associated with high aggression in an Italian sample [77], the Mannheim Study of Children at Risk study [78], and the Ben-Gurion University Infant Developmental Study [79]”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as [79]

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Authors
Farbiash, T., Berger, A., Atzaba-Poria, N., & Auerbach, J. G.
Affiliations
Ben-Gurion University of the Negev (IL)
Corresponding author
Farbiash, Tali
Venue
Journal of Abnormal Child Psychology
Published
2013-08-09
Volume
42
Issue
3
Pages
489-499
ISSN
  • 0091-0627 (ISSN-L)
  • 1573-2835
OpenAlex
W1997885346
Cited by
37
References
67
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 7
FWCI
3.07
Type
journal article
Language
en
Open access
closed
Locations
  • Research on Child and Adolescent Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
home chaos, mediation, maternal ADHD, inattention, hyperactivity/impulsivity, child aggression, gene-environment interaction, early childhood development
MeSH terms
Adult, Aggression, Attention Deficit Disorder with Hyperactivity, Child Behavior Disorders, Child, Preschool, Female, Genotype, Humans, Longitudinal Studies, Male, Parent-Child Relations, Parents, Polymorphism, Genetic, Social Environment, Child of Impaired Parents, Parenting, Genetic Predisposition to Disease, Receptors, Dopamine D4

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